PMC:7534795 / 13415-15208
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T3398 | 118-123 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T88788 | 192-204 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T22811 | 192-196 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T77558 | 354-363 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T39426 | 366-374 | Body_part | denotes | Cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T46176 | 554-563 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T75133 | 565-569 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T75911 | 640-646 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T73994 | 874-900 | Body_part | denotes | sympathetic nervous system | http://purl.org/sig/ont/fma/fma9906 |
| T29906 | 1159-1167 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T7234 | 1389-1399 | Body_part | denotes | Fibroblast | http://purl.org/sig/ont/fma/fma63877 |
| T47304 | 1419-1430 | Body_part | denotes | Interleukin | http://purl.org/sig/ont/fma/fma86578 |
| T54282 | 1456-1464 | Body_part | denotes | Monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T42464 | 1481-1488 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T97113 | 1552-1557 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T66341 | 1604-1611 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T21 | 640-646 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T22 | 874-900 | Body_part | denotes | sympathetic nervous system | http://purl.obolibrary.org/obo/UBERON_0000013 |
| T23 | 886-900 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T128 | 31-39 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T129 | 80-84 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T130 | 223-231 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T131 | 252-258 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T132 | 429-437 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T133 | 668-676 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T134 | 687-696 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T135 | 916-925 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T136 | 1077-1085 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T137 | 1087-1095 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T138 | 1206-1223 | Disease | denotes | venous thrombosis | http://purl.obolibrary.org/obo/MONDO_0008559 |
| T139 | 1213-1223 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T140 | 1243-1251 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T141 | 1322-1328 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T142 | 1657-1665 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T143 | 1669-1706 | Disease | denotes | Severe and acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T144 | 1727-1732 | Disease | denotes | Tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T59769 | 118-123 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T86299 | 192-196 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T49434 | 523-533 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T83084 | 578-580 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T87274 | 800-808 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T44105 | 856-866 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T34660 | 1017-1018 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T93838 | 1193-1201 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
| T73015 | 1193-1201 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
| T80406 | 1389-1399 | http://purl.obolibrary.org/obo/CL_0000057 | denotes | Fibroblast |
| T16585 | 1456-1464 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | Monocyte |
| T3991 | 1495-1496 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T1452 | 1540-1549 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T62771 | 1550-1557 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B-cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T96 | 391-393 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T98 | 565-567 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T100 | 575-577 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T102 | 611-613 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T104 | 781-784 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T105 | 1042-1044 | Chemical | denotes | O2 | http://purl.obolibrary.org/obo/CHEBI_15379 |
| T106 | 1336-1347 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T107 | 1375-1382 | Chemical | denotes | Calcium | http://purl.obolibrary.org/obo/CHEBI_22984 |
| T108 | 1415-1417 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T110 | 1449-1452 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
| T112 | 1481-1488 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T113 | 1492-1494 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T116 | 1604-1611 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T117 | 1615-1617 | Chemical | denotes | O2 | http://purl.obolibrary.org/obo/CHEBI_15379 |
| T118 | 1619-1625 | Chemical | denotes | Oxygen | http://purl.obolibrary.org/obo/CHEBI_15379 |
| T119 | 1627-1630 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T120 | 1632-1655 | Chemical | denotes | Reactive oxygen species | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T121 | 1641-1647 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T29310 | 296-312 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T28779 | 456-478 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune response |
| T84577 | 463-478 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T84552 | 759-770 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T31599 | 935-951 | http://purl.obolibrary.org/obo/GO_0042310 | denotes | vasoconstriction |
| T74952 | 1159-1179 | http://purl.obolibrary.org/obo/GO_0070527 | denotes | platelet aggregation |
| T61815 | 1400-1406 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T64045 | 1733-1741 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T41562 | 1733-1741 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T38342 | 1733-1741 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T85159 | 1733-1741 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T12536 | 1779-1785 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T83 | 0-79 | Sentence | denotes | Fig. 1 Potential mechanisms of SARS-CoV-2-induced cardiovascular complications. |
| T84 | 80-205 | Sentence | denotes | SARS-Cov-2 may be taken up by cardiac cells using different routes, such as via ACE2 receptors expressed on the cell surface. |
| T85 | 206-428 | Sentence | denotes | Following entry, SARS-CoV-2 may exert cardiac injury by direct action and/or induction of immune responses resulting in release of pro-inflammatory cytokines (‘Cytokine storm’) such as IL, TNF-α, INF-γ, FGF, MCP1 and VEGF. |
| T86 | 429-667 | Sentence | denotes | SARS-CoV-2 can trigger the innate immune response involving NLRP3 inflammasomes which lead to activation of pro-inflammatory cytokines, IL-1β and IL-18 and the inflammatory cascade (IL-6 and TNF-α) resulting in tissue damage and fibrosis. |
| T87 | 668-855 | Sentence | denotes | SARS-CoV-2-induced pneumonia results in the development of hypoxemia which can impair Ca2+ homeostasis, increase ROS production and activate NLRP3 inflammasomes leading to cardiac damage. |
| T88 | 856-1000 | Sentence | denotes | Activation of the sympathetic nervous system in response to pneumonia leads to vasoconstriction and tachycardia compromising coronary perfusion. |
| T89 | 1001-1086 | Sentence | denotes | This results in a mismatch of myocardial O2 demand and supply precipitating ischemia. |
| T90 | 1087-1224 | Sentence | denotes | SARS-CoV-2 can destabilize coronary atherosclerotic plaques and mediate platelet aggregation resulting in arterial and venous thrombosis. |
| T91 | 1225-1329 | Sentence | denotes | Altogether, these SARS-CoV-2 mediated effects may be contributing to the observed cardiovascular injury. |
| T92 | 1330-1793 | Sentence | denotes | ACE2, Angiotensin-converting enzyme-2; Ca2+, Calcium; FGF, Fibroblast growth factor; IL, Interleukin; INF, Interferon; MCP-1, Monocyte chemoattractant protein-1; NFκB, Nuclear factor kappa-light-chain enhancer activated B-cells; NLRP3, NACHT, LRR and PYD domains-containing protein 3; O2, Oxygen; ROS, Reactive oxygen species; SARS-CoV-2, Severe and acute respiratory syndrome coronavirus; TNF-α, Tumor necrosis factor-α; VEGF, Vascular endothelial growth factor. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T66 | 366-380 | Phenotype | denotes | Cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T67 | 687-696 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T68 | 727-736 | Phenotype | denotes | hypoxemia | http://purl.obolibrary.org/obo/HP_0012418 |
| T69 | 772-795 | Phenotype | denotes | increase ROS production | http://purl.obolibrary.org/obo/HP_0025464 |
| T70 | 916-925 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T71 | 956-967 | Phenotype | denotes | tachycardia | http://purl.obolibrary.org/obo/HP_0001649 |
| T72 | 1206-1223 | Phenotype | denotes | venous thrombosis | http://purl.obolibrary.org/obo/HP_0004936 |
| T73 | 1727-1732 | Phenotype | denotes | Tumor | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 465 | 160-164 | Gene | denotes | ACE2 | Gene:59272 |
| 466 | 395-400 | Gene | denotes | TNF-α | Gene:7124 |
| 467 | 414-418 | Gene | denotes | MCP1 | Gene:6347 |
| 468 | 423-427 | Gene | denotes | VEGF | Gene:7422 |
| 469 | 489-494 | Gene | denotes | NLRP3 | Gene:114548 |
| 470 | 565-570 | Gene | denotes | IL-1β | Gene:3552 |
| 471 | 575-580 | Gene | denotes | IL-18 | Gene:3606 |
| 472 | 611-615 | Gene | denotes | IL-6 | Gene:3569 |
| 473 | 620-625 | Gene | denotes | TNF-α | Gene:7124 |
| 474 | 809-814 | Gene | denotes | NLRP3 | Gene:114548 |
| 475 | 1330-1334 | Gene | denotes | ACE2 | Gene:59272 |
| 476 | 1336-1367 | Gene | denotes | Angiotensin-converting enzyme-2 | Gene:59272 |
| 477 | 1449-1454 | Gene | denotes | MCP-1 | Gene:6347 |
| 478 | 1456-1490 | Gene | denotes | Monocyte chemoattractant protein-1 | Gene:6347 |
| 479 | 1559-1564 | Gene | denotes | NLRP3 | Gene:114548 |
| 480 | 1566-1613 | Gene | denotes | NACHT, LRR and PYD domains-containing protein 3 | Gene:114548 |
| 481 | 1720-1725 | Gene | denotes | TNF-α | Gene:7124 |
| 482 | 1727-1750 | Gene | denotes | Tumor necrosis factor-α | Gene:7124 |
| 483 | 1752-1756 | Gene | denotes | VEGF | Gene:7422 |
| 484 | 1758-1792 | Gene | denotes | Vascular endothelial growth factor | Gene:7422 |
| 485 | 31-41 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 486 | 80-90 | Species | denotes | SARS-Cov-2 | Tax:2697049 |
| 487 | 223-233 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 488 | 429-439 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 489 | 668-678 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 490 | 1087-1097 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 491 | 1243-1253 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 492 | 1657-1667 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 493 | 1707-1718 | Species | denotes | coronavirus | Tax:11118 |
| 494 | 754-758 | Chemical | denotes | Ca2+ | MESH:D000069285 |
| 495 | 781-784 | Chemical | denotes | ROS | MESH:D017382 |
| 496 | 1042-1044 | Chemical | denotes | O2 | MESH:D010100 |
| 497 | 50-78 | Disease | denotes | cardiovascular complications | MESH:D002318 |
| 498 | 244-258 | Disease | denotes | cardiac injury | MESH:D006331 |
| 499 | 658-666 | Disease | denotes | fibrosis | MESH:D005355 |
| 500 | 687-696 | Disease | denotes | pneumonia | MESH:D011014 |
| 501 | 727-736 | Disease | denotes | hypoxemia | MESH:D000860 |
| 502 | 840-854 | Disease | denotes | cardiac damage | MESH:D006331 |
| 503 | 916-925 | Disease | denotes | pneumonia | MESH:D011014 |
| 504 | 956-967 | Disease | denotes | tachycardia | MESH:D013610 |
| 505 | 1077-1085 | Disease | denotes | ischemia | MESH:D007511 |
| 506 | 1114-1146 | Disease | denotes | coronary atherosclerotic plaques | MESH:D003324 |
| 507 | 1159-1179 | Disease | denotes | platelet aggregation | MESH:D001791 |
| 508 | 1206-1223 | Disease | denotes | venous thrombosis | MESH:D020246 |
| 509 | 1307-1328 | Disease | denotes | cardiovascular injury | MESH:D002318 |