PMC:7532132 / 11620-13134 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7532132","sourcedb":"PMC","sourceid":"7532132","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7532132","text":"At first, physical-chemical properties of raw material were characterized to investigate changing in drug solid state after formulation. ATR-FTIR was used to assess main peaks related to PVA, PHEA, and ibuprofen sodium, respectively. Notably, this method allows identification of creation of hydrogen bonding that might indicate the formation of new bonds between drug and polymers (35). Figure 1 presents ATR-FTIR spectra for raw material and peak assignation was reported in Table II. Peak assignation was coherent with literature, and ibuprofen sodium spectra resulted in being consistent with pure drug spectra in the crystalline form (36–38).\nFig. 1 ATR-FTIR spectra of raw materials PVA, PHEA, and ibuprofen sodium\nTable II Peak Assignation for Each Raw Material PVA, PHEA, and Ibuprofen Sodium. Data Are Coherent with Literature Findings (36–38)\nRaw material Peaks Assignation\nPVA 3290 cm−1 Stretching O–H group\n2939 cm−1 Asymmetric stretching C–H group\n1732 cm−1 Stretching C=O\n1567 cm−1 Stretching C=C\n1421 cm−1 Symmetric bending CH2 group\nPHEA 3276 cm−1 Stretching O–H bond\n2938 cm−1 Aliphatic stretching C–H group\n1633 cm−1 Stretching C=O group\n1525 cm−1 Vibrations N–H group\n1427 cm−1 Aliphatic bending C–H group\n1362 cm−1 Bending O–H group\n1056 cm−1 Ester group\nIbuprofen sodium 2951 cm−1 Asymmetric stretching CH3 group\n1698 cm−1 Stretching C=O group\n1545 cm−1 Stretching vibrations C=C\n1251 cm−1 C–O stretching\n748 cm−1 Vibration CH2 group\nPVA polyvinyl alcohol, PHEA poly-N-hydroxyethyl-aspartamide","divisions":[{"label":"figure","span":{"begin":648,"end":720}},{"label":"label","span":{"begin":648,"end":654}},{"label":"caption","span":{"begin":655,"end":720}},{"label":"p","span":{"begin":655,"end":720}},{"label":"label","span":{"begin":721,"end":729}},{"label":"caption","span":{"begin":730,"end":852}},{"label":"p","span":{"begin":730,"end":852}},{"label":"table","span":{"begin":853,"end":1454}},{"label":"tr","span":{"begin":853,"end":883}},{"label":"th","span":{"begin":853,"end":865}},{"label":"th","span":{"begin":866,"end":871}},{"label":"th","span":{"begin":872,"end":883}},{"label":"tr","span":{"begin":884,"end":918}},{"label":"td","span":{"begin":884,"end":887}},{"label":"td","span":{"begin":888,"end":897}},{"label":"td","span":{"begin":898,"end":918}},{"label":"tr","span":{"begin":919,"end":960}},{"label":"td","span":{"begin":919,"end":928}},{"label":"td","span":{"begin":929,"end":960}},{"label":"tr","span":{"begin":961,"end":985}},{"label":"td","span":{"begin":961,"end":970}},{"label":"td","span":{"begin":971,"end":985}},{"label":"tr","span":{"begin":986,"end":1010}},{"label":"td","span":{"begin":986,"end":995}},{"label":"td","span":{"begin":996,"end":1010}},{"label":"tr","span":{"begin":1011,"end":1048}},{"label":"td","span":{"begin":1011,"end":1020}},{"label":"td","span":{"begin":1021,"end":1048}},{"label":"tr","span":{"begin":1049,"end":1083}},{"label":"td","span":{"begin":1049,"end":1053}},{"label":"td","span":{"begin":1054,"end":1063}},{"label":"td","span":{"begin":1064,"end":1083}},{"label":"tr","span":{"begin":1084,"end":1124}},{"label":"td","span":{"begin":1084,"end":1093}},{"label":"td","span":{"begin":1094,"end":1124}},{"label":"tr","span":{"begin":1125,"end":1155}},{"label":"td","span":{"begin":1125,"end":1134}},{"label":"td","span":{"begin":1135,"end":1155}},{"label":"tr","span":{"begin":1156,"end":1186}},{"label":"td","span":{"begin":1156,"end":1165}},{"label":"td","span":{"begin":1166,"end":1186}},{"label":"tr","span":{"begin":1187,"end":1224}},{"label":"td","span":{"begin":1187,"end":1196}},{"label":"td","span":{"begin":1197,"end":1224}},{"label":"tr","span":{"begin":1225,"end":1252}},{"label":"td","span":{"begin":1225,"end":1234}},{"label":"td","span":{"begin":1235,"end":1252}},{"label":"tr","span":{"begin":1253,"end":1274}},{"label":"td","span":{"begin":1253,"end":1262}},{"label":"td","span":{"begin":1263,"end":1274}},{"label":"tr","span":{"begin":1275,"end":1333}},{"label":"td","span":{"begin":1275,"end":1291}},{"label":"td","span":{"begin":1292,"end":1301}},{"label":"td","span":{"begin":1302,"end":1333}},{"label":"tr","span":{"begin":1334,"end":1364}},{"label":"td","span":{"begin":1334,"end":1343}},{"label":"td","span":{"begin":1344,"end":1364}},{"label":"tr","span":{"begin":1365,"end":1400}},{"label":"td","span":{"begin":1365,"end":1374}},{"label":"td","span":{"begin":1375,"end":1400}},{"label":"tr","span":{"begin":1401,"end":1425}},{"label":"td","span":{"begin":1401,"end":1410}},{"label":"td","span":{"begin":1411,"end":1425}},{"label":"tr","span":{"begin":1426,"end":1454}},{"label":"td","span":{"begin":1426,"end":1434}},{"label":"td","span":{"begin":1435,"end":1454}}],"tracks":[{"project":"2_test","denotations":[{"id":"33006710-11755266-28307","span":{"begin":383,"end":385},"obj":"11755266"}],"attributes":[{"subj":"33006710-11755266-28307","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#eca393","default":true}]}]}}