PMC:7523471 / 64131-65070 JSONTXT

{"project":"TEST0","denotations":[{"id":"33041751-149-157-816664","span":{"begin":149,"end":153},"obj":"[\"8280117\"]"},{"id":"33041751-172-180-816665","span":{"begin":172,"end":176},"obj":"[\"11910111\"]"},{"id":"33041751-192-200-816666","span":{"begin":192,"end":196},"obj":"[\"14522007\"]"},{"id":"33041751-209-217-816667","span":{"begin":209,"end":213},"obj":"[\"26484906\"]"},{"id":"33041751-228-236-816668","span":{"begin":228,"end":232},"obj":"[\"26005850\"]"},{"id":"33041751-232-240-816669","span":{"begin":250,"end":254},"obj":"[\"29377008\"]"},{"id":"33041751-147-155-816670","span":{"begin":664,"end":668},"obj":"[\"15728564\"]"},{"id":"33041751-131-139-816671","span":{"begin":802,"end":806},"obj":"[\"32376954\"]"}],"text":"In the brain, the BBB plays an indispensable role in mediating clearance of Aβ through its efflux in the cerebral vascular network (Zlokovic et al., 1993; DeMattos et al., 2002; Banks et al., 2003; Do et al., 2015; Zhao et al., 2015; Sweeney et al., 2018). The BBB is established by endothelial cells forming vessel walls, astrocyte end-feet, and pericytes in the basement membrane. In comparison, the BRB is composed of tight junctions of retinal endothelial and epithelial cells together with supporting pericytes. Despite their organ-specific functions, the BBB and BRB display very similar functions in transport and permeation characteristics (Steuer et al., 2005). A recent study has established a correlation among BBB, ApoE ε4 and cognitive decline regardless of AD pathology (Montagne et al., 2020). The recent findings implicated pericytes in AD pathogenesis and future investigations may shed light on the role of the BRB in AD."}

{"project":"2_test","denotations":[{"id":"33041751-8280117-38666450","span":{"begin":149,"end":153},"obj":"8280117"},{"id":"33041751-11910111-38666451","span":{"begin":172,"end":176},"obj":"11910111"},{"id":"33041751-14522007-38666452","span":{"begin":192,"end":196},"obj":"14522007"},{"id":"33041751-26484906-38666453","span":{"begin":209,"end":213},"obj":"26484906"},{"id":"33041751-26005850-38666454","span":{"begin":228,"end":232},"obj":"26005850"},{"id":"33041751-29377008-38666455","span":{"begin":250,"end":254},"obj":"29377008"},{"id":"33041751-15728564-38666456","span":{"begin":664,"end":668},"obj":"15728564"},{"id":"33041751-32376954-38666457","span":{"begin":802,"end":806},"obj":"32376954"}],"text":"In the brain, the BBB plays an indispensable role in mediating clearance of Aβ through its efflux in the cerebral vascular network (Zlokovic et al., 1993; DeMattos et al., 2002; Banks et al., 2003; Do et al., 2015; Zhao et al., 2015; Sweeney et al., 2018). The BBB is established by endothelial cells forming vessel walls, astrocyte end-feet, and pericytes in the basement membrane. In comparison, the BRB is composed of tight junctions of retinal endothelial and epithelial cells together with supporting pericytes. Despite their organ-specific functions, the BBB and BRB display very similar functions in transport and permeation characteristics (Steuer et al., 2005). A recent study has established a correlation among BBB, ApoE ε4 and cognitive decline regardless of AD pathology (Montagne et al., 2020). The recent findings implicated pericytes in AD pathogenesis and future investigations may shed light on the role of the BRB in AD."}

{"project":"0_colil","denotations":[{"id":"33041751-8280117-816664","span":{"begin":149,"end":153},"obj":"8280117"},{"id":"33041751-11910111-816665","span":{"begin":172,"end":176},"obj":"11910111"},{"id":"33041751-14522007-816666","span":{"begin":192,"end":196},"obj":"14522007"},{"id":"33041751-26484906-816667","span":{"begin":209,"end":213},"obj":"26484906"},{"id":"33041751-26005850-816668","span":{"begin":228,"end":232},"obj":"26005850"},{"id":"33041751-29377008-816669","span":{"begin":250,"end":254},"obj":"29377008"},{"id":"33041751-15728564-816670","span":{"begin":664,"end":668},"obj":"15728564"},{"id":"33041751-32376954-816671","span":{"begin":802,"end":806},"obj":"32376954"}],"text":"In the brain, the BBB plays an indispensable role in mediating clearance of Aβ through its efflux in the cerebral vascular network (Zlokovic et al., 1993; DeMattos et al., 2002; Banks et al., 2003; Do et al., 2015; Zhao et al., 2015; Sweeney et al., 2018). The BBB is established by endothelial cells forming vessel walls, astrocyte end-feet, and pericytes in the basement membrane. In comparison, the BRB is composed of tight junctions of retinal endothelial and epithelial cells together with supporting pericytes. Despite their organ-specific functions, the BBB and BRB display very similar functions in transport and permeation characteristics (Steuer et al., 2005). A recent study has established a correlation among BBB, ApoE ε4 and cognitive decline regardless of AD pathology (Montagne et al., 2020). The recent findings implicated pericytes in AD pathogenesis and future investigations may shed light on the role of the BRB in AD."}