PMC:7523471 / 18778-19816
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7523471","sourcedb":"PMC","sourceid":"7523471","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7523471","text":"A quantitative histological analysis of whole-mount retinas in a subset of confirmed AD patients compared to age- and sex-matched cognitively normal controls revealed a significant 4.7-fold increase in Aβ42-containing retinal plaque burden in patients (Figure 2D; Koronyo et al., 2017). Another group, using a sample of retinas isolated from 10 neuropathologically and clinically confirmed AD and 10 control patients, demonstrated a significant 2.7-fold increase in the number of retinal Aβ42 plaques that were also found to be larger in volume relative to deposits detected in normal control tissue (Grimaldi et al., 2019). Importantly, although retinal Aβ plaques are typically smaller in size compared to brain plaques, their burden in the retina significantly correlated with severity of plaque pathology in the brain (Figures 2E,F; Koronyo et al., 2017). In particular, retinal amyloid deposits were more strongly correlated with plaque burden in the primary visual cortex and the entorhinal cortex (Figure 2F; Koronyo et al., 2017).","tracks":[{"project":"TEST0","denotations":[{"id":"33041751-228-236-816337","span":{"begin":280,"end":284},"obj":"[\"28814675\"]"},{"id":"33041751-228-236-816338","span":{"begin":618,"end":622},"obj":"[\"31551688\"]"},{"id":"33041751-228-236-816339","span":{"begin":853,"end":857},"obj":"[\"28814675\"]"},{"id":"33041751-172-180-816340","span":{"begin":1032,"end":1036},"obj":"[\"28814675\"]"}],"attributes":[{"subj":"33041751-228-236-816337","pred":"source","obj":"TEST0"},{"subj":"33041751-228-236-816338","pred":"source","obj":"TEST0"},{"subj":"33041751-228-236-816339","pred":"source","obj":"TEST0"},{"subj":"33041751-172-180-816340","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"33041751-28814675-38666123","span":{"begin":280,"end":284},"obj":"28814675"},{"id":"33041751-31551688-38666124","span":{"begin":618,"end":622},"obj":"31551688"},{"id":"33041751-28814675-38666125","span":{"begin":853,"end":857},"obj":"28814675"},{"id":"33041751-28814675-38666126","span":{"begin":1032,"end":1036},"obj":"28814675"}],"attributes":[{"subj":"33041751-28814675-38666123","pred":"source","obj":"2_test"},{"subj":"33041751-31551688-38666124","pred":"source","obj":"2_test"},{"subj":"33041751-28814675-38666125","pred":"source","obj":"2_test"},{"subj":"33041751-28814675-38666126","pred":"source","obj":"2_test"}]},{"project":"0_colil","denotations":[{"id":"33041751-28814675-816337","span":{"begin":280,"end":284},"obj":"28814675"},{"id":"33041751-31551688-816338","span":{"begin":618,"end":622},"obj":"31551688"},{"id":"33041751-28814675-816339","span":{"begin":853,"end":857},"obj":"28814675"},{"id":"33041751-28814675-816340","span":{"begin":1032,"end":1036},"obj":"28814675"}],"attributes":[{"subj":"33041751-28814675-816337","pred":"source","obj":"0_colil"},{"subj":"33041751-31551688-816338","pred":"source","obj":"0_colil"},{"subj":"33041751-28814675-816339","pred":"source","obj":"0_colil"},{"subj":"33041751-28814675-816340","pred":"source","obj":"0_colil"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ec93cf","default":true},{"id":"2_test","color":"#93e9ec"},{"id":"0_colil","color":"#ecd593"}]}]}}