PMC:7507645 / 8389-9669 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7507645","sourcedb":"PMC","sourceid":"7507645","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7507645","text":"Statistical analyses\nThe post hoc analyses reported here were performed on subgroups of patients in the full analysis set (FAS) population: randomized patients who received ≥1 dose of study drug and had ≥10 days of post-baseline efficacy assessments on the primary endpoint (i.e., a daily headache diary) [16]. The subgroups included patients with MO at baseline versus without MO at baseline; and patients who did revert from MO at baseline to no MO during the study versus patients who did not revert from MO at baseline to no MO during the study. Least-square (LS) mean changes from baseline were evaluated using an analysis of covariance with treatment, sex, region, and baseline preventive migraine medication use as fixed effects, and baseline values and years since onset of migraines as covariates. The Cochran-Mantel-Haenszel test was used to analyze treatment differences between proportions of patients, with baseline preventive medication use as the stratification variable. Patients who prematurely discontinued from the study were considered as non-responders for overall analysis. For subgroups defined by treatment outcomes (i.e., patients who did or did not revert from MO at baseline to no MO during the study), data were summarized using descriptive statistics.","divisions":[{"label":"title","span":{"begin":0,"end":20}}],"tracks":[{"project":"TEST0","denotations":[{"id":"32958075-234-240-1506677","span":{"begin":306,"end":308},"obj":"[\"29171818\"]"}],"attributes":[{"subj":"32958075-234-240-1506677","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"32958075-29171818-60560884","span":{"begin":306,"end":308},"obj":"29171818"}],"attributes":[{"subj":"32958075-29171818-60560884","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ec93d1","default":true},{"id":"2_test","color":"#93ebec"}]}]}}