PMC:7499584 / 11613-12940
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7499584","sourcedb":"PMC","sourceid":"7499584","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7499584","text":"E-selectin is a key to the first step in inflammation where E-selectin ligand Sialyl LeX binds E-selectin on capillary endothelium for neutrophil extravasation. Mulligan et al. (1993) early showed in a mouse lung inflammation model of ARDS that oligosaccharides containing Sialyl LeX inhibited neutrophils from causing the pneumonic symptoms. Glycomimetics, Inc., under John Magnani’s scientific direction, has developed pan-selectin inhibitors and follow-on compounds that may also be effective in interdiction of the ARDS pathology (Chang et al. 2010). Magnani et al. developed a potent anti-inflammatory Sialyl LeX analog that interdicted inflammation in sickle cell anemia (Chang et al. 2010), and this and follow-on compounds from glycomimetics could be employed to test COVID19 lung and cardiac inflammation. Neelamegham, Matta et al. (Wang et al. 2018) reported using thioglycoside N-glycosylation decoys to hijack E-selectin ligand glycosylation, such that neutrophils treated with acetylated GlcNAc-S-NAP are 90% inhibited in rolling and tethering, and 90% inhibited in extravasation in a mouse ex-vivo model. Experiments with lung inflammation mouse models such as used by Mulligan et al. (1993) should be pursued toward finding drugs for the deadly pneumonic phase of COVID19 that is responsible for most fatalities.","tracks":[{"project":"2_test","denotations":[{"id":"32829416-7688029-45163181","span":{"begin":178,"end":182},"obj":"7688029"},{"id":"32829416-20508165-45163182","span":{"begin":548,"end":552},"obj":"20508165"},{"id":"32829416-20508165-45163183","span":{"begin":691,"end":695},"obj":"20508165"},{"id":"32829416-30344053-45163184","span":{"begin":854,"end":858},"obj":"30344053"},{"id":"32829416-7688029-45163185","span":{"begin":1200,"end":1204},"obj":"7688029"},{"id":"T41545","span":{"begin":178,"end":182},"obj":"7688029"},{"id":"T42464","span":{"begin":548,"end":552},"obj":"20508165"},{"id":"T61472","span":{"begin":691,"end":695},"obj":"20508165"},{"id":"T68997","span":{"begin":854,"end":858},"obj":"30344053"},{"id":"T15556","span":{"begin":1200,"end":1204},"obj":"7688029"}],"attributes":[{"subj":"32829416-7688029-45163181","pred":"source","obj":"2_test"},{"subj":"32829416-20508165-45163182","pred":"source","obj":"2_test"},{"subj":"32829416-20508165-45163183","pred":"source","obj":"2_test"},{"subj":"32829416-30344053-45163184","pred":"source","obj":"2_test"},{"subj":"32829416-7688029-45163185","pred":"source","obj":"2_test"},{"subj":"T41545","pred":"source","obj":"2_test"},{"subj":"T42464","pred":"source","obj":"2_test"},{"subj":"T61472","pred":"source","obj":"2_test"},{"subj":"T68997","pred":"source","obj":"2_test"},{"subj":"T15556","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#c193ec","default":true}]}]}}