PMC:7497282 / 69012-70234
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7497282","sourcedb":"PMC","sourceid":"7497282","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7497282","text":"A 2005 study used a DEB model to characterize WPV in the absence of vaccines, which characterized polio as a disease of development (i.e. a disease that becomes worse as hygienic conditions improve such that individuals become infected at relatively older ages when the symptoms present as more severe) [149]. In 2008, following widespread recognition of cVDPVs, one study applied a DEB model to explore three alternative eradication strategies using pulsed OPV or continuous or pulsed IPV immunization and different levels of coverage [150]. However, this theoretical analysis ignored the benefits of secondary transmission of OPV and the complexity of reinfection and included simple modeling of the reversion of OPV given to vaccine recipients, which the authors refer to as cVDPVs but which behave more like VAPP [150]. A 2010 study by the same authors applied a DEB model that included secondary OPV transmission, which explored continuous and pulsed OPV immunization strategies [151]. A 2011 simple theoretical DEB model assumed that IPV can precipitate paralysis in a patient already incubating a poliovirus infection, and suggested sick and unimmunized children should not receive IPV during polio epidemics [152].","tracks":[{"project":"MyTest","denotations":[{"id":"32741232-15975604-29927188","span":{"begin":304,"end":307},"obj":"15975604"},{"id":"32741232-17934778-29927189","span":{"begin":537,"end":540},"obj":"17934778"},{"id":"32741232-17934778-29927190","span":{"begin":818,"end":821},"obj":"17934778"},{"id":"32741232-19735670-29927191","span":{"begin":985,"end":988},"obj":"19735670"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32741232-15975604-29927188","pred":"source","obj":"MyTest"},{"subj":"32741232-17934778-29927189","pred":"source","obj":"MyTest"},{"subj":"32741232-17934778-29927190","pred":"source","obj":"MyTest"},{"subj":"32741232-19735670-29927191","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"32741232-15975604-29927188","span":{"begin":304,"end":307},"obj":"15975604"},{"id":"32741232-17934778-29927189","span":{"begin":537,"end":540},"obj":"17934778"},{"id":"32741232-17934778-29927190","span":{"begin":818,"end":821},"obj":"17934778"},{"id":"32741232-19735670-29927191","span":{"begin":985,"end":988},"obj":"19735670"}],"attributes":[{"subj":"32741232-15975604-29927188","pred":"source","obj":"2_test"},{"subj":"32741232-17934778-29927189","pred":"source","obj":"2_test"},{"subj":"32741232-17934778-29927190","pred":"source","obj":"2_test"},{"subj":"32741232-19735670-29927191","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#ec9493","default":true},{"id":"2_test","color":"#93abec"}]}]}}