PMC:7497282 / 95561-97303
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7497282","sourcedb":"PMC","sourceid":"7497282","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7497282","text":"KRI represents the only group that published integrated dynamic disease transmission and economic models that prospectively explore(d) the risks, costs, and benefits of strategies and policies to support the GPEI. By design, prospective models represent inherently uncertain projections into the future, and the results and insights from these models are only as good as the assumptions and the underlying available evidence. The KRI dynamic poliovirus transmission models [10, 33, 202] rely on using the available evidence and subject matter expert opinion to characterize the dynamics of poliovirus transmission as a function of differential equations, with consideration of some of the variability that exists among countries based on stratification by WBILs and relevant inputs related to transmission, seasonality, and actual vaccine use. KRI uses a model with high complexity and checks its models retrospectively to ensure that they provide estimates consistent with historical data of cases caused by WPVs and VDPVs, die out, and children with non-polio acute flaccid paralysis (NP-AFP) with a history of zero doses of vaccine, and then applies them prospectively to address policy and strategy questions [10, 33, 202]. The KRI poliovirus transmission and OPV evolution model include assumptions about a multi-stage infection process with infection stages of variable infectiousness that impacts the kinetics of infections and die-out and depends on choices about the number of stages used to model OPV evolution. These choices influence the flows of people and timing of transitions between reversion stages, while actual OPV evolution and the emergence of cVDPVs depend on random events and micro-level population dynamics [33, 202]","tracks":[{"project":"MyTest","denotations":[{"id":"32741232-16014773-29927523","span":{"begin":474,"end":476},"obj":"16014773"},{"id":"32741232-23521018-29927524","span":{"begin":478,"end":480},"obj":"23521018"},{"id":"32741232-16014773-29927525","span":{"begin":1214,"end":1216},"obj":"16014773"},{"id":"32741232-23521018-29927526","span":{"begin":1218,"end":1220},"obj":"23521018"},{"id":"32741232-23521018-29927527","span":{"begin":1734,"end":1736},"obj":"23521018"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32741232-16014773-29927523","pred":"source","obj":"MyTest"},{"subj":"32741232-23521018-29927524","pred":"source","obj":"MyTest"},{"subj":"32741232-16014773-29927525","pred":"source","obj":"MyTest"},{"subj":"32741232-23521018-29927526","pred":"source","obj":"MyTest"},{"subj":"32741232-23521018-29927527","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"32741232-16014773-29927523","span":{"begin":474,"end":476},"obj":"16014773"},{"id":"32741232-23521018-29927524","span":{"begin":478,"end":480},"obj":"23521018"},{"id":"32741232-16014773-29927525","span":{"begin":1214,"end":1216},"obj":"16014773"},{"id":"32741232-23521018-29927526","span":{"begin":1218,"end":1220},"obj":"23521018"},{"id":"32741232-23521018-29927527","span":{"begin":1734,"end":1736},"obj":"23521018"}],"attributes":[{"subj":"32741232-16014773-29927523","pred":"source","obj":"2_test"},{"subj":"32741232-23521018-29927524","pred":"source","obj":"2_test"},{"subj":"32741232-16014773-29927525","pred":"source","obj":"2_test"},{"subj":"32741232-23521018-29927526","pred":"source","obj":"2_test"},{"subj":"32741232-23521018-29927527","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#93ecaf","default":true},{"id":"2_test","color":"#ec9493"}]}]}}