PMC:7499584 / 1311-2388 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7499584","sourcedb":"PMC","sourceid":"7499584","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7499584","text":"Copious literature suggests that glycosylation inhibitors are potent antivirals for enveloped viruses with a coat or spike protein. In the 1970s and 1980s, a number of investigators examined interference with glycan synthesis on viral coat proteins as a mode for viral inhibition. Compans showed in 1971, D-glucosamine and 2-deoxy-D-glucose inhibited glycoprotein maturation in Sindbis virus (Compans 1971). Several other studies used these two compounds for inhibition of Semliki Forest virus (Kaluza et al. 1972), enveloped RNA viruses (Kaluza et al. 1973), Influenza (Klenk et al. 1972), VSV, Newcastle disease (Scholtissek et al. 1974) and enveloped viruses in general (Scholtissek et al. 1975). In 1973, Okayama et al. showed that ß-xylosides could stimulate free GAG chains and inhibit GAG formation on proteoglycan core proteins (Okayama et al. 1973). Later, a number of researchers showed that GAGs were important as cellular receptors in HSV and HCV and that ß-xylosides could inhibit viral infectivity by sidetracking GAG synthesis to soluble saccharides (see below).","tracks":[{"project":"2_test","denotations":[{"id":"32829416-5283617-45163139","span":{"begin":401,"end":405},"obj":"5283617"},{"id":"32829416-4336520-45163140","span":{"begin":509,"end":513},"obj":"4336520"},{"id":"32829416-4736595-45163141","span":{"begin":553,"end":557},"obj":"4736595"},{"id":"32829416-4364895-45163142","span":{"begin":634,"end":638},"obj":"4364895"},{"id":"32829416-163046-45163143","span":{"begin":693,"end":697},"obj":"163046"},{"id":"T10784","span":{"begin":401,"end":405},"obj":"5283617"},{"id":"T28958","span":{"begin":509,"end":513},"obj":"4336520"},{"id":"T1883","span":{"begin":553,"end":557},"obj":"4736595"},{"id":"T99243","span":{"begin":634,"end":638},"obj":"4364895"},{"id":"T55178","span":{"begin":693,"end":697},"obj":"163046"}],"attributes":[{"subj":"32829416-5283617-45163139","pred":"source","obj":"2_test"},{"subj":"32829416-4336520-45163140","pred":"source","obj":"2_test"},{"subj":"32829416-4736595-45163141","pred":"source","obj":"2_test"},{"subj":"32829416-4364895-45163142","pred":"source","obj":"2_test"},{"subj":"32829416-163046-45163143","pred":"source","obj":"2_test"},{"subj":"T10784","pred":"source","obj":"2_test"},{"subj":"T28958","pred":"source","obj":"2_test"},{"subj":"T1883","pred":"source","obj":"2_test"},{"subj":"T99243","pred":"source","obj":"2_test"},{"subj":"T55178","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93ab","default":true}]}]}}