PMC:7534795 / 13422-15208
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T3398 | 111-116 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T88788 | 185-197 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T22811 | 185-189 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T77558 | 347-356 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T39426 | 359-367 | Body_part | denotes | Cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T46176 | 547-556 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T75133 | 558-562 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T75911 | 633-639 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T73994 | 867-893 | Body_part | denotes | sympathetic nervous system | http://purl.org/sig/ont/fma/fma9906 |
| T29906 | 1152-1160 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T7234 | 1382-1392 | Body_part | denotes | Fibroblast | http://purl.org/sig/ont/fma/fma63877 |
| T47304 | 1412-1423 | Body_part | denotes | Interleukin | http://purl.org/sig/ont/fma/fma86578 |
| T54282 | 1449-1457 | Body_part | denotes | Monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T42464 | 1474-1481 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T97113 | 1545-1550 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T66341 | 1597-1604 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T21 | 633-639 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T22 | 867-893 | Body_part | denotes | sympathetic nervous system | http://purl.obolibrary.org/obo/UBERON_0000013 |
| T23 | 879-893 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T128 | 24-32 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T129 | 73-77 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T130 | 216-224 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T131 | 245-251 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T132 | 422-430 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T133 | 661-669 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T134 | 680-689 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T135 | 909-918 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T136 | 1070-1078 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T137 | 1080-1088 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T138 | 1199-1216 | Disease | denotes | venous thrombosis | http://purl.obolibrary.org/obo/MONDO_0008559 |
| T139 | 1206-1216 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T140 | 1236-1244 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T141 | 1315-1321 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T142 | 1650-1658 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T143 | 1662-1699 | Disease | denotes | Severe and acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T144 | 1720-1725 | Disease | denotes | Tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T59769 | 111-116 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T86299 | 185-189 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T49434 | 516-526 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T83084 | 571-573 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T87274 | 793-801 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T44105 | 849-859 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T34660 | 1010-1011 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T93838 | 1186-1194 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
| T73015 | 1186-1194 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
| T80406 | 1382-1392 | http://purl.obolibrary.org/obo/CL_0000057 | denotes | Fibroblast |
| T16585 | 1449-1457 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | Monocyte |
| T3991 | 1488-1489 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T1452 | 1533-1542 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T62771 | 1543-1550 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B-cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T96 | 384-386 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T98 | 558-560 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T100 | 568-570 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T102 | 604-606 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T104 | 774-777 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T105 | 1035-1037 | Chemical | denotes | O2 | http://purl.obolibrary.org/obo/CHEBI_15379 |
| T106 | 1329-1340 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T107 | 1368-1375 | Chemical | denotes | Calcium | http://purl.obolibrary.org/obo/CHEBI_22984 |
| T108 | 1408-1410 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T110 | 1442-1445 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
| T112 | 1474-1481 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T113 | 1485-1487 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T116 | 1597-1604 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T117 | 1608-1610 | Chemical | denotes | O2 | http://purl.obolibrary.org/obo/CHEBI_15379 |
| T118 | 1612-1618 | Chemical | denotes | Oxygen | http://purl.obolibrary.org/obo/CHEBI_15379 |
| T119 | 1620-1623 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T120 | 1625-1648 | Chemical | denotes | Reactive oxygen species | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T121 | 1634-1640 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T29310 | 289-305 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T28779 | 449-471 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune response |
| T84577 | 456-471 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T84552 | 752-763 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T31599 | 928-944 | http://purl.obolibrary.org/obo/GO_0042310 | denotes | vasoconstriction |
| T74952 | 1152-1172 | http://purl.obolibrary.org/obo/GO_0070527 | denotes | platelet aggregation |
| T61815 | 1393-1399 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T64045 | 1726-1734 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T41562 | 1726-1734 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T38342 | 1726-1734 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T85159 | 1726-1734 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T12536 | 1772-1778 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T84 | 73-198 | Sentence | denotes | SARS-Cov-2 may be taken up by cardiac cells using different routes, such as via ACE2 receptors expressed on the cell surface. |
| T85 | 199-421 | Sentence | denotes | Following entry, SARS-CoV-2 may exert cardiac injury by direct action and/or induction of immune responses resulting in release of pro-inflammatory cytokines (‘Cytokine storm’) such as IL, TNF-α, INF-γ, FGF, MCP1 and VEGF. |
| T86 | 422-660 | Sentence | denotes | SARS-CoV-2 can trigger the innate immune response involving NLRP3 inflammasomes which lead to activation of pro-inflammatory cytokines, IL-1β and IL-18 and the inflammatory cascade (IL-6 and TNF-α) resulting in tissue damage and fibrosis. |
| T87 | 661-848 | Sentence | denotes | SARS-CoV-2-induced pneumonia results in the development of hypoxemia which can impair Ca2+ homeostasis, increase ROS production and activate NLRP3 inflammasomes leading to cardiac damage. |
| T88 | 849-993 | Sentence | denotes | Activation of the sympathetic nervous system in response to pneumonia leads to vasoconstriction and tachycardia compromising coronary perfusion. |
| T89 | 994-1079 | Sentence | denotes | This results in a mismatch of myocardial O2 demand and supply precipitating ischemia. |
| T90 | 1080-1217 | Sentence | denotes | SARS-CoV-2 can destabilize coronary atherosclerotic plaques and mediate platelet aggregation resulting in arterial and venous thrombosis. |
| T91 | 1218-1322 | Sentence | denotes | Altogether, these SARS-CoV-2 mediated effects may be contributing to the observed cardiovascular injury. |
| T92 | 1323-1786 | Sentence | denotes | ACE2, Angiotensin-converting enzyme-2; Ca2+, Calcium; FGF, Fibroblast growth factor; IL, Interleukin; INF, Interferon; MCP-1, Monocyte chemoattractant protein-1; NFκB, Nuclear factor kappa-light-chain enhancer activated B-cells; NLRP3, NACHT, LRR and PYD domains-containing protein 3; O2, Oxygen; ROS, Reactive oxygen species; SARS-CoV-2, Severe and acute respiratory syndrome coronavirus; TNF-α, Tumor necrosis factor-α; VEGF, Vascular endothelial growth factor. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T66 | 359-373 | Phenotype | denotes | Cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T67 | 680-689 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T68 | 720-729 | Phenotype | denotes | hypoxemia | http://purl.obolibrary.org/obo/HP_0012418 |
| T69 | 765-788 | Phenotype | denotes | increase ROS production | http://purl.obolibrary.org/obo/HP_0025464 |
| T70 | 909-918 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T71 | 949-960 | Phenotype | denotes | tachycardia | http://purl.obolibrary.org/obo/HP_0001649 |
| T72 | 1199-1216 | Phenotype | denotes | venous thrombosis | http://purl.obolibrary.org/obo/HP_0004936 |
| T73 | 1720-1725 | Phenotype | denotes | Tumor | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 465 | 153-157 | Gene | denotes | ACE2 | Gene:59272 |
| 466 | 388-393 | Gene | denotes | TNF-α | Gene:7124 |
| 467 | 407-411 | Gene | denotes | MCP1 | Gene:6347 |
| 468 | 416-420 | Gene | denotes | VEGF | Gene:7422 |
| 469 | 482-487 | Gene | denotes | NLRP3 | Gene:114548 |
| 470 | 558-563 | Gene | denotes | IL-1β | Gene:3552 |
| 471 | 568-573 | Gene | denotes | IL-18 | Gene:3606 |
| 472 | 604-608 | Gene | denotes | IL-6 | Gene:3569 |
| 473 | 613-618 | Gene | denotes | TNF-α | Gene:7124 |
| 474 | 802-807 | Gene | denotes | NLRP3 | Gene:114548 |
| 475 | 1323-1327 | Gene | denotes | ACE2 | Gene:59272 |
| 476 | 1329-1360 | Gene | denotes | Angiotensin-converting enzyme-2 | Gene:59272 |
| 477 | 1442-1447 | Gene | denotes | MCP-1 | Gene:6347 |
| 478 | 1449-1483 | Gene | denotes | Monocyte chemoattractant protein-1 | Gene:6347 |
| 479 | 1552-1557 | Gene | denotes | NLRP3 | Gene:114548 |
| 480 | 1559-1606 | Gene | denotes | NACHT, LRR and PYD domains-containing protein 3 | Gene:114548 |
| 481 | 1713-1718 | Gene | denotes | TNF-α | Gene:7124 |
| 482 | 1720-1743 | Gene | denotes | Tumor necrosis factor-α | Gene:7124 |
| 483 | 1745-1749 | Gene | denotes | VEGF | Gene:7422 |
| 484 | 1751-1785 | Gene | denotes | Vascular endothelial growth factor | Gene:7422 |
| 485 | 24-34 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 486 | 73-83 | Species | denotes | SARS-Cov-2 | Tax:2697049 |
| 487 | 216-226 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 488 | 422-432 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 489 | 661-671 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 490 | 1080-1090 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 491 | 1236-1246 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 492 | 1650-1660 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 493 | 1700-1711 | Species | denotes | coronavirus | Tax:11118 |
| 494 | 747-751 | Chemical | denotes | Ca2+ | MESH:D000069285 |
| 495 | 774-777 | Chemical | denotes | ROS | MESH:D017382 |
| 496 | 1035-1037 | Chemical | denotes | O2 | MESH:D010100 |
| 497 | 43-71 | Disease | denotes | cardiovascular complications | MESH:D002318 |
| 498 | 237-251 | Disease | denotes | cardiac injury | MESH:D006331 |
| 499 | 651-659 | Disease | denotes | fibrosis | MESH:D005355 |
| 500 | 680-689 | Disease | denotes | pneumonia | MESH:D011014 |
| 501 | 720-729 | Disease | denotes | hypoxemia | MESH:D000860 |
| 502 | 833-847 | Disease | denotes | cardiac damage | MESH:D006331 |
| 503 | 909-918 | Disease | denotes | pneumonia | MESH:D011014 |
| 504 | 949-960 | Disease | denotes | tachycardia | MESH:D013610 |
| 505 | 1070-1078 | Disease | denotes | ischemia | MESH:D007511 |
| 506 | 1107-1139 | Disease | denotes | coronary atherosclerotic plaques | MESH:D003324 |
| 507 | 1152-1172 | Disease | denotes | platelet aggregation | MESH:D001791 |
| 508 | 1199-1216 | Disease | denotes | venous thrombosis | MESH:D020246 |
| 509 | 1300-1321 | Disease | denotes | cardiovascular injury | MESH:D002318 |