PMC:7534206 / 3631-6047 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7534206","sourcedb":"PMC","sourceid":"7534206","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7534206","text":"Methods\n\nStudy design\nInstitutional review board of Thomas Jefferson University Hospital (12D:534) approved the study protocol and waived the need for informed consent. A retrospective analysis was conducted across two institutions between 20 March and 20 May 2020. Twenty-two patients were identified with the diagnosis of acute cerebrovascular disease and COVID-19 infection. Medical charts were queried for baseline patient characteristics (age, gender), comorbidities (heart disease, lung disease, liver disease, kidney disease, atrial fibrillation, and diabetes mellitus), COVID-19 symptoms (fever, cough, pneumonia), duration between COVID-19 symptoms and the neurological manifestation, cerebrovascular insult (aneurysm rupture, intracranial hemorrhage, and stroke), National Institute of Health Stroke Scale (NIHSS) at presentation, procedure detail (duration from the sheath into sheath out and thrombolysis in cerebral infarction (TICI) score, laboratory results, and mortality.\nAdditionally, total ischemic stroke admissions, mechanical thrombectomy (MT) procedures, and telestroke consults during the period between 15 March and 30 April 2020 were compared to the mean cases of the previous three years (15 March–30 April 2017, 2018, 2019) at Thomas Jefferson University Hospital in one of the institutions, which is a tertiary telestroke referral network.\nLastly, using the PubMed search engine, we performed a literature search on 3 May 2020 with no time limitations for all articles in English, using different combinations of the terms Coronavirus, COVID, SARS-CoV-2, ACE2, stroke, and large vessel occlusion. Abstracts were screened to determine if the study matched our requirements. Then the full-text was read indepth, to determine the correlation between viral infection and stroke, and outcomes of ischemic stroke due to large vessel occlusion in the setting of COVID-19. We excluded manuscripts that had grouped transient ischemic attack, small vessel occlusion or hemorrhagic stroke with LVO, as it was not possible to identify the details for patients with LVO.\nVariables collected for pooled analysis included number of LVO cases, mean age, male gender, NIHSS at admission, number of involved vessels, MT treatment, usage of Solumbra technique (aspiration with retriever), number of attempts to retrieve the clot, TICI 2B/3, symptomatic ischemic or hemorrhagic complications, and 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