PMC:7536919 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7536919","sourcedb":"PMC","sourceid":"7536919","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7536919","text":"Peripheral biomarkers’ panel for severe COVID‐19 patients\nD'ALESSANDRO et al.\n\nAbstract\nAbstract\nIt is widely reported in the literature that CD4, CD8 and total T cell count are significantly reduced in critically ill patients with COVID‐19. Few weeks ago, we suggested natural killer (NK) cell count as a marker of severity in 34 hospitalized COVID‐19 patients. On this topic, our research group firstly described a novel potential COVID19 severity marker, Krebs von den Lungen‐6. This study aimed to investigate how a combination of COVID19 severity markers could be helpful in the clinical management of these patients. The combination of these validated, reproducible and non‐expensive bioindicators showed a good accuracy in discriminating between severe and non‐severe patients, suggesting a promising value of this approach in the early prediction of a more aggressive disease phenotype. Despite its monocentric design, our study confirms the reliable dysregulation of innate immune responses, particularly involving NK cells, and suggests that surveillance of a peripheral biomarkers’ panel, including lymphocyte cell counts and KL‐6, may be useful in the clinical management of severe COVID‐19 patients.\nThis article is protected by copyright. All rights reserved.\n\n","divisions":[{"label":"article-title","span":{"begin":0,"end":57}},{"label":"alt-title","span":{"begin":58,"end":77}},{"label":"abstract","span":{"begin":88,"end":1273}},{"label":"title","span":{"begin":88,"end":96}},{"label":"p","span":{"begin":97,"end":1212}},{"label":"p","span":{"begin":1213,"end":1273}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":163,"end":167},"obj":"Body_part"},{"id":"T2","span":{"begin":285,"end":294},"obj":"Body_part"},{"id":"T3","span":{"begin":290,"end":294},"obj":"Body_part"},{"id":"T4","span":{"begin":1024,"end":1032},"obj":"Body_part"},{"id":"T5","span":{"begin":1027,"end":1032},"obj":"Body_part"},{"id":"T6","span":{"begin":1110,"end":1120},"obj":"Body_part"},{"id":"T7","span":{"begin":1121,"end":1125},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":40,"end":48},"obj":"Disease"},{"id":"T2","span":{"begin":232,"end":240},"obj":"Disease"},{"id":"T3","span":{"begin":344,"end":352},"obj":"Disease"},{"id":"T4","span":{"begin":433,"end":440},"obj":"Disease"},{"id":"T5","span":{"begin":535,"end":542},"obj":"Disease"},{"id":"T6","span":{"begin":1194,"end":1202},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":142,"end":145},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T2","span":{"begin":147,"end":150},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T3","span":{"begin":161,"end":167},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T4","span":{"begin":285,"end":294},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T5","span":{"begin":304,"end":305},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":328,"end":330},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T7","span":{"begin":415,"end":416},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":518,"end":519},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9","span":{"begin":711,"end":712},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T10","span":{"begin":796,"end":797},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T11","span":{"begin":858,"end":859},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T12","span":{"begin":1024,"end":1032},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T13","span":{"begin":1068,"end":1069},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":1121,"end":1125},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"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