PMC:7523471 / 57551-58592 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7523471","sourcedb":"PMC","sourceid":"7523471","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7523471","text":"Numerous reports have broadly described vascular dysfunctions in the AD retina, including increased tortuosity, narrowed veins, decreased blood flow, microvascular network damage, and compromised branching complexity (Berisha et al., 2007; Frost et al., 2010, 2013; Cheung et al., 2014; Feke et al., 2015; Williams et al., 2015; Einarsdottir et al., 2016; Abbasi, 2017; Cabrera DeBuc et al., 2018; O’Bryhim et al., 2018), similar to earlier findings in the brain (Smith et al., 1999; Bookheimer et al., 2000; Kimbrough et al., 2015). Such studies have extensively focused on live imaging of retinal blood flow dynamics of AD patients, yet there is a significant lack of understanding regarding the precise molecular and cellular mediators involved in retinal vascular AD pathology, which could lead to the discovery of potential intervention points of treatments and guide the development of next-generation retinal imaging. Thus, more in-depth investigations of the pathogenic mechanisms of retinal vasculature in AD development are 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