PMC:7532482 / 17209-24609
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T34 | 421-444 | Body_part | denotes | upper respiratory tract | http://purl.org/sig/ont/fma/fma45661 |
| T35 | 481-487 | Body_part | denotes | throat | http://purl.org/sig/ont/fma/fma228738 |
| T36 | 2827-2845 | Body_part | denotes | lipopolysaccharide | http://purl.org/sig/ont/fma/fma82785 |
| T37 | 2926-2934 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T38 | 3058-3067 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T39 | 3216-3220 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T40 | 3605-3609 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T41 | 3662-3666 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T42 | 3667-3671 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T43 | 3741-3750 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T44 | 3789-3797 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T45 | 3981-3994 | Body_part | denotes | Bronchiolitis | http://purl.org/sig/ont/fma/fma76497 |
| T46 | 4070-4083 | Body_part | denotes | bronchiolitis | http://purl.org/sig/ont/fma/fma76497 |
| T47 | 4089-4093 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T48 | 4140-4144 | Body_part | denotes | Gene | http://purl.org/sig/ont/fma/fma74402 |
| T49 | 4280-4284 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T50 | 4614-4630 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T51 | 4625-4630 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T52 | 4632-4657 | Body_part | denotes | alveolar epithelial cells | http://purl.org/sig/ont/fma/fma62499 |
| T53 | 4652-4657 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T54 | 4668-4685 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T55 | 4680-4685 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T56 | 4700-4711 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T57 | 4830-4839 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T58 | 4844-4854 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
| T59 | 5086-5095 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T60 | 5347-5351 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T61 | 5636-5644 | Body_part | denotes | cysteine | http://purl.org/sig/ont/fma/fma82751 |
| T62 | 5743-5751 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T63 | 5800-5808 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T64 | 5856-5861 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T65 | 6088-6094 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T66 | 6225-6233 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T67 | 7148-7152 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T13 | 421-444 | Body_part | denotes | upper respiratory tract | http://purl.obolibrary.org/obo/UBERON_0001557 |
| T14 | 427-444 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
| T15 | 481-487 | Body_part | denotes | throat | http://purl.obolibrary.org/obo/UBERON_0000341 |
| T16 | 3605-3609 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T17 | 3667-3671 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T18 | 4089-4093 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T72 | 139-147 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T73 | 421-455 | Disease | denotes | upper respiratory tract infections | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T74 | 465-474 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T75 | 476-487 | Disease | denotes | sore throat | http://purl.obolibrary.org/obo/MONDO_0002258 |
| T76 | 489-494 | Disease | denotes | mumps | http://purl.obolibrary.org/obo/MONDO_0000989 |
| T77 | 581-589 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T78 | 959-967 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T79 | 1597-1603 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T80 | 1832-1838 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T81 | 2122-2130 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T82 | 2731-2733 | Disease | denotes | MF | http://purl.obolibrary.org/obo/MONDO_0009691|http://purl.obolibrary.org/obo/MONDO_0020481 |
| T84 | 2904-2906 | Disease | denotes | BH | http://purl.obolibrary.org/obo/MONDO_0010873 |
| T85 | 2953-2961 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T86 | 2962-2972 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T87 | 3108-3116 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T88 | 3356-3371 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T89 | 3362-3371 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T90 | 3382-3396 | Disease | denotes | Kaposi sarcoma | http://purl.obolibrary.org/obo/MONDO_0005055 |
| T91 | 3389-3396 | Disease | denotes | sarcoma | http://purl.obolibrary.org/obo/MONDO_0005089 |
| T92 | 3408-3429 | Disease | denotes | herpesvirus infection | http://purl.obolibrary.org/obo/MONDO_0005794 |
| T93 | 3420-3429 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T94 | 3437-3462 | Disease | denotes | cytomegalovirus infection | http://purl.obolibrary.org/obo/MONDO_0005132 |
| T95 | 3453-3462 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T96 | 3464-3475 | Disease | denotes | Hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
| T97 | 3464-3473 | Disease | denotes | Hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T98 | 3477-3486 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T99 | 3490-3518 | Disease | denotes | Epstein-Barr virus infection | http://purl.obolibrary.org/obo/MONDO_0005111 |
| T100 | 3503-3518 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T101 | 3509-3518 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T102 | 3526-3542 | Disease | denotes | immunodeficiency | http://purl.obolibrary.org/obo/MONDO_0021094 |
| T103 | 3551-3560 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T104 | 3565-3572 | Disease | denotes | Measles | http://purl.obolibrary.org/obo/MONDO_0004619 |
| T105 | 3605-3617 | Disease | denotes | lung disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T106 | 3628-3640 | Disease | denotes | tuberculosis | http://purl.obolibrary.org/obo/MONDO_0018076 |
| T107 | 3642-3651 | Disease | denotes | pertussis | http://purl.obolibrary.org/obo/MONDO_0005077 |
| T108 | 3656-3678 | Disease | denotes | small cell lung cancer | http://purl.obolibrary.org/obo/MONDO_0008433 |
| T109 | 3667-3678 | Disease | denotes | lung cancer | http://purl.obolibrary.org/obo/MONDO_0008903 |
| T110 | 3672-3678 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T111 | 3762-3774 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T112 | 3973-3979 | Disease | denotes | Asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
| T113 | 3981-3994 | Disease | denotes | Bronchiolitis | http://purl.obolibrary.org/obo/MONDO_0002465 |
| T114 | 4030-4053 | Disease | denotes | Infections, respiratory | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T115 | 4070-4083 | Disease | denotes | bronchiolitis | http://purl.obolibrary.org/obo/MONDO_0002465 |
| T116 | 4115-4130 | Disease | denotes | Virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T117 | 4121-4130 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T118 | 4416-4463 | Disease | denotes | Severe Acute Respiratory Syndrome-Coronavirus-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T119 | 4416-4449 | Disease | denotes | Severe Acute Respiratory Syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T120 | 4465-4469 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T121 | 4477-4486 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T122 | 4509-4527 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T123 | 4518-4527 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T124 | 4570-4574 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T125 | 5139-5148 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T126 | 5152-5160 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T127 | 5421-5433 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T128 | 5584-5592 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T129 | 5593-5602 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T130 | 5834-5843 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T131 | 5867-5875 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T132 | 6071-6079 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T133 | 6291-6299 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T134 | 6440-6448 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T135 | 6540-6548 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T136 | 6664-6672 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T137 | 6725-6733 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T138 | 6843-6851 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T139 | 7230-7239 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T140 | 7329-7337 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T178 | 29-32 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T179 | 106-109 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T180 | 110-111 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T181 | 155-158 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T182 | 355-357 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
| T183 | 368-369 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T184 | 531-534 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T185 | 590-592 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T186 | 658-661 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T187 | 853-855 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T188 | 888-894 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T189 | 1198-1203 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T190 | 1298-1303 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T191 | 1335-1336 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T192 | 1380-1385 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T193 | 1483-1484 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T194 | 1516-1519 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T195 | 1540-1548 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T196 | 1689-1697 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T197 | 1745-1749 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | a, a |
| T198 | 1900-1901 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T199 | 2141-2142 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T200 | 2364-2369 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T201 | 2408-2413 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T202 | 2490-2491 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T203 | 2509-2514 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T204 | 2584-2589 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T205 | 2590-2595 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T206 | 2610-2615 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T207 | 2640-2645 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T208 | 2727-2729 | http://purl.obolibrary.org/obo/GO_0005575 | denotes | CC |
| T209 | 2867-2875 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T210 | 2882-2890 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T211 | 2983-2984 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T212 | 3040-3041 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T213 | 3073-3082 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T214 | 3167-3168 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T215 | 3182-3185 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T216 | 3216-3220 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T217 | 3431-3436 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T218 | 3474-3475 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T219 | 3487-3488 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T220 | 3503-3508 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T221 | 3520-3525 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T222 | 3543-3548 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T223 | 3605-3609 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T224 | 3605-3609 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T225 | 3662-3666 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T226 | 3667-3671 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T227 | 3667-3671 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T228 | 3727-3737 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T229 | 3822-3831 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T230 | 3848-3857 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T231 | 3981-3994 | http://purl.obolibrary.org/obo/UBERON_0002186 | denotes | Bronchiolitis |
| T232 | 4024-4029 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T233 | 4064-4069 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T234 | 4070-4083 | http://purl.obolibrary.org/obo/UBERON_0002186 | denotes | bronchiolitis |
| T235 | 4089-4093 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T236 | 4089-4093 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T237 | 4115-4120 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T238 | 4140-4144 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | Gene |
| T239 | 4204-4209 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T240 | 4280-4284 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T241 | 4301-4306 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T242 | 4375-4380 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T243 | 4534-4535 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T244 | 4581-4586 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T245 | 4614-4624 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T246 | 4625-4630 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T247 | 4641-4651 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T248 | 4652-4657 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T249 | 4668-4685 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T250 | 4893-4895 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T251 | 4904-4906 | http://purl.obolibrary.org/obo/CLO_0007074 | denotes | kB |
| T252 | 4904-4906 | http://purl.obolibrary.org/obo/CLO_0051988 | denotes | kB |
| T253 | 4929-4930 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T254 | 4978-4987 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activator |
| T255 | 4993-5002 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T256 | 5347-5351 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T257 | 5446-5456 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T258 | 5624-5625 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T259 | 5713-5723 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T260 | 5809-5811 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
| T261 | 5847-5850 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T262 | 5847-5850 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T263 | 5847-5850 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T264 | 5847-5850 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T265 | 5847-5850 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T266 | 5847-5850 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T267 | 5847-5850 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T268 | 5856-5861 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T269 | 5876-5885 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T270 | 5997-6006 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T271 | 6088-6094 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T272 | 6165-6166 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T273 | 6179-6188 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humanized |
| T274 | 6194-6199 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T275 | 6359-6361 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T276 | 6366-6369 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T277 | 7008-7009 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T278 | 7135-7140 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T279 | 7148-7152 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T106 | 25-28 | Chemical | denotes | TCM | http://purl.obolibrary.org/obo/CHEBI_145500 |
| T107 | 102-105 | Chemical | denotes | TCM | http://purl.obolibrary.org/obo/CHEBI_145500 |
| T108 | 298-306 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T109 | 390-398 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T110 | 555-559 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T111 | 635-643 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T112 | 1313-1320 | Chemical | denotes | Wogonin | http://purl.obolibrary.org/obo/CHEBI_10043 |
| T113 | 1341-1349 | Chemical | denotes | acacetin | http://purl.obolibrary.org/obo/CHEBI_57284 |
| T114 | 1474-1481 | Chemical | denotes | Wogonin | http://purl.obolibrary.org/obo/CHEBI_10043 |
| T115 | 1505-1514 | Chemical | denotes | flavonoid | http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544 |
| T117 | 1659-1666 | Chemical | denotes | wogonin | http://purl.obolibrary.org/obo/CHEBI_10043|http://purl.obolibrary.org/obo/CHEBI_78338 |
| T119 | 1750-1759 | Chemical | denotes | flavonoid | http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544 |
| T121 | 1890-1898 | Chemical | denotes | Acacetin | http://purl.obolibrary.org/obo/CHEBI_15335 |
| T122 | 1900-1909 | Chemical | denotes | a flavone | http://purl.obolibrary.org/obo/CHEBI_24043 |
| T123 | 1902-1909 | Chemical | denotes | flavone | http://purl.obolibrary.org/obo/CHEBI_42491 |
| T124 | 2027-2035 | Chemical | denotes | acacetin | http://purl.obolibrary.org/obo/CHEBI_57284 |
| T125 | 2050-2052 | Chemical | denotes | PR | http://purl.obolibrary.org/obo/CHEBI_73645 |
| T126 | 2054-2056 | Chemical | denotes | IR | http://purl.obolibrary.org/obo/CHEBI_74061 |
| T127 | 2259-2262 | Chemical | denotes | PPI | http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614 |
| T129 | 2723-2725 | Chemical | denotes | BP | http://purl.obolibrary.org/obo/CHEBI_29865 |
| T130 | 2727-2729 | Chemical | denotes | CC | http://purl.obolibrary.org/obo/CHEBI_28940 |
| T131 | 2731-2733 | Chemical | denotes | MF | http://purl.obolibrary.org/obo/CHEBI_74708 |
| T132 | 2827-2845 | Chemical | denotes | lipopolysaccharide | http://purl.obolibrary.org/obo/CHEBI_16412 |
| T133 | 3169-3172 | Chemical | denotes | TCM | http://purl.obolibrary.org/obo/CHEBI_145500 |
| T134 | 3816-3818 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T136 | 4734-4745 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T137 | 4866-4868 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T139 | 4877-4879 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T141 | 4901-4903 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T144 | 5487-5502 | Chemical | denotes | MAPK inhibitors | http://purl.obolibrary.org/obo/CHEBI_79091 |
| T145 | 5492-5502 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T146 | 5636-5644 | Chemical | denotes | cysteine | http://purl.obolibrary.org/obo/CHEBI_15356 |
| T147 | 5743-5751 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T148 | 5800-5808 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T149 | 6104-6106 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T151 | 6200-6202 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T153 | 6986-6993 | Chemical | denotes | Wogonin | http://purl.obolibrary.org/obo/CHEBI_10043 |
| T154 | 7014-7022 | Chemical | denotes | acacetin | http://purl.obolibrary.org/obo/CHEBI_57284 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 237 | 139-147 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 238 | 421-455 | Disease | denotes | upper respiratory tract infections | MESH:D012141 |
| 239 | 476-487 | Disease | denotes | sore throat | MESH:D010608 |
| 240 | 581-589 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 241 | 959-967 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 255 | 1715-1719 | Gene | denotes | AMPK | Gene:5562 |
| 256 | 1313-1320 | Chemical | denotes | Wogonin | MESH:C085514 |
| 257 | 1322-1336 | Chemical | denotes | licochalcone a | MESH:C070840 |
| 258 | 1341-1349 | Chemical | denotes | acacetin | MESH:C023717 |
| 259 | 1474-1481 | Chemical | denotes | Wogonin | MESH:C085514 |
| 260 | 1505-1514 | Chemical | denotes | flavonoid | MESH:D005419 |
| 261 | 1732-1746 | Chemical | denotes | Licochalcone a | MESH:C070840 |
| 262 | 1750-1759 | Chemical | denotes | flavonoid | MESH:D005419 |
| 263 | 1890-1898 | Chemical | denotes | Acacetin | MESH:C023717 |
| 264 | 1902-1909 | Chemical | denotes | flavone | MESH:C043562 |
| 265 | 1582-1590 | Disease | denotes | fibrosis | MESH:D005355 |
| 266 | 1597-1603 | Disease | denotes | cancer | MESH:D009369 |
| 267 | 1832-1838 | Disease | denotes | cancer | MESH:D009369 |
| 273 | 2054-2056 | Gene | denotes | IR | Gene:3643 |
| 274 | 2020-2022 | Gene | denotes | OB | Gene:1009 |
| 275 | 2050-2052 | Gene | denotes | PR | Gene:140738 |
| 276 | 2027-2035 | Chemical | denotes | acacetin | MESH:C023717 |
| 277 | 2122-2130 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 279 | 2584-2589 | Species | denotes | human | Tax:9606 |
| 284 | 2827-2845 | Chemical | denotes | lipopolysaccharide | MESH:D008070 |
| 285 | 2953-2961 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 286 | 2962-2972 | Disease | denotes | infections | MESH:D007239 |
| 287 | 3108-3116 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 303 | 3816-3821 | Gene | denotes | IL-17 | Gene:3605 |
| 304 | 3844-3847 | Gene | denotes | TNF | Gene:7124 |
| 305 | 3356-3371 | Disease | denotes | viral infection | MESH:D001102 |
| 306 | 3382-3429 | Disease | denotes | Kaposi sarcoma-associated herpesvirus infection | MESH:D012514 |
| 307 | 3437-3462 | Disease | denotes | cytomegalovirus infection | MESH:D003586 |
| 308 | 3464-3475 | Disease | denotes | Hepatitis B | MESH:D006509 |
| 309 | 3490-3518 | Disease | denotes | Epstein-Barr virus infection | MESH:D020031 |
| 310 | 3526-3560 | Disease | denotes | immunodeficiency virus 1 infection | MESH:D001102 |
| 311 | 3605-3617 | Disease | denotes | lung disease | MESH:D008171 |
| 312 | 3628-3640 | Disease | denotes | tuberculosis | MESH:D014376 |
| 313 | 3656-3678 | Disease | denotes | small cell lung cancer | MESH:D055752 |
| 314 | 3762-3774 | Disease | denotes | inflammation | MESH:D007249 |
| 315 | 3981-4040 | Disease | denotes | Bronchiolitis Viral, Respiratory Syncytial Virus Infections | |
| 316 | 4042-4083 | Disease | denotes | respiratory syncytial virus bronchiolitis | |
| 317 | 4115-4138 | Disease | denotes | Virus infection disease | MESH:D001102 |
| 365 | 4235-4239 | Gene | denotes | RELA | Gene:5970 |
| 366 | 4315-4320 | Gene | denotes | MAPK1 | Gene:5594 |
| 367 | 4322-4328 | Gene | denotes | MAPK14 | Gene:1432 |
| 368 | 4330-4335 | Gene | denotes | CASP3 | Gene:836 |
| 369 | 4337-4342 | Gene | denotes | CASP8 | Gene:841 |
| 370 | 4347-4350 | Gene | denotes | IL6 | Gene:3569 |
| 371 | 4734-4765 | Gene | denotes | Angiotensin converting enzyme 2 | Gene:59272 |
| 372 | 4767-4771 | Gene | denotes | ACE2 | Gene:59272 |
| 373 | 4866-4870 | Gene | denotes | IL-6 | Gene:3569 |
| 374 | 4872-4875 | Gene | denotes | TNF | Gene:7124 |
| 375 | 4877-4882 | Gene | denotes | IL-10 | Gene:3586 |
| 376 | 4887-4891 | Gene | denotes | MCP1 | Gene:6347 |
| 377 | 4921-4925 | Gene | denotes | RELA | Gene:5970 |
| 378 | 5100-5104 | Gene | denotes | RELA | Gene:5970 |
| 379 | 5162-5167 | Gene | denotes | MAPK1 | Gene:5594 |
| 380 | 5172-5178 | Gene | denotes | MAPK14 | Gene:1432 |
| 381 | 5607-5612 | Gene | denotes | CASP3 | Gene:836 |
| 382 | 5617-5622 | Gene | denotes | CASP8 | Gene:841 |
| 383 | 5923-5931 | Gene | denotes | caspase3 | Gene:836 |
| 384 | 5933-5942 | Gene | denotes | caspase 8 | Gene:841 |
| 385 | 5974-5979 | Gene | denotes | CASP3 | Gene:836 |
| 386 | 5984-5989 | Gene | denotes | CASP8 | Gene:841 |
| 387 | 6104-6108 | Gene | denotes | IL-6 | Gene:3569 |
| 388 | 4416-4463 | Species | denotes | Severe Acute Respiratory Syndrome-Coronavirus-2 | Tax:2697049 |
| 389 | 4465-4475 | Species | denotes | SARS-COV-2 | Tax:2697049 |
| 390 | 4570-4580 | Species | denotes | SARS-COV-2 | Tax:2697049 |
| 391 | 5395-5400 | Species | denotes | CoV-2 | Tax:2697049 |
| 392 | 5867-5875 | Species | denotes | SARS-CoV | Tax:694009 |
| 393 | 6126-6134 | Species | denotes | patients | Tax:9606 |
| 394 | 6300-6308 | Species | denotes | patients | Tax:9606 |
| 395 | 4602-4613 | Species | denotes | respiratory | Tax:12814 |
| 396 | 6194-6199 | Species | denotes | human | Tax:9606 |
| 397 | 6152-6163 | Chemical | denotes | Tocilizumab | MESH:C502936 |
| 398 | 4477-4486 | Disease | denotes | infection | MESH:D007239 |
| 399 | 4509-4527 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 400 | 5139-5148 | Disease | denotes | infection | MESH:D007239 |
| 401 | 5152-5160 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 402 | 5370-5376 | Disease | denotes | Joseph | MESH:D017827 |
| 403 | 5421-5433 | Disease | denotes | inflammation | MESH:D007249 |
| 404 | 5584-5592 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 405 | 5593-5602 | Disease | denotes | infection | MESH:D007239 |
| 406 | 5834-5843 | Disease | denotes | infection | MESH:D007239 |
| 407 | 6071-6079 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 408 | 6140-6148 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 409 | 6291-6299 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 410 | 6349-6358 | Disease | denotes | mortality | MESH:D003643 |
| 411 | 5847-5855 | CellLine | denotes | 293/ACE2 | CVCL:L310 |
| 421 | 6549-6557 | Species | denotes | patients | Tax:9606 |
| 422 | 6673-6681 | Species | denotes | patients | Tax:9606 |
| 423 | 6713-6720 | Chemical | denotes | Arbidol | MESH:C086979 |
| 424 | 6761-6768 | Chemical | denotes | Arbidol | MESH:C086979 |
| 425 | 6440-6448 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 426 | 6540-6548 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 427 | 6664-6672 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 428 | 6725-6733 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 429 | 6843-6851 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 441 | 7071-7075 | Gene | denotes | RELA | Gene:5970 |
| 442 | 7077-7082 | Gene | denotes | MAPK1 | Gene:5594 |
| 443 | 7084-7090 | Gene | denotes | MAPK14 | Gene:1432 |
| 444 | 7092-7097 | Gene | denotes | CASP3 | Gene:836 |
| 445 | 7099-7104 | Gene | denotes | CASP8 | Gene:841 |
| 446 | 7109-7112 | Gene | denotes | IL6 | Gene:3569 |
| 447 | 6986-6993 | Chemical | denotes | Wogonin | MESH:C085514 |
| 448 | 6995-7009 | Chemical | denotes | licochalcone a | MESH:C070840 |
| 449 | 7014-7022 | Chemical | denotes | acacetin | MESH:C023717 |
| 450 | 7212-7239 | Disease | denotes | novel coronavirus pneumonia | MESH:C000657245 |
| 451 | 7329-7337 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T24 | 421-455 | Phenotype | denotes | upper respiratory tract infections | http://purl.obolibrary.org/obo/HP_0002788 |
| T25 | 476-487 | Phenotype | denotes | sore throat | http://purl.obolibrary.org/obo/HP_0033050 |
| T26 | 1597-1603 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T27 | 1832-1838 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T28 | 3382-3396 | Phenotype | denotes | Kaposi sarcoma | http://purl.obolibrary.org/obo/HP_0100726 |
| T29 | 3464-3473 | Phenotype | denotes | Hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T30 | 3526-3542 | Phenotype | denotes | immunodeficiency | http://purl.obolibrary.org/obo/HP_0002721 |
| T31 | 3605-3617 | Phenotype | denotes | lung disease | http://purl.obolibrary.org/obo/HP_0002088 |
| T32 | 3656-3678 | Phenotype | denotes | small cell lung cancer | http://purl.obolibrary.org/obo/HP_0030357 |
| T33 | 3973-3979 | Phenotype | denotes | Asthma | http://purl.obolibrary.org/obo/HP_0002099 |
| T34 | 3981-3994 | Phenotype | denotes | Bronchiolitis | http://purl.obolibrary.org/obo/HP_0011950 |
| T35 | 4070-4083 | Phenotype | denotes | bronchiolitis | http://purl.obolibrary.org/obo/HP_0011950 |
| T36 | 5279-5295 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T37 | 7230-7239 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T15 | 1715-1719 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T16 | 1715-1719 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T17 | 1715-1719 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T18 | 2815-2845 | http://purl.obolibrary.org/obo/GO_0032496 | denotes | response to lipopolysaccharide |
| T19 | 2992-3007 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T20 | 3356-3371 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T21 | 3762-3774 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T22 | 3822-3839 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T23 | 3822-3831 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T24 | 3848-3865 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T25 | 3848-3857 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T26 | 4543-4564 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T27 | 4962-4977 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T28 | 5198-5202 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T29 | 5239-5257 | http://purl.obolibrary.org/obo/GO_0009987 | denotes | cellular processes |
| T30 | 5267-5295 | http://purl.obolibrary.org/obo/GO_0006979 | denotes | response to oxidative stress |
| T31 | 5316-5331 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T32 | 5333-5342 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T33 | 5333-5342 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T34 | 5347-5365 | http://purl.obolibrary.org/obo/GO_0008283 | denotes | cell proliferation |
| T35 | 5421-5433 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T36 | 5461-5465 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T37 | 5487-5491 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T38 | 5764-5775 | http://purl.obolibrary.org/obo/GO_0006508 | denotes | proteolysis |
| T39 | 5876-5895 | http://purl.obolibrary.org/obo/GO_0043065 | denotes | activated apoptosis |
| T40 | 5886-5895 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T41 | 5886-5895 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T146 | 0-10 | Sentence | denotes | Discussion |
| T147 | 11-91 | Sentence | denotes | The theory of TCM has been formed and developed for thousands of years in China. |
| T148 | 92-216 | Sentence | denotes | In China, TCM has a good therapeutic effect on COVID-19, which has been written into the diagnosis and treatment guidelines. |
| T149 | 217-358 | Sentence | denotes | The guideline points out that the combination of traditional Chinese and western medicine should be strengthened in the treatment process 34. |
| T150 | 359-515 | Sentence | denotes | SFJDC is a traditional Chinese medicine, mainly used to treat upper respiratory tract infections, such as influenza, sore throat, mumps, streptococcus, etc. |
| T151 | 516-519 | Sentence | denotes | 21. |
| T152 | 520-593 | Sentence | denotes | Now, SFJDC has become an effective drug for the treatment of COVID-19 35. |
| T153 | 594-728 | Sentence | denotes | In recent years, the research on Chinese medicine prescriptions has developed to the level of effective parts, components, components. |
| T154 | 729-856 | Sentence | denotes | Network pharmacology can better understand and demonstrate the interaction between multi-component multi-target and disease 36. |
| T155 | 857-997 | Sentence | denotes | This study aims to analyze the active components and potential mechanism of SFJDC in the treatment of COVID-19 through network pharmacology. |
| T156 | 998-1115 | Sentence | denotes | In the present study, the ingredients-targets network of SFJDC was constructed using 110 ingredients and 120 targets. |
| T157 | 1116-1216 | Sentence | denotes | The network contained 117 nodes and 419 edges which indicated the compound-target genes interaction. |
| T158 | 1217-1400 | Sentence | denotes | The results showed that most compounds of SFJDC were affected by multiple target genes, such as Wogonin, licochalcone a and acacetin acted on 42, 30 and 23 target genes, respectively. |
| T159 | 1401-1473 | Sentence | denotes | Various compounds of SFJDC may have the same targets to achieve synergy. |
| T160 | 1474-1640 | Sentence | denotes | Wogonin, a naturally occurring flavonoid, has been shown to multi-activity, such as anti-inflammatory, anti-fibrosis, anti-cancer and chondroprotective properties 37. |
| T161 | 1641-1731 | Sentence | denotes | Study showed that wogonin had an anti-infulenza activity by modulation of AMPK pathway 38. |
| T162 | 1732-1889 | Sentence | denotes | Licochalcone a, a flavonoid extracted from licorice toot, was known for its anti-inflammatory, anti-cancer, anti-oxidative and anti-bacterial bioactivity 39. |
| T163 | 1890-1991 | Sentence | denotes | Acacetin, a flavone compound, played an important role in anti-inflammatory and anti-peroxidative 40. |
| T164 | 1992-2067 | Sentence | denotes | In addition, they have high OB and acacetin from 2 herbs (PR, IR) of SFJDC. |
| T165 | 2068-2173 | Sentence | denotes | The three main ingredients were anti-inflammatory and COVID-19 caused by a series of inflammatory storms. |
| T166 | 2174-2258 | Sentence | denotes | Hence, they might be the crucial effective compounds of SFJDC according the network. |
| T167 | 2259-2370 | Sentence | denotes | PPI network of SFJDC against NCP were visualized using Cytoscape software to obtain the candidate target genes. |
| T168 | 2371-2504 | Sentence | denotes | In order to obtain the more accurate genes, two parameters including DC and BC were used to screen nodes and structure a new network. |
| T169 | 2505-2616 | Sentence | denotes | 169 genes were eventually identified for SFJDC against NCP including 156 other human genes and 13 target genes. |
| T170 | 2617-2701 | Sentence | denotes | Twenty-three candidate genes (CGs) were identified by using the VennDiagram package. |
| T171 | 2702-2760 | Sentence | denotes | CGs were enriched in BP, CC, MF by GO enrichment analysis. |
| T172 | 2761-2952 | Sentence | denotes | Based on GO terms data, we found that some terms were response to lipopolysaccharide or bacterial origin, membrane raft, membrane microdomain, BH domain binding and cytokine receptor binding. |
| T173 | 2953-3156 | Sentence | denotes | COVID-19 infections leaded to a strong immune response and inflammatory storm in which a large number of cytokines were activated, so SFJDC might regulate COVID-19 through the above biological processes. |
| T174 | 3157-3236 | Sentence | denotes | SFJDC, as a TCM formula, has multi-component, multi-target-gene, multi-pathway. |
| T175 | 3237-3305 | Sentence | denotes | In the present study, 110 KEGG pathways were significantly enriched. |
| T176 | 3306-3679 | Sentence | denotes | Seven of the top 20 pathways were associated with viral infection including Kaposi sarcoma-associated herpesvirus infection, Human cytomegalovirus infection, Hepatitis B, Influenza A, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection and Measles, and three were associated with lung disease contained tuberculosis, pertussis and small cell lung cancer. |
| T177 | 3680-3866 | Sentence | denotes | Multiple targets of SFJDC may also inhibit the activation of cytokines and reduce inflammation by regulating cytokine pathways, such as IL-17 signaling pathway and TNF signaling pathway. |
| T178 | 3867-3942 | Sentence | denotes | In this study, we obtained 20 functional annotation clusters through DAVID. |
| T179 | 3943-4139 | Sentence | denotes | Annotation Cluster1 including Asthma, Bronchiolitis Viral, Respiratory Syncytial Virus Infections, respiratory syncytial virus bronchiolitis were lung related diseases and Virus infection disease. |
| T180 | 4140-4210 | Sentence | denotes | Gene-pathway network was constructed to the core and key target genes. |
| T181 | 4211-4285 | Sentence | denotes | The network showed that RELA had largest degree, was the core target gene. |
| T182 | 4286-4381 | Sentence | denotes | Other top five genes such as MAPK1, MAPK14, CASP3, CASP8 and IL6 might be the key target genes. |
| T183 | 4382-4565 | Sentence | denotes | The pathophysiological process of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-COV-2) infection is similar to that of SARS-CoV infection, with a strong inflammatory response. |
| T184 | 4566-4896 | Sentence | denotes | The SARS-COV-2 virus mainly targets respiratory epithelial cells, alveolar epithelial cells, vascular endothelial cells and pulmonary macrophages, all of which express Angiotensin converting enzyme 2 (ACE2) receptor, triggering the generation of pro- inflammatory cytokines and chemokines (including IL-6, TNF, IL-10 and MCP1) 41. |
| T185 | 4897-5099 | Sentence | denotes | The NF-kB family member RELA is a widely expressed and effective transcriptional activator that activates the expression of many inflammatory through exposure to pathogens and inflammatory cytokines 42. |
| T186 | 5100-5161 | Sentence | denotes | RELA may play an important role in the infection of COVID-19. |
| T187 | 5162-5369 | Sentence | denotes | MAPK1 and MAPK14 are members of the MAPK family, which can regulate multiple cellular processes, such as response to oxidative stress, anti-inflammatory, immune response, apoptosis and cell proliferation 43. |
| T188 | 5370-5606 | Sentence | denotes | Joseph et al showed SASR-CoV-2 could induce severe inflammation by directly activating p38 MAPK pathway and many p38 MAPK inhibitors are in the clinical stage and should be considered for clinical trial for severe COVID-19 infection 44. |
| T189 | 5607-5812 | Sentence | denotes | CASP3 and CASP8, a family of cysteine-dependent proteases, play an important role in these events through activation of other apoptotic proteins mediated by proteolysis and cleavage of nuclear proteins 45. |
| T190 | 5813-5945 | Sentence | denotes | In Krahling's study, infection of 293/ACE2 cells with SARS-CoV activated apoptosis-associated events, such as caspase3, caspase 846. |
| T191 | 5946-6080 | Sentence | denotes | Therefore, we conclude that CASP3 and CASP8 may be activated and play an important role in the pathophysiological process of COVID-19. |
| T192 | 6081-6151 | Sentence | denotes | Higher plasma level of IL-6 was found in ICU patients with COVID-1947. |
| T193 | 6152-6362 | Sentence | denotes | Tocilizumab, a recombinant humanized anti-human IL-6 receptor monoclonal antibody, improved the clinical outcome in 20 severe and critical COVID-19 patients and is an effective treatment to reduce mortality 48. |
| T194 | 6363-6449 | Sentence | denotes | It has been clinically confirmed that SFJDC is effective in the treatment of COVID-19. |
| T195 | 6450-6636 | Sentence | denotes | Wang et al shown that conventional treatment combined with SFJDC treatment for 4 cases of COVID-19 patients could significantly improve symptoms and promote viral negative conversion 49. |
| T196 | 6637-6875 | Sentence | denotes | Another study including 70 COVID-19 patients found that SFJDC combined with Arbidol for COVID-19 compared with single using Arbidol could significantly shorten the time of clinical symptoms improvement and COVID-19 negative conversion 50. |
| T197 | 6876-6985 | Sentence | denotes | To summarise, the compound and targets of SFJDC were systematically studied by applying network pharmacology. |
| T198 | 6986-7070 | Sentence | denotes | Wogonin, licochalcone a and acacetin regulated the most targets associated with NCP. |
| T199 | 7071-7195 | Sentence | denotes | RELA, MAPK1, MAPK14, CASP3, CASP8 and IL6 were the core and key genes in the gene-network of SFJDC for the treatment of NCP. |
| T200 | 7196-7338 | Sentence | denotes | SFJDC regulated novel coronavirus pneumonia by multi-compound and multi-target, which provided theoretical support for SFJDC against COVID-19. |
| T201 | 7339-7400 | Sentence | denotes | More mechanism and roles require further clinical validation. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 33029094-23787177-50187134 | 853-855 | 23787177 | denotes | 36 |
| 33029094-28237856-50187135 | 1637-1639 | 28237856 | denotes | 37 |
| 33029094-29521106-50187136 | 1728-1730 | 29521106 | denotes | 38 |
| 33029094-22400806-50187137 | 1886-1888 | 22400806 | denotes | 39 |
| 33029094-29243040-50187138 | 1988-1990 | 29243040 | denotes | 40 |
| 33029094-32346093-50187139 | 4893-4895 | 32346093 | denotes | 41 |
| 33029094-32101750-50187140 | 5096-5098 | 32101750 | denotes | 42 |
| 33029094-28550733-50187141 | 5366-5368 | 28550733 | denotes | 43 |
| 33029094-32422320-50187142 | 5603-5605 | 32422320 | denotes | 44 |
| 33029094-19109397-50187143 | 5941-5944 | 19109397 | denotes | 846 |
| 33029094-32350134-50187144 | 6359-6361 | 32350134 | denotes | 48 |
| T10094 | 853-855 | 23787177 | denotes | 36 |
| T33835 | 1637-1639 | 28237856 | denotes | 37 |
| T23665 | 1728-1730 | 29521106 | denotes | 38 |
| T6828 | 1886-1888 | 22400806 | denotes | 39 |
| T7761 | 1988-1990 | 29243040 | denotes | 40 |
| T53886 | 4893-4895 | 32346093 | denotes | 41 |
| T53825 | 5096-5098 | 32101750 | denotes | 42 |
| T29108 | 5366-5368 | 28550733 | denotes | 43 |
| T27530 | 5603-5605 | 32422320 | denotes | 44 |
| T42089 | 5941-5944 | 19109397 | denotes | 846 |
| T80753 | 6359-6361 | 32350134 | denotes | 48 |