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PMC:7536913 / 10473-11498 JSONTXT

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LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T29 134-181 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T30 134-167 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T31 183-187 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T54 102-105 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T55 409-410 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T56 547-549 http://purl.obolibrary.org/obo/CLO_0008935 denotes S9
T57 814-815 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 924-931 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T7 23-27 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T8 943-947 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
92 134-181 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
93 315-323 Species denotes patients Tax:9606
94 1009-1017 Species denotes patients Tax:9606
95 183-192 Species denotes SARS‐CoV2 Tax:2697049
96 543-546 Disease denotes ICH MESH:D002543
97 846-849 Disease denotes ICH MESH:D002543

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T5 670-678 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T70 0-324 Sentence denotes The global support for drug and vaccine development, including streamlining nonclinical requirements, has allowed candidates, such as severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2) antibodies, to move quickly into the clinic to most efficiently determine if the experimental treatment is effective for patients.
T71 325-542 Sentence denotes The practice of deferring or eliminating certain preclinical studies while there is a degree of uncertainty in the experimental candidate for specific life‐threatening illnesses with no effective treatment is not new.
T72 543-691 Sentence denotes ICH S9 Guideline “Nonclinical Evaluation for Anticancer Pharmaceuticals” provides for such regulatory flexibility for advanced oncology indications.
T73 692-850 Sentence denotes We encourage regulators to apply this approach to other life‐threatening illnesses across therapeutic areas, and to model a global harmonized approach as ICH.
T74 851-1025 Sentence denotes The benefits to society could be significant—by reducing the need to use animals, modernize drug development, and potentially make new therapies available to patients faster.