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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7530350","sourcedb":"PMC","sourceid":"7530350","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7530350","text":"Background\nEvidence links COVID-19 severity to hyper-inflammation. Treatment with tocilizumab, a monoclonal antibody directed against the interleukin-6 (IL-6) receptor, was shown to lead to clinical improvement in patients with severe COVID-19. We, therefore, performed the present systematic review and meta-analysis to investigate whether the circulating levels of IL-6 is a reliable indicator of disease severity among patients affected with 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