PMC:7534795 / 62648-63906
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T252 | 769-775 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T253 | 1069-1076 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T254 | 1082-1093 | Body_part | denotes | Interleukin | http://purl.org/sig/ont/fma/fma86578 |
| T255 | 1102-1119 | Body_part | denotes | Mitochondrial DNA | http://purl.org/sig/ont/fma/fma67199 |
| T256 | 1116-1119 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T257 | 1144-1154 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T90 | 769-775 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T425 | 76-84 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T426 | 363-379 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T427 | 802-814 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
| T428 | 950-962 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T429 | 989-997 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T430 | 1213-1218 | Disease | denotes | Tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T374 | 87-88 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T375 | 202-203 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T376 | 407-415 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T377 | 458-468 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T378 | 688-693 | http://purl.obolibrary.org/obo/CLO_0037161 | denotes | (E) N |
| T379 | 911-912 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T380 | 1213-1240 | http://purl.obolibrary.org/obo/PR_000000134 | denotes | Tumor necrosis factor alpha |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T80175 | 52-57 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T24234 | 94-99 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T7018 | 209-214 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T98746 | 324-329 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T70497 | 530-535 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T32324 | 696-701 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T84667 | 710-721 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T12453 | 785-790 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T24148 | 860-872 | Chemical | denotes | triglyceride | http://purl.obolibrary.org/obo/CHEBI_17855 |
| T15454 | 896-901 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T67393 | 1004-1015 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T14430 | 1040-1051 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T31050 | 1069-1076 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T10144 | 1078-1080 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T4756 | 1116-1119 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T24904 | 1121-1125 | Chemical | denotes | PUFA | http://purl.obolibrary.org/obo/CHEBI_26208|http://purl.obolibrary.org/obo/CHEBI_76567 |
| T70192 | 1132-1154 | Chemical | denotes | unsaturated fatty acid | http://purl.obolibrary.org/obo/CHEBI_27208 |
| T55358 | 1144-1154 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T92131 | 1150-1154 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T82150 | 1156-1159 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T62728 | 1161-1184 | Chemical | denotes | Reactive oxygen species | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T4591 | 1170-1176 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T61931 | 1235-1240 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T3853 | 1242-1244 | Chemical | denotes | TX | http://purl.obolibrary.org/obo/CHEBI_26995 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T110 | 124-140 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T111 | 299-314 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T112 | 363-379 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T113 | 950-962 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T114 | 1219-1227 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T115 | 1219-1227 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T116 | 1219-1227 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T117 | 1219-1227 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T474 | 0-998 | Sentence | denotes | Fig. 2 Potential cardioprotective mechanisms of n-3 PUFAs in the setting of COVID-19. (A) N-3 PUFAs ameliorate uncontrolled immune responses and exert anti-inflammatory effects via several mechanisms. (B) N-3 PUFAs attenuate the vicious cycle/interaction of mitochondrial dysfunction and aggravated immune response. (C) N-3 PUFAs have the capability to attenuate viral infections via both direct effects on membrane integrity and indirect mechanisms through activating the humoral response to decrease overall viral load. (D) N-3 PUFAs have the ability to regulate the RAAS system in the favor of the vasodilatory, the anti-inflammatory and the cardioprotective ACE2/Ang (1–7) effectors. (E) N-3 PUFAs enhance antioxidant capacity and attenuate oxidative stress in the tissue. (F) N-3 PUFAs ameliorate coagulopathy by exerting anti-thrombotic effects. (G) The triglyceride-lowering effect of n-3 PUFAs may play a key role in blunting the exaggerated inflammation observed in patients with COVID-19. |
| T475 | 999-1258 | Sentence | denotes | ACE, Angiotensin-converting enzyme; Ang, Angiotensin; CRP, C-reactive protein; IL, Interleukin; mtDNA, Mitochondrial DNA; PUFA, Poly unsaturated fatty acid; ROS, Reactive oxygen species; TGs, Triglycerides; TNF-α, Tumor necrosis factor alpha; TX, Thromboxane. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T200 | 258-283 | Phenotype | denotes | mitochondrial dysfunction | http://purl.obolibrary.org/obo/HP_0003287 |
| T201 | 745-761 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T202 | 802-814 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
| T203 | 1213-1218 | Phenotype | denotes | Tumor | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1848 | 662-666 | Gene | denotes | ACE2 | Gene:59272 |
| 1849 | 999-1002 | Gene | denotes | ACE | Gene:1636 |
| 1850 | 1004-1033 | Gene | denotes | Angiotensin-converting enzyme | Gene:1636 |
| 1851 | 1035-1038 | Gene | denotes | Ang | Gene:283 |
| 1852 | 1053-1056 | Gene | denotes | CRP | Gene:1401 |
| 1853 | 1058-1076 | Gene | denotes | C-reactive protein | Gene:1401 |
| 1854 | 1121-1125 | Gene | denotes | PUFA | Gene:9933 |
| 1855 | 1206-1211 | Gene | denotes | TNF-α | Gene:7124 |
| 1856 | 1213-1240 | Gene | denotes | Tumor necrosis factor alpha | Gene:7124 |
| 1857 | 975-983 | Species | denotes | patients | Tax:9606 |
| 1858 | 90-99 | Chemical | denotes | N-3 PUFAs | MESH:D015525 |
| 1859 | 205-214 | Chemical | denotes | N-3 PUFAs | MESH:D015525 |
| 1860 | 526-535 | Chemical | denotes | N-3 PUFAs | MESH:D015525 |
| 1861 | 692-701 | Chemical | denotes | N-3 PUFAs | MESH:D015525 |
| 1862 | 781-790 | Chemical | denotes | N-3 PUFAs | MESH:D015525 |
| 1863 | 860-872 | Chemical | denotes | triglyceride | MESH:D014280 |
| 1864 | 1127-1154 | Chemical | denotes | Poly unsaturated fatty acid | MESH:D005231 |
| 1865 | 1156-1159 | Chemical | denotes | ROS | MESH:D017382 |
| 1866 | 1161-1184 | Chemical | denotes | Reactive oxygen species | MESH:D017382 |
| 1867 | 1186-1189 | Chemical | denotes | TGs | MESH:C026285 |
| 1868 | 1191-1204 | Chemical | denotes | Triglycerides | MESH:D014280 |
| 1869 | 1246-1257 | Chemical | denotes | Thromboxane | MESH:D013931 |
| 1870 | 76-84 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1871 | 258-283 | Disease | denotes | mitochondrial dysfunction | MESH:D028361 |
| 1872 | 363-379 | Disease | denotes | viral infections | MESH:D001102 |
| 1873 | 802-814 | Disease | denotes | coagulopathy | MESH:D001778 |
| 1874 | 950-962 | Disease | denotes | inflammation | MESH:D007249 |
| 1875 | 989-997 | Disease | denotes | COVID-19 | MESH:C000657245 |