PMC:7532132 / 4853-6257 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7532132","sourcedb":"PMC","sourceid":"7532132","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7532132","text":"The overall aim of this study was to formulate a solid microcrystalline dispersion as a pharmaceutical film to investigate the effect of the combination of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA) concentration to increase drug dissolution profile by maintaining its crystalline state. PVA was selected as based polymer due to its water solubility and excellent film-forming properties (24). Furthermore, it is odorless and non-toxic. PVA was combined with novel polymer PHEA (25–27) that has many attractive properties, such as water solubility and absence of toxicity (28). Additionally, it is biodegradable and was used previously in drug delivery systems (29). PHEA is also very hydrophilic and has a high degree of mucoadhesion when formulated at 2.5% w/v in combination with PVA at 5% w/v (30). Present work aimed to prove that increasing concentration of PVA in conjunction with new polymer PHEA would allow obtaining a fast-release profile. Ibuprofen sodium was used as model drugs due to its low solubility of 0.0219 mg/mL (31). The oral film was produced via solvent casting and film physicochemical properties were characterized using attenuated total reflection Fourier transform infrared spectroscopy (ATR­FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). In vitro dissolution studies mimicking oral cavity were also conducted.","tracks":[{"project":"2_test","denotations":[{"id":"33006710-23201736-28301","span":{"begin":413,"end":415},"obj":"23201736"},{"id":"33006710-25366547-28302","span":{"begin":503,"end":505},"obj":"25366547"},{"id":"33006710-32261945-28302","span":{"begin":503,"end":505},"obj":"32261945"},{"id":"33006710-28457379-28303","span":{"begin":686,"end":688},"obj":"28457379"},{"id":"33006710-27346416-28304","span":{"begin":1059,"end":1061},"obj":"27346416"}],"attributes":[{"subj":"33006710-23201736-28301","pred":"source","obj":"2_test"},{"subj":"33006710-25366547-28302","pred":"source","obj":"2_test"},{"subj":"33006710-32261945-28302","pred":"source","obj":"2_test"},{"subj":"33006710-28457379-28303","pred":"source","obj":"2_test"},{"subj":"33006710-27346416-28304","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93d1ec","default":true}]}]}}