PMC:7519301 / 31142-32111 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7519301","sourcedb":"PMC","sourceid":"7519301","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7519301","text":"These findings, together with our results, illustrate that mutations can spread through the population without necessarily having a selective advantage, especially at the beginning of an epidemic when most individuals are susceptible. Mutations occur more frequently after a host switch, and even slightly deleterious mutations may have an opportunity to spread. Hence, the main signal in our study was one of purifying selection that can ultimately eliminate mildly deleterious mutations. Our analyses showed limited evidence of diversifying selection, with comparable substitution rates in structural proteins versus nonstructural proteins (under a selection paradigm, structural proteins which are essential for viral entry and the target of the host immune response would have higher rates than the nonessential proteins), low estimates of genetic differentiation following the initial outbreak, and phylogenetic patterns adhering to a neutral process of evolution.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T106","span":{"begin":603,"end":611},"obj":"Body_part"},{"id":"T107","span":{"begin":633,"end":641},"obj":"Body_part"},{"id":"T108","span":{"begin":682,"end":690},"obj":"Body_part"},{"id":"T109","span":{"begin":816,"end":824},"obj":"Body_part"}],"attributes":[{"id":"A106","pred":"fma_id","subj":"T106","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A107","pred":"fma_id","subj":"T107","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T253","span":{"begin":130,"end":131},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T254","span":{"begin":273,"end":274},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T255","span":{"begin":379,"end":385},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T256","span":{"begin":649,"end":650},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T257","span":{"begin":938,"end":939},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T253","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T91","span":{"begin":603,"end":611},"obj":"Chemical"},{"id":"T92","span":{"begin":633,"end":641},"obj":"Chemical"},{"id":"T93","span":{"begin":682,"end":690},"obj":"Chemical"},{"id":"T94","span":{"begin":816,"end":824},"obj":"Chemical"}],"attributes":[{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A92","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A93","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A94","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"457","span":{"begin":603,"end":641},"obj":"Disease"}],"attributes":[{"id":"A457","pred":"tao:has_database_id","subj":"457","obj":"MESH:D018455"},{"subj":"457","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":754,"end":769},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T7","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T190","span":{"begin":0,"end":234},"obj":"Sentence"},{"id":"T191","span":{"begin":235,"end":362},"obj":"Sentence"},{"id":"T192","span":{"begin":363,"end":489},"obj":"Sentence"},{"id":"T193","span":{"begin":490,"end":969},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T190","pred":"source","obj":"LitCovid-sentences"},{"subj":"T191","pred":"source","obj":"LitCovid-sentences"},{"subj":"T192","pred":"source","obj":"LitCovid-sentences"},{"subj":"T193","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93abec","default":true},{"id":"LitCovid-PD-CLO","color":"#c5ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93df"},{"id":"LitCovid-PubTator","color":"#93ecdf"},{"id":"LitCovid-PD-GO-BP","color":"#ecc593"},{"id":"LitCovid-sentences","color":"#ab93ec"}]}]}}