PMC:7497282 / 61954-63564
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7497282","sourcedb":"PMC","sourceid":"7497282","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7497282","text":"Between 2000 and 2019, IC also contributed a number of reviews to the literature. Recognizing the wealth of studies published over decades, IC systematically reviewed the OPV challenge studies that evaluated the induction of immunity from OPV and/or IPV against shedding, which concluded that immunization with IPV would likely show limited impact on poliovirus transmission in countries characterized by fecal-oral poliovirus transmission [94]. IC discussed some of the challenges for the polio endgame with a focus on issues related to OPV vaccine failure [95], results of clinical trials performed by others that added IPV to routine immunization schedules in OPV-only using countries [118, 119] including potential impacts of IPV on mucosal immunity [120], and showing no benefits of adding IPV in mOPV2 outbreak response SIAs [121]. IC also commented on biological challenges that limit the effectiveness of vaccines in the developing world, including OPV [122], and the need for innovation in poliovirus surveillance, vaccines, and vaccination strategies [123]. IC also systematically reviewed IPV vaccine effectiveness studies [96] and the impact of IPV on mucosal immunity [124], and suggested that IPV use could play a key role in halting poliovirus transmission and hasten polio eradication due to boosting of immunity of individuals previously given OPV [124]. IC also systematically reviewed the characteristics of known iVDPVs [125], interventions to improve oral vaccine performance [126], and the effect of different vaccine schedules on humoral and intestinal immunity against poliovirus [127].","tracks":[{"project":"MyTest","denotations":[{"id":"32741232-22532797-29927148","span":{"begin":441,"end":443},"obj":"22532797"},{"id":"32741232-23798688-29927149","span":{"begin":559,"end":561},"obj":"23798688"},{"id":"32741232-26093978-29927150","span":{"begin":689,"end":692},"obj":"26093978"},{"id":"32741232-27212428-29927151","span":{"begin":694,"end":697},"obj":"27212428"},{"id":"32741232-27638358-29927152","span":{"begin":755,"end":758},"obj":"27638358"},{"id":"32741232-29571818-29927153","span":{"begin":832,"end":835},"obj":"29571818"},{"id":"32741232-30376096-29927154","span":{"begin":1062,"end":1065},"obj":"30376096"},{"id":"32741232-24634499-29927155","span":{"begin":1135,"end":1137},"obj":"24634499"},{"id":"32741232-26159938-29927156","span":{"begin":1182,"end":1185},"obj":"26159938"},{"id":"32741232-26159938-29927157","span":{"begin":1366,"end":1369},"obj":"26159938"},{"id":"32741232-28993765-29927158","span":{"begin":1441,"end":1444},"obj":"28993765"},{"id":"32741232-30712836-29927159","span":{"begin":1498,"end":1501},"obj":"30712836"},{"id":"32741232-31350192-29927160","span":{"begin":1605,"end":1608},"obj":"31350192"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32741232-22532797-29927148","pred":"source","obj":"MyTest"},{"subj":"32741232-23798688-29927149","pred":"source","obj":"MyTest"},{"subj":"32741232-26093978-29927150","pred":"source","obj":"MyTest"},{"subj":"32741232-27212428-29927151","pred":"source","obj":"MyTest"},{"subj":"32741232-27638358-29927152","pred":"source","obj":"MyTest"},{"subj":"32741232-29571818-29927153","pred":"source","obj":"MyTest"},{"subj":"32741232-30376096-29927154","pred":"source","obj":"MyTest"},{"subj":"32741232-24634499-29927155","pred":"source","obj":"MyTest"},{"subj":"32741232-26159938-29927156","pred":"source","obj":"MyTest"},{"subj":"32741232-26159938-29927157","pred":"source","obj":"MyTest"},{"subj":"32741232-28993765-29927158","pred":"source","obj":"MyTest"},{"subj":"32741232-30712836-29927159","pred":"source","obj":"MyTest"},{"subj":"32741232-31350192-29927160","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"32741232-22532797-29927148","span":{"begin":441,"end":443},"obj":"22532797"},{"id":"32741232-23798688-29927149","span":{"begin":559,"end":561},"obj":"23798688"},{"id":"32741232-26093978-29927150","span":{"begin":689,"end":692},"obj":"26093978"},{"id":"32741232-27212428-29927151","span":{"begin":694,"end":697},"obj":"27212428"},{"id":"32741232-27638358-29927152","span":{"begin":755,"end":758},"obj":"27638358"},{"id":"32741232-29571818-29927153","span":{"begin":832,"end":835},"obj":"29571818"},{"id":"32741232-30376096-29927154","span":{"begin":1062,"end":1065},"obj":"30376096"},{"id":"32741232-24634499-29927155","span":{"begin":1135,"end":1137},"obj":"24634499"},{"id":"32741232-26159938-29927156","span":{"begin":1182,"end":1185},"obj":"26159938"},{"id":"32741232-26159938-29927157","span":{"begin":1366,"end":1369},"obj":"26159938"},{"id":"32741232-28993765-29927158","span":{"begin":1441,"end":1444},"obj":"28993765"},{"id":"32741232-30712836-29927159","span":{"begin":1498,"end":1501},"obj":"30712836"},{"id":"32741232-31350192-29927160","span":{"begin":1605,"end":1608},"obj":"31350192"}],"attributes":[{"subj":"32741232-22532797-29927148","pred":"source","obj":"2_test"},{"subj":"32741232-23798688-29927149","pred":"source","obj":"2_test"},{"subj":"32741232-26093978-29927150","pred":"source","obj":"2_test"},{"subj":"32741232-27212428-29927151","pred":"source","obj":"2_test"},{"subj":"32741232-27638358-29927152","pred":"source","obj":"2_test"},{"subj":"32741232-29571818-29927153","pred":"source","obj":"2_test"},{"subj":"32741232-30376096-29927154","pred":"source","obj":"2_test"},{"subj":"32741232-24634499-29927155","pred":"source","obj":"2_test"},{"subj":"32741232-26159938-29927156","pred":"source","obj":"2_test"},{"subj":"32741232-26159938-29927157","pred":"source","obj":"2_test"},{"subj":"32741232-28993765-29927158","pred":"source","obj":"2_test"},{"subj":"32741232-30712836-29927159","pred":"source","obj":"2_test"},{"subj":"32741232-31350192-29927160","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#ec9593","default":true},{"id":"2_test","color":"#93aaec"}]}]}}