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PMC:7519301 / 26993-34292 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T97 166-178 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T98 317-325 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T99 546-554 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T100 1838-1846 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T101 2452-2456 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T102 2761-2765 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T103 3607-3619 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T104 3693-3698 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T105 3783-3787 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T106 4752-4760 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T107 4782-4790 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T108 4831-4839 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T109 4965-4973 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T110 6377-6384 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T111 6872-6875 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T112 6989-6997 Body_part denotes Appendix http://purl.org/sig/ont/fma/fma14542

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T134 46-54 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T135 46-50 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T136 142-150 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T137 370-378 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T138 370-374 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T139 441-449 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T140 441-445 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T141 604-612 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 604-608 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T143 1204-1212 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 1204-1208 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T145 1716-1724 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T146 1716-1720 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T147 1907-1916 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T148 2008-2016 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T149 2008-2012 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T150 2156-2164 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T151 2156-2160 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T152 2637-2645 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T153 2637-2641 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T154 2743-2751 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 2743-2747 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T156 2794-2802 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T157 2794-2798 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T158 3467-3472 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T159 3639-3647 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T160 3639-3643 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T161 5311-5319 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T162 5311-5315 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T163 5632-5642 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T164 6070-6078 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T165 6070-6074 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T166 6430-6438 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T167 6430-6434 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T168 6644-6652 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T169 6644-6648 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T170 6694-6702 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T171 6694-6698 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T172 6879-6888 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T173 6893-6899 Disease denotes Dengue http://purl.obolibrary.org/obo/MONDO_0005502
T174 6966-6974 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T175 6966-6970 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T176 7143-7151 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T177 7143-7147 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T178 7288-7296 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T179 7288-7292 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T216 44-45 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T217 68-69 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T218 156-163 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus’s
T219 231-232 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T220 255-260 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T221 439-440 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T222 465-469 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T223 498-505 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T224 584-585 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T225 641-642 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T226 948-955 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T227 1001-1002 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T228 1065-1068 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T229 1335-1336 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 1513-1514 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T231 1577-1582 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T232 1653-1655 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T233 1780-1781 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 1798-1799 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T235 2233-2236 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T236 2269-2276 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T237 2346-2347 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T238 2452-2456 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T239 2655-2661 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T240 2691-2692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T241 2761-2765 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T242 2997-3004 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T243 3040-3041 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T244 3562-3567 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T245 3671-3676 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T246 3693-3698 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T247 3783-3793 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T248 3870-3877 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T249 3904-3909 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T250 3923-3930 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes primate
T251 3939-3941 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T252 4072-4075 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T253 4279-4280 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 4422-4423 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T255 4528-4534 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T256 4798-4799 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T257 5087-5088 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 5243-5244 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T259 5440-5441 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T260 5442-5447 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T261 5609-5610 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T262 6081-6084 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T263 6101-6102 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T264 6165-6168 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T265 6176-6177 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T266 6477-6482 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T267 6494-6495 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 6705-6712 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T269 6755-6756 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 6803-6806 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T271 6856-6863 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T272 6911-6918 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T273 6935-6936 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T274 6977-6984 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T275 7122-7123 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T85 166-178 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T86 478-487 Chemical denotes immunogen http://purl.obolibrary.org/obo/CHEBI_60816
T87 546-554 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T88 1346-1353 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T89 1789-1796 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T90 3607-3619 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T91 4752-4760 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T92 4782-4790 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T93 4831-4839 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T94 4965-4973 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T95 6377-6384 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T96 6986-6988 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
394 1045-1046 Gene denotes S Gene:43740568
395 509-510 Gene denotes S Gene:43740568
396 470-471 Gene denotes S Gene:43740568
397 344-345 Gene denotes S Gene:43740568
398 164-165 Gene denotes S Gene:43740568
399 46-56 Species denotes SARS-CoV-2 Tax:2697049
400 441-451 Species denotes SARS-CoV-2 Tax:2697049
401 604-614 Species denotes SARS-CoV-2 Tax:2697049
402 1204-1214 Species denotes SARS-CoV-2 Tax:2697049
403 1548-1556 Species denotes MERS-CoV Tax:1335626
404 1716-1726 Species denotes SARS-CoV-2 Tax:2697049
405 2008-2018 Species denotes SARS-CoV-2 Tax:2697049
406 1907-1916 Species denotes influenza Tax:11309
407 1502-1506 Chemical denotes D614
408 142-150 Disease denotes COVID-19 MESH:C000657245
409 370-389 Disease denotes SARS-CoV-2−infected MESH:C000657245
410 1698-1703 Mutation denotes D614G p.D614G
411 1424-1429 Mutation denotes D614G p.D614G
412 1224-1229 Mutation denotes D614G p.D614G
413 1525-1530 Mutation denotes S612L p.S612L
414 1027-1032 Mutation denotes D614G p.D614G
415 2057-2062 Mutation denotes N439K p.N439K
430 2832-2833 Gene denotes S Gene:43740568
431 2156-2166 Species denotes SARS-CoV-2 Tax:2697049
432 2637-2647 Species denotes SARS-CoV-2 Tax:2697049
433 2655-2661 Species denotes humans Tax:9606
434 2743-2751 Species denotes SARS-CoV Tax:694009
435 2794-2804 Species denotes SARS-CoV-2 Tax:2697049
436 3277-3281 Species denotes ncov Tax:2697049
437 2306-2313 Disease denotes fitness MESH:D012640
438 3162-3167 Mutation denotes D614G p.D614G
439 3018-3023 Mutation denotes D614G p.D614G
440 2826-2831 Mutation denotes D614G p.D614G
441 2486-2491 Mutation denotes D614G p.D614G
442 2282-2287 Mutation denotes D614G p.D614G
443 2202-2207 Mutation denotes D614G p.D614G
450 3633-3634 Gene denotes S Gene:43740568
451 3467-3472 Species denotes Ebola Tax:1570291
452 3639-3649 Species denotes SARS-CoV-2 Tax:2697049
453 3904-3909 Species denotes mouse Tax:10090
454 3586-3590 Mutation denotes A82V p.A82V
455 4116-4121 Mutation denotes D614G p.D614G
457 4752-4790 Disease denotes proteins versus nonstructural proteins MESH:D018455
463 5311-5321 Species denotes SARS-CoV-2 Tax:2697049
464 5632-5642 Disease denotes infections MESH:D007239
465 6007-6012 Mutation denotes D614G p.D614G
466 5461-5466 Mutation denotes D614G p.D614G
467 5236-5241 Mutation denotes D614G p.D614G
479 6070-6080 Species denotes SARS-CoV-2 Tax:2697049
480 6430-6440 Species denotes SARS-CoV-2 Tax:2697049
481 6477-6482 Species denotes human Tax:9606
482 6644-6654 Species denotes SARS-CoV-2 Tax:2697049
483 6694-6704 Species denotes SARS-CoV-2 Tax:2697049
484 6872-6877 Species denotes HIV-1 Tax:11676
485 6966-6976 Species denotes SARS-CoV-2 Tax:2697049
486 7143-7153 Species denotes SARS-CoV-2 Tax:2697049
487 7288-7298 Species denotes SARS-CoV-2 Tax:2697049
488 6879-6888 Species denotes influenza Tax:11309
489 6322-6327 Mutation denotes D614G p.D614G

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 2960-2972 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T4 3232-3244 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T5 3671-3698 http://purl.obolibrary.org/obo/GO_0046718 denotes virus entry into host cells
T6 3677-3692 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into host
T7 4903-4918 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T165 0-10 Sentence denotes Discussion
T166 11-151 Sentence denotes There remains an urgent need for a SARS-CoV-2 vaccine as a primary countermeasure to mitigate and eventually contain the spread of COVID-19.
T167 152-303 Sentence denotes The virus’s S glycoprotein makes an attractive vaccine target because it plays a key role in mediating virus entry and is known to be immunogenic (40).
T168 304-488 Sentence denotes Neutralizing antibody responses against S have been identified in SARS-CoV-2−infected individuals (2), and several clinical trials for a SARS-CoV-2 vaccine will test S as an immunogen.
T169 489-583 Sentence denotes While we focused on S, our comparative analyses of other proteins yielded similar conclusions:
T170 584-839 Sentence denotes A randomly selected SARS-CoV-2 sequence could be used as a vaccine candidate, given the similarity of any sequence to the computationally derived optimum vaccine candidate (as defined by the MRCAs or consensus sequence based on all circulating sequences).
T171 840-956 Sentence denotes Vaccines developed using any of these sequences should, theoretically, be effective against all circulating viruses.
T172 957-1095 Sentence denotes Vaccine developers could consider designing a vaccine insert with the D614G mutation in S, as this mutation has become dominant worldwide.
T173 1096-1230 Sentence denotes While mutations that become fixed are often linked to the host immune pressure, this seems unlikely for the SARS-CoV-2 mutation D614G.
T174 1231-1395 Sentence denotes Because this residue lies at the interface between two subunits, it would not be expected to be part of a critical epitope for vaccine-mediated protection (Fig. 4).
T175 1396-1512 Sentence denotes As such, pseudoviruses with D614G were as susceptible to neutralization as those with the initial residue D614 (25).
T176 1513-1797 Sentence denotes A mutation, S612L, that emerged in MERS-CoV after passaging the virus in the presence of two antibodies (in 5/15 clones after 20 passages) (41) warrants the evaluation of the analogous D614G mutation in SARS-CoV-2 for its ability to interfere with the recognition of a distal epitope.
T177 1798-1926 Sentence denotes A more direct path to viral escape from antibody recognition would be mutations in the RBD, as described for influenza (42, 43).
T178 1927-2132 Sentence denotes Importantly, we found no mutation in the RBD that was present in more than 1% of SARS-CoV-2 sequences (highest frequency was 0.2% N439K); such rare variants are unlikely to interfere with vaccine efficacy.
T179 2133-2319 Sentence denotes In the context of rare SARS-CoV-2 mutations, the rapid spread of the D614G mutation is singular and has led authors to hypothesize that viruses with D614G may have enhanced fitness (24).
T180 2320-2500 Sentence denotes The strongest evidence of a biological effect for this mutation comes from recent reports of an increase in in vitro infectivity or cell entry for pseudoviruses with D614G (25–28).
T181 2501-2729 Sentence denotes Additional work is needed to evaluate whether the increase in infectivity in vitro translates to increased transmissibility (spread) of SARS-CoV-2 across humans, as there is not necessarily a linear relationship between the two.
T182 2730-2849 Sentence denotes For example, SARS-CoV mediates cell entry more efficiently than SARS-CoV-2 (with or without the D614G S mutation) (26).
T183 2850-3033 Sentence denotes Hence, it would be important to understand whether, controlling for epidemiological factors, there are higher reproduction numbers associated with viruses carrying the D614G mutation.
T184 3034-3380 Sentence denotes While a preliminary comparison of the lineages with either D or G in Washington State did not indicate an obvious advantage for D614G mutants, as they found similar maximal values for the effective reproduction number (https://github.com/blab/ncov-wa-phylodynamics), additional comparisons in different geographic locations should be informative.
T185 3381-3455 Sentence denotes Correlating in vitro findings with clinical phenotypes can be complicated.
T186 3456-3568 Sentence denotes During the Ebola outbreak of 2013–2016, some fixed mutations were suspected to confer an advantage to the virus.
T187 3569-3755 Sentence denotes Specifically, an A82V mutation in the glycoprotein, which, like S for SARS-CoV-2, is critical for the virus entry into host cells, was associated with an increase in infectivity (44–46).
T188 3756-4041 Sentence denotes Yet, effects varied across cell types (47), and no phenotypic differences were associated with the mutations when viruses were evaluated in vivo in mouse and nonhuman primate models (48), highlighting the difficulty in linking biological mechanisms to outcomes at the population level.
T189 4042-4148 Sentence denotes So far, no causal association has been identified between the presence of D614G and disease severity (24).
T190 4149-4383 Sentence denotes These findings, together with our results, illustrate that mutations can spread through the population without necessarily having a selective advantage, especially at the beginning of an epidemic when most individuals are susceptible.
T191 4384-4511 Sentence denotes Mutations occur more frequently after a host switch, and even slightly deleterious mutations may have an opportunity to spread.
T192 4512-4638 Sentence denotes Hence, the main signal in our study was one of purifying selection that can ultimately eliminate mildly deleterious mutations.
T193 4639-5118 Sentence denotes Our analyses showed limited evidence of diversifying selection, with comparable substitution rates in structural proteins versus nonstructural proteins (under a selection paradigm, structural proteins which are essential for viral entry and the target of the host immune response would have higher rates than the nonessential proteins), low estimates of genetic differentiation following the initial outbreak, and phylogenetic patterns adhering to a neutral process of evolution.
T194 5119-5242 Sentence denotes These data indicate that epidemiologic factors could be sufficient to explain the global spread of mutations such as D614G.
T195 5243-5409 Sentence denotes A founder effect means that these mutations were likely exported to SARS-CoV-2 naive areas early in the outbreak and therefore given the opportunity to spread widely.
T196 5410-5546 Sentence denotes As such, on January 28, 2020, a virus carrying the D614G mutation, which was rare among sequences from China, was identified in Germany.
T197 5547-5750 Sentence denotes Host and environmental factors permitted the establishment of a sustained cluster of infections that propagated this mutation until it became dominant among European sequences and then globally (Fig. 2).
T198 5751-5913 Sentence denotes We found no evidence that the frequent identification of this mutation was caused by convergent selection events that would have occurred in multiple individuals.
T199 5914-6022 Sentence denotes Further analyses are needed to characterize the biologic mechanisms behind the spread of the D614G mutation.
T200 6023-6247 Sentence denotes In summary, our results indicate that, so far, SARS-CoV-2 has evolved through a nondeterministic, noisy process and that random genetic drift has played a dominant role in disseminating unique mutations throughout the world.
T201 6248-6429 Sentence denotes Yet, it is important to note that founder effects do not exclude that the D614G can confer distinguishing properties in terms of protein stability, infectivity, or transmissibility.
T202 6430-6573 Sentence denotes SARS-CoV-2 was only recently identified in the human population—a short time frame relative to adaptive processes that can take years to occur.
T203 6574-6786 Sentence denotes Although we cannot predict whether adaptive selection will be seen in SARS-CoV-2 in the future, the key finding is that SARS-CoV-2 viruses that are currently circulating constitute a homogeneous viral population.
T204 6787-7009 Sentence denotes Viral diversity has challenged vaccine development efforts for other viruses such as HIV-1, influenza, or Dengue, but these viruses each constitute a more diverse population than SARS-CoV-2 viruses (SI Appendix, Fig. S12).
T205 7010-7299 Sentence denotes We can therefore be cautiously optimistic that viral diversity should not be an obstacle for the development of a broadly protective SARS-CoV-2 vaccine, and that vaccines in current development should elicit responses that are reactive against currently circulating variants of SARS-CoV-2.

2_test

Id Subject Object Predicate Lexical cue
32868447-19538115-132542403 299-301 19538115 denotes 40
32868447-29514901-132542404 1653-1655 29514901 denotes 41
32868447-25414313-132542405 1918-1920 25414313 denotes 42
32868447-31452511-132542406 1922-1924 31452511 denotes 43
32868447-32697968-132542407 2315-2317 32697968 denotes 24
32868447-28238624-132542408 3748-3750 28238624 denotes 44
32868447-28084671-132542408 3748-3750 28084671 denotes 44
32868447-27847361-132542408 3748-3750 27847361 denotes 44
32868447-30333174-132542409 3795-3797 30333174 denotes 47
32868447-29742435-132542410 3939-3941 29742435 denotes 48
32868447-32697968-132542411 4144-4146 32697968 denotes 24