PMC:7473770 / 29889-31046 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T217","span":{"begin":670,"end":674},"obj":"Body_part"},{"id":"T218","span":{"begin":968,"end":972},"obj":"Body_part"},{"id":"T219","span":{"begin":1060,"end":1064},"obj":"Body_part"},{"id":"T220","span":{"begin":1096,"end":1102},"obj":"Body_part"}],"attributes":[{"id":"A217","pred":"fma_id","subj":"T217","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A218","pred":"fma_id","subj":"T218","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A219","pred":"fma_id","subj":"T219","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A220","pred":"fma_id","subj":"T220","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"On the side of imaging technology and exploitation, there is still ample room for improvement: higher resolution could be achieved by further geometric zooms, waveguide optics with higher numerical aperture, in combination with pixel detector technology, and further improvements in holographic reconstruction. Equally important to extend the length scales covered to small scales is the further upscaling of the FOV based on stitching different sub-tomograms. At the same time the scales should be extended by including more than two zoom levels, based on different detector and illumination settings. In this way, one could bridge scales to cover the entire lobe of a lung. To this end, optimized recording and data flow is a larger bottleneck than photons and optics, in particular since 4th generation synchrotron radiation sources are about to deliver unprecedented brilliance. Finally, in view of exploitation and information gain, specific labels for different cell types and 3D immunostaining coupled to radiocontrast agents should be developed. Here, lung offers an advantage over other tissue in view of volume accessibility and label diffusivity."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T212","span":{"begin":350,"end":356},"obj":"Body_part"},{"id":"T213","span":{"begin":374,"end":380},"obj":"Body_part"},{"id":"T214","span":{"begin":482,"end":488},"obj":"Body_part"},{"id":"T215","span":{"begin":633,"end":639},"obj":"Body_part"},{"id":"T216","span":{"begin":660,"end":664},"obj":"Body_part"},{"id":"T217","span":{"begin":670,"end":674},"obj":"Body_part"},{"id":"T218","span":{"begin":1060,"end":1064},"obj":"Body_part"},{"id":"T219","span":{"begin":1096,"end":1102},"obj":"Body_part"}],"attributes":[{"id":"A212","pred":"uberon_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A213","pred":"uberon_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A214","pred":"uberon_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A215","pred":"uberon_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A216","pred":"uberon_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/UBERON_3010752"},{"id":"A217","pred":"uberon_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A218","pred":"uberon_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A219","pred":"uberon_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"On the side of imaging technology and exploitation, there is still ample room for improvement: higher resolution could be achieved by further geometric zooms, waveguide optics with higher numerical aperture, in combination with pixel detector technology, and further improvements in holographic reconstruction. Equally important to extend the length scales covered to small scales is the further upscaling of the FOV based on stitching different sub-tomograms. At the same time the scales should be extended by including more than two zoom levels, based on different detector and illumination settings. In this way, one could bridge scales to cover the entire lobe of a lung. To this end, optimized recording and data flow is a larger bottleneck than photons and optics, in particular since 4th generation synchrotron radiation sources are about to deliver unprecedented brilliance. Finally, in view of exploitation and information gain, specific labels for different cell types and 3D immunostaining coupled to radiocontrast agents should be developed. Here, lung offers an advantage over other tissue in view of volume accessibility and label diffusivity."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T310","span":{"begin":668,"end":669},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T311","span":{"begin":670,"end":674},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T312","span":{"begin":670,"end":674},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T313","span":{"begin":726,"end":727},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T314","span":{"begin":947,"end":953},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"},{"id":"T315","span":{"begin":968,"end":978},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T316","span":{"begin":1060,"end":1064},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T317","span":{"begin":1060,"end":1064},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T318","span":{"begin":1139,"end":1144},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"}],"text":"On the side of imaging technology and exploitation, there is still ample room for improvement: higher resolution could be achieved by further geometric zooms, waveguide optics with higher numerical aperture, in combination with pixel detector technology, and further improvements in holographic reconstruction. Equally important to extend the length scales covered to small scales is the further upscaling of the FOV based on stitching different sub-tomograms. At the same time the scales should be extended by including more than two zoom levels, based on different detector and illumination settings. In this way, one could bridge scales to cover the entire lobe of a lung. To this end, optimized recording and data flow is a larger bottleneck than photons and optics, in particular since 4th generation synchrotron radiation sources are about to deliver unprecedented brilliance. Finally, in view of exploitation and information gain, specific labels for different cell types and 3D immunostaining coupled to radiocontrast agents should be developed. Here, lung offers an advantage over other tissue in view of volume accessibility and label diffusivity."}

{"project":"LitCovid-sentences","denotations":[{"id":"T228","span":{"begin":0,"end":310},"obj":"Sentence"},{"id":"T229","span":{"begin":311,"end":460},"obj":"Sentence"},{"id":"T230","span":{"begin":461,"end":602},"obj":"Sentence"},{"id":"T231","span":{"begin":603,"end":675},"obj":"Sentence"},{"id":"T232","span":{"begin":676,"end":882},"obj":"Sentence"},{"id":"T233","span":{"begin":883,"end":1053},"obj":"Sentence"},{"id":"T234","span":{"begin":1054,"end":1157},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"On the side of imaging technology and exploitation, there is still ample room for improvement: higher resolution could be achieved by further geometric zooms, waveguide optics with higher numerical aperture, in combination with pixel detector technology, and further improvements in holographic reconstruction. Equally important to extend the length scales covered to small scales is the further upscaling of the FOV based on stitching different sub-tomograms. At the same time the scales should be extended by including more than two zoom levels, based on different detector and illumination settings. In this way, one could bridge scales to cover the entire lobe of a lung. To this end, optimized recording and data flow is a larger bottleneck than photons and optics, in particular since 4th generation synchrotron radiation sources are about to deliver unprecedented brilliance. Finally, in view of exploitation and information gain, specific labels for different cell types and 3D immunostaining coupled to radiocontrast agents should be developed. Here, lung offers an advantage over other tissue in view of volume accessibility and label diffusivity."}