PMC:7502678 / 15286-16456 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7502678","sourcedb":"PMC","sourceid":"7502678","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7502678","text":"Initially thought to be mainly a respiratory infection, it is now clear that COVID-19 is associated with neurological involvement in more than 30% of patients, with approximately 25% having symptoms indicating CNS dysfunction. Fortunately, the incidence of seizures appears to be low (0.5%).3 Although there are case reports of seizures at onset in both adults and children, new-onset seizures and status epilepticus (SE) are rarely described. In a recent multicenter, retrospective study of 304 people with no known history of epilepsy in China, neither acute symptomatic seizures nor SE was observed.4 Two people had seizure-like symptoms during hospitalization that were thought to be related to acute stress reaction and hypocalcemia. There was no evidence suggesting an additional risk of acute symptomatic seizures in people with COVID-19. About a third (30%) of respondents in the current survey reported seeing COVID-19 patients with new-onset seizures. This high rate, which is much higher than we might expect given the reported rate of new-onset seizures in the literature (0.5%), is likely reflective of the population surveyed, namely epilepsy 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