PMC:7519301 / 457-1133 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":101,"end":108},"obj":"Body_part"},{"id":"T2","span":{"begin":135,"end":142},"obj":"Body_part"},{"id":"T3","span":{"begin":560,"end":567},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"ral evolution, rather than adaptive selection, can explain the rare mutations seen across SARS-CoV-2 genomes. In the immunogenic Spike protein, the D614G mutation has become consensus, yet there is no evidence of mutations affecting binding to the ACE2 receptor. Our results suggest that, to date, the limited diversity seen in SARS-CoV-2 should not preclude a single vaccine from providing global protection.\n\nAbstract\nThe magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective vaccine. Many vaccine candidates focus on the Spike protein, as it is targeted by neutralizing antibodies and plays a key role in viral entry. Here we investigate the d"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T8","span":{"begin":90,"end":98},"obj":"Disease"},{"id":"T9","span":{"begin":90,"end":94},"obj":"Disease"},{"id":"T10","span":{"begin":328,"end":336},"obj":"Disease"},{"id":"T11","span":{"begin":328,"end":332},"obj":"Disease"},{"id":"T12","span":{"begin":441,"end":449},"obj":"Disease"}],"attributes":[{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"ral evolution, rather than adaptive selection, can explain the rare mutations seen across SARS-CoV-2 genomes. In the immunogenic Spike protein, the D614G mutation has become consensus, yet there is no evidence of mutations affecting binding to the ACE2 receptor. Our results suggest that, to date, the limited diversity seen in SARS-CoV-2 should not preclude a single vaccine from providing global protection.\n\nAbstract\nThe magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective vaccine. Many vaccine candidates focus on the Spike protein, as it is targeted by neutralizing antibodies and plays a key role in viral entry. Here we investigate the d"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T6","span":{"begin":163,"end":166},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T7","span":{"begin":359,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":487,"end":488},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9","span":{"begin":541,"end":546},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T10","span":{"begin":624,"end":625},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"ral evolution, rather than adaptive selection, can explain the rare mutations seen across SARS-CoV-2 genomes. In the immunogenic Spike protein, the D614G mutation has become consensus, yet there is no evidence of mutations affecting binding to the ACE2 receptor. Our results suggest that, to date, the limited diversity seen in SARS-CoV-2 should not preclude a single vaccine from providing global protection.\n\nAbstract\nThe magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective vaccine. Many vaccine candidates focus on the Spike protein, as it is targeted by neutralizing antibodies and plays a key role in viral entry. Here we investigate the d"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":135,"end":142},"obj":"Chemical"},{"id":"T2","span":{"begin":560,"end":567},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"ral evolution, rather than adaptive selection, can explain the rare mutations seen across SARS-CoV-2 genomes. In the immunogenic Spike protein, the D614G mutation has become consensus, yet there is no evidence of mutations affecting binding to the ACE2 receptor. Our results suggest that, to date, the limited diversity seen in SARS-CoV-2 should not preclude a single vaccine from providing global protection.\n\nAbstract\nThe magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective vaccine. Many vaccine candidates focus on the Spike protein, as it is targeted by neutralizing antibodies and plays a key role in viral entry. Here we investigate the d"}

{"project":"LitCovid-PubTator","denotations":[{"id":"10","span":{"begin":129,"end":134},"obj":"Gene"},{"id":"11","span":{"begin":248,"end":252},"obj":"Gene"},{"id":"14","span":{"begin":90,"end":100},"obj":"Species"},{"id":"15","span":{"begin":328,"end":338},"obj":"Species"},{"id":"17","span":{"begin":148,"end":153},"obj":"Mutation"},{"id":"29","span":{"begin":554,"end":559},"obj":"Gene"},{"id":"37","span":{"begin":441,"end":449},"obj":"Disease"}],"attributes":[{"id":"A10","pred":"tao:has_database_id","subj":"10","obj":"Gene:43740568"},{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"Gene:59272"},{"id":"A14","pred":"tao:has_database_id","subj":"14","obj":"Tax:2697049"},{"id":"A15","pred":"tao:has_database_id","subj":"15","obj":"Tax:2697049"},{"id":"A17","pred":"tao:has_standard_notation","subj":"17","obj":"p.D614G"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Gene:43740568"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ral evolution, rather than adaptive selection, can explain the rare mutations seen across SARS-CoV-2 genomes. In the immunogenic Spike protein, the D614G mutation has become consensus, yet there is no evidence of mutations affecting binding to the ACE2 receptor. Our results suggest that, to date, the limited diversity seen in SARS-CoV-2 should not preclude a single vaccine from providing global protection.\n\nAbstract\nThe magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective vaccine. Many vaccine candidates focus on the Spike protein, as it is targeted by neutralizing antibodies and plays a key role in viral entry. Here we investigate the d"}

{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":110,"end":262},"obj":"Sentence"},{"id":"T8","span":{"begin":263,"end":409},"obj":"Sentence"},{"id":"T9","span":{"begin":411,"end":419},"obj":"Sentence"},{"id":"T10","span":{"begin":420,"end":516},"obj":"Sentence"},{"id":"T11","span":{"begin":517,"end":650},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ral evolution, rather than adaptive selection, can explain the rare mutations seen across SARS-CoV-2 genomes. In the immunogenic Spike protein, the D614G mutation has become consensus, yet there is no evidence of mutations affecting binding to the ACE2 receptor. Our results suggest that, to date, the limited diversity seen in SARS-CoV-2 should not preclude a single vaccine from providing global protection.\n\nAbstract\nThe magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective vaccine. Many vaccine candidates focus on the Spike protein, as it is targeted by neutralizing antibodies and plays a key role in viral entry. Here we investigate the d"}