PMC:7473770 / 1342-2958 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T12","span":{"begin":175,"end":180},"obj":"Body_part"},{"id":"T13","span":{"begin":248,"end":252},"obj":"Body_part"},{"id":"T14","span":{"begin":321,"end":326},"obj":"Body_part"},{"id":"T15","span":{"begin":529,"end":533},"obj":"Body_part"},{"id":"T16","span":{"begin":662,"end":670},"obj":"Body_part"},{"id":"T17","span":{"begin":1091,"end":1109},"obj":"Body_part"},{"id":"T18","span":{"begin":1205,"end":1213},"obj":"Body_part"},{"id":"T19","span":{"begin":1214,"end":1223},"obj":"Body_part"},{"id":"T20","span":{"begin":1429,"end":1434},"obj":"Body_part"},{"id":"T21","span":{"begin":1576,"end":1581},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma63194"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma68877"}],"text":"Severe progression of the 2019 coronavirus disease (Covid-19) is frequently accompanied by the clinical acute respiratory distress syndrome (ARDS) and respiratory failure, an organ manifestation responsible for the majority of Covid-19 fatalities. Lung injury associated with ARDS can be readily detected by radiographic chest imaging and clinical computed tomography (CT), which have assisted the diagnosis and management of Covid-19 patients (Lee et al., 2020; Shi et al., 2020; Chung et al., 2020). Here, so-called peripheral lung ground-glass opacities are the main radiological hallmark of ARDS, and can be linked to the histological observation of diffuse alveolar damage (DAD) with edema, hemorrhage, and intraalveolar fibrin deposition (Ackermann et al., 2020). These findings have also been reported for infections by Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and influenza viruses. Distinctive features of pulmonary involvement of Covid-19 include severe endothelial injury associated with the presence of intracellular virions and inflammation, disrupted cellular membranes, as well as widespread thrombosis with microangiopathy. As reported in Ackermann et al., 2020, alveolar capillary microthrombi were found to be nine times as prevalent in patients with Covid-19 as in patients with the also very aggressive H1N1 influenza A virus, also referred to as swine flu. Importantly, in Covid-19 lungs, a specific variant of new vessel growth - intussusceptive angiogenesis - was significantly more prevalent, that is, 2.7 times as high as in lungs of patients with H1N1 influenza A."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T10","span":{"begin":175,"end":180},"obj":"Body_part"},{"id":"T11","span":{"begin":248,"end":252},"obj":"Body_part"},{"id":"T12","span":{"begin":321,"end":326},"obj":"Body_part"},{"id":"T13","span":{"begin":529,"end":533},"obj":"Body_part"},{"id":"T14","span":{"begin":1214,"end":1223},"obj":"Body_part"},{"id":"T15","span":{"begin":1462,"end":1468},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0001982"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0000055"}],"text":"Severe progression of the 2019 coronavirus disease (Covid-19) is frequently accompanied by the clinical acute respiratory distress syndrome (ARDS) and respiratory failure, an organ manifestation responsible for the majority of Covid-19 fatalities. Lung injury associated with ARDS can be readily detected by radiographic chest imaging and clinical computed tomography (CT), which have assisted the diagnosis and management of Covid-19 patients (Lee et al., 2020; Shi et al., 2020; Chung et al., 2020). Here, so-called peripheral lung ground-glass opacities are the main radiological hallmark of ARDS, and can be linked to the histological observation of diffuse alveolar damage (DAD) with edema, hemorrhage, and intraalveolar fibrin deposition (Ackermann et al., 2020). These findings have also been reported for infections by Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and influenza viruses. Distinctive features of pulmonary involvement of Covid-19 include severe endothelial injury associated with the presence of intracellular virions and inflammation, disrupted cellular membranes, as well as widespread thrombosis with microangiopathy. As reported in Ackermann et al., 2020, alveolar capillary microthrombi were found to be nine times as prevalent in patients with Covid-19 as in patients with the also very aggressive H1N1 influenza A virus, also referred to as swine flu. Importantly, in Covid-19 lungs, a specific variant of new vessel growth - intussusceptive angiogenesis - was significantly more prevalent, that is, 2.7 times as high as in lungs of patients with H1N1 influenza A."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":104,"end":139},"obj":"Disease"},{"id":"T2","span":{"begin":110,"end":139},"obj":"Disease"},{"id":"T3","span":{"begin":141,"end":145},"obj":"Disease"},{"id":"T4","span":{"begin":151,"end":170},"obj":"Disease"},{"id":"T5","span":{"begin":253,"end":259},"obj":"Disease"},{"id":"T6","span":{"begin":276,"end":280},"obj":"Disease"},{"id":"T7","span":{"begin":595,"end":599},"obj":"Disease"},{"id":"T8","span":{"begin":813,"end":823},"obj":"Disease"},{"id":"T9","span":{"begin":884,"end":892},"obj":"Disease"},{"id":"T10","span":{"begin":898,"end":907},"obj":"Disease"},{"id":"T11","span":{"begin":1002,"end":1008},"obj":"Disease"},{"id":"T12","span":{"begin":1067,"end":1079},"obj":"Disease"},{"id":"T13","span":{"begin":1133,"end":1143},"obj":"Disease"},{"id":"T14","span":{"begin":1349,"end":1363},"obj":"Disease"},{"id":"T15","span":{"begin":1354,"end":1363},"obj":"Disease"},{"id":"T16","span":{"begin":1393,"end":1402},"obj":"Disease"},{"id":"T17","span":{"begin":1399,"end":1402},"obj":"Disease"},{"id":"T18","span":{"begin":1599,"end":1613},"obj":"Disease"},{"id":"T19","span":{"begin":1604,"end":1613},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005460"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005460"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005460"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"Severe progression of the 2019 coronavirus disease (Covid-19) is frequently accompanied by the clinical acute respiratory distress syndrome (ARDS) and respiratory failure, an organ manifestation responsible for the majority of Covid-19 fatalities. Lung injury associated with ARDS can be readily detected by radiographic chest imaging and clinical computed tomography (CT), which have assisted the diagnosis and management of Covid-19 patients (Lee et al., 2020; Shi et al., 2020; Chung et al., 2020). Here, so-called peripheral lung ground-glass opacities are the main radiological hallmark of ARDS, and can be linked to the histological observation of diffuse alveolar damage (DAD) with edema, hemorrhage, and intraalveolar fibrin deposition (Ackermann et al., 2020). These findings have also been reported for infections by Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and influenza viruses. Distinctive features of pulmonary involvement of Covid-19 include severe endothelial injury associated with the presence of intracellular virions and inflammation, disrupted cellular membranes, as well as widespread thrombosis with microangiopathy. As reported in Ackermann et al., 2020, alveolar capillary microthrombi were found to be nine times as prevalent in patients with Covid-19 as in patients with the also very aggressive H1N1 influenza A virus, also referred to as swine flu. Importantly, in Covid-19 lungs, a specific variant of new vessel growth - intussusceptive angiogenesis - was significantly more prevalent, that is, 2.7 times as high as in lungs of patients with H1N1 influenza A."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T13","span":{"begin":175,"end":180},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T14","span":{"begin":248,"end":252},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T15","span":{"begin":248,"end":252},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T16","span":{"begin":321,"end":326},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T17","span":{"begin":529,"end":533},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T18","span":{"begin":529,"end":533},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T19","span":{"begin":908,"end":915},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T20","span":{"begin":1100,"end":1109},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T21","span":{"begin":1364,"end":1365},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T22","span":{"begin":1366,"end":1371},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T23","span":{"begin":1429,"end":1434},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T24","span":{"begin":1436,"end":1437},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T25","span":{"begin":1462,"end":1468},"obj":"http://purl.obolibrary.org/obo/UBERON_0000055"},{"id":"T26","span":{"begin":1576,"end":1581},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T27","span":{"begin":1614,"end":1615},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Severe progression of the 2019 coronavirus disease (Covid-19) is frequently accompanied by the clinical acute respiratory distress syndrome (ARDS) and respiratory failure, an organ manifestation responsible for the majority of Covid-19 fatalities. Lung injury associated with ARDS can be readily detected by radiographic chest imaging and clinical computed tomography (CT), which have assisted the diagnosis and management of Covid-19 patients (Lee et al., 2020; Shi et al., 2020; Chung et al., 2020). Here, so-called peripheral lung ground-glass opacities are the main radiological hallmark of ARDS, and can be linked to the histological observation of diffuse alveolar damage (DAD) with edema, hemorrhage, and intraalveolar fibrin deposition (Ackermann et al., 2020). These findings have also been reported for infections by Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and influenza viruses. Distinctive features of pulmonary involvement of Covid-19 include severe endothelial injury associated with the presence of intracellular virions and inflammation, disrupted cellular membranes, as well as widespread thrombosis with microangiopathy. As reported in Ackermann et al., 2020, alveolar capillary microthrombi were found to be nine times as prevalent in patients with Covid-19 as in patients with the also very aggressive H1N1 influenza A virus, also referred to as swine flu. Importantly, in Covid-19 lungs, a specific variant of new vessel growth - intussusceptive angiogenesis - was significantly more prevalent, that is, 2.7 times as high as in lungs of patients with H1N1 influenza A."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":1067,"end":1079},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T5","span":{"begin":1469,"end":1475},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T6","span":{"begin":1478,"end":1506},"obj":"http://purl.obolibrary.org/obo/GO_0002041"},{"id":"T7","span":{"begin":1494,"end":1506},"obj":"http://purl.obolibrary.org/obo/GO_0001525"}],"text":"Severe progression of the 2019 coronavirus disease (Covid-19) is frequently accompanied by the clinical acute respiratory distress syndrome (ARDS) and respiratory failure, an organ manifestation responsible for the majority of Covid-19 fatalities. Lung injury associated with ARDS can be readily detected by radiographic chest imaging and clinical computed tomography (CT), which have assisted the diagnosis and management of Covid-19 patients (Lee et al., 2020; Shi et al., 2020; Chung et al., 2020). Here, so-called peripheral lung ground-glass opacities are the main radiological hallmark of ARDS, and can be linked to the histological observation of diffuse alveolar damage (DAD) with edema, hemorrhage, and intraalveolar fibrin deposition (Ackermann et al., 2020). These findings have also been reported for infections by Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and influenza viruses. Distinctive features of pulmonary involvement of Covid-19 include severe endothelial injury associated with the presence of intracellular virions and inflammation, disrupted cellular membranes, as well as widespread thrombosis with microangiopathy. As reported in Ackermann et al., 2020, alveolar capillary microthrombi were found to be nine times as prevalent in patients with Covid-19 as in patients with the also very aggressive H1N1 influenza A virus, also referred to as swine flu. Importantly, in Covid-19 lungs, a specific variant of new vessel growth - intussusceptive angiogenesis - was significantly more prevalent, that is, 2.7 times as high as in lungs of patients with H1N1 influenza A."}

{"project":"LitCovid-sentences","denotations":[{"id":"T9","span":{"begin":0,"end":247},"obj":"Sentence"},{"id":"T10","span":{"begin":248,"end":501},"obj":"Sentence"},{"id":"T11","span":{"begin":502,"end":769},"obj":"Sentence"},{"id":"T12","span":{"begin":770,"end":916},"obj":"Sentence"},{"id":"T13","span":{"begin":917,"end":1165},"obj":"Sentence"},{"id":"T14","span":{"begin":1166,"end":1403},"obj":"Sentence"},{"id":"T15","span":{"begin":1404,"end":1616},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Severe progression of the 2019 coronavirus disease (Covid-19) is frequently accompanied by the clinical acute respiratory distress syndrome (ARDS) and respiratory failure, an organ manifestation responsible for the majority of Covid-19 fatalities. Lung injury associated with ARDS can be readily detected by radiographic chest imaging and clinical computed tomography (CT), which have assisted the diagnosis and management of Covid-19 patients (Lee et al., 2020; Shi et al., 2020; Chung et al., 2020). Here, so-called peripheral lung ground-glass opacities are the main radiological hallmark of ARDS, and can be linked to the histological observation of diffuse alveolar damage (DAD) with edema, hemorrhage, and intraalveolar fibrin deposition (Ackermann et al., 2020). These findings have also been reported for infections by Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and influenza viruses. Distinctive features of pulmonary involvement of Covid-19 include severe endothelial injury associated with the presence of intracellular virions and inflammation, disrupted cellular membranes, as well as widespread thrombosis with microangiopathy. As reported in Ackermann et al., 2020, alveolar capillary microthrombi were found to be nine times as prevalent in patients with Covid-19 as in patients with the also very aggressive H1N1 influenza A virus, also referred to as swine flu. Importantly, in Covid-19 lungs, a specific variant of new vessel growth - intussusceptive angiogenesis - was significantly more prevalent, that is, 2.7 times as high as in lungs of patients with H1N1 influenza A."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T3","span":{"begin":110,"end":130},"obj":"Phenotype"},{"id":"T4","span":{"begin":151,"end":170},"obj":"Phenotype"},{"id":"T5","span":{"begin":654,"end":677},"obj":"Phenotype"},{"id":"T6","span":{"begin":679,"end":682},"obj":"Phenotype"},{"id":"T7","span":{"begin":689,"end":694},"obj":"Phenotype"},{"id":"T8","span":{"begin":1478,"end":1493},"obj":"Phenotype"}],"attributes":[{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0000969"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002576"}],"text":"Severe progression of the 2019 coronavirus disease (Covid-19) is frequently accompanied by the clinical acute respiratory distress syndrome (ARDS) and respiratory failure, an organ manifestation responsible for the majority of Covid-19 fatalities. Lung injury associated with ARDS can be readily detected by radiographic chest imaging and clinical computed tomography (CT), which have assisted the diagnosis and management of Covid-19 patients (Lee et al., 2020; Shi et al., 2020; Chung et al., 2020). Here, so-called peripheral lung ground-glass opacities are the main radiological hallmark of ARDS, and can be linked to the histological observation of diffuse alveolar damage (DAD) with edema, hemorrhage, and intraalveolar fibrin deposition (Ackermann et al., 2020). These findings have also been reported for infections by Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and influenza viruses. Distinctive features of pulmonary involvement of Covid-19 include severe endothelial injury associated with the presence of intracellular virions and inflammation, disrupted cellular membranes, as well as widespread thrombosis with microangiopathy. As reported in Ackermann et al., 2020, alveolar capillary microthrombi were found to be nine times as prevalent in patients with Covid-19 as in patients with the also very aggressive H1N1 influenza A virus, also referred to as swine flu. Importantly, in Covid-19 lungs, a specific variant of new vessel growth - intussusceptive angiogenesis - was significantly more prevalent, that is, 2.7 times as high as in lungs of patients with H1N1 influenza A."}

{"project":"2_test","denotations":[{"id":"32815517-32105641-26997839","span":{"begin":457,"end":461},"obj":"32105641"},{"id":"32815517-32105637-26997840","span":{"begin":475,"end":479},"obj":"32105637"},{"id":"32815517-32017661-26997841","span":{"begin":495,"end":499},"obj":"32017661"},{"id":"32815517-32437596-26997842","span":{"begin":763,"end":767},"obj":"32437596"},{"id":"32815517-32437596-26997843","span":{"begin":1199,"end":1203},"obj":"32437596"}],"text":"Severe progression of the 2019 coronavirus disease (Covid-19) is frequently accompanied by the clinical acute respiratory distress syndrome (ARDS) and respiratory failure, an organ manifestation responsible for the majority of Covid-19 fatalities. Lung injury associated with ARDS can be readily detected by radiographic chest imaging and clinical computed tomography (CT), which have assisted the diagnosis and management of Covid-19 patients (Lee et al., 2020; Shi et al., 2020; Chung et al., 2020). Here, so-called peripheral lung ground-glass opacities are the main radiological hallmark of ARDS, and can be linked to the histological observation of diffuse alveolar damage (DAD) with edema, hemorrhage, and intraalveolar fibrin deposition (Ackermann et al., 2020). These findings have also been reported for infections by Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and influenza viruses. Distinctive features of pulmonary involvement of Covid-19 include severe endothelial injury associated with the presence of intracellular virions and inflammation, disrupted cellular membranes, as well as widespread thrombosis with microangiopathy. As reported in Ackermann et al., 2020, alveolar capillary microthrombi were found to be nine times as prevalent in patients with Covid-19 as in patients with the also very aggressive H1N1 influenza A virus, also referred to as swine flu. Importantly, in Covid-19 lungs, a specific variant of new vessel growth - intussusceptive angiogenesis - was significantly more prevalent, that is, 2.7 times as high as in lungs of patients with H1N1 influenza A."}

{"project":"MyTest","denotations":[{"id":"32815517-32105641-26997839","span":{"begin":457,"end":461},"obj":"32105641"},{"id":"32815517-32105637-26997840","span":{"begin":475,"end":479},"obj":"32105637"},{"id":"32815517-32017661-26997841","span":{"begin":495,"end":499},"obj":"32017661"},{"id":"32815517-32437596-26997842","span":{"begin":763,"end":767},"obj":"32437596"},{"id":"32815517-32437596-26997843","span":{"begin":1199,"end":1203},"obj":"32437596"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Severe progression of the 2019 coronavirus disease (Covid-19) is frequently accompanied by the clinical acute respiratory distress syndrome (ARDS) and respiratory failure, an organ manifestation responsible for the majority of Covid-19 fatalities. Lung injury associated with ARDS can be readily detected by radiographic chest imaging and clinical computed tomography (CT), which have assisted the diagnosis and management of Covid-19 patients (Lee et al., 2020; Shi et al., 2020; Chung et al., 2020). Here, so-called peripheral lung ground-glass opacities are the main radiological hallmark of ARDS, and can be linked to the histological observation of diffuse alveolar damage (DAD) with edema, hemorrhage, and intraalveolar fibrin deposition (Ackermann et al., 2020). These findings have also been reported for infections by Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and influenza viruses. Distinctive features of pulmonary involvement of Covid-19 include severe endothelial injury associated with the presence of intracellular virions and inflammation, disrupted cellular membranes, as well as widespread thrombosis with microangiopathy. As reported in Ackermann et al., 2020, alveolar capillary microthrombi were found to be nine times as prevalent in patients with Covid-19 as in patients with the also very aggressive H1N1 influenza A virus, also referred to as swine flu. Importantly, in Covid-19 lungs, a specific variant of new vessel growth - intussusceptive angiogenesis - was significantly more prevalent, that is, 2.7 times as high as in lungs of patients with H1N1 influenza A."}

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