PMC:7536954 / 2677-3684
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7536954","sourcedb":"PMC","sourceid":"7536954","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7536954","text":"After 20 weeks of secukinumab therapy (Fig. 1b), improvement of disease severity was observed (IHS4: 8, pain‐NRS: 0/10, and itch‐NRS: 3/10; HidraDisk: 13; DLQI:5; HiSCR: positive). After 24weeks of secukinumab therapy, the patient referred a flu‐like episode initially characterized by diarrhea and then followed by ageusia, anosmia, sinusitis, fever (body temperature \u003e38 °C), asthenia, myalgia, and arthralgia, without cough or dyspnea. Nasopharyngeal swab was performed, as per COVID‐19 surveillance guidelines, resulting positive for SARS‐CoV‐2 on polymerase chain reaction (PCR) assay. Secukinumab was interrupted, and azithromycin was combined with hydroxychloroquine for 2 weeks. COVID‐19‐related symptoms completely resolved after 3 weeks with no worsening of HS manifestations. Two nasopharyngeal swabs with a 48‐hour interval were performed after complete resolution of COVID‐19 symptoms and resulted negative. 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