PMC:7534206 / 6057-9662 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7534206","sourcedb":"PMC","sourceid":"7534206","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7534206","text":"The total sample size was 22 patients. The mean age was 59.5 ± 16.0 years, and 12 patients were female (54.4%). Twelve (54.4%) of the patients had no significant prior medical history. Ten patients (45.5%) had a cerebrovascular event as the initial manifestation of COVID-19. For patients who were symptomatic of COVID-19, the duration from symptom onset and neurological manifestation was 8.8 ± 4.4 days. The cerebrovascular pathologies were 17 cases of acute ischemic stroke, 3 cases of aneurysm rupture, and 2 cases of sinus thrombosis. Of the stroke and sinus thrombosis patients, the mean NIHSS was 13.8 ± 8.0, and 16 (84.2%) patients underwent a MT procedure within 6 h of symptom onset. Of the 16 patients who underwent MT, 13/16 (81.2%) patients received general endotracheal anesthesia. A Solumbra technique, aspiration plus stentriever, was used in 13/16 (81.2%) to retrieve the clot completely. The mean number of passes was 2.1, and the average procedure duration from groin access to achieving final TICI score was 42.2 ± 36.3 min. Of note, 3/16 (18.8%) of all patients required intracranial stenting as a rescue measure to maintain the vessel patency. A favorable TICI score (≥2B/3) was achieved in all patients. The mortality incidence was 5/16 (31.3%). Of all patients (22), three (13.6%) patients developed hemorrhagic conversion requiring decompressive surgery. Eleven patients (50%) had poor functional status (mRS 3–6) at discharge, and the total mortality incidence was eight (36.3%) (Table 1).\nTable 1. Demographics, procedure details, outcomes, and laboratory findings\nVariables Mean ± standard deviation; N (%)\nAge (years) 59.5 ± 16.0\nFemale gender 12 (55.5)\nComorbidities\n Hypertension 10 (45.0)\n Chronic heart disease 3 (13.6)\n Chronic lung disease 0 (0.0)\n Chronic kidney disease 1 (4.5)\n Chronic liver disease 0 (0.0)\n Diabetes mellitus 2 (9.1)\n Atrial fibrillation 3 (13.6)\n No comorbidities 12 (54.4)\nCOVID-19 characteristics\n Neurological insult as initial  manifestation of COVID-19 10 (45.5)\n Duration between COVID-19  symptoms and neurological  insults (days) 8.8 ± 4.4\n Fever 11 (50.0)\n Cough 11 (50.0)\n Pneumonia 9 (40.9)\nCerebrovascular insult\n Hemorrhagic stroke 3 (13.6)\n Ischemic stroke 19 (86.4)\nHemorrhagic stroke characteristics and outcomes\n 5.0 mm dissecting PICA aneurysm HH3, flow diversion\n 15 mm PCOM aneurysm HH4, clipped\n 1.4 mm anterior choroidal  artery aneurysm HH1, flow diversion\nIschemic stroke characteristics and outcomes\n Involved vessels 1.4 ± 0.7\n  ICA 3 (15.8)\n  M1 11 (57.9)\n  M2 1 (5.3)\n  Absent LVO 2 (10.5)\n  CVT 2 (10.5)\n NIHSS at admission 13.8 ± 8.0\n Onset to groin access (min) 272.2 ± 169.5\n Mechanical thrombectomy 16 (84.2)\n  General endotracheal anesthesia 13 (81.3)\n  MT technique\n   Contact aspiration 2 (12.5)\n   Stent retriever 1 (6.25)\n   Contact aspiration    + stent retriever 13 (81.3)\n  Procedure duration (min) 42.2 ± 36.3\n  Number of passes 2.1 ± 1.3\n  Rescue stenting 3 (18.8)\n  TICI 2B/3 16 (100)\n Symptomatic intracerebral  hemorrhage 3 (13.6)\nLaboratory findings\n CRP (mg/dl) 20.8 ± 37.9\n D-dimer (ng/dl) 3497.4 ± 6754.3\n Fibrinogen (mg/dl) 329.5 ± 235.4\n Interleukin-6 (pg/dl) 41.6 ± 62.0\nOutcomes at discharge\n mRS 3–6 11 (50)\n Mortality 8 (36.4)\nCOVID-19: coronavirus disease 2019; CRP: C-Reactive Protein; CVT: Cerebral Venous Thrombosis; ICA: Internal Carotid Artery; LVO: Large Vessel Occlusion; MT: mechanical thrombectomy; NIHSS: National Institute of Health Stroke Scale; PCOM: Posterior Cerebral Communicating Artery; PICA: Posterior Inferior Cerebellar Artery; TICI: thrombolysis in cerebral 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