PMC:7537225 / 2617-4783 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":1147,"end":1153},"obj":"Body_part"},{"id":"T2","span":{"begin":1384,"end":1388},"obj":"Body_part"},{"id":"T3","span":{"begin":1495,"end":1501},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma264279"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma264279"}],"text":"One such factor is the presence (or absence) of other people. To date, most of the existing studies on human isolation and confinement are naturalistic observational studies, such as the SEALAB project (Radloff \u0026 Helmreich, 1968), or the South African National Research station (SANAE) in Antarctica (Vermeulen, 1977). Under these difficult circumstances of a physically and socially restricted environment, participants reported high indices of severe hostility, depression, insomnia, and anxiety. Studies on prisoner populations suggest that social factors can significantly boost prisoner’s well‐being, which can otherwise be disrupted by jail isolation (Kyprianides \u0026 Easterbrook, 2020). The conditions in which participants of the aforementioned studies were put are far from what people are experiencing now. Although being relatively isolated from the outside world, many of us remain within the comfort of our own homes, usually surrounded by friends or relatives. However, there are also people who are getting through this time alone. Living alone has been previously linked to higher indices of depression and anxiety, and other common mental disorders (Jacob et al., 2019). Therefore, those who live alone might experience more stress due to the COVID‐19 situation than those living with people who may be a source of potential support (Cohen \u0026 Wills, 1985). On the other hand, being around others might be stress‐enhancing. Specifically, the company of others can be detrimental to mental health when one is subjected to overcrowding—or, in the current situation—residential or household crowding, highly prevalent in developing countries (Epstein, 1981). Studies suggest that this type of chronic stress is often accompanied by a lack of privacy, a higher number of unwanted social interactions, possible deterioration of relationships with the family or flatmates, and so forth (Fuller et al., 1996). Considering the above, we hypothesise that the relationship between the number of people one is stuck with during isolation is somewhat U‐shaped—those who live alone and those who are subjected to overcrowding experience the highest levels of stress."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":1384,"end":1388},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"}],"text":"One such factor is the presence (or absence) of other people. To date, most of the existing studies on human isolation and confinement are naturalistic observational studies, such as the SEALAB project (Radloff \u0026 Helmreich, 1968), or the South African National Research station (SANAE) in Antarctica (Vermeulen, 1977). Under these difficult circumstances of a physically and socially restricted environment, participants reported high indices of severe hostility, depression, insomnia, and anxiety. Studies on prisoner populations suggest that social factors can significantly boost prisoner’s well‐being, which can otherwise be disrupted by jail isolation (Kyprianides \u0026 Easterbrook, 2020). The conditions in which participants of the aforementioned studies were put are far from what people are experiencing now. Although being relatively isolated from the outside world, many of us remain within the comfort of our own homes, usually surrounded by friends or relatives. However, there are also people who are getting through this time alone. Living alone has been previously linked to higher indices of depression and anxiety, and other common mental disorders (Jacob et al., 2019). Therefore, those who live alone might experience more stress due to the COVID‐19 situation than those living with people who may be a source of potential support (Cohen \u0026 Wills, 1985). On the other hand, being around others might be stress‐enhancing. Specifically, the company of others can be detrimental to mental health when one is subjected to overcrowding—or, in the current situation—residential or household crowding, highly prevalent in developing countries (Epstein, 1981). Studies suggest that this type of chronic stress is often accompanied by a lack of privacy, a higher number of unwanted social interactions, possible deterioration of relationships with the family or flatmates, and so forth (Fuller et al., 1996). Considering the above, we hypothesise that the relationship between the number of people one is stuck with during isolation is somewhat U‐shaped—those who live alone and those who are subjected to overcrowding experience the highest levels of stress."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T13","span":{"begin":464,"end":474},"obj":"Disease"},{"id":"T14","span":{"begin":476,"end":484},"obj":"Disease"},{"id":"T15","span":{"begin":490,"end":497},"obj":"Disease"},{"id":"T17","span":{"begin":1106,"end":1116},"obj":"Disease"},{"id":"T18","span":{"begin":1121,"end":1128},"obj":"Disease"},{"id":"T20","span":{"begin":1147,"end":1163},"obj":"Disease"},{"id":"T22","span":{"begin":1258,"end":1266},"obj":"Disease"}],"attributes":[{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0002050"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0013600"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005618"},{"id":"A16","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0011918"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0002050"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005618"},{"id":"A19","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0011918"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0002025"},{"id":"A21","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0005084"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"One such factor is the presence (or absence) of other people. To date, most of the existing studies on human isolation and confinement are naturalistic observational studies, such as the SEALAB project (Radloff \u0026 Helmreich, 1968), or the South African National Research station (SANAE) in Antarctica (Vermeulen, 1977). Under these difficult circumstances of a physically and socially restricted environment, participants reported high indices of severe hostility, depression, insomnia, and anxiety. Studies on prisoner populations suggest that social factors can significantly boost prisoner’s well‐being, which can otherwise be disrupted by jail isolation (Kyprianides \u0026 Easterbrook, 2020). The conditions in which participants of the aforementioned studies were put are far from what people are experiencing now. Although being relatively isolated from the outside world, many of us remain within the comfort of our own homes, usually surrounded by friends or relatives. However, there are also people who are getting through this time alone. Living alone has been previously linked to higher indices of depression and anxiety, and other common mental disorders (Jacob et al., 2019). Therefore, those who live alone might experience more stress due to the COVID‐19 situation than those living with people who may be a source of potential support (Cohen \u0026 Wills, 1985). On the other hand, being around others might be stress‐enhancing. Specifically, the company of others can be detrimental to mental health when one is subjected to overcrowding—or, in the current situation—residential or household crowding, highly prevalent in developing countries (Epstein, 1981). Studies suggest that this type of chronic stress is often accompanied by a lack of privacy, a higher number of unwanted social interactions, possible deterioration of relationships with the family or flatmates, and so forth (Fuller et al., 1996). Considering the above, we hypothesise that the relationship between the number of people one is stuck with during isolation is somewhat U‐shaped—those who live alone and those who are subjected to overcrowding experience the highest levels of stress."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T10","span":{"begin":103,"end":108},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T11","span":{"begin":358,"end":359},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T12","span":{"begin":1058,"end":1061},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T13","span":{"begin":1318,"end":1319},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":1742,"end":1743},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T15","span":{"begin":1761,"end":1762},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"One such factor is the presence (or absence) of other people. To date, most of the existing studies on human isolation and confinement are naturalistic observational studies, such as the SEALAB project (Radloff \u0026 Helmreich, 1968), or the South African National Research station (SANAE) in Antarctica (Vermeulen, 1977). Under these difficult circumstances of a physically and socially restricted environment, participants reported high indices of severe hostility, depression, insomnia, and anxiety. Studies on prisoner populations suggest that social factors can significantly boost prisoner’s well‐being, which can otherwise be disrupted by jail isolation (Kyprianides \u0026 Easterbrook, 2020). The conditions in which participants of the aforementioned studies were put are far from what people are experiencing now. Although being relatively isolated from the outside world, many of us remain within the comfort of our own homes, usually surrounded by friends or relatives. However, there are also people who are getting through this time alone. Living alone has been previously linked to higher indices of depression and anxiety, and other common mental disorders (Jacob et al., 2019). Therefore, those who live alone might experience more stress due to the COVID‐19 situation than those living with people who may be a source of potential support (Cohen \u0026 Wills, 1985). On the other hand, being around others might be stress‐enhancing. Specifically, the company of others can be detrimental to mental health when one is subjected to overcrowding—or, in the current situation—residential or household crowding, highly prevalent in developing countries (Epstein, 1981). Studies suggest that this type of chronic stress is often accompanied by a lack of privacy, a higher number of unwanted social interactions, possible deterioration of relationships with the family or flatmates, and so forth (Fuller et al., 1996). Considering the above, we hypothesise that the relationship between the number of people one is stuck with during isolation is somewhat U‐shaped—those who live alone and those who are subjected to overcrowding experience the highest levels of stress."}

{"project":"LitCovid-PubTator","denotations":[{"id":"27","span":{"begin":464,"end":474},"obj":"Disease"},{"id":"28","span":{"begin":476,"end":484},"obj":"Disease"},{"id":"29","span":{"begin":490,"end":497},"obj":"Disease"},{"id":"30","span":{"begin":1106,"end":1116},"obj":"Disease"},{"id":"31","span":{"begin":1121,"end":1128},"obj":"Disease"},{"id":"32","span":{"begin":1147,"end":1163},"obj":"Disease"},{"id":"33","span":{"begin":1258,"end":1266},"obj":"Disease"}],"attributes":[{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D000275"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D007319"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D001007"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D000275"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:D001007"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D001523"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"One such factor is the presence (or absence) of other people. To date, most of the existing studies on human isolation and confinement are naturalistic observational studies, such as the SEALAB project (Radloff \u0026 Helmreich, 1968), or the South African National Research station (SANAE) in Antarctica (Vermeulen, 1977). Under these difficult circumstances of a physically and socially restricted environment, participants reported high indices of severe hostility, depression, insomnia, and anxiety. Studies on prisoner populations suggest that social factors can significantly boost prisoner’s well‐being, which can otherwise be disrupted by jail isolation (Kyprianides \u0026 Easterbrook, 2020). The conditions in which participants of the aforementioned studies were put are far from what people are experiencing now. Although being relatively isolated from the outside world, many of us remain within the comfort of our own homes, usually surrounded by friends or relatives. However, there are also people who are getting through this time alone. Living alone has been previously linked to higher indices of depression and anxiety, and other common mental disorders (Jacob et al., 2019). Therefore, those who live alone might experience more stress due to the COVID‐19 situation than those living with people who may be a source of potential support (Cohen \u0026 Wills, 1985). On the other hand, being around others might be stress‐enhancing. Specifically, the company of others can be detrimental to mental health when one is subjected to overcrowding—or, in the current situation—residential or household crowding, highly prevalent in developing countries (Epstein, 1981). Studies suggest that this type of chronic stress is often accompanied by a lack of privacy, a higher number of unwanted social interactions, possible deterioration of relationships with the family or flatmates, and so forth (Fuller et al., 1996). Considering the above, we hypothesise that the relationship between the number of people one is stuck with during isolation is somewhat U‐shaped—those who live alone and those who are subjected to overcrowding experience the highest levels of stress."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T2","span":{"begin":453,"end":462},"obj":"Phenotype"},{"id":"T3","span":{"begin":464,"end":474},"obj":"Phenotype"},{"id":"T4","span":{"begin":476,"end":484},"obj":"Phenotype"},{"id":"T5","span":{"begin":490,"end":497},"obj":"Phenotype"},{"id":"T6","span":{"begin":1106,"end":1116},"obj":"Phenotype"},{"id":"T7","span":{"begin":1121,"end":1128},"obj":"Phenotype"},{"id":"T8","span":{"begin":1789,"end":1808},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0031473"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0000716"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0100785"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0000739"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0000716"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0000739"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0008763"}],"text":"One such factor is the presence (or absence) of other people. To date, most of the existing studies on human isolation and confinement are naturalistic observational studies, such as the SEALAB project (Radloff \u0026 Helmreich, 1968), or the South African National Research station (SANAE) in Antarctica (Vermeulen, 1977). Under these difficult circumstances of a physically and socially restricted environment, participants reported high indices of severe hostility, depression, insomnia, and anxiety. Studies on prisoner populations suggest that social factors can significantly boost prisoner’s well‐being, which can otherwise be disrupted by jail isolation (Kyprianides \u0026 Easterbrook, 2020). The conditions in which participants of the aforementioned studies were put are far from what people are experiencing now. Although being relatively isolated from the outside world, many of us remain within the comfort of our own homes, usually surrounded by friends or relatives. However, there are also people who are getting through this time alone. Living alone has been previously linked to higher indices of depression and anxiety, and other common mental disorders (Jacob et al., 2019). Therefore, those who live alone might experience more stress due to the COVID‐19 situation than those living with people who may be a source of potential support (Cohen \u0026 Wills, 1985). On the other hand, being around others might be stress‐enhancing. Specifically, the company of others can be detrimental to mental health when one is subjected to overcrowding—or, in the current situation—residential or household crowding, highly prevalent in developing countries (Epstein, 1981). Studies suggest that this type of chronic stress is often accompanied by a lack of privacy, a higher number of unwanted social interactions, possible deterioration of relationships with the family or flatmates, and so forth (Fuller et al., 1996). Considering the above, we hypothesise that the relationship between the number of people one is stuck with during isolation is somewhat U‐shaped—those who live alone and those who are subjected to overcrowding experience the highest levels of stress."}

{"project":"LitCovid-sentences","denotations":[{"id":"T26","span":{"begin":0,"end":61},"obj":"Sentence"},{"id":"T27","span":{"begin":62,"end":318},"obj":"Sentence"},{"id":"T28","span":{"begin":319,"end":498},"obj":"Sentence"},{"id":"T29","span":{"begin":499,"end":691},"obj":"Sentence"},{"id":"T30","span":{"begin":692,"end":814},"obj":"Sentence"},{"id":"T31","span":{"begin":815,"end":972},"obj":"Sentence"},{"id":"T32","span":{"begin":973,"end":1044},"obj":"Sentence"},{"id":"T33","span":{"begin":1045,"end":1185},"obj":"Sentence"},{"id":"T34","span":{"begin":1186,"end":1370},"obj":"Sentence"},{"id":"T35","span":{"begin":1371,"end":1436},"obj":"Sentence"},{"id":"T36","span":{"begin":1437,"end":1668},"obj":"Sentence"},{"id":"T37","span":{"begin":1669,"end":1915},"obj":"Sentence"},{"id":"T38","span":{"begin":1916,"end":2166},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"One such factor is the presence (or absence) of other people. To date, most of the existing studies on human isolation and confinement are naturalistic observational studies, such as the SEALAB project (Radloff \u0026 Helmreich, 1968), or the South African National Research station (SANAE) in Antarctica (Vermeulen, 1977). Under these difficult circumstances of a physically and socially restricted environment, participants reported high indices of severe hostility, depression, insomnia, and anxiety. Studies on prisoner populations suggest that social factors can significantly boost prisoner’s well‐being, which can otherwise be disrupted by jail isolation (Kyprianides \u0026 Easterbrook, 2020). The conditions in which participants of the aforementioned studies were put are far from what people are experiencing now. Although being relatively isolated from the outside world, many of us remain within the comfort of our own homes, usually surrounded by friends or relatives. However, there are also people who are getting through this time alone. Living alone has been previously linked to higher indices of depression and anxiety, and other common mental disorders (Jacob et al., 2019). Therefore, those who live alone might experience more stress due to the COVID‐19 situation than those living with people who may be a source of potential support (Cohen \u0026 Wills, 1985). On the other hand, being around others might be stress‐enhancing. Specifically, the company of others can be detrimental to mental health when one is subjected to overcrowding—or, in the current situation—residential or household crowding, highly prevalent in developing countries (Epstein, 1981). Studies suggest that this type of chronic stress is often accompanied by a lack of privacy, a higher number of unwanted social interactions, possible deterioration of relationships with the family or flatmates, and so forth (Fuller et al., 1996). Considering the above, we hypothesise that the relationship between the number of people one is stuck with during isolation is somewhat U‐shaped—those who live alone and those who are subjected to overcrowding experience the highest levels of stress."}