PMC:7537094 / 100277-102245 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7537094","sourcedb":"PMC","sourceid":"7537094","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7537094","text":"Of interest in this section is the scarcest level. In extreme situations where there are simply not enough resources to accommodate everyone in need, giving protection to the vulnerable could take a backseat as medical vulnerability, in the sense of having comorbidities, could be seen to indicate futility of critical care that includes ventilatory support. An early study showed that for COVID‐19, the Case Fatality Rate (CFR) was elevated among those with preexisting comorbid conditions such as cardiovascular disease, diabetes, chronic respiratory disease, hypertension, and cancer.153 Wu, Z., \u0026 McGoogan, J.M. (2020, February 24). Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID‐19) Outbreak in China: Summary of a Report of 72,314 Cases from the Chinese Center for Disease Control and Prevention. JAMA. Retrieved March 26, 2020, from http://dx.doi.org/10.1001/jama.2020.2648\nAnother study of laboratory‐confirmed cases of COVID‐19 showed that “patients with any comorbidity yielded poorer clinical outcomes than those without” and “a greater number of comorbidities also correlated with poorer clinical outcomes.”154 Guan, W., et al. (2020). Comorbidity and its Impact on 1590 Patients with Covid‐19 in China: a Nationwide Analysis. European Respiratory Journal. Retrieved April 20, 2020, from https://doi.org/10.1183/13993003.00547‐2020\nMoreover, “persons with underlying chronic illnesses are more likely to contract the virus and become severely ill, . . . [while those] with history of hypertension, obesity, chronic lung disease, diabetes, and cardiovascular disease have the worst prognosis and most often end up with deteriorating outcomes such as acute respiratory distress syndrome (ARDS) and pneumonia.”155 Sanyaolu, A., et al. (2020, June 25). Comorbidity and its Impact on Patients with COVID‐19. SN Comprehensive Clinical Medicine. 2, 1–8. 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