PMC:7473478 / 5809-7698
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T74 | 41-52 | Body_part | denotes | bone marrow | http://purl.org/sig/ont/fma/fma9608 |
| T75 | 54-68 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
| T76 | 70-81 | Body_part | denotes | dental pulp | http://purl.org/sig/ont/fma/fma55631 |
| T77 | 83-97 | Body_part | denotes | umbilical cord | http://purl.org/sig/ont/fma/fma85541 |
| T78 | 99-114 | Body_part | denotes | Wharton’s jelly | http://purl.org/sig/ont/fma/fma323134 |
| T79 | 116-124 | Body_part | denotes | placenta | http://purl.org/sig/ont/fma/fma63934 |
| T80 | 126-140 | Body_part | denotes | synovial fluid | http://purl.org/sig/ont/fma/fma12277 |
| T81 | 142-153 | Body_part | denotes | endometrium | http://purl.org/sig/ont/fma/fma17742 |
| T82 | 170-175 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T83 | 183-188 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T84 | 207-219 | Body_part | denotes | cell-surface | http://purl.org/sig/ont/fma/fma67653 |
| T85 | 207-211 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T86 | 700-705 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T87 | 742-755 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T88 | 817-822 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T89 | 960-965 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T90 | 1164-1177 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T91 | 1320-1331 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T92 | 1419-1434 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
| T93 | 1429-1434 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T94 | 1468-1473 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T95 | 1572-1581 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T96 | 1742-1747 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T97 | 1756-1761 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T98 | 1791-1796 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T99 | 1853-1863 | Body_part | denotes | hepatocyte | http://purl.org/sig/ont/fma/fma14515 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T8 | 41-52 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
| T9 | 54-68 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T10 | 62-68 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T11 | 70-81 | Body_part | denotes | dental pulp | http://purl.obolibrary.org/obo/UBERON_0001754 |
| T12 | 83-97 | Body_part | denotes | umbilical cord | http://purl.obolibrary.org/obo/UBERON_0002331 |
| T13 | 116-124 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T14 | 126-140 | Body_part | denotes | synovial fluid | http://purl.obolibrary.org/obo/UBERON_0001090 |
| T15 | 142-153 | Body_part | denotes | endometrium | http://purl.obolibrary.org/obo/UBERON_0001295 |
| T16 | 170-175 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T17 | 742-755 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T18 | 1164-1177 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T71 | 41-45 | http://purl.obolibrary.org/obo/UBERON_0002481 | denotes | bone |
| T72 | 54-68 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
| T73 | 83-97 | http://purl.obolibrary.org/obo/UBERON_0002331 | denotes | umbilical cord |
| T74 | 83-97 | http://www.ebi.ac.uk/efo/EFO_0001415 | denotes | umbilical cord |
| T75 | 116-124 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
| T76 | 116-124 | http://www.ebi.ac.uk/efo/EFO_0001407 | denotes | placenta |
| T77 | 142-153 | http://purl.obolibrary.org/obo/UBERON_0001295 | denotes | endometrium |
| T78 | 170-175 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T79 | 170-175 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T80 | 183-188 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T81 | 207-211 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T82 | 248-249 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T83 | 641-643 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T84 | 700-705 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T85 | 742-755 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T86 | 817-822 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T87 | 837-845 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T88 | 960-965 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T89 | 1164-1177 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T90 | 1264-1269 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Tregs |
| T91 | 1365-1367 | http://purl.obolibrary.org/obo/CLO_0002860 | denotes | E2 |
| T92 | 1419-1434 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
| T93 | 1468-1473 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T94 | 1475-1477 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T95 | 1724-1727 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T96 | 1742-1747 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T97 | 1749-1752 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T98 | 1754-1761 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T99 | 1786-1796 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | (NK) cells |
| T100 | 1879-1882 | http://purl.obolibrary.org/obo/CLO_0003740 | denotes | HGF |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T48 | 1278-1280 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T50 | 1351-1367 | Chemical | denotes | prostaglandin E2 | http://purl.obolibrary.org/obo/CHEBI_15551|http://purl.obolibrary.org/obo/CHEBI_606564 |
| T52 | 1351-1364 | Chemical | denotes | prostaglandin | http://purl.obolibrary.org/obo/CHEBI_26333 |
| T53 | 1369-1373 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
| T54 | 1395-1402 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T55 | 1459-1467 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
| T56 | 1633-1635 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T58 | 1644-1648 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 183 | 1186-1215 | Gene | denotes | transforming growth factor b1 | Gene:7040 |
| 184 | 1217-1222 | Gene | denotes | TGFβ1 | Gene:7040 |
| 185 | 1278-1282 | Gene | denotes | IL-6 | Gene:3569 |
| 186 | 1591-1596 | Gene | denotes | IFN-γ | Gene:3458 |
| 187 | 1627-1631 | Gene | denotes | TGFβ | Gene:7039 |
| 188 | 1633-1638 | Gene | denotes | IL-10 | Gene:3586 |
| 189 | 1724-1727 | Gene | denotes | CD4 | Gene:920 |
| 190 | 1843-1848 | Gene | denotes | TGFβ1 | Gene:7040 |
| 191 | 1853-1877 | Gene | denotes | hepatocyte growth factor | Gene:3082 |
| 192 | 1879-1882 | Gene | denotes | HGF | Gene:3082 |
| 193 | 1749-1752 | Gene | denotes | CD8 | Gene:925 |
| 194 | 1264-1269 | Chemical | denotes | Tregs | |
| 195 | 1351-1367 | Chemical | denotes | prostaglandin E2 | MESH:D015232 |
| 196 | 1369-1373 | Chemical | denotes | PGE2 | MESH:D015232 |
| 197 | 1644-1648 | Chemical | denotes | PGE2 | MESH:D015232 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T23 | 1199-1205 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T24 | 1395-1415 | http://purl.obolibrary.org/obo/GO_0019882 | denotes | antigen presentation |
| T25 | 1419-1453 | http://purl.obolibrary.org/obo/GO_0044565 | denotes | dendritic cells and proliferations |
| T26 | 1864-1870 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T49 | 0-176 | Sentence | denotes | MSCs are predominantly isolated from the bone marrow, adipose tissue, dental pulp, umbilical cord, Wharton’s jelly, placenta, synovial fluid, endometrium, and peripheral blood. |
| T50 | 177-289 | Sentence | denotes | These cells exhibit different cell-surface markers and can be used for a variety of treatment options (Table 1). |
| T51 | 290-469 | Sentence | denotes | MSCs can undergo in vitro amplification and self-renewal, and have low immunogenicity and immune-modulatory functions; the latter have attracted attention in clinical trials (16). |
| T52 | 470-645 | Sentence | denotes | MSCs have been widely used in various cellular therapies, such as pre-clinical studies, as well as in some clinical trials, because of their high safety and efficacy (17, 18). |
| T53 | 646-756 | Sentence | denotes | MSCs can exert immune-modu-latory effects in the host cells of both the innate and the adaptive immune system. |
| T54 | 757-882 | Sentence | denotes | The direct or indirect interactions of MSCs with the immune cells make the MSCs activate the immunomodulatory responses (19). |
| T55 | 883-1058 | Sentence | denotes | The immunomodulatory functions of MSCs depend on the environment of the host cells; based on the inflammatory status, the MSCs decide the type of immunoregulatory effect (20). |
| T56 | 1059-1145 | Sentence | denotes | MSCs represent pro-inflammatory immune reactions and anti-inflammatory reactions (21). |
| T57 | 1146-1483 | Sentence | denotes | MSCs regulate the immune system via the transforming growth factor b1 (TGFβ1), which can trigger the proliferation of Tregs, induce IL-6, which prevents the proliferation of neutrophils, and stimulate the prostaglandin E2 (PGE2), which inhibits the antigen presentation by dendritic cells and proliferations of T-effector cells (22, 23). |
| T58 | 1484-1654 | Sentence | denotes | MSCs mediate these kinds of effects by direct contact, where it releases the regulatory cytokines, such as IFN-γ, indoleamine 2,3-dioxygenase, TGFβ, IL-10, and PGE2 (24). |
| T59 | 1655-1889 | Sentence | denotes | Moreover, MSCs can hinder the proliferation and/or func-tions of the CD4+ Th1 and TH17 cells, CD8+ T cells, and the natural killer (NK) cells, mainly by secreting soluble factors, such as TGFβ1 and hepatocyte growth factor (HGF) (16). |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32731913-27769637-8028468 | 637-639 | 27769637 | denotes | 17 |
| 32731913-25529339-8028469 | 641-643 | 25529339 | denotes | 18 |
| 32731913-19172693-8028470 | 878-880 | 19172693 | denotes | 19 |
| 32731913-18371435-8028471 | 1054-1056 | 18371435 | denotes | 20 |
| 32731913-20436665-8028472 | 1141-1143 | 20436665 | denotes | 21 |
| 32731913-20382885-8028473 | 1475-1477 | 20382885 | denotes | 22 |
| 32731913-17932421-8028474 | 1479-1481 | 17932421 | denotes | 23 |
| 32731913-26294919-8028475 | 1650-1652 | 26294919 | denotes | 24 |