PMC:7534206 / 12009-15203
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T24 | 622-633 | Body_part | denotes | vasculature | http://purl.org/sig/ont/fma/fma69050 |
T25 | 1208-1216 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T26 | 1241-1249 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T27 | 1958-1962 | Body_part | denotes | head | http://purl.org/sig/ont/fma/fma7154 |
T28 | 2283-2285 | Body_part | denotes | A1 | http://purl.org/sig/ont/fma/fma66592 |
T29 | 2731-2733 | Body_part | denotes | A1 | http://purl.org/sig/ont/fma/fma66592 |
T30 | 2856-2858 | Body_part | denotes | A1 | http://purl.org/sig/ont/fma/fma66592 |
T31 | 2974-2979 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T35 | 622-633 | Body_part | denotes | vasculature | http://purl.obolibrary.org/obo/UBERON_0002049 |
T36 | 684-690 | Body_part | denotes | vessel | http://purl.obolibrary.org/obo/UBERON_0000055 |
T37 | 1403-1410 | Body_part | denotes | vessels | http://purl.obolibrary.org/obo/UBERON_0000055 |
T38 | 1713-1719 | Body_part | denotes | vessel | http://purl.obolibrary.org/obo/UBERON_0000055 |
T39 | 1958-1962 | Body_part | denotes | head | http://purl.obolibrary.org/obo/UBERON_0000033 |
T40 | 2974-2979 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T147 | 141-149 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T148 | 203-206 | Disease | denotes | AIS | http://purl.obolibrary.org/obo/MONDO_0003218|http://purl.obolibrary.org/obo/MONDO_0019154 |
T150 | 384-390 | Disease | denotes | stroke | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
T152 | 431-437 | Disease | denotes | stroke | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
T154 | 470-478 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T155 | 528-536 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T156 | 656-662 | Disease | denotes | stroke | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
T158 | 937-943 | Disease | denotes | stroke | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
T160 | 1152-1167 | Disease | denotes | hypercoagulable | http://purl.obolibrary.org/obo/MONDO_0002305 |
T161 | 1279-1287 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T162 | 1592-1600 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T163 | 1620-1626 | Disease | denotes | stroke | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T121 | 429-430 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T122 | 494-495 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T123 | 496-499 | http://purl.obolibrary.org/obo/CLO_0050236 | denotes | lag |
T124 | 602-610 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
T125 | 602-610 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
T126 | 676-677 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T127 | 684-690 | http://purl.obolibrary.org/obo/UBERON_0000055 | denotes | vessel |
T128 | 1150-1151 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T129 | 1183-1184 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T130 | 1224-1225 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T131 | 1403-1410 | http://purl.obolibrary.org/obo/UBERON_0000055 | denotes | vessels |
T132 | 1503-1504 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T133 | 1566-1567 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T134 | 1618-1619 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T135 | 1630-1631 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T136 | 1713-1719 | http://purl.obolibrary.org/obo/UBERON_0000055 | denotes | vessel |
T137 | 1846-1850 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
T138 | 1846-1850 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
T139 | 1958-1962 | http://purl.obolibrary.org/obo/UBERON_0000033 | denotes | head |
T140 | 1958-1962 | http://www.ebi.ac.uk/efo/EFO_0000964 | denotes | head |
T141 | 1998-2001 | http://purl.obolibrary.org/obo/CLO_0053275 | denotes | tPA |
T142 | 1998-2001 | http://purl.obolibrary.org/obo/CLO_0053276 | denotes | tPA |
T143 | 1998-2001 | http://purl.obolibrary.org/obo/CLO_0053277 | denotes | tPA |
T144 | 2035-2036 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T145 | 2065-2067 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
T146 | 2089-2090 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T147 | 2172-2173 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T148 | 2181-2183 | http://purl.obolibrary.org/obo/CLO_0007448 | denotes | M1 |
T149 | 2181-2183 | http://purl.obolibrary.org/obo/CLO_0050175 | denotes | M1 |
T150 | 2379-2380 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T151 | 2389-2398 | http://purl.obolibrary.org/obo/UBERON_0001353 | denotes | posterior |
T152 | 2400-2402 | http://purl.obolibrary.org/obo/CLO_0001547 | denotes | AP |
T153 | 2404-2411 | http://www.ebi.ac.uk/efo/EFO_0000881 | denotes | digital |
T154 | 2445-2446 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T155 | 2519-2525 | http://purl.obolibrary.org/obo/CL_0000613 | denotes | (b) AP |
T156 | 2600-2602 | http://purl.obolibrary.org/obo/CLO_0001547 | denotes | AP |
T157 | 2623-2625 | http://purl.obolibrary.org/obo/CLO_0007448 | denotes | M1 |
T158 | 2623-2625 | http://purl.obolibrary.org/obo/CLO_0050175 | denotes | M1 |
T159 | 2641-2643 | http://purl.obolibrary.org/obo/CLO_0001547 | denotes | AP |
T160 | 2707-2709 | http://purl.obolibrary.org/obo/CLO_0001547 | denotes | AP |
T161 | 2756-2757 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T162 | 2781-2782 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T163 | 2848-2850 | http://purl.obolibrary.org/obo/CLO_0007448 | denotes | M1 |
T164 | 2848-2850 | http://purl.obolibrary.org/obo/CLO_0050175 | denotes | M1 |
T165 | 2864-2865 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T166 | 2974-2979 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T167 | 2974-2979 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T168 | 3059-3060 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T169 | 3091-3098 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T37 | 714-716 | Chemical | denotes | MT | http://purl.obolibrary.org/obo/CHEBI_73614 |
T38 | 1106-1108 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T40 | 1175-1177 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T42 | 1359-1364 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
T43 | 1424-1426 | Chemical | denotes | MT | http://purl.obolibrary.org/obo/CHEBI_73614 |
T44 | 1846-1850 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
T45 | 2037-2039 | Chemical | denotes | MT | http://purl.obolibrary.org/obo/CHEBI_73614 |
T46 | 2097-2100 | Chemical | denotes | ICA | http://purl.obolibrary.org/obo/CHEBI_29202 |
T47 | 2181-2183 | Chemical | denotes | M1 | http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826 |
T51 | 2228-2231 | Chemical | denotes | ICA | http://purl.obolibrary.org/obo/CHEBI_29202 |
T52 | 2400-2402 | Chemical | denotes | AP | http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686 |
T55 | 2453-2456 | Chemical | denotes | ICA | http://purl.obolibrary.org/obo/CHEBI_29202 |
T56 | 2506-2509 | Chemical | denotes | ICA | http://purl.obolibrary.org/obo/CHEBI_29202 |
T57 | 2523-2525 | Chemical | denotes | AP | http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686 |
T60 | 2591-2594 | Chemical | denotes | ICA | http://purl.obolibrary.org/obo/CHEBI_29202 |
T61 | 2600-2602 | Chemical | denotes | AP | http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686 |
T64 | 2623-2625 | Chemical | denotes | M1 | http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826 |
T68 | 2641-2643 | Chemical | denotes | AP | http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686 |
T71 | 2690-2693 | Chemical | denotes | ICA | http://purl.obolibrary.org/obo/CHEBI_29202 |
T72 | 2707-2709 | Chemical | denotes | AP | http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686 |
T75 | 2843-2846 | Chemical | denotes | ICA | http://purl.obolibrary.org/obo/CHEBI_29202 |
T76 | 2848-2850 | Chemical | denotes | M1 | http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T60 | 384-390 | Phenotype | denotes | stroke | http://purl.obolibrary.org/obo/HP_0001297 |
T61 | 431-437 | Phenotype | denotes | stroke | http://purl.obolibrary.org/obo/HP_0001297 |
T62 | 656-662 | Phenotype | denotes | stroke | http://purl.obolibrary.org/obo/HP_0001297 |
T63 | 937-943 | Phenotype | denotes | stroke | http://purl.obolibrary.org/obo/HP_0001297 |
T64 | 1241-1255 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T65 | 1620-1626 | Phenotype | denotes | stroke | http://purl.obolibrary.org/obo/HP_0001297 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T157 | 0-290 | Sentence | denotes | With the paucity of evidence from large cohorts, it is crucial to maintain vigilance in the management of the neurological manifestations of COVID-19, especially for life-threatening pathologies such as AIS.2,4,10 Our data demonstrate multiple critical outcomes that are essential to share. |
T158 | 291-576 | Sentence | denotes | First, the mean age of the patients was 59.5 years, which is lower than historical non-COVID stroke series.11,12 Half of the patients had a stroke as the initial manifestation of COVID-19, and there was a lag period of nine days between COVID-19 symptoms and the cerebrovascular event. |
T159 | 577-717 | Sentence | denotes | Occlusions involved both arterial and venous vasculature (10.5%), and 84.2% of stroke patients had a large vessel occlusion treated with MT. |
T160 | 718-802 | Sentence | denotes | The procedures were complicated due to the clot burden and consistency of the clots. |
T161 | 803-976 | Sentence | denotes | Despite treating all patients within an average of 4.5 h from symptom onset and achieving favorable revascularization outcomes in all stroke patients, mortality reached 31%. |
T162 | 977-1078 | Sentence | denotes | Three patients developed hemorrhagic conversion (18.8%), requiring surgical decompression (Figure 1). |
T163 | 1079-1174 | Sentence | denotes | Inflammatory markers (CRP, IL-6) and d-dimer were elevated, indicating a hypercoagulable state. |
T164 | 1175-1288 | Sentence | denotes | IL-6 is a potent proinflammatory cytokine and is a marker of the “cytokine storm” seen in patients with COVID-19. |
T165 | 1289-1533 | Sentence | denotes | The pooled analysis of LVO demonstrated similar outcomes: younger age group (59.5 years), involvement of multiple vessels, complicated MT procedures requiring multiple attempts, high complication rate (15.4%), and a high mortality rate (45.9%). |
T166 | 1534-1816 | Sentence | denotes | Previous studies have described a similar experience with COVID-19 patients: having a stroke at a younger age, having worse radiographic and clinical outcomes after EVT, multiple vessel occlusion, clot fragility, and high rate of distal embolization with extensive clot burden.3,5–7 |
T167 | 1817-1826 | Sentence | denotes | Figure 1. |
T168 | 1827-1920 | Sentence | denotes | Fifty-one-year-old male with no past medical concerns developed an acute neurological insult. |
T169 | 1921-2012 | Sentence | denotes | On admission his NIHSS score was 15, head CT did not show any hemorrhage and tPA was given. |
T170 | 2013-2072 | Sentence | denotes | The patient underwent a MT procedure within 3 h and 52 min. |
T171 | 2073-2194 | Sentence | denotes | The patient had a right ICA occlusion from the cervical segment into the supraclinoid segment with a tandem M1 occlusion. |
T172 | 2195-2286 | Sentence | denotes | The procedure was complicated by ICA re-occlusion and distal embolization occluding the A1. |
T173 | 2287-3194 | Sentence | denotes | The insult progressed into complete infarct, and the patient passed away three days later. (a) Antero-posterior (AP) digital subtraction angiography (DCA) of a right ICA injection showing complete occlusion at cervical ICA segment; (b) AP DCA view showing an occlusion of the supraclinoid segment of the ICA; (c) AP DCA view showing an M1 occlusion; (d) AP DCA view showing re-occlusion of the cervical ICA segment; (e) AP DCA occlusion of the A1 segment either due to a distal embolization or a dissection; (f) final view showing revascularization of the ICA, M1, and A1 with a TICI 2B result by deploying intracranial and extracranial rescue stents; (g) non-contrast axial view of the brain, day 1 post mechanical thrombectomy showing the progression of the insult into a complete infarct; (h) all the devices in the room are draped; and (i) showing the powered air-purifying respirator used by operators. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
329 | 2017-2024 | Species | denotes | patient | Tax:9606 |
330 | 2077-2084 | Species | denotes | patient | Tax:9606 |
331 | 2340-2347 | Species | denotes | patient | Tax:9606 |
332 | 1998-2001 | Chemical | denotes | tPA | |
333 | 1983-1993 | Disease | denotes | hemorrhage | MESH:D006470 |
334 | 2323-2330 | Disease | denotes | infarct | MESH:D007238 |
335 | 3070-3077 | Disease | denotes | infarct | MESH:D007238 |
363 | 1101-1104 | Gene | denotes | CRP | Gene:1401 |
364 | 1106-1110 | Gene | denotes | IL-6 | Gene:3569 |
365 | 1175-1179 | Gene | denotes | IL-6 | Gene:3569 |
366 | 318-326 | Species | denotes | patients | Tax:9606 |
367 | 416-424 | Species | denotes | patients | Tax:9606 |
368 | 663-671 | Species | denotes | patients | Tax:9606 |
369 | 824-832 | Species | denotes | patients | Tax:9606 |
370 | 944-952 | Species | denotes | patients | Tax:9606 |
371 | 983-991 | Species | denotes | patients | Tax:9606 |
372 | 1265-1273 | Species | denotes | patients | Tax:9606 |
373 | 1601-1609 | Species | denotes | patients | Tax:9606 |
374 | 714-716 | Chemical | denotes | MT | |
375 | 1699-1702 | Chemical | denotes | EVT | |
376 | 141-149 | Disease | denotes | COVID-19 | MESH:C000657245 |
377 | 378-390 | Disease | denotes | COVID stroke | MESH:C000657245 |
378 | 431-437 | Disease | denotes | stroke | MESH:D020521 |
379 | 470-478 | Disease | denotes | COVID-19 | MESH:C000657245 |
380 | 528-536 | Disease | denotes | COVID-19 | MESH:C000657245 |
381 | 615-633 | Disease | denotes | venous vasculature | MESH:C565633 |
382 | 656-662 | Disease | denotes | stroke | MESH:D020521 |
383 | 937-943 | Disease | denotes | stroke | MESH:D020521 |
384 | 954-963 | Disease | denotes | mortality | MESH:D003643 |
385 | 1002-1013 | Disease | denotes | hemorrhagic | MESH:D006470 |
386 | 1279-1287 | Disease | denotes | COVID-19 | MESH:C000657245 |
387 | 1510-1519 | Disease | denotes | mortality | MESH:D003643 |
388 | 1592-1600 | Disease | denotes | COVID-19 | MESH:C000657245 |
389 | 1620-1626 | Disease | denotes | stroke | MESH:D020521 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32501751-32343504-53715178 | 209-210 | 32343504 | denotes | 4 |
32501751-32294339-53715179 | 211-213 | 32294339 | denotes | 10 |
32501751-30418596-53715180 | 398-400 | 30418596 | denotes | 11 |
32501751-28763550-53715181 | 401-403 | 28763550 | denotes | 12 |
32501751-32310015-53715182 | 1813-1814 | 32310015 | denotes | 5 |
T88684 | 209-210 | 32343504 | denotes | 4 |
T90181 | 211-213 | 32294339 | denotes | 10 |
T1001 | 398-400 | 30418596 | denotes | 11 |
T8727 | 401-403 | 28763550 | denotes | 12 |
T94062 | 1813-1814 | 32310015 | denotes | 5 |