PMC:7497282 / 79423-81602
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7497282","sourcedb":"PMC","sourceid":"7497282","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7497282","text":"Abbreviations: IC, Imperial College; IDM, Institute for Disease Modeling; IPV, inactivated poliovirus vaccine; iVDPVs, immunodeficiency-associated vaccine-derived poliovirus; KRI, Kid Risk, Inc.; OPV, oral poliovirus vaccine; SIAs, supplementary immunization activities.\n* As indicated in text, defined differently by the 3 modeling groups: KRI focuses on modeling infection and defines ‘population immunity to transmission’ based on all individuals of all ages integrated over all immunity states in a DEB model as a function of serotype, population-specific inputs, and time, which is a model-based concept that does not vary by paper (see details in [34, 202]). KRI publications earlier than 2013 discussed ‘population immunity’ as the same concept (i.e. over the entire population), but characterized it as an input for some analyses based on data (see e.g. [10]); IC focuses only paralysis (i.e. not infection) and defines ‘population immunity’ including only vaccine-induced immunity (i.e. excluding immunity from maternal antibodies and immunity induced by infection with any live poliovirus via community spread), and varies by paper depending on the data used (e.g. nonpolio AFP data for: serotype 1 only for children \u003c5 years old [83, 84, 87], serotypes 1 and 3 for children \u003c2 years old [89], serotypes 1, 2, and 3 for children \u003c36 months [92], serotype 1 for children \u003c5 years old [101], serotype 2 for children \u003c2 years [100], serotype 2 for children \u003c36 months [111, 113], and serotype 1 for children \u003c36 months [102]; multiple metrics used for regression analyses [93, 109], see individual papers for specific definitions); IDM definition of ‘population immunity’ includes only vaccine-induced immunity (i.e. excluding immunity from maternal antibodies and immunity induced by infection with any live poliovirus via community spread), focuses on paralysis (i.e. not infection), and varies by paper depending on data used (e.g. OPV-induced immunity for nonpolio AFP cases in children \u003c5 years old in a district within a 6-month period [131, 133, 141, 142], children \u003c15 years old [140], dose estimates based on SIAs, see individual papers for specific 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