PMC:7473770 / 29159-29888 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T212","span":{"begin":221,"end":225},"obj":"Body_part"},{"id":"T213","span":{"begin":347,"end":360},"obj":"Body_part"},{"id":"T214","span":{"begin":347,"end":352},"obj":"Body_part"},{"id":"T215","span":{"begin":442,"end":446},"obj":"Body_part"},{"id":"T216","span":{"begin":718,"end":726},"obj":"Body_part"}],"attributes":[{"id":"A212","pred":"fma_id","subj":"T212","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A213","pred":"fma_id","subj":"T213","obj":"http://purl.org/sig/ont/fma/fma63183"},{"id":"A214","pred":"fma_id","subj":"T214","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A215","pred":"fma_id","subj":"T215","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A216","pred":"fma_id","subj":"T216","obj":"http://purl.org/sig/ont/fma/fma14542"}],"text":"The advantage of 3D histology compared to conventional histology relates to the simple fact that features can be visualized and investigated in their full native dimensionality. This enables the accurate determination of cell densities, the quantification of morphological parameters such as the distance metrics shown in Figure 6, and tracing of blood vessels. Standard histology and in particular immunohistochemical staining, on the other hand, can inform us more precisely on the biomolecular origin of the structure, while immunostaining coupled with x-ray contrast agents is not yet within reach. Importantly, since PC-CT is nondestructive, histology can be performed on well-chosen sections after the scan, see Appendix 1."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T208","span":{"begin":347,"end":360},"obj":"Body_part"},{"id":"T209","span":{"begin":347,"end":352},"obj":"Body_part"},{"id":"T210","span":{"begin":353,"end":360},"obj":"Body_part"},{"id":"T211","span":{"begin":442,"end":446},"obj":"Body_part"}],"attributes":[{"id":"A208","pred":"uberon_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/UBERON_0001981"},{"id":"A209","pred":"uberon_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A210","pred":"uberon_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/UBERON_0000055"},{"id":"A211","pred":"uberon_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"}],"text":"The advantage of 3D histology compared to conventional histology relates to the simple fact that features can be visualized and investigated in their full native dimensionality. This enables the accurate determination of cell densities, the quantification of morphological parameters such as the distance metrics shown in Figure 6, and tracing of blood vessels. Standard histology and in particular immunohistochemical staining, on the other hand, can inform us more precisely on the biomolecular origin of the structure, while immunostaining coupled with x-ray contrast agents is not yet within reach. Importantly, since PC-CT is nondestructive, histology can be performed on well-chosen sections after the scan, see Appendix 1."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T307","span":{"begin":221,"end":225},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T308","span":{"begin":347,"end":360},"obj":"http://purl.obolibrary.org/obo/UBERON_0001981"},{"id":"T309","span":{"begin":347,"end":360},"obj":"http://www.ebi.ac.uk/efo/EFO_0000817"}],"text":"The advantage of 3D histology compared to conventional histology relates to the simple fact that features can be visualized and investigated in their full native dimensionality. This enables the accurate determination of cell densities, the quantification of morphological parameters such as the distance metrics shown in Figure 6, and tracing of blood vessels. Standard histology and in particular immunohistochemical staining, on the other hand, can inform us more precisely on the biomolecular origin of the structure, while immunostaining coupled with x-ray contrast agents is not yet within reach. Importantly, since PC-CT is nondestructive, histology can be performed on well-chosen sections after the scan, see Appendix 1."}

{"project":"LitCovid-sentences","denotations":[{"id":"T224","span":{"begin":0,"end":177},"obj":"Sentence"},{"id":"T225","span":{"begin":178,"end":361},"obj":"Sentence"},{"id":"T226","span":{"begin":362,"end":602},"obj":"Sentence"},{"id":"T227","span":{"begin":603,"end":729},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The advantage of 3D histology compared to conventional histology relates to the simple fact that features can be visualized and investigated in their full native dimensionality. This enables the accurate determination of cell densities, the quantification of morphological parameters such as the distance metrics shown in Figure 6, and tracing of blood vessels. Standard histology and in particular immunohistochemical staining, on the other hand, can inform us more precisely on the biomolecular origin of the structure, while immunostaining coupled with x-ray contrast agents is not yet within reach. Importantly, since PC-CT is nondestructive, histology can be performed on well-chosen sections after the scan, see Appendix 1."}

{"project":"LitCovid-PubTator","denotations":[{"id":"249","span":{"begin":622,"end":627},"obj":"CellLine"}],"attributes":[{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"CVCL:B848"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The advantage of 3D histology compared to conventional histology relates to the simple fact that features can be visualized and investigated in their full native dimensionality. This enables the accurate determination of cell densities, the quantification of morphological parameters such as the distance metrics shown in Figure 6, and tracing of blood vessels. Standard histology and in particular immunohistochemical staining, on the other hand, can inform us more precisely on the biomolecular origin of the structure, while immunostaining coupled with x-ray contrast agents is not yet within reach. Importantly, since PC-CT is nondestructive, histology can be performed on well-chosen sections after the scan, see Appendix 1."}