PMC:7537094 / 105437-107270 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":1341,"end":1354},"obj":"Body_part"},{"id":"T3","span":{"begin":1712,"end":1725},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma9825"}],"text":"Yet, the acceptance of advanced age in itself as an indicator of medical futility has to be conclusively established by evidence. Statistical findings of high mortality rates among patients belonging to the highest age groups can merely be reiterative of the high mortality rates among patients with comorbidities ‐‐ elderly patients have a higher likelihood of having more comorbidities. If we overlook this point, the elderly could be exposed to unfair allocation of resources based simply on their age rather than on their having comorbidities that leave them with poor chances of surviving with the use of critical care devices.164 de Castro‐Hamoy, L., \u0026 de Castro, L.D. (2020). Age Matters but it Should not Be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID‐19. Asian Bioethics Review. 12, 331–340. Retrieved August 16, 2020, from https://doi.org/10.1007/s41649‐020‐00130‐6\nAs George Kuchel asserts, “having multiple chronic diseases and frailty is in many ways as or more important than chronological age” and “an 80‐year‐old who is otherwise healthy and not frail might be more resilient in fighting off infection than a 60‐year‐old with many chronic conditions.”165 Begley, S. (2020, March 30). What Explains COVID‐19’s Lethality for the Elderly? Scientists Look to ‘Twilight’ of the Immune System. STAT News. Retrieved April 15, 2020, from https://www.statnews.com/2020/03/30/what‐explains‐coronavirus‐lethality‐for‐elderly/\nIn addition, recent studies have generated optimism about the success of measures to delay or minimize age‐related immunological defects.166 Nikolich‐Žugich, J. (2017). The Twilight of Immunity: Emerging Concepts in Aging of the Immune System. Nature Immunology. 19(1), 10–19. Retrieved August 16, 2020, from https://doi.org/10.1038/s41590‐017‐0006‐x"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T29","span":{"begin":1341,"end":1354},"obj":"Body_part"},{"id":"T30","span":{"begin":1712,"end":1725},"obj":"Body_part"}],"attributes":[{"id":"A29","pred":"uberon_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"Yet, the acceptance of advanced age in itself as an indicator of medical futility has to be conclusively established by evidence. Statistical findings of high mortality rates among patients belonging to the highest age groups can merely be reiterative of the high mortality rates among patients with comorbidities ‐‐ elderly patients have a higher likelihood of having more comorbidities. If we overlook this point, the elderly could be exposed to unfair allocation of resources based simply on their age rather than on their having comorbidities that leave them with poor chances of surviving with the use of critical care devices.164 de Castro‐Hamoy, L., \u0026 de Castro, L.D. (2020). Age Matters but it Should not Be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID‐19. Asian Bioethics Review. 12, 331–340. Retrieved August 16, 2020, from https://doi.org/10.1007/s41649‐020‐00130‐6\nAs George Kuchel asserts, “having multiple chronic diseases and frailty is in many ways as or more important than chronological age” and “an 80‐year‐old who is otherwise healthy and not frail might be more resilient in fighting off infection than a 60‐year‐old with many chronic conditions.”165 Begley, S. (2020, March 30). What Explains COVID‐19’s Lethality for the Elderly? Scientists Look to ‘Twilight’ of the Immune System. STAT News. Retrieved April 15, 2020, from https://www.statnews.com/2020/03/30/what‐explains‐coronavirus‐lethality‐for‐elderly/\nIn addition, recent studies have generated optimism about the success of measures to delay or minimize age‐related immunological defects.166 Nikolich‐Žugich, J. (2017). The Twilight of Immunity: Emerging Concepts in Aging of the Immune System. Nature Immunology. 19(1), 10–19. Retrieved August 16, 2020, from https://doi.org/10.1038/s41590‐017‐0006‐x"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T189","span":{"begin":806,"end":814},"obj":"Disease"},{"id":"T190","span":{"begin":1160,"end":1169},"obj":"Disease"},{"id":"T191","span":{"begin":1266,"end":1274},"obj":"Disease"}],"attributes":[{"id":"A189","pred":"mondo_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A190","pred":"mondo_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A191","pred":"mondo_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Yet, the acceptance of advanced age in itself as an indicator of medical futility has to be conclusively established by evidence. Statistical findings of high mortality rates among patients belonging to the highest age groups can merely be reiterative of the high mortality rates among patients with comorbidities ‐‐ elderly patients have a higher likelihood of having more comorbidities. If we overlook this point, the elderly could be exposed to unfair allocation of resources based simply on their age rather than on their having comorbidities that leave them with poor chances of surviving with the use of critical care devices.164 de Castro‐Hamoy, L., \u0026 de Castro, L.D. (2020). Age Matters but it Should not Be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID‐19. Asian Bioethics Review. 12, 331–340. Retrieved August 16, 2020, from https://doi.org/10.1007/s41649‐020‐00130‐6\nAs George Kuchel asserts, “having multiple chronic diseases and frailty is in many ways as or more important than chronological age” and “an 80‐year‐old who is otherwise healthy and not frail might be more resilient in fighting off infection than a 60‐year‐old with many chronic conditions.”165 Begley, S. (2020, March 30). What Explains COVID‐19’s Lethality for the Elderly? Scientists Look to ‘Twilight’ of the Immune System. STAT News. Retrieved April 15, 2020, from https://www.statnews.com/2020/03/30/what‐explains‐coronavirus‐lethality‐for‐elderly/\nIn addition, recent studies have generated optimism about the success of measures to delay or minimize age‐related immunological defects.166 Nikolich‐Žugich, J. (2017). The Twilight of Immunity: Emerging Concepts in Aging of the Immune System. Nature Immunology. 19(1), 10–19. Retrieved August 16, 2020, from https://doi.org/10.1038/s41590‐017‐0006‐x"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T30","span":{"begin":82,"end":85},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T31","span":{"begin":339,"end":340},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T32","span":{"begin":624,"end":631},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T33","span":{"begin":1175,"end":1176},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T34","span":{"begin":1341,"end":1354},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T35","span":{"begin":1712,"end":1725},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"Yet, the acceptance of advanced age in itself as an indicator of medical futility has to be conclusively established by evidence. Statistical findings of high mortality rates among patients belonging to the highest age groups can merely be reiterative of the high mortality rates among patients with comorbidities ‐‐ elderly patients have a higher likelihood of having more comorbidities. If we overlook this point, the elderly could be exposed to unfair allocation of resources based simply on their age rather than on their having comorbidities that leave them with poor chances of surviving with the use of critical care devices.164 de Castro‐Hamoy, L., \u0026 de Castro, L.D. (2020). Age Matters but it Should not Be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID‐19. Asian Bioethics Review. 12, 331–340. Retrieved August 16, 2020, from https://doi.org/10.1007/s41649‐020‐00130‐6\nAs George Kuchel asserts, “having multiple chronic diseases and frailty is in many ways as or more important than chronological age” and “an 80‐year‐old who is otherwise healthy and not frail might be more resilient in fighting off infection than a 60‐year‐old with many chronic conditions.”165 Begley, S. (2020, March 30). What Explains COVID‐19’s Lethality for the Elderly? Scientists Look to ‘Twilight’ of the Immune System. STAT News. Retrieved April 15, 2020, from https://www.statnews.com/2020/03/30/what‐explains‐coronavirus‐lethality‐for‐elderly/\nIn addition, recent studies have generated optimism about the success of measures to delay or minimize age‐related immunological defects.166 Nikolich‐Žugich, J. (2017). The Twilight of Immunity: Emerging Concepts in Aging of the Immune System. Nature Immunology. 19(1), 10–19. Retrieved August 16, 2020, from https://doi.org/10.1038/s41590‐017‐0006‐x"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T71240","span":{"begin":52,"end":61},"obj":"Chemical"}],"attributes":[{"id":"A27284","pred":"chebi_id","subj":"T71240","obj":"http://purl.obolibrary.org/obo/CHEBI_47867"}],"text":"Yet, the acceptance of advanced age in itself as an indicator of medical futility has to be conclusively established by evidence. Statistical findings of high mortality rates among patients belonging to the highest age groups can merely be reiterative of the high mortality rates among patients with comorbidities ‐‐ elderly patients have a higher likelihood of having more comorbidities. If we overlook this point, the elderly could be exposed to unfair allocation of resources based simply on their age rather than on their having comorbidities that leave them with poor chances of surviving with the use of critical care devices.164 de Castro‐Hamoy, L., \u0026 de Castro, L.D. (2020). Age Matters but it Should not Be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID‐19. Asian Bioethics Review. 12, 331–340. Retrieved August 16, 2020, from https://doi.org/10.1007/s41649‐020‐00130‐6\nAs George Kuchel asserts, “having multiple chronic diseases and frailty is in many ways as or more important than chronological age” and “an 80‐year‐old who is otherwise healthy and not frail might be more resilient in fighting off infection than a 60‐year‐old with many chronic conditions.”165 Begley, S. (2020, March 30). What Explains COVID‐19’s Lethality for the Elderly? Scientists Look to ‘Twilight’ of the Immune System. STAT News. Retrieved April 15, 2020, from https://www.statnews.com/2020/03/30/what‐explains‐coronavirus‐lethality‐for‐elderly/\nIn addition, recent studies have generated optimism about the success of measures to delay or minimize age‐related immunological defects.166 Nikolich‐Žugich, J. (2017). The Twilight of Immunity: Emerging Concepts in Aging of the Immune System. Nature Immunology. 19(1), 10–19. Retrieved August 16, 2020, from https://doi.org/10.1038/s41590‐017‐0006‐x"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":1699,"end":1704},"obj":"http://purl.obolibrary.org/obo/GO_0007568"}],"text":"Yet, the acceptance of advanced age in itself as an indicator of medical futility has to be conclusively established by evidence. Statistical findings of high mortality rates among patients belonging to the highest age groups can merely be reiterative of the high mortality rates among patients with comorbidities ‐‐ elderly patients have a higher likelihood of having more comorbidities. If we overlook this point, the elderly could be exposed to unfair allocation of resources based simply on their age rather than on their having comorbidities that leave them with poor chances of surviving with the use of critical care devices.164 de Castro‐Hamoy, L., \u0026 de Castro, L.D. (2020). Age Matters but it Should not Be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID‐19. Asian Bioethics Review. 12, 331–340. Retrieved August 16, 2020, from https://doi.org/10.1007/s41649‐020‐00130‐6\nAs George Kuchel asserts, “having multiple chronic diseases and frailty is in many ways as or more important than chronological age” and “an 80‐year‐old who is otherwise healthy and not frail might be more resilient in fighting off infection than a 60‐year‐old with many chronic conditions.”165 Begley, S. (2020, March 30). What Explains COVID‐19’s Lethality for the Elderly? Scientists Look to ‘Twilight’ of the Immune System. STAT News. Retrieved April 15, 2020, from https://www.statnews.com/2020/03/30/what‐explains‐coronavirus‐lethality‐for‐elderly/\nIn addition, recent studies have generated optimism about the success of measures to delay or minimize age‐related immunological defects.166 Nikolich‐Žugich, J. (2017). The Twilight of Immunity: Emerging Concepts in Aging of the Immune System. Nature Immunology. 19(1), 10–19. Retrieved August 16, 2020, from https://doi.org/10.1038/s41590‐017‐0006‐x"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1179","span":{"begin":806,"end":814},"obj":"Disease"},{"id":"1182","span":{"begin":1448,"end":1459},"obj":"Species"},{"id":"1183","span":{"begin":1266,"end":1274},"obj":"Disease"},{"id":"1191","span":{"begin":181,"end":189},"obj":"Species"},{"id":"1192","span":{"begin":286,"end":294},"obj":"Species"},{"id":"1193","span":{"begin":325,"end":333},"obj":"Species"},{"id":"1194","span":{"begin":159,"end":168},"obj":"Disease"},{"id":"1195","span":{"begin":264,"end":273},"obj":"Disease"},{"id":"1196","span":{"begin":1160,"end":1169},"obj":"Disease"},{"id":"1197","span":{"begin":1598,"end":1619},"obj":"Disease"}],"attributes":[{"id":"A1179","pred":"tao:has_database_id","subj":"1179","obj":"MESH:C000657245"},{"id":"A1182","pred":"tao:has_database_id","subj":"1182","obj":"Tax:11118"},{"id":"A1183","pred":"tao:has_database_id","subj":"1183","obj":"MESH:C000657245"},{"id":"A1191","pred":"tao:has_database_id","subj":"1191","obj":"Tax:9606"},{"id":"A1192","pred":"tao:has_database_id","subj":"1192","obj":"Tax:9606"},{"id":"A1193","pred":"tao:has_database_id","subj":"1193","obj":"Tax:9606"},{"id":"A1194","pred":"tao:has_database_id","subj":"1194","obj":"MESH:D003643"},{"id":"A1195","pred":"tao:has_database_id","subj":"1195","obj":"MESH:D003643"},{"id":"A1196","pred":"tao:has_database_id","subj":"1196","obj":"MESH:D007239"},{"id":"A1197","pred":"tao:has_database_id","subj":"1197","obj":"MESH:D007153"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Yet, the acceptance of advanced age in itself as an indicator of medical futility has to be conclusively established by evidence. Statistical findings of high mortality rates among patients belonging to the highest age groups can merely be reiterative of the high mortality rates among patients with comorbidities ‐‐ elderly patients have a higher likelihood of having more comorbidities. If we overlook this point, the elderly could be exposed to unfair allocation of resources based simply on their age rather than on their having comorbidities that leave them with poor chances of surviving with the use of critical care devices.164 de Castro‐Hamoy, L., \u0026 de Castro, L.D. (2020). Age Matters but it Should not Be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID‐19. Asian Bioethics Review. 12, 331–340. Retrieved August 16, 2020, from https://doi.org/10.1007/s41649‐020‐00130‐6\nAs George Kuchel asserts, “having multiple chronic diseases and frailty is in many ways as or more important than chronological age” and “an 80‐year‐old who is otherwise healthy and not frail might be more resilient in fighting off infection than a 60‐year‐old with many chronic conditions.”165 Begley, S. (2020, March 30). What Explains COVID‐19’s Lethality for the Elderly? Scientists Look to ‘Twilight’ of the Immune System. STAT News. Retrieved April 15, 2020, from https://www.statnews.com/2020/03/30/what‐explains‐coronavirus‐lethality‐for‐elderly/\nIn addition, recent studies have generated optimism about the success of measures to delay or minimize age‐related immunological defects.166 Nikolich‐Žugich, J. (2017). The Twilight of Immunity: Emerging Concepts in Aging of the Immune System. Nature Immunology. 19(1), 10–19. Retrieved August 16, 2020, from https://doi.org/10.1038/s41590‐017‐0006‐x"}

{"project":"LitCovid-sentences","denotations":[{"id":"T946","span":{"begin":0,"end":129},"obj":"Sentence"},{"id":"T947","span":{"begin":130,"end":388},"obj":"Sentence"},{"id":"T948","span":{"begin":389,"end":682},"obj":"Sentence"},{"id":"T949","span":{"begin":683,"end":815},"obj":"Sentence"},{"id":"T950","span":{"begin":816,"end":839},"obj":"Sentence"},{"id":"T951","span":{"begin":840,"end":852},"obj":"Sentence"},{"id":"T952","span":{"begin":853,"end":927},"obj":"Sentence"},{"id":"T953","span":{"begin":928,"end":1251},"obj":"Sentence"},{"id":"T954","span":{"begin":1252,"end":1303},"obj":"Sentence"},{"id":"T955","span":{"begin":1304,"end":1355},"obj":"Sentence"},{"id":"T956","span":{"begin":1356,"end":1366},"obj":"Sentence"},{"id":"T957","span":{"begin":1367,"end":1482},"obj":"Sentence"},{"id":"T958","span":{"begin":1483,"end":1651},"obj":"Sentence"},{"id":"T959","span":{"begin":1652,"end":1677},"obj":"Sentence"},{"id":"T960","span":{"begin":1678,"end":1726},"obj":"Sentence"},{"id":"T961","span":{"begin":1727,"end":1745},"obj":"Sentence"},{"id":"T962","span":{"begin":1746,"end":1759},"obj":"Sentence"},{"id":"T963","span":{"begin":1760,"end":1833},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Yet, the acceptance of advanced age in itself as an indicator of medical futility has to be conclusively established by evidence. Statistical findings of high mortality rates among patients belonging to the highest age groups can merely be reiterative of the high mortality rates among patients with comorbidities ‐‐ elderly patients have a higher likelihood of having more comorbidities. If we overlook this point, the elderly could be exposed to unfair allocation of resources based simply on their age rather than on their having comorbidities that leave them with poor chances of surviving with the use of critical care devices.164 de Castro‐Hamoy, L., \u0026 de Castro, L.D. (2020). Age Matters but it Should not Be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID‐19. Asian Bioethics Review. 12, 331–340. Retrieved August 16, 2020, from https://doi.org/10.1007/s41649‐020‐00130‐6\nAs George Kuchel asserts, “having multiple chronic diseases and frailty is in many ways as or more important than chronological age” and “an 80‐year‐old who is otherwise healthy and not frail might be more resilient in fighting off infection than a 60‐year‐old with many chronic conditions.”165 Begley, S. (2020, March 30). What Explains COVID‐19’s Lethality for the Elderly? Scientists Look to ‘Twilight’ of the Immune System. STAT News. Retrieved April 15, 2020, from https://www.statnews.com/2020/03/30/what‐explains‐coronavirus‐lethality‐for‐elderly/\nIn addition, recent studies have generated optimism about the success of measures to delay or minimize age‐related immunological defects.166 Nikolich‐Žugich, J. (2017). The Twilight of Immunity: Emerging Concepts in Aging of the Immune System. Nature Immunology. 19(1), 10–19. Retrieved August 16, 2020, from https://doi.org/10.1038/s41590‐017‐0006‐x"}