PMC:7532132 / 2516-3328 JSONTXT

{"project":"2_test","denotations":[{"id":"33006710-26001175-28288","span":{"begin":103,"end":104},"obj":"26001175"},{"id":"33006710-24911355-28289","span":{"begin":503,"end":505},"obj":"24911355"},{"id":"33006710-12379928-28290","span":{"begin":506,"end":508},"obj":"12379928"},{"id":"33006710-28734784-28291","span":{"begin":662,"end":663},"obj":"28734784"},{"id":"33006710-24879936-28292","span":{"begin":664,"end":666},"obj":"24879936"},{"id":"33006710-21130875-28293","span":{"begin":667,"end":669},"obj":"21130875"},{"id":"33006710-23999459-28294","span":{"begin":808,"end":810},"obj":"23999459"}],"text":"Oral cavity film administration has recently emerged as a promising alternative to solid dosage forms (9). Drug delivery via the oral cavity can take place by placing film under the tongue or placing the film on inner cheek allowing rapid absorption of the drug and is, therefore, suitable for fast-release formulations (10). An important factor influencing oral cavity drug delivery is lack of keratinization in cheek mucosa and sublingual regions resulting in high permeability and systemic delivery (11,12). Therefore, patches applied to buccal mucosa have a potential advantage to by-pass first-pass metabolism leading to an increase in the bioavailability (7,13,14). Furthermore, in comparison to oral tablets, films are ultrathin, flexible, and tend to be less obtrusive and therefore more acceptable (15)."}