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PMC:7536954 / 157-1303 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 66-70 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 66-70 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T6 0-24 Disease denotes Hidradenitis suppurativa http://purl.obolibrary.org/obo/MONDO_0006559
T7 26-28 Disease denotes HS http://purl.obolibrary.org/obo/MONDO_0006559
T8 53-78 Disease denotes inflammatory skin disease http://purl.obolibrary.org/obo/MONDO_0006501
T9 66-78 Disease denotes skin disease http://purl.obolibrary.org/obo/MONDO_0005093
T10 260-265 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T11 369-397 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T12 378-397 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T13 399-402 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T14 488-506 Disease denotes drug‐induced lupus http://purl.obolibrary.org/obo/MONDO_0016474
T15 501-506 Disease denotes lupus http://purl.obolibrary.org/obo/MONDO_0004670
T16 543-545 Disease denotes HS http://purl.obolibrary.org/obo/MONDO_0006559
T17 551-554 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T18 662-670 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 708-710 Disease denotes HS http://purl.obolibrary.org/obo/MONDO_0006559
T20 715-718 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T21 733-741 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 742-751 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T23 838-846 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 847-856 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T25 973-981 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 33-34 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 66-70 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T3 66-70 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T4 66-70 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T5 66-70 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T6 66-70 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T7 260-287 http://purl.obolibrary.org/obo/PR_000000134 denotes tumor necrosis factor‐alpha
T8 289-292 http://purl.obolibrary.org/obo/PR_000000134 denotes TNF
T9 419-420 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 452-455 http://purl.obolibrary.org/obo/PR_000000134 denotes TNF
T11 575-580 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T12 778-783 http://purl.obolibrary.org/obo/CLO_0007225 denotes label

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 26-28 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056
T2 151-162 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T3 164-173 Chemical denotes retinoids http://purl.obolibrary.org/obo/CHEBI_26537
T4 282-287 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T5 458-468 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T6 488-492 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T7 543-545 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056
T8 575-580 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T9 708-710 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056
T10 778-783 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T11 812-830 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T12 905-917 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T13 936-954 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
29 260-287 Gene denotes tumor necrosis factor‐alpha Gene:7124
30 288-295 Gene denotes (TNF)‐α Gene:7124
31 452-457 Gene denotes TNF‐α Gene:7124
32 695-702 Species denotes patient Tax:9606
33 164-173 Chemical denotes retinoids MESH:D012176
34 224-234 Chemical denotes adalimumab MESH:D000068879
35 812-830 Chemical denotes hydroxychloroquine MESH:D006886
36 905-917 Chemical denotes azithromycin MESH:D017963
37 936-954 Chemical denotes hydroxychloroquine MESH:D006886
38 0-24 Disease denotes Hidradenitis suppurativa MESH:D017497
39 66-78 Disease denotes skin disease MESH:D012871
40 369-397 Disease denotes systemic lupus erythematosus MESH:D008180
41 399-402 Disease denotes SLE MESH:D008180
42 551-554 Disease denotes SLE MESH:D008180
43 662-670 Disease denotes COVID‐19 MESH:C000657245
44 715-718 Disease denotes SLE MESH:D008180
45 733-741 Disease denotes COVID‐19 MESH:C000657245
46 742-751 Disease denotes infection MESH:D007239
47 838-846 Disease denotes COVID‐19 MESH:C000657245
48 847-856 Disease denotes infection MESH:D007239
49 973-981 Disease denotes COVID‐19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 0-24 Phenotype denotes Hidradenitis suppurativa http://purl.obolibrary.org/obo/HP_0040154
T4 26-28 Phenotype denotes HS http://purl.obolibrary.org/obo/HP_0040154
T5 53-78 Phenotype denotes inflammatory skin disease http://purl.obolibrary.org/obo/HP_0011123
T6 260-265 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T7 333-354 Phenotype denotes autoimmune conditions http://purl.obolibrary.org/obo/HP_0002960
T8 369-397 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T9 399-402 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T10 543-545 Phenotype denotes HS http://purl.obolibrary.org/obo/HP_0040154
T11 551-554 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T12 708-710 Phenotype denotes HS http://purl.obolibrary.org/obo/HP_0040154
T13 715-718 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 266-274 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T2 266-274 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T3 266-274 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T4 266-274 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T4 0-302 Sentence denotes Hidradenitis suppurativa (HS) is a chronic disabling inflammatory skin disease that, in moderate to severe cases, usually requires the use of systemic antibiotics, retinoids, and immunosuppressants/immunomodulants including adalimumab, the first‐approved anti‐tumor necrosis factor‐alpha (TNF)‐α agent.
T5 303-507 Sentence denotes Nevertheless, the presence of autoimmune conditions, particularly systemic lupus erythematosus (SLE), may represent a contraindication to the use of TNF‐α inhibitors due to the risk of drug‐induced lupus.
T6 508-680 Sentence denotes 1 Thus, the unique association of HS with SLE may require the off‐label use of immune‐targeted therapies that is cautiously monitored during the current COVID‐19 pandemic.
T7 681-831 Sentence denotes We report one patient with HS and SLE who developed COVID‐19 infection during treatment with off‐label secukinumab associated with hydroxychloroquine.
T8 832-967 Sentence denotes Since COVID‐19 infection was diagnosed, secukinumab was interrupted, and azithromycin was combined with hydroxychloroquine for 2 weeks.
T9 968-1146 Sentence denotes When COVID‐19‐related symptoms completely resolved, nasopharyngeal swab results were negative and secukinumab therapy was reintroduced after 8 weeks from the last administration.