PMC:7523471 / 44222-45132 JSONTXT

{"project":"TEST0","denotations":[{"id":"33041751-232-240-816552","span":{"begin":271,"end":275},"obj":"[\"26267479\"]"},{"id":"33041751-212-220-816553","span":{"begin":490,"end":494},"obj":"[\"32256305\"]"},{"id":"33041751-158-166-816554","span":{"begin":655,"end":659},"obj":"[\"32256305\"]"},{"id":"33041751-231-239-816555","span":{"begin":904,"end":908},"obj":"[\"28774322\"]"}],"text":"In the South American rodent O. degus, previously reported to develop several spontaneous AD-like pathologies without genetic manipulation, elevated levels of pTau were primarily detected in the GCL to NFL regions of the retina in both adult and aged animals (Du et al., 2015). In a subsequent study by the same group, early punctate AT8 immunoreactivity in the IPL was reported in young degus, compared with the denser expression in IPL to NFL of juvenile and adult animals (Chang et al., 2020). Interestingly, p(tau)-positive aggregates both appeared and propagated to other inner retinal layers earlier than Aβ deposits in these animals (Chang et al., 2020). Similarly, retinal accumulation of total tau and epitope-specific hyperphosphorylation were also reported to precede onset of behavioral deficits and brain tauopathy as early as 3 months of age in the 3xTg mouse model of AD (Chiasseu et al., 2017)."}

{"project":"2_test","denotations":[{"id":"33041751-26267479-38666338","span":{"begin":271,"end":275},"obj":"26267479"},{"id":"33041751-32256305-38666339","span":{"begin":490,"end":494},"obj":"32256305"},{"id":"33041751-32256305-38666340","span":{"begin":655,"end":659},"obj":"32256305"},{"id":"33041751-28774322-38666341","span":{"begin":904,"end":908},"obj":"28774322"}],"text":"In the South American rodent O. degus, previously reported to develop several spontaneous AD-like pathologies without genetic manipulation, elevated levels of pTau were primarily detected in the GCL to NFL regions of the retina in both adult and aged animals (Du et al., 2015). In a subsequent study by the same group, early punctate AT8 immunoreactivity in the IPL was reported in young degus, compared with the denser expression in IPL to NFL of juvenile and adult animals (Chang et al., 2020). Interestingly, p(tau)-positive aggregates both appeared and propagated to other inner retinal layers earlier than Aβ deposits in these animals (Chang et al., 2020). Similarly, retinal accumulation of total tau and epitope-specific hyperphosphorylation were also reported to precede onset of behavioral deficits and brain tauopathy as early as 3 months of age in the 3xTg mouse model of AD (Chiasseu et al., 2017)."}

{"project":"0_colil","denotations":[{"id":"33041751-26267479-816552","span":{"begin":271,"end":275},"obj":"26267479"},{"id":"33041751-32256305-816553","span":{"begin":490,"end":494},"obj":"32256305"},{"id":"33041751-32256305-816554","span":{"begin":655,"end":659},"obj":"32256305"},{"id":"33041751-28774322-816555","span":{"begin":904,"end":908},"obj":"28774322"}],"text":"In the South American rodent O. degus, previously reported to develop several spontaneous AD-like pathologies without genetic manipulation, elevated levels of pTau were primarily detected in the GCL to NFL regions of the retina in both adult and aged animals (Du et al., 2015). In a subsequent study by the same group, early punctate AT8 immunoreactivity in the IPL was reported in young degus, compared with the denser expression in IPL to NFL of juvenile and adult animals (Chang et al., 2020). Interestingly, p(tau)-positive aggregates both appeared and propagated to other inner retinal layers earlier than Aβ deposits in these animals (Chang et al., 2020). Similarly, retinal accumulation of total tau and epitope-specific hyperphosphorylation were also reported to precede onset of behavioral deficits and brain tauopathy as early as 3 months of age in the 3xTg mouse model of AD (Chiasseu et al., 2017)."}