PMC:7497282 / 57712-59571
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7497282","sourcedb":"PMC","sourceid":"7497282","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7497282","text":"Following the introduction of bOPV, in 2012, IC performed a case–control study using data from young children in Pakistan and Afghanistan that reported comparable effectiveness of bOPV to mOPV1 for serotype 1 and commented on the poor and declining immunization coverage in these countries [89]. In 2014, IC reported on the results of trials in India that demonstrated that the delivery of a supplemental IPV dose to previously-OPV-vaccinated children \u003c5 years old boosted their intestinal immunity [90], and does so more effectively than a supplemental OPV dose [91]. Following this study cohort, in 2017 IC reported that the duration of boosting by IPV of intestinal immunity in OPV-vaccinated children remained elevated for 6 and 11 months, but showed evidence of waning [103]. Using data from Nigeria, in 2014 IC explored the vaccine effectiveness for the different formulations of OPVs in use (i.e. mOPVs, bOPV, tOPV) and suggested that immunity in children \u003c3 years old to serotypes 1 and 3 had improved with the use of mOPVs and bOPV [92]. In 2016, using data from Indian infants 5–11 months old, IC reported that the number of tOPV doses received represented the main determinant of serotype 3 seropositivity [104], and reported results from a clinical trial that suggested that a 3-day course of azithromycin prior to delivery did not improve the immunogenicity of mOPV3 [105]. In 2018–19, using this same population, IC reported findings that showed a correlation between the quantity of virus shed and the magnitude of the serum neutralizing antibody response at 21 or 28 days [106], showed a greater impact on OPV response by enteric viruses than bacterial microbiota [107], and that did not show an association between seroconversion from one dose of mOPV3 and FUT2 genotype (i.e. single-nucleotide polymorphisms G428A, C302 T, and A385 T) [108].","tracks":[{"project":"MyTest","denotations":[{"id":"32741232-22766207-29927130","span":{"begin":291,"end":293},"obj":"22766207"},{"id":"32741232-25018120-29927131","span":{"begin":500,"end":502},"obj":"25018120"},{"id":"32741232-25146288-29927132","span":{"begin":564,"end":566},"obj":"25146288"},{"id":"32741232-28003352-29927133","span":{"begin":775,"end":778},"obj":"28003352"},{"id":"32741232-25104665-29927134","span":{"begin":1042,"end":1044},"obj":"25104665"},{"id":"32741232-27566901-29927135","span":{"begin":1218,"end":1221},"obj":"27566901"},{"id":"32741232-27156189-29927136","span":{"begin":1381,"end":1384},"obj":"27156189"},{"id":"32741232-29300947-29927137","span":{"begin":1589,"end":1592},"obj":"29300947"},{"id":"32741232-30247561-29927138","span":{"begin":1681,"end":1684},"obj":"30247561"},{"id":"32741232-30239830-29927139","span":{"begin":1854,"end":1857},"obj":"30239830"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32741232-22766207-29927130","pred":"source","obj":"MyTest"},{"subj":"32741232-25018120-29927131","pred":"source","obj":"MyTest"},{"subj":"32741232-25146288-29927132","pred":"source","obj":"MyTest"},{"subj":"32741232-28003352-29927133","pred":"source","obj":"MyTest"},{"subj":"32741232-25104665-29927134","pred":"source","obj":"MyTest"},{"subj":"32741232-27566901-29927135","pred":"source","obj":"MyTest"},{"subj":"32741232-27156189-29927136","pred":"source","obj":"MyTest"},{"subj":"32741232-29300947-29927137","pred":"source","obj":"MyTest"},{"subj":"32741232-30247561-29927138","pred":"source","obj":"MyTest"},{"subj":"32741232-30239830-29927139","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"32741232-22766207-29927130","span":{"begin":291,"end":293},"obj":"22766207"},{"id":"32741232-25018120-29927131","span":{"begin":500,"end":502},"obj":"25018120"},{"id":"32741232-25146288-29927132","span":{"begin":564,"end":566},"obj":"25146288"},{"id":"32741232-28003352-29927133","span":{"begin":775,"end":778},"obj":"28003352"},{"id":"32741232-25104665-29927134","span":{"begin":1042,"end":1044},"obj":"25104665"},{"id":"32741232-27566901-29927135","span":{"begin":1218,"end":1221},"obj":"27566901"},{"id":"32741232-27156189-29927136","span":{"begin":1381,"end":1384},"obj":"27156189"},{"id":"32741232-29300947-29927137","span":{"begin":1589,"end":1592},"obj":"29300947"},{"id":"32741232-30247561-29927138","span":{"begin":1681,"end":1684},"obj":"30247561"},{"id":"32741232-30239830-29927139","span":{"begin":1854,"end":1857},"obj":"30239830"}],"attributes":[{"subj":"32741232-22766207-29927130","pred":"source","obj":"2_test"},{"subj":"32741232-25018120-29927131","pred":"source","obj":"2_test"},{"subj":"32741232-25146288-29927132","pred":"source","obj":"2_test"},{"subj":"32741232-28003352-29927133","pred":"source","obj":"2_test"},{"subj":"32741232-25104665-29927134","pred":"source","obj":"2_test"},{"subj":"32741232-27566901-29927135","pred":"source","obj":"2_test"},{"subj":"32741232-27156189-29927136","pred":"source","obj":"2_test"},{"subj":"32741232-29300947-29927137","pred":"source","obj":"2_test"},{"subj":"32741232-30247561-29927138","pred":"source","obj":"2_test"},{"subj":"32741232-30239830-29927139","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#93ecec","default":true},{"id":"2_test","color":"#ecd293"}]}]}}