PMC:7534795 / 12701-15208
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T3398 | 832-837 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T88788 | 906-918 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T22811 | 906-910 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T77558 | 1068-1077 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T39426 | 1080-1088 | Body_part | denotes | Cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T46176 | 1268-1277 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T75133 | 1279-1283 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T75911 | 1354-1360 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T73994 | 1588-1614 | Body_part | denotes | sympathetic nervous system | http://purl.org/sig/ont/fma/fma9906 |
| T29906 | 1873-1881 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T7234 | 2103-2113 | Body_part | denotes | Fibroblast | http://purl.org/sig/ont/fma/fma63877 |
| T47304 | 2133-2144 | Body_part | denotes | Interleukin | http://purl.org/sig/ont/fma/fma86578 |
| T54282 | 2170-2178 | Body_part | denotes | Monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T42464 | 2195-2202 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T97113 | 2266-2271 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T66341 | 2318-2325 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T21 | 1354-1360 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T22 | 1588-1614 | Body_part | denotes | sympathetic nervous system | http://purl.obolibrary.org/obo/UBERON_0000013 |
| T23 | 1600-1614 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T122 | 70-78 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T123 | 150-156 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T124 | 170-178 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T125 | 314-324 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T126 | 472-481 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T127 | 665-673 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T128 | 745-753 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T129 | 794-798 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T130 | 937-945 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T131 | 966-972 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T132 | 1143-1151 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T133 | 1382-1390 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T134 | 1401-1410 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T135 | 1630-1639 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T136 | 1791-1799 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T137 | 1801-1809 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T138 | 1920-1937 | Disease | denotes | venous thrombosis | http://purl.obolibrary.org/obo/MONDO_0008559 |
| T139 | 1927-1937 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T140 | 1957-1965 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T141 | 2036-2042 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T142 | 2371-2379 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T143 | 2383-2420 | Disease | denotes | Severe and acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T144 | 2441-2446 | Disease | denotes | Tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T79454 | 225-230 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T59769 | 832-837 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T86299 | 906-910 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T49434 | 1237-1247 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T83084 | 1292-1294 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T87274 | 1514-1522 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T44105 | 1570-1580 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T34660 | 1731-1732 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T93838 | 1907-1915 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
| T73015 | 1907-1915 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
| T80406 | 2103-2113 | http://purl.obolibrary.org/obo/CL_0000057 | denotes | Fibroblast |
| T16585 | 2170-2178 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | Monocyte |
| T3991 | 2209-2210 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T1452 | 2254-2263 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T62771 | 2264-2271 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B-cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T95 | 380-383 | Chemical | denotes | Guo | http://purl.obolibrary.org/obo/CHEBI_16750 |
| T96 | 1105-1107 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T98 | 1279-1281 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T100 | 1289-1291 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T102 | 1325-1327 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T104 | 1495-1498 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T105 | 1756-1758 | Chemical | denotes | O2 | http://purl.obolibrary.org/obo/CHEBI_15379 |
| T106 | 2050-2061 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T107 | 2089-2096 | Chemical | denotes | Calcium | http://purl.obolibrary.org/obo/CHEBI_22984 |
| T108 | 2129-2131 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T110 | 2163-2166 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
| T112 | 2195-2202 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T113 | 2206-2208 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T116 | 2318-2325 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T117 | 2329-2331 | Chemical | denotes | O2 | http://purl.obolibrary.org/obo/CHEBI_15379 |
| T118 | 2333-2339 | Chemical | denotes | Oxygen | http://purl.obolibrary.org/obo/CHEBI_15379 |
| T119 | 2341-2344 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T120 | 2346-2369 | Chemical | denotes | Reactive oxygen species | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T121 | 2355-2361 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T50684 | 257-279 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
| T29310 | 1010-1026 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T28779 | 1170-1192 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune response |
| T84577 | 1177-1192 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T84552 | 1473-1484 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T31599 | 1649-1665 | http://purl.obolibrary.org/obo/GO_0042310 | denotes | vasoconstriction |
| T74952 | 1873-1893 | http://purl.obolibrary.org/obo/GO_0070527 | denotes | platelet aggregation |
| T61815 | 2114-2120 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T64045 | 2447-2455 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T41562 | 2447-2455 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T38342 | 2447-2455 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T85159 | 2447-2455 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T12536 | 2493-2499 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T79 | 0-194 | Sentence | denotes | To date, there have been few reports about the pathologic features of COVID-19 and consequently the exact pathophysiological mechanisms of myocardial injury secondary to COVID-19 remain elusive. |
| T80 | 195-442 | Sentence | denotes | However, direct damage by the virus, exaggerated uncontrolled inflammatory responses, instability of coronary plaques, thrombosis and hypoxia have been proposed as possible mechanisms (Guo et al., 2020; Zheng et al., 2020; Zhou, Yu, et al., 2020). |
| T81 | 443-585 | Sentence | denotes | Importantly, the severity of infection, patient characteristics and host reaction all participate in the development of cardiac complications. |
| T82 | 586-713 | Sentence | denotes | The main proposed mechanisms for cardiovascular deterioration in patients with COVID-19 can be summarized as follows (Fig. 1 ). |
| T83 | 714-793 | Sentence | denotes | Fig. 1 Potential mechanisms of SARS-CoV-2-induced cardiovascular complications. |
| T84 | 794-919 | Sentence | denotes | SARS-Cov-2 may be taken up by cardiac cells using different routes, such as via ACE2 receptors expressed on the cell surface. |
| T85 | 920-1142 | Sentence | denotes | Following entry, SARS-CoV-2 may exert cardiac injury by direct action and/or induction of immune responses resulting in release of pro-inflammatory cytokines (‘Cytokine storm’) such as IL, TNF-α, INF-γ, FGF, MCP1 and VEGF. |
| T86 | 1143-1381 | Sentence | denotes | SARS-CoV-2 can trigger the innate immune response involving NLRP3 inflammasomes which lead to activation of pro-inflammatory cytokines, IL-1β and IL-18 and the inflammatory cascade (IL-6 and TNF-α) resulting in tissue damage and fibrosis. |
| T87 | 1382-1569 | Sentence | denotes | SARS-CoV-2-induced pneumonia results in the development of hypoxemia which can impair Ca2+ homeostasis, increase ROS production and activate NLRP3 inflammasomes leading to cardiac damage. |
| T88 | 1570-1714 | Sentence | denotes | Activation of the sympathetic nervous system in response to pneumonia leads to vasoconstriction and tachycardia compromising coronary perfusion. |
| T89 | 1715-1800 | Sentence | denotes | This results in a mismatch of myocardial O2 demand and supply precipitating ischemia. |
| T90 | 1801-1938 | Sentence | denotes | SARS-CoV-2 can destabilize coronary atherosclerotic plaques and mediate platelet aggregation resulting in arterial and venous thrombosis. |
| T91 | 1939-2043 | Sentence | denotes | Altogether, these SARS-CoV-2 mediated effects may be contributing to the observed cardiovascular injury. |
| T92 | 2044-2507 | Sentence | denotes | ACE2, Angiotensin-converting enzyme-2; Ca2+, Calcium; FGF, Fibroblast growth factor; IL, Interleukin; INF, Interferon; MCP-1, Monocyte chemoattractant protein-1; NFκB, Nuclear factor kappa-light-chain enhancer activated B-cells; NLRP3, NACHT, LRR and PYD domains-containing protein 3; O2, Oxygen; ROS, Reactive oxygen species; SARS-CoV-2, Severe and acute respiratory syndrome coronavirus; TNF-α, Tumor necrosis factor-α; VEGF, Vascular endothelial growth factor. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T65 | 329-336 | Phenotype | denotes | hypoxia | http://purl.obolibrary.org/obo/HP_0012418 |
| T66 | 1080-1094 | Phenotype | denotes | Cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T67 | 1401-1410 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T68 | 1441-1450 | Phenotype | denotes | hypoxemia | http://purl.obolibrary.org/obo/HP_0012418 |
| T69 | 1486-1509 | Phenotype | denotes | increase ROS production | http://purl.obolibrary.org/obo/HP_0025464 |
| T70 | 1630-1639 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T71 | 1670-1681 | Phenotype | denotes | tachycardia | http://purl.obolibrary.org/obo/HP_0001649 |
| T72 | 1920-1937 | Phenotype | denotes | venous thrombosis | http://purl.obolibrary.org/obo/HP_0004936 |
| T73 | 2441-2446 | Phenotype | denotes | Tumor | http://purl.obolibrary.org/obo/HP_0002664 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 33031856-32171076-84038834 | 436-440 | 32171076 | denotes | 2020 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 465 | 874-878 | Gene | denotes | ACE2 | Gene:59272 |
| 466 | 1109-1114 | Gene | denotes | TNF-α | Gene:7124 |
| 467 | 1128-1132 | Gene | denotes | MCP1 | Gene:6347 |
| 468 | 1137-1141 | Gene | denotes | VEGF | Gene:7422 |
| 469 | 1203-1208 | Gene | denotes | NLRP3 | Gene:114548 |
| 470 | 1279-1284 | Gene | denotes | IL-1β | Gene:3552 |
| 471 | 1289-1294 | Gene | denotes | IL-18 | Gene:3606 |
| 472 | 1325-1329 | Gene | denotes | IL-6 | Gene:3569 |
| 473 | 1334-1339 | Gene | denotes | TNF-α | Gene:7124 |
| 474 | 1523-1528 | Gene | denotes | NLRP3 | Gene:114548 |
| 475 | 2044-2048 | Gene | denotes | ACE2 | Gene:59272 |
| 476 | 2050-2081 | Gene | denotes | Angiotensin-converting enzyme-2 | Gene:59272 |
| 477 | 2163-2168 | Gene | denotes | MCP-1 | Gene:6347 |
| 478 | 2170-2204 | Gene | denotes | Monocyte chemoattractant protein-1 | Gene:6347 |
| 479 | 2273-2278 | Gene | denotes | NLRP3 | Gene:114548 |
| 480 | 2280-2327 | Gene | denotes | NACHT, LRR and PYD domains-containing protein 3 | Gene:114548 |
| 481 | 2434-2439 | Gene | denotes | TNF-α | Gene:7124 |
| 482 | 2441-2464 | Gene | denotes | Tumor necrosis factor-α | Gene:7124 |
| 483 | 2466-2470 | Gene | denotes | VEGF | Gene:7422 |
| 484 | 2472-2506 | Gene | denotes | Vascular endothelial growth factor | Gene:7422 |
| 485 | 745-755 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 486 | 794-804 | Species | denotes | SARS-Cov-2 | Tax:2697049 |
| 487 | 937-947 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 488 | 1143-1153 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 489 | 1382-1392 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 490 | 1801-1811 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 491 | 1957-1967 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 492 | 2371-2381 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 493 | 2421-2432 | Species | denotes | coronavirus | Tax:11118 |
| 494 | 1468-1472 | Chemical | denotes | Ca2+ | MESH:D000069285 |
| 495 | 1495-1498 | Chemical | denotes | ROS | MESH:D017382 |
| 496 | 1756-1758 | Chemical | denotes | O2 | MESH:D010100 |
| 497 | 764-792 | Disease | denotes | cardiovascular complications | MESH:D002318 |
| 498 | 958-972 | Disease | denotes | cardiac injury | MESH:D006331 |
| 499 | 1372-1380 | Disease | denotes | fibrosis | MESH:D005355 |
| 500 | 1401-1410 | Disease | denotes | pneumonia | MESH:D011014 |
| 501 | 1441-1450 | Disease | denotes | hypoxemia | MESH:D000860 |
| 502 | 1554-1568 | Disease | denotes | cardiac damage | MESH:D006331 |
| 503 | 1630-1639 | Disease | denotes | pneumonia | MESH:D011014 |
| 504 | 1670-1681 | Disease | denotes | tachycardia | MESH:D013610 |
| 505 | 1791-1799 | Disease | denotes | ischemia | MESH:D007511 |
| 506 | 1828-1860 | Disease | denotes | coronary atherosclerotic plaques | MESH:D003324 |
| 507 | 1873-1893 | Disease | denotes | platelet aggregation | MESH:D001791 |
| 508 | 1920-1937 | Disease | denotes | venous thrombosis | MESH:D020246 |
| 509 | 2021-2042 | Disease | denotes | cardiovascular injury | MESH:D002318 |
| 521 | 483-490 | Species | denotes | patient | Tax:9606 |
| 522 | 651-659 | Species | denotes | patients | Tax:9606 |
| 523 | 70-78 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 524 | 139-156 | Disease | denotes | myocardial injury | MESH:D009202 |
| 525 | 170-178 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 526 | 314-324 | Disease | denotes | thrombosis | MESH:D013927 |
| 527 | 329-336 | Disease | denotes | hypoxia | MESH:D000860 |
| 528 | 472-481 | Disease | denotes | infection | MESH:D007239 |
| 529 | 563-584 | Disease | denotes | cardiac complications | MESH:D005117 |
| 530 | 619-647 | Disease | denotes | cardiovascular deterioration | MESH:D002318 |
| 531 | 665-673 | Disease | denotes | COVID-19 | MESH:C000657245 |