PMC:7523471 / 29008-30407
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7523471","sourcedb":"PMC","sourceid":"7523471","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7523471","text":"Hyperphosphorylation of tau has been shown to drive the formation of fibrillar tau inclusions and neurofibrillary tangles, leading to disruptions in axonal transport as well as metabolic and oxidative stress, and is closely associated with neuronal death (Iqbal et al., 2009). Although several histological staining approaches have been utilized to confirm the presence of fibrillar inclusions of pTau in human AD retinas, thus far many have been unsuccessful (Schön et al., 2012; den Haan et al., 2018). To date, only one study using Gallyas silver staining detected NFT-like structures in postmortem retinas of definitive AD patients (Figures 4C,D; Koronyo et al., 2017). As mentioned above, there is an apparent gap in results obtained from different groups, possibly driven by the lack of standardized experimental procedures. For instance, the same antibodies against pTau reported to produce negative results by one group (Schön et al., 2012) detected pTau staining patterns similar to AT8-immunoreactivity in a later study (den Haan et al., 2018). Still, by utilizing AT100 antibody, two independent groups detected similar patterns of pTau in postmortem retinas from AD patients (Figure 4E; den Haan et al., 2018; Grimaldi et al., 2019). Future investigations would therefore be necessary to confirm the presence or absence of disease-associated tau conformers in the retinas of AD patients.","tracks":[{"project":"TEST0","denotations":[{"id":"33041751-233-241-816385","span":{"begin":270,"end":274},"obj":"[\"19184068\"]"},{"id":"33041751-198-206-816386","span":{"begin":475,"end":479},"obj":"[\"23300938\"]"},{"id":"33041751-221-229-816387","span":{"begin":498,"end":502},"obj":"[\"30593285\"]"},{"id":"33041751-162-170-816388","span":{"begin":667,"end":671},"obj":"[\"28814675\"]"},{"id":"33041751-112-120-816389","span":{"begin":943,"end":947},"obj":"[\"23300938\"]"},{"id":"33041751-217-225-816390","span":{"begin":1048,"end":1052},"obj":"[\"30593285\"]"},{"id":"33041751-161-169-816391","span":{"begin":1216,"end":1220},"obj":"[\"30593285\"]"},{"id":"33041751-184-192-816392","span":{"begin":1239,"end":1243},"obj":"[\"31551688\"]"}],"attributes":[{"subj":"33041751-233-241-816385","pred":"source","obj":"TEST0"},{"subj":"33041751-198-206-816386","pred":"source","obj":"TEST0"},{"subj":"33041751-221-229-816387","pred":"source","obj":"TEST0"},{"subj":"33041751-162-170-816388","pred":"source","obj":"TEST0"},{"subj":"33041751-112-120-816389","pred":"source","obj":"TEST0"},{"subj":"33041751-217-225-816390","pred":"source","obj":"TEST0"},{"subj":"33041751-161-169-816391","pred":"source","obj":"TEST0"},{"subj":"33041751-184-192-816392","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"33041751-19184068-38666171","span":{"begin":270,"end":274},"obj":"19184068"},{"id":"33041751-23300938-38666172","span":{"begin":475,"end":479},"obj":"23300938"},{"id":"33041751-30593285-38666173","span":{"begin":498,"end":502},"obj":"30593285"},{"id":"33041751-28814675-38666174","span":{"begin":667,"end":671},"obj":"28814675"},{"id":"33041751-23300938-38666175","span":{"begin":943,"end":947},"obj":"23300938"},{"id":"33041751-30593285-38666176","span":{"begin":1048,"end":1052},"obj":"30593285"},{"id":"33041751-30593285-38666177","span":{"begin":1216,"end":1220},"obj":"30593285"},{"id":"33041751-31551688-38666178","span":{"begin":1239,"end":1243},"obj":"31551688"}],"attributes":[{"subj":"33041751-19184068-38666171","pred":"source","obj":"2_test"},{"subj":"33041751-23300938-38666172","pred":"source","obj":"2_test"},{"subj":"33041751-30593285-38666173","pred":"source","obj":"2_test"},{"subj":"33041751-28814675-38666174","pred":"source","obj":"2_test"},{"subj":"33041751-23300938-38666175","pred":"source","obj":"2_test"},{"subj":"33041751-30593285-38666176","pred":"source","obj":"2_test"},{"subj":"33041751-30593285-38666177","pred":"source","obj":"2_test"},{"subj":"33041751-31551688-38666178","pred":"source","obj":"2_test"}]},{"project":"0_colil","denotations":[{"id":"33041751-19184068-816385","span":{"begin":270,"end":274},"obj":"19184068"},{"id":"33041751-23300938-816386","span":{"begin":475,"end":479},"obj":"23300938"},{"id":"33041751-30593285-816387","span":{"begin":498,"end":502},"obj":"30593285"},{"id":"33041751-28814675-816388","span":{"begin":667,"end":671},"obj":"28814675"},{"id":"33041751-23300938-816389","span":{"begin":943,"end":947},"obj":"23300938"},{"id":"33041751-30593285-816390","span":{"begin":1048,"end":1052},"obj":"30593285"},{"id":"33041751-30593285-816391","span":{"begin":1216,"end":1220},"obj":"30593285"},{"id":"33041751-31551688-816392","span":{"begin":1239,"end":1243},"obj":"31551688"}],"attributes":[{"subj":"33041751-19184068-816385","pred":"source","obj":"0_colil"},{"subj":"33041751-23300938-816386","pred":"source","obj":"0_colil"},{"subj":"33041751-30593285-816387","pred":"source","obj":"0_colil"},{"subj":"33041751-28814675-816388","pred":"source","obj":"0_colil"},{"subj":"33041751-23300938-816389","pred":"source","obj":"0_colil"},{"subj":"33041751-30593285-816390","pred":"source","obj":"0_colil"},{"subj":"33041751-30593285-816391","pred":"source","obj":"0_colil"},{"subj":"33041751-31551688-816392","pred":"source","obj":"0_colil"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ecc093","default":true},{"id":"2_test","color":"#a693ec"},{"id":"0_colil","color":"#9aec93"}]}]}}