PMC:7530274 / 8362-10819
Annnotations
LitCovid-PD-FMA-UBERON
{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T25","span":{"begin":327,"end":331},"obj":"Body_part"}],"attributes":[{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma7163"}],"text":"Feasibility of Home-based Tdcs\nIt is essential that the home-based tDCS device is specifically designed (Charvet et al., 2015) for this purpose, with safety measures that prevent the incorrect use of the equipment and guarantee the correct placement of the electrodes, since improper use of the device has been associated with skin burns. In order to mitigate such risk, most home-based tDCS devices have pre-programmed the intensity and duration of the stimulation and do not allow the patient to change them (Bikson et al., 2020), while others can be remotely controlled and adjusted by a technician.\nRemote supervision using telehealth solutions (Riggs et al., 2018) are paramount to ensure safety and encourage adherence to the stimulation protocols, allowing the researcher to reassure the subject that mild and temporary sensations of tingling, itching, burning, or headache could occur during the stimulation, while also monitoring for unexpected or more severe adverse events, even if unrelated to the stimulation. With the current development of telehealth and ubiquitous use of remote visits, both patients and healthcare providers are becoming increasingly comfortable with this technology. The same data safety and cybersecurity measures used in regular remote clinical work can be used to monitor the use of home-based tDCS, safeguard the patient's privacy, and correct the use of the equipment. In the research setting, the use of electronic informed consent (eIC) is also becoming widely accepted to ensure the proper legal and ethical requirements are met.\nAlthough it is a fairly simple technique with minimal risks associated with the electrical current delivery when done within pre-defined safety parameters, we do not encourage the use of any do-it-yourself stimulation devices. We strongly recommend closely monitoring and supervision, mainly due to the dangers of misuse and overuse.\nTo date, protocols that have used home-based tDCS have started with an in-person training session, either a home visit from a technician or a visit to the research facility by the subject. This was done to ensure that the individuals understood and properly used it (Kasschau et al., 2016). In the context of stricter social isolation situations such as a quarantine or complete lockdown, future protocols could potentially use solutions with all the instruction and orientation sessions done remotely, but that would require testing for feasibility."}
LitCovid-PD-UBERON
{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T20","span":{"begin":327,"end":331},"obj":"Body_part"}],"attributes":[{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"}],"text":"Feasibility of Home-based Tdcs\nIt is essential that the home-based tDCS device is specifically designed (Charvet et al., 2015) for this purpose, with safety measures that prevent the incorrect use of the equipment and guarantee the correct placement of the electrodes, since improper use of the device has been associated with skin burns. In order to mitigate such risk, most home-based tDCS devices have pre-programmed the intensity and duration of the stimulation and do not allow the patient to change them (Bikson et al., 2020), while others can be remotely controlled and adjusted by a technician.\nRemote supervision using telehealth solutions (Riggs et al., 2018) are paramount to ensure safety and encourage adherence to the stimulation protocols, allowing the researcher to reassure the subject that mild and temporary sensations of tingling, itching, burning, or headache could occur during the stimulation, while also monitoring for unexpected or more severe adverse events, even if unrelated to the stimulation. With the current development of telehealth and ubiquitous use of remote visits, both patients and healthcare providers are becoming increasingly comfortable with this technology. The same data safety and cybersecurity measures used in regular remote clinical work can be used to monitor the use of home-based tDCS, safeguard the patient's privacy, and correct the use of the equipment. In the research setting, the use of electronic informed consent (eIC) is also becoming widely accepted to ensure the proper legal and ethical requirements are met.\nAlthough it is a fairly simple technique with minimal risks associated with the electrical current delivery when done within pre-defined safety parameters, we do not encourage the use of any do-it-yourself stimulation devices. We strongly recommend closely monitoring and supervision, mainly due to the dangers of misuse and overuse.\nTo date, protocols that have used home-based tDCS have started with an in-person training session, either a home visit from a technician or a visit to the research facility by the subject. This was done to ensure that the individuals understood and properly used it (Kasschau et al., 2016). In the context of stricter social isolation situations such as a quarantine or complete lockdown, future protocols could potentially use solutions with all the instruction and orientation sessions done remotely, but that would require testing for feasibility."}
LitCovid-PD-CLO
{"project":"LitCovid-PD-CLO","denotations":[{"id":"T46","span":{"begin":72,"end":78},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T47","span":{"begin":295,"end":301},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T48","span":{"begin":302,"end":305},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T49","span":{"begin":327,"end":331},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T50","span":{"begin":327,"end":331},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T51","span":{"begin":327,"end":331},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T52","span":{"begin":327,"end":331},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T53","span":{"begin":327,"end":331},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"},{"id":"T54","span":{"begin":392,"end":399},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T55","span":{"begin":589,"end":590},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T56","span":{"begin":664,"end":668},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T57","span":{"begin":1588,"end":1589},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T58","span":{"begin":1791,"end":1798},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T59","span":{"begin":2013,"end":2014},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T60","span":{"begin":2031,"end":2032},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T61","span":{"begin":2047,"end":2048},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T62","span":{"begin":2261,"end":2262},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T63","span":{"begin":2433,"end":2440},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"Feasibility of Home-based Tdcs\nIt is essential that the home-based tDCS device is specifically designed (Charvet et al., 2015) for this purpose, with safety measures that prevent the incorrect use of the equipment and guarantee the correct placement of the electrodes, since improper use of the device has been associated with skin burns. In order to mitigate such risk, most home-based tDCS devices have pre-programmed the intensity and duration of the stimulation and do not allow the patient to change them (Bikson et al., 2020), while others can be remotely controlled and adjusted by a technician.\nRemote supervision using telehealth solutions (Riggs et al., 2018) are paramount to ensure safety and encourage adherence to the stimulation protocols, allowing the researcher to reassure the subject that mild and temporary sensations of tingling, itching, burning, or headache could occur during the stimulation, while also monitoring for unexpected or more severe adverse events, even if unrelated to the stimulation. With the current development of telehealth and ubiquitous use of remote visits, both patients and healthcare providers are becoming increasingly comfortable with this technology. The same data safety and cybersecurity measures used in regular remote clinical work can be used to monitor the use of home-based tDCS, safeguard the patient's privacy, and correct the use of the equipment. In the research setting, the use of electronic informed consent (eIC) is also becoming widely accepted to ensure the proper legal and ethical requirements are met.\nAlthough it is a fairly simple technique with minimal risks associated with the electrical current delivery when done within pre-defined safety parameters, we do not encourage the use of any do-it-yourself stimulation devices. We strongly recommend closely monitoring and supervision, mainly due to the dangers of misuse and overuse.\nTo date, protocols that have used home-based tDCS have started with an in-person training session, either a home visit from a technician or a visit to the research facility by the subject. This was done to ensure that the individuals understood and properly used it (Kasschau et al., 2016). In the context of stricter social isolation situations such as a quarantine or complete lockdown, future protocols could potentially use solutions with all the instruction and orientation sessions done remotely, but that would require testing for feasibility."}
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"83","span":{"begin":487,"end":494},"obj":"Species"},{"id":"89","span":{"begin":1108,"end":1116},"obj":"Species"},{"id":"90","span":{"begin":1352,"end":1359},"obj":"Species"},{"id":"91","span":{"begin":827,"end":849},"obj":"Disease"},{"id":"92","span":{"begin":851,"end":858},"obj":"Disease"},{"id":"93","span":{"begin":872,"end":880},"obj":"Disease"}],"attributes":[{"id":"A83","pred":"tao:has_database_id","subj":"83","obj":"Tax:9606"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"Tax:9606"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"Tax:9606"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"MESH:D012678"},{"id":"A92","pred":"tao:has_database_id","subj":"92","obj":"MESH:D011537"},{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"MESH:D006261"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Feasibility of Home-based Tdcs\nIt is essential that the home-based tDCS device is specifically designed (Charvet et al., 2015) for this purpose, with safety measures that prevent the incorrect use of the equipment and guarantee the correct placement of the electrodes, since improper use of the device has been associated with skin burns. In order to mitigate such risk, most home-based tDCS devices have pre-programmed the intensity and duration of the stimulation and do not allow the patient to change them (Bikson et al., 2020), while others can be remotely controlled and adjusted by a technician.\nRemote supervision using telehealth solutions (Riggs et al., 2018) are paramount to ensure safety and encourage adherence to the stimulation protocols, allowing the researcher to reassure the subject that mild and temporary sensations of tingling, itching, burning, or headache could occur during the stimulation, while also monitoring for unexpected or more severe adverse events, even if unrelated to the stimulation. With the current development of telehealth and ubiquitous use of remote visits, both patients and healthcare providers are becoming increasingly comfortable with this technology. The same data safety and cybersecurity measures used in regular remote clinical work can be used to monitor the use of home-based tDCS, safeguard the patient's privacy, and correct the use of the equipment. In the research setting, the use of electronic informed consent (eIC) is also becoming widely accepted to ensure the proper legal and ethical requirements are met.\nAlthough it is a fairly simple technique with minimal risks associated with the electrical current delivery when done within pre-defined safety parameters, we do not encourage the use of any do-it-yourself stimulation devices. We strongly recommend closely monitoring and supervision, mainly due to the dangers of misuse and overuse.\nTo date, protocols that have used home-based tDCS have started with an in-person training session, either a home visit from a technician or a visit to the research facility by the subject. This was done to ensure that the individuals understood and properly used it (Kasschau et al., 2016). In the context of stricter social isolation situations such as a quarantine or complete lockdown, future protocols could potentially use solutions with all the instruction and orientation sessions done remotely, but that would require testing for feasibility."}
LitCovid-PD-HP
{"project":"LitCovid-PD-HP","denotations":[{"id":"T11","span":{"begin":841,"end":849},"obj":"Phenotype"},{"id":"T12","span":{"begin":851,"end":858},"obj":"Phenotype"},{"id":"T13","span":{"begin":872,"end":880},"obj":"Phenotype"}],"attributes":[{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0003401"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0000989"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0002315"}],"text":"Feasibility of Home-based Tdcs\nIt is essential that the home-based tDCS device is specifically designed (Charvet et al., 2015) for this purpose, with safety measures that prevent the incorrect use of the equipment and guarantee the correct placement of the electrodes, since improper use of the device has been associated with skin burns. In order to mitigate such risk, most home-based tDCS devices have pre-programmed the intensity and duration of the stimulation and do not allow the patient to change them (Bikson et al., 2020), while others can be remotely controlled and adjusted by a technician.\nRemote supervision using telehealth solutions (Riggs et al., 2018) are paramount to ensure safety and encourage adherence to the stimulation protocols, allowing the researcher to reassure the subject that mild and temporary sensations of tingling, itching, burning, or headache could occur during the stimulation, while also monitoring for unexpected or more severe adverse events, even if unrelated to the stimulation. With the current development of telehealth and ubiquitous use of remote visits, both patients and healthcare providers are becoming increasingly comfortable with this technology. The same data safety and cybersecurity measures used in regular remote clinical work can be used to monitor the use of home-based tDCS, safeguard the patient's privacy, and correct the use of the equipment. In the research setting, the use of electronic informed consent (eIC) is also becoming widely accepted to ensure the proper legal and ethical requirements are met.\nAlthough it is a fairly simple technique with minimal risks associated with the electrical current delivery when done within pre-defined safety parameters, we do not encourage the use of any do-it-yourself stimulation devices. We strongly recommend closely monitoring and supervision, mainly due to the dangers of misuse and overuse.\nTo date, protocols that have used home-based tDCS have started with an in-person training session, either a home visit from a technician or a visit to the research facility by the subject. This was done to ensure that the individuals understood and properly used it (Kasschau et al., 2016). In the context of stricter social isolation situations such as a quarantine or complete lockdown, future protocols could potentially use solutions with all the instruction and orientation sessions done remotely, but that would require testing for feasibility."}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T43","span":{"begin":0,"end":30},"obj":"Sentence"},{"id":"T44","span":{"begin":31,"end":338},"obj":"Sentence"},{"id":"T45","span":{"begin":339,"end":602},"obj":"Sentence"},{"id":"T46","span":{"begin":603,"end":1022},"obj":"Sentence"},{"id":"T47","span":{"begin":1023,"end":1201},"obj":"Sentence"},{"id":"T48","span":{"begin":1202,"end":1408},"obj":"Sentence"},{"id":"T49","span":{"begin":1409,"end":1572},"obj":"Sentence"},{"id":"T50","span":{"begin":1573,"end":1799},"obj":"Sentence"},{"id":"T51","span":{"begin":1800,"end":1906},"obj":"Sentence"},{"id":"T52","span":{"begin":1907,"end":2095},"obj":"Sentence"},{"id":"T53","span":{"begin":2096,"end":2197},"obj":"Sentence"},{"id":"T54","span":{"begin":2198,"end":2457},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Feasibility of Home-based Tdcs\nIt is essential that the home-based tDCS device is specifically designed (Charvet et al., 2015) for this purpose, with safety measures that prevent the incorrect use of the equipment and guarantee the correct placement of the electrodes, since improper use of the device has been associated with skin burns. In order to mitigate such risk, most home-based tDCS devices have pre-programmed the intensity and duration of the stimulation and do not allow the patient to change them (Bikson et al., 2020), while others can be remotely controlled and adjusted by a technician.\nRemote supervision using telehealth solutions (Riggs et al., 2018) are paramount to ensure safety and encourage adherence to the stimulation protocols, allowing the researcher to reassure the subject that mild and temporary sensations of tingling, itching, burning, or headache could occur during the stimulation, while also monitoring for unexpected or more severe adverse events, even if unrelated to the stimulation. With the current development of telehealth and ubiquitous use of remote visits, both patients and healthcare providers are becoming increasingly comfortable with this technology. The same data safety and cybersecurity measures used in regular remote clinical work can be used to monitor the use of home-based tDCS, safeguard the patient's privacy, and correct the use of the equipment. In the research setting, the use of electronic informed consent (eIC) is also becoming widely accepted to ensure the proper legal and ethical requirements are met.\nAlthough it is a fairly simple technique with minimal risks associated with the electrical current delivery when done within pre-defined safety parameters, we do not encourage the use of any do-it-yourself stimulation devices. We strongly recommend closely monitoring and supervision, mainly due to the dangers of misuse and overuse.\nTo date, protocols that have used home-based tDCS have started with an in-person training session, either a home visit from a technician or a visit to the research facility by the subject. This was done to ensure that the individuals understood and properly used it (Kasschau et al., 2016). In the context of stricter social isolation situations such as a quarantine or complete lockdown, future protocols could potentially use solutions with all the instruction and orientation sessions done remotely, but that would require testing for feasibility."}
2_test
{"project":"2_test","denotations":[{"id":"33071764-25852494-35512728","span":{"begin":121,"end":125},"obj":"25852494"},{"id":"33071764-32413554-35512729","span":{"begin":526,"end":530},"obj":"32413554"},{"id":"33071764-29872381-35512730","span":{"begin":664,"end":668},"obj":"29872381"},{"id":"33071764-27089545-35512731","span":{"begin":2191,"end":2195},"obj":"27089545"}],"text":"Feasibility of Home-based Tdcs\nIt is essential that the home-based tDCS device is specifically designed (Charvet et al., 2015) for this purpose, with safety measures that prevent the incorrect use of the equipment and guarantee the correct placement of the electrodes, since improper use of the device has been associated with skin burns. In order to mitigate such risk, most home-based tDCS devices have pre-programmed the intensity and duration of the stimulation and do not allow the patient to change them (Bikson et al., 2020), while others can be remotely controlled and adjusted by a technician.\nRemote supervision using telehealth solutions (Riggs et al., 2018) are paramount to ensure safety and encourage adherence to the stimulation protocols, allowing the researcher to reassure the subject that mild and temporary sensations of tingling, itching, burning, or headache could occur during the stimulation, while also monitoring for unexpected or more severe adverse events, even if unrelated to the stimulation. With the current development of telehealth and ubiquitous use of remote visits, both patients and healthcare providers are becoming increasingly comfortable with this technology. The same data safety and cybersecurity measures used in regular remote clinical work can be used to monitor the use of home-based tDCS, safeguard the patient's privacy, and correct the use of the equipment. In the research setting, the use of electronic informed consent (eIC) is also becoming widely accepted to ensure the proper legal and ethical requirements are met.\nAlthough it is a fairly simple technique with minimal risks associated with the electrical current delivery when done within pre-defined safety parameters, we do not encourage the use of any do-it-yourself stimulation devices. We strongly recommend closely monitoring and supervision, mainly due to the dangers of misuse and overuse.\nTo date, protocols that have used home-based tDCS have started with an in-person training session, either a home visit from a technician or a visit to the research facility by the subject. This was done to ensure that the individuals understood and properly used it (Kasschau et al., 2016). In the context of stricter social isolation situations such as a quarantine or complete lockdown, future protocols could potentially use solutions with all the instruction and orientation sessions done remotely, but that would require testing for feasibility."}
MyTest
{"project":"MyTest","denotations":[{"id":"33071764-25852494-35512728","span":{"begin":121,"end":125},"obj":"25852494"},{"id":"33071764-32413554-35512729","span":{"begin":526,"end":530},"obj":"32413554"},{"id":"33071764-29872381-35512730","span":{"begin":664,"end":668},"obj":"29872381"},{"id":"33071764-27089545-35512731","span":{"begin":2191,"end":2195},"obj":"27089545"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Feasibility of Home-based Tdcs\nIt is essential that the home-based tDCS device is specifically designed (Charvet et al., 2015) for this purpose, with safety measures that prevent the incorrect use of the equipment and guarantee the correct placement of the electrodes, since improper use of the device has been associated with skin burns. In order to mitigate such risk, most home-based tDCS devices have pre-programmed the intensity and duration of the stimulation and do not allow the patient to change them (Bikson et al., 2020), while others can be remotely controlled and adjusted by a technician.\nRemote supervision using telehealth solutions (Riggs et al., 2018) are paramount to ensure safety and encourage adherence to the stimulation protocols, allowing the researcher to reassure the subject that mild and temporary sensations of tingling, itching, burning, or headache could occur during the stimulation, while also monitoring for unexpected or more severe adverse events, even if unrelated to the stimulation. With the current development of telehealth and ubiquitous use of remote visits, both patients and healthcare providers are becoming increasingly comfortable with this technology. The same data safety and cybersecurity measures used in regular remote clinical work can be used to monitor the use of home-based tDCS, safeguard the patient's privacy, and correct the use of the equipment. In the research setting, the use of electronic informed consent (eIC) is also becoming widely accepted to ensure the proper legal and ethical requirements are met.\nAlthough it is a fairly simple technique with minimal risks associated with the electrical current delivery when done within pre-defined safety parameters, we do not encourage the use of any do-it-yourself stimulation devices. We strongly recommend closely monitoring and supervision, mainly due to the dangers of misuse and overuse.\nTo date, protocols that have used home-based tDCS have started with an in-person training session, either a home visit from a technician or a visit to the research facility by the subject. This was done to ensure that the individuals understood and properly used it (Kasschau et al., 2016). In the context of stricter social isolation situations such as a quarantine or complete lockdown, future protocols could potentially use solutions with all the instruction and orientation sessions done remotely, but that would require testing for feasibility."}