PMC:7473770 / 33428-34619 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T228","span":{"begin":44,"end":50},"obj":"Body_part"},{"id":"T229","span":{"begin":271,"end":277},"obj":"Body_part"},{"id":"T230","span":{"begin":383,"end":389},"obj":"Body_part"},{"id":"T231","span":{"begin":962,"end":966},"obj":"Body_part"}],"attributes":[{"id":"A228","pred":"fma_id","subj":"T228","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A229","pred":"fma_id","subj":"T229","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A230","pred":"fma_id","subj":"T230","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A231","pred":"fma_id","subj":"T231","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"From each of the six Covid-19 patients, two tissue samples with edge lengths of about 4 mm each were analyzed. To one sample of each patient, a metal containing stain (uranium acetate, UA) was applied, the other samples remained unstained. Separated for their stain, six tissue samples were dehydrated and embedded in the same multi-sample paraffin block. The size of the postmortem tissue samples made available for the study varied between the different patients (I-VI), with maximum cross-section of about 4 mm after dehydration. From all six samples, biopsy punches were taken by either a 8 mm or a 3.5 mm punch, depending on the individual size. The punches were then transferred onto a holder for the parallel-beam local tomography acquisition, followed by a further reduction in size (after measurement of the entire sample) to a 1 mm biopsy punch, for further tomographic recordings. A sketch of the sample preparation is shown in Figure 1b. The control lung sample was first mounted in an Eppendorf tube for parallel beam acquisitions, and a 1 mm biopsy punch was then transferred into a polyimide tube similar to the paraffin-embedded ones, but scanned in fixative buffer solution."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T225","span":{"begin":44,"end":50},"obj":"Body_part"},{"id":"T226","span":{"begin":271,"end":277},"obj":"Body_part"},{"id":"T227","span":{"begin":383,"end":389},"obj":"Body_part"},{"id":"T228","span":{"begin":962,"end":966},"obj":"Body_part"},{"id":"T229","span":{"begin":1008,"end":1012},"obj":"Body_part"},{"id":"T230","span":{"begin":1107,"end":1111},"obj":"Body_part"}],"attributes":[{"id":"A225","pred":"uberon_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A226","pred":"uberon_id","subj":"T226","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A227","pred":"uberon_id","subj":"T227","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A228","pred":"uberon_id","subj":"T228","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A229","pred":"uberon_id","subj":"T229","obj":"http://purl.obolibrary.org/obo/UBERON_0000025"},{"id":"A230","pred":"uberon_id","subj":"T230","obj":"http://purl.obolibrary.org/obo/UBERON_0000025"}],"text":"From each of the six Covid-19 patients, two tissue samples with edge lengths of about 4 mm each were analyzed. To one sample of each patient, a metal containing stain (uranium acetate, UA) was applied, the other samples remained unstained. Separated for their stain, six tissue samples were dehydrated and embedded in the same multi-sample paraffin block. The size of the postmortem tissue samples made available for the study varied between the different patients (I-VI), with maximum cross-section of about 4 mm after dehydration. From all six samples, biopsy punches were taken by either a 8 mm or a 3.5 mm punch, depending on the individual size. The punches were then transferred onto a holder for the parallel-beam local tomography acquisition, followed by a further reduction in size (after measurement of the entire sample) to a 1 mm biopsy punch, for further tomographic recordings. A sketch of the sample preparation is shown in Figure 1b. The control lung sample was first mounted in an Eppendorf tube for parallel beam acquisitions, and a 1 mm biopsy punch was then transferred into a polyimide tube similar to the paraffin-embedded ones, but scanned in fixative buffer solution."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T331","span":{"begin":142,"end":143},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T332","span":{"begin":591,"end":594},"obj":"http://purl.obolibrary.org/obo/CLO_0050154"},{"id":"T333","span":{"begin":601,"end":602},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T334","span":{"begin":690,"end":691},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T335","span":{"begin":763,"end":764},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T336","span":{"begin":835,"end":836},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T337","span":{"begin":892,"end":893},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T338","span":{"begin":962,"end":966},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T339","span":{"begin":962,"end":966},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T340","span":{"begin":1008,"end":1012},"obj":"http://purl.obolibrary.org/obo/UBERON_0000025"},{"id":"T341","span":{"begin":1049,"end":1050},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T342","span":{"begin":1095,"end":1096},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T343","span":{"begin":1107,"end":1111},"obj":"http://purl.obolibrary.org/obo/UBERON_0000025"}],"text":"From each of the six Covid-19 patients, two tissue samples with edge lengths of about 4 mm each were analyzed. To one sample of each patient, a metal containing stain (uranium acetate, UA) was applied, the other samples remained unstained. Separated for their stain, six tissue samples were dehydrated and embedded in the same multi-sample paraffin block. The size of the postmortem tissue samples made available for the study varied between the different patients (I-VI), with maximum cross-section of about 4 mm after dehydration. From all six samples, biopsy punches were taken by either a 8 mm or a 3.5 mm punch, depending on the individual size. The punches were then transferred onto a holder for the parallel-beam local tomography acquisition, followed by a further reduction in size (after measurement of the entire sample) to a 1 mm biopsy punch, for further tomographic recordings. A sketch of the sample preparation is shown in Figure 1b. The control lung sample was first mounted in an Eppendorf tube for parallel beam acquisitions, and a 1 mm biopsy punch was then transferred into a polyimide tube similar to the paraffin-embedded ones, but scanned in fixative buffer solution."}

{"project":"LitCovid-sentences","denotations":[{"id":"T261","span":{"begin":111,"end":239},"obj":"Sentence"},{"id":"T262","span":{"begin":240,"end":355},"obj":"Sentence"},{"id":"T263","span":{"begin":356,"end":532},"obj":"Sentence"},{"id":"T264","span":{"begin":533,"end":650},"obj":"Sentence"},{"id":"T265","span":{"begin":651,"end":891},"obj":"Sentence"},{"id":"T266","span":{"begin":892,"end":949},"obj":"Sentence"},{"id":"T267","span":{"begin":950,"end":1191},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"From each of the six Covid-19 patients, two tissue samples with edge lengths of about 4 mm each were analyzed. To one sample of each patient, a metal containing stain (uranium acetate, UA) was applied, the other samples remained unstained. Separated for their stain, six tissue samples were dehydrated and embedded in the same multi-sample paraffin block. The size of the postmortem tissue samples made available for the study varied between the different patients (I-VI), with maximum cross-section of about 4 mm after dehydration. From all six samples, biopsy punches were taken by either a 8 mm or a 3.5 mm punch, depending on the individual size. The punches were then transferred onto a holder for the parallel-beam local tomography acquisition, followed by a further reduction in size (after measurement of the entire sample) to a 1 mm biopsy punch, for further tomographic recordings. A sketch of the sample preparation is shown in Figure 1b. The control lung sample was first mounted in an Eppendorf tube for parallel beam acquisitions, and a 1 mm biopsy punch was then transferred into a polyimide tube similar to the paraffin-embedded ones, but scanned in fixative buffer solution."}

{"project":"LitCovid-PubTator","denotations":[{"id":"298","span":{"begin":30,"end":38},"obj":"Species"},{"id":"299","span":{"begin":133,"end":140},"obj":"Species"},{"id":"300","span":{"begin":456,"end":464},"obj":"Species"},{"id":"301","span":{"begin":144,"end":149},"obj":"Chemical"},{"id":"302","span":{"begin":168,"end":183},"obj":"Chemical"},{"id":"303","span":{"begin":340,"end":348},"obj":"Chemical"},{"id":"304","span":{"begin":1097,"end":1106},"obj":"Chemical"},{"id":"305","span":{"begin":1127,"end":1135},"obj":"Chemical"},{"id":"306","span":{"begin":21,"end":29},"obj":"Disease"},{"id":"307","span":{"begin":520,"end":531},"obj":"Disease"}],"attributes":[{"id":"A298","pred":"tao:has_database_id","subj":"298","obj":"Tax:9606"},{"id":"A299","pred":"tao:has_database_id","subj":"299","obj":"Tax:9606"},{"id":"A300","pred":"tao:has_database_id","subj":"300","obj":"Tax:9606"},{"id":"A301","pred":"tao:has_database_id","subj":"301","obj":"MESH:D008670"},{"id":"A302","pred":"tao:has_database_id","subj":"302","obj":"MESH:C005460"},{"id":"A303","pred":"tao:has_database_id","subj":"303","obj":"MESH:D010232"},{"id":"A305","pred":"tao:has_database_id","subj":"305","obj":"MESH:D010232"},{"id":"A306","pred":"tao:has_database_id","subj":"306","obj":"MESH:C000657245"},{"id":"A307","pred":"tao:has_database_id","subj":"307","obj":"MESH:D003681"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"From each of the six Covid-19 patients, two tissue samples with edge lengths of about 4 mm each were analyzed. To one sample of each patient, a metal containing stain (uranium acetate, UA) was applied, the other samples remained unstained. Separated for their stain, six tissue samples were dehydrated and embedded in the same multi-sample paraffin block. The size of the postmortem tissue samples made available for the study varied between the different patients (I-VI), with maximum cross-section of about 4 mm after dehydration. From all six samples, biopsy punches were taken by either a 8 mm or a 3.5 mm punch, depending on the individual size. The punches were then transferred onto a holder for the parallel-beam local tomography acquisition, followed by a further reduction in size (after measurement of the entire sample) to a 1 mm biopsy punch, for further tomographic recordings. A sketch of the sample preparation is shown in Figure 1b. The control lung sample was first mounted in an Eppendorf tube for parallel beam acquisitions, and a 1 mm biopsy punch was then transferred into a polyimide tube similar to the paraffin-embedded ones, but scanned in fixative buffer solution."}