PMC:7534206 / 18102-18709 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7534206","sourcedb":"PMC","sourceid":"7534206","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7534206","text":"Figure 3. (a) and (b) Access route for the SARS-CoV-2 to the CNS via the olfactory route and hematogenous route via direct access or via a Trojan. (c) The hyperinflammatory, hypercoagulable state induced by SARS-CoV-2. (d) The downregulation of ACE2 receptor at the endothelium level. This blocks the conversion of angiotensin I and II into their active metabolites. The decline in Angiotensin (1–7) levels leads to loss of neuroprotective effect and sympathetic hyperactivity. ACE2: angiotensin-converting enzyme 2; ANG (1–7): angiotensin (1–7); SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.","divisions":[{"label":"label","span":{"begin":0,"end":9}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T41","span":{"begin":61,"end":64},"obj":"Body_part"},{"id":"T42","span":{"begin":266,"end":277},"obj":"Body_part"}],"attributes":[{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A42","pred":"fma_id","subj":"T42","obj":"http://purl.org/sig/ont/fma/fma63916"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T47","span":{"begin":61,"end":64},"obj":"Body_part"},{"id":"T48","span":{"begin":266,"end":277},"obj":"Body_part"}],"attributes":[{"id":"A47","pred":"uberon_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A48","pred":"uberon_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/UBERON_0001986"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T188","span":{"begin":43,"end":51},"obj":"Disease"},{"id":"T189","span":{"begin":174,"end":189},"obj":"Disease"},{"id":"T190","span":{"begin":207,"end":215},"obj":"Disease"},{"id":"T191","span":{"begin":547,"end":555},"obj":"Disease"},{"id":"T192","span":{"begin":559,"end":606},"obj":"Disease"},{"id":"T193","span":{"begin":559,"end":592},"obj":"Disease"}],"attributes":[{"id":"A188","pred":"mondo_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A189","pred":"mondo_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/MONDO_0002305"},{"id":"A190","pred":"mondo_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A191","pred":"mondo_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A192","pred":"mondo_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A193","pred":"mondo_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T188","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T189","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T190","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T191","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T192","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T193","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T202","span":{"begin":11,"end":12},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T203","span":{"begin":19,"end":20},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T204","span":{"begin":61,"end":64},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T205","span":{"begin":61,"end":64},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T206","span":{"begin":61,"end":64},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T207","span":{"begin":137,"end":138},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T208","span":{"begin":266,"end":277},"obj":"http://purl.obolibrary.org/obo/UBERON_0001986"},{"id":"T209","span":{"begin":347,"end":353},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T202","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T204","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T205","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T206","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T207","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T208","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T209","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T83","span":{"begin":22,"end":28},"obj":"Chemical"},{"id":"T84","span":{"begin":315,"end":326},"obj":"Chemical"},{"id":"T85","span":{"begin":333,"end":335},"obj":"Chemical"},{"id":"T86","span":{"begin":354,"end":365},"obj":"Chemical"},{"id":"T87","span":{"begin":382,"end":393},"obj":"Chemical"},{"id":"T88","span":{"begin":484,"end":495},"obj":"Chemical"},{"id":"T89","span":{"begin":528,"end":539},"obj":"Chemical"}],"attributes":[{"id":"A83","pred":"chebi_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/CHEBI_34922"},{"id":"A84","pred":"chebi_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A85","pred":"chebi_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A86","pred":"chebi_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A88","pred":"chebi_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T88","span":{"begin":463,"end":476},"obj":"Phenotype"}],"attributes":[{"id":"A88","pred":"hp_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/HP_0000752"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T188","span":{"begin":0,"end":284},"obj":"Sentence"},{"id":"T189","span":{"begin":285,"end":366},"obj":"Sentence"},{"id":"T190","span":{"begin":367,"end":477},"obj":"Sentence"},{"id":"T191","span":{"begin":478,"end":607},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T188","pred":"source","obj":"LitCovid-sentences"},{"subj":"T189","pred":"source","obj":"LitCovid-sentences"},{"subj":"T190","pred":"source","obj":"LitCovid-sentences"},{"subj":"T191","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"463","span":{"begin":245,"end":249},"obj":"Gene"},{"id":"464","span":{"begin":478,"end":482},"obj":"Gene"},{"id":"465","span":{"begin":484,"end":515},"obj":"Gene"},{"id":"466","span":{"begin":43,"end":53},"obj":"Species"},{"id":"467","span":{"begin":207,"end":217},"obj":"Species"},{"id":"468","span":{"begin":547,"end":557},"obj":"Species"},{"id":"469","span":{"begin":559,"end":606},"obj":"Species"},{"id":"470","span":{"begin":315,"end":335},"obj":"Chemical"},{"id":"471","span":{"begin":463,"end":476},"obj":"Disease"}],"attributes":[{"id":"A463","pred":"tao:has_database_id","subj":"463","obj":"Gene:59272"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"Gene:59272"},{"id":"A465","pred":"tao:has_database_id","subj":"465","obj":"Gene:59272"},{"id":"A466","pred":"tao:has_database_id","subj":"466","obj":"Tax:2697049"},{"id":"A467","pred":"tao:has_database_id","subj":"467","obj":"Tax:2697049"},{"id":"A468","pred":"tao:has_database_id","subj":"468","obj":"Tax:2697049"},{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"Tax:2697049"},{"id":"A471","pred":"tao:has_database_id","subj":"471","obj":"MESH:D006948"},{"subj":"463","pred":"source","obj":"LitCovid-PubTator"},{"subj":"464","pred":"source","obj":"LitCovid-PubTator"},{"subj":"465","pred":"source","obj":"LitCovid-PubTator"},{"subj":"466","pred":"source","obj":"LitCovid-PubTator"},{"subj":"467","pred":"source","obj":"LitCovid-PubTator"},{"subj":"468","pred":"source","obj":"LitCovid-PubTator"},{"subj":"469","pred":"source","obj":"LitCovid-PubTator"},{"subj":"470","pred":"source","obj":"LitCovid-PubTator"},{"subj":"471","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#df93ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#93ecc5"},{"id":"LitCovid-PD-MONDO","color":"#ecab93"},{"id":"LitCovid-PD-CLO","color":"#9395ec"},{"id":"LitCovid-PD-CHEBI","color":"#afec93"},{"id":"LitCovid-PD-HP","color":"#ec93c9"},{"id":"LitCovid-sentences","color":"#93e3ec"},{"id":"LitCovid-PubTator","color":"#ecdb93"}]}]}}