PMC:7473770 / 28541-29158 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T211","span":{"begin":124,"end":128},"obj":"Body_part"}],"attributes":[{"id":"A211","pred":"fma_id","subj":"T211","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"In summary, we have demonstrated that multi-scale x-ray phase contrast tomography can firstly augment pathohistology of the lung to full three dimensions, and secondly provide a link between microscopic and macroscopic scales. For the first time, characteristic morphological changes associated with DAD such as hyaline membranes and pronounced inflammation have been imaged in three dimensions, in particular in Covid-19, the most severe pandemic which mankind has faced for decades. Moreover, we conducted our study in FFPE material, a fixation method established for well over a century and ubiquitously available."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T205","span":{"begin":44,"end":49},"obj":"Body_part"},{"id":"T206","span":{"begin":124,"end":128},"obj":"Body_part"},{"id":"T207","span":{"begin":219,"end":225},"obj":"Body_part"}],"attributes":[{"id":"A205","pred":"uberon_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A206","pred":"uberon_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A207","pred":"uberon_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"}],"text":"In summary, we have demonstrated that multi-scale x-ray phase contrast tomography can firstly augment pathohistology of the lung to full three dimensions, and secondly provide a link between microscopic and macroscopic scales. For the first time, characteristic morphological changes associated with DAD such as hyaline membranes and pronounced inflammation have been imaged in three dimensions, in particular in Covid-19, the most severe pandemic which mankind has faced for decades. Moreover, we conducted our study in FFPE material, a fixation method established for well over a century and ubiquitously available."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T53","span":{"begin":345,"end":357},"obj":"Disease"}],"attributes":[{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"In summary, we have demonstrated that multi-scale x-ray phase contrast tomography can firstly augment pathohistology of the lung to full three dimensions, and secondly provide a link between microscopic and macroscopic scales. For the first time, characteristic morphological changes associated with DAD such as hyaline membranes and pronounced inflammation have been imaged in three dimensions, in particular in Covid-19, the most severe pandemic which mankind has faced for decades. Moreover, we conducted our study in FFPE material, a fixation method established for well over a century and ubiquitously available."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T299","span":{"begin":124,"end":128},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T300","span":{"begin":124,"end":128},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T301","span":{"begin":176,"end":177},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T302","span":{"begin":320,"end":329},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T303","span":{"begin":462,"end":465},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T304","span":{"begin":466,"end":471},"obj":"http://purl.obolibrary.org/obo/UBERON_0001456"},{"id":"T305","span":{"begin":536,"end":537},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T306","span":{"begin":580,"end":581},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"In summary, we have demonstrated that multi-scale x-ray phase contrast tomography can firstly augment pathohistology of the lung to full three dimensions, and secondly provide a link between microscopic and macroscopic scales. For the first time, characteristic morphological changes associated with DAD such as hyaline membranes and pronounced inflammation have been imaged in three dimensions, in particular in Covid-19, the most severe pandemic which mankind has faced for decades. Moreover, we conducted our study in FFPE material, a fixation method established for well over a century and ubiquitously available."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T36","span":{"begin":345,"end":357},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"In summary, we have demonstrated that multi-scale x-ray phase contrast tomography can firstly augment pathohistology of the lung to full three dimensions, and secondly provide a link between microscopic and macroscopic scales. For the first time, characteristic morphological changes associated with DAD such as hyaline membranes and pronounced inflammation have been imaged in three dimensions, in particular in Covid-19, the most severe pandemic which mankind has faced for decades. Moreover, we conducted our study in FFPE material, a fixation method established for well over a century and ubiquitously available."}

{"project":"LitCovid-sentences","denotations":[{"id":"T221","span":{"begin":0,"end":226},"obj":"Sentence"},{"id":"T222","span":{"begin":227,"end":484},"obj":"Sentence"},{"id":"T223","span":{"begin":485,"end":617},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In summary, we have demonstrated that multi-scale x-ray phase contrast tomography can firstly augment pathohistology of the lung to full three dimensions, and secondly provide a link between microscopic and macroscopic scales. For the first time, characteristic morphological changes associated with DAD such as hyaline membranes and pronounced inflammation have been imaged in three dimensions, in particular in Covid-19, the most severe pandemic which mankind has faced for decades. Moreover, we conducted our study in FFPE material, a fixation method established for well over a century and ubiquitously available."}

{"project":"LitCovid-PubTator","denotations":[{"id":"246","span":{"begin":345,"end":357},"obj":"Disease"},{"id":"247","span":{"begin":413,"end":421},"obj":"Disease"}],"attributes":[{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"MESH:D007249"},{"id":"A247","pred":"tao:has_database_id","subj":"247","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In summary, we have demonstrated that multi-scale x-ray phase contrast tomography can firstly augment pathohistology of the lung to full three dimensions, and secondly provide a link between microscopic and macroscopic scales. For the first time, characteristic morphological changes associated with DAD such as hyaline membranes and pronounced inflammation have been imaged in three dimensions, in particular in Covid-19, the most severe pandemic which mankind has faced for decades. Moreover, we conducted our study in FFPE material, a fixation method established for well over a century and ubiquitously available."}