PMC:7519301 / 25862-26991
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7519301","sourcedb":"PMC","sourceid":"7519301","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7519301","text":"Mutations across SARS-CoV-2 S sequences. (A) Structure of SARS-CoV (5 × 58) (shown instead of SARS-CoV-2 for completeness of the Receptor Binding Motif [RBM]). (B–D) The three protomers in the closed SARS-CoV-2 S glycoprotein (Protein Data Bank ID code 6VXX) are colored in yellow, cyan, and white. Sites with mutations are shown as spheres. (B) Near-identity of potential vaccine candidates. The MRCA and Wuhan-Hu-1 reference sequences were identical, while the consensus derived from all circulating sequences showed a mutation (D614G). Site 614 is located at the interface between two subunits. (C) Sequence segments that differed between human and pangolin or bat hosts. Amino acid segments 439 to 455 and 482 to 501 impact receptor binding, while the 574 to 690 segment corresponds to the S2 cleavage site. (D) Sites with shared mutations across SARS-CoV-2 circulating sequences. The colors of the spheres correspond to the proportion of SARS-CoV-2 sequences that differed from the Wuhan-Hu-1 sequence (GISAID: EPI_ISL_402125, GenBank: NC_045512). 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