PMC:7532132 / 22999-23826 JSONTXT

{"project":"2_test","denotations":[{"id":"33006710-25976316-28325","span":{"begin":823,"end":825},"obj":"25976316"}],"text":"The results from drug content studies indicate that the F5 film contained 6.82% of the drug, while F6 film contained 7.01% of the drug. This result was lower than the content of medicine expected to be in the film (10%). Small drug content could be due to method of preparation of drug content studies, which could have influenced content uniformity of films in experimental conditions used and is registered when the formulation is not provided with a stabilizer (19). Moreover, evaluation of PDI demonstrated that particles were not monodispersed in the polymer matrix. Woertz et al. conducted content uniformity studies on loperamide films. They found that some of the films had lower drug content than expected which could be attributed to numerous reasons, such as the concentration of polymer and drug used in films (59)."}