PMC:7534206 / 17069-18709
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T38 | 531-548 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T39 | 543-548 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T40 | 553-567 | Body_part | denotes | cardiomyocytes | http://purl.org/sig/ont/fma/fma14067 |
| T41 | 1094-1097 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
| T42 | 1299-1310 | Body_part | denotes | endothelium | http://purl.org/sig/ont/fma/fma63916 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T47 | 1094-1097 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T48 | 1299-1310 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T175 | 49-57 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T176 | 84-108 | Disease | denotes | cerebrovascular diseases | http://purl.obolibrary.org/obo/MONDO_0011057 |
| T177 | 216-222 | Disease | denotes | stroke | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
| T179 | 252-275 | Disease | denotes | cerebrovascular disease | http://purl.obolibrary.org/obo/MONDO_0011057 |
| T180 | 279-287 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T181 | 361-369 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T182 | 669-684 | Disease | denotes | hypercoagulable | http://purl.obolibrary.org/obo/MONDO_0002305 |
| T183 | 696-708 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
| T184 | 870-881 | Disease | denotes | hypotension | http://purl.obolibrary.org/obo/MONDO_0005468 |
| T185 | 917-938 | Disease | denotes | stress cardiomyopathy | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T186 | 924-938 | Disease | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/MONDO_0004994 |
| T187 | 1008-1027 | Disease | denotes | atrial fibrillation | http://purl.obolibrary.org/obo/MONDO_0004981 |
| T188 | 1076-1084 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T189 | 1207-1222 | Disease | denotes | hypercoagulable | http://purl.obolibrary.org/obo/MONDO_0002305 |
| T190 | 1240-1248 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T191 | 1580-1588 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T192 | 1592-1639 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T193 | 1592-1625 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T194 | 468-473 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T195 | 514-517 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T196 | 518-519 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T197 | 531-548 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T198 | 553-567 | http://purl.obolibrary.org/obo/CL_0000746 | denotes | cardiomyocytes |
| T199 | 609-610 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T200 | 639-640 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T201 | 797-798 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T202 | 1044-1045 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T203 | 1052-1053 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T204 | 1094-1097 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
| T205 | 1094-1097 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
| T206 | 1094-1097 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
| T207 | 1170-1171 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T208 | 1299-1310 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
| T209 | 1380-1386 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T82 | 391-402 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T83 | 1055-1061 | Chemical | denotes | Access | http://purl.obolibrary.org/obo/CHEBI_34922 |
| T84 | 1348-1359 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T85 | 1366-1368 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T86 | 1387-1398 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T87 | 1415-1426 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T88 | 1517-1528 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T89 | 1561-1572 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T82 | 216-222 | Phenotype | denotes | stroke | http://purl.obolibrary.org/obo/HP_0001297 |
| T83 | 696-708 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
| T84 | 710-731 | Phenotype | denotes | thromboembolic events | http://purl.obolibrary.org/obo/HP_0001907 |
| T85 | 870-881 | Phenotype | denotes | hypotension | http://purl.obolibrary.org/obo/HP_0002615 |
| T86 | 924-938 | Phenotype | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/HP_0001638 |
| T87 | 1008-1027 | Phenotype | denotes | atrial fibrillation | http://purl.obolibrary.org/obo/HP_0005110 |
| T88 | 1496-1509 | Phenotype | denotes | hyperactivity | http://purl.obolibrary.org/obo/HP_0000752 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 520-527 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T4 | 611-627 | http://purl.obolibrary.org/obo/GO_0003008 | denotes | systemic process |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T183 | 0-109 | Sentence | denotes | It is too early to determine the exact impact of COVID-19 on the incidence of acute cerebrovascular diseases. |
| T184 | 110-228 | Sentence | denotes | However, our reported observations provide an opportunity to anticipate and prepare for the challenges in stroke care. |
| T185 | 229-323 | Sentence | denotes | The pathophysiology of cerebrovascular disease in COVID-19 patients may be direct or indirect. |
| T186 | 324-463 | Sentence | denotes | Direct factors may be related to the SARS-CoV-2 ability to bind to angiotensin-converting enzyme 2 (ACE2) and reduce its downstream effect. |
| T187 | 464-1032 | Sentence | denotes | The virus is neuroinvasive and neurovirulent, and has a tropism to endothelial cells and cardiomyocytes.13,14 Indirect factors are mainly due to a systemic process, including a hyperinflammatory response, hypercoagulable state, and coagulopathy (thromboembolic events and microangiopathy) (Figure 3).15–19 Additional factors include a prolonged intensive care unit (ICU) stay, which may be associated with hypotension and inadequate cerebral perfusion, stress cardiomyopathy and concomitant reduction in left ventricular ejection fraction, and atrial fibrillation.3,20 |
| T188 | 1033-1317 | Sentence | denotes | Figure 3. (a) and (b) Access route for the SARS-CoV-2 to the CNS via the olfactory route and hematogenous route via direct access or via a Trojan. (c) The hyperinflammatory, hypercoagulable state induced by SARS-CoV-2. (d) The downregulation of ACE2 receptor at the endothelium level. |
| T189 | 1318-1399 | Sentence | denotes | This blocks the conversion of angiotensin I and II into their active metabolites. |
| T190 | 1400-1510 | Sentence | denotes | The decline in Angiotensin (1–7) levels leads to loss of neuroprotective effect and sympathetic hyperactivity. |
| T191 | 1511-1640 | Sentence | denotes | ACE2: angiotensin-converting enzyme 2; ANG (1–7): angiotensin (1–7); SARS-CoV-2: severe acute respiratory syndrome coronavirus 2. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 463 | 1278-1282 | Gene | denotes | ACE2 | Gene:59272 |
| 464 | 1511-1515 | Gene | denotes | ACE2 | Gene:59272 |
| 465 | 1517-1548 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
| 466 | 1076-1086 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 467 | 1240-1250 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 468 | 1580-1590 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 469 | 1592-1639 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
| 470 | 1348-1368 | Chemical | denotes | angiotensin I and II | |
| 471 | 1496-1509 | Disease | denotes | hyperactivity | MESH:D006948 |
| 487 | 391-422 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
| 488 | 424-428 | Gene | denotes | ACE2 | Gene:59272 |
| 489 | 288-296 | Species | denotes | patients | Tax:9606 |
| 490 | 361-371 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 491 | 49-57 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 492 | 84-108 | Disease | denotes | cerebrovascular diseases | MESH:D002561 |
| 493 | 216-222 | Disease | denotes | stroke | MESH:D020521 |
| 494 | 252-275 | Disease | denotes | cerebrovascular disease | MESH:D002561 |
| 495 | 279-287 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 496 | 696-708 | Disease | denotes | coagulopathy | MESH:D001778 |
| 497 | 710-724 | Disease | denotes | thromboembolic | MESH:D013923 |
| 498 | 736-751 | Disease | denotes | microangiopathy | MESH:D000783 |
| 499 | 870-881 | Disease | denotes | hypotension | MESH:D007022 |
| 500 | 917-938 | Disease | denotes | stress cardiomyopathy | MESH:D054549 |
| 501 | 1008-1027 | Disease | denotes | atrial fibrillation | MESH:D001281 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32501751-32325026-53715183 | 568-570 | 32325026 | denotes | 13 |
| 32501751-32474757-53715184 | 764-766 | 32474757 | denotes | 15 |
| 32501751-32220112-53715184 | 764-766 | 32220112 | denotes | 15 |
| 32501751-32271624-53715184 | 764-766 | 32271624 | denotes | 15 |
| 32501751-32073213-53715184 | 764-766 | 32073213 | denotes | 15 |
| T43612 | 568-570 | 32325026 | denotes | 13 |
| T94784 | 764-766 | 32474757 | denotes | 15 |
| T41216 | 764-766 | 32220112 | denotes | 15 |
| T46405 | 764-766 | 32271624 | denotes | 15 |
| T94870 | 764-766 | 32073213 | denotes | 15 |