PMC:7534795 / 60677-61675 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7534795","sourcedb":"PMC","sourceid":"7534795","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7534795","text":"lerotic plaques and reducing the incidence of thrombus formation (Plutzky, 1999; Thies et al., 2003). Furthermore, n-3 PUFAs can enrich cell membranes and alter the lipid raft structure and function leading to improved organelle and cellular function (Din et al., 2008), autonomic tone (Abuissa, O'Keefe Jr., Harris, \u0026 Lavie, 2005; O'Keefe Jr., Abuissa, Sastre, Steinhaus, \u0026 Harris, 2006), elevated arrhythmic thresholds (Anand, Alkadri, Lavie, \u0026 Milani, 2008) and ameliorating hypertension (Geleijnse, Giltay, Grobbee, Donders, \u0026 Kok, 2002; O'Keefe Jr. et al., 2006). Importantly, several experimental, clinical and epidemiological studies hypothesize that the cardioprotective effects of n-3 PUFAs and their metabolites are attributed mainly to their immunomodulatory properties. Notably, emerging evidence demonstrates the ability of n-3 PUFAs to reduce circulating levels of inflammatory chemokines, cytokines, and the pro-inflammatory metabolites derived from n-6 PUFAs (Calder, 2013, Calder, 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