
PMC:7473478 / 1173-16782
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T13 | 314-322 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T14 | 407-415 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T15 | 471-480 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T16 | 550-558 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T17 | 783-793 | Body_part | denotes | Stem cells | http://purl.org/sig/ont/fma/fma63368 |
T18 | 788-793 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T19 | 810-815 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T20 | 854-858 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T21 | 908-913 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T22 | 915-936 | Body_part | denotes | Mesenchymal stem cell | http://purl.org/sig/ont/fma/fma0326143 |
T23 | 932-936 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T24 | 987-996 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T25 | 1065-1071 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T26 | 1283-1289 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T27 | 1391-1404 | Body_part | denotes | IMMUNE SYSTEM | http://purl.org/sig/ont/fma/fma9825 |
T28 | 1573-1579 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
T29 | 1590-1594 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T30 | 1631-1639 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
T31 | 1674-1684 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
T32 | 1698-1705 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T33 | 1726-1729 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T34 | 1915-1920 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T35 | 1925-1933 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T36 | 1928-1933 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T37 | 1996-2001 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T38 | 2017-2030 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
T39 | 2055-2069 | Body_part | denotes | helper T cells | http://purl.org/sig/ont/fma/fma70572 |
T40 | 2064-2069 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T41 | 2095-2100 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T42 | 2106-2124 | Body_part | denotes | regulatory T cells | http://purl.org/sig/ont/fma/fma84070 |
T43 | 2119-2124 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T44 | 2238-2256 | Body_part | denotes | regulatory T cells | http://purl.org/sig/ont/fma/fma84070 |
T45 | 2251-2256 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T46 | 2389-2394 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T47 | 2418-2423 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T48 | 2496-2501 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T49 | 2593-2601 | Body_part | denotes | CYTOKINE | http://purl.org/sig/ont/fma/fma84050 |
T50 | 2700-2704 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T51 | 2752-2766 | Body_part | denotes | immune systems | http://purl.org/sig/ont/fma/fma9825 |
T52 | 2812-2822 | Body_part | denotes | leukocytes | http://purl.org/sig/ont/fma/fma62852 |
T53 | 2827-2838 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
T54 | 2914-2919 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T55 | 2938-2946 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T56 | 3011-3015 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T57 | 3032-3037 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T58 | 3046-3057 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T59 | 3370-3374 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T60 | 3441-3445 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T61 | 3481-3485 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T62 | 3560-3567 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T63 | 3623-3630 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T64 | 3910-3918 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T65 | 3930-3939 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
T66 | 4105-4117 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
T67 | 4105-4109 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T68 | 4178-4197 | Body_part | denotes | extracellular space | http://purl.org/sig/ont/fma/fma70022 |
T69 | 4327-4331 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T70 | 4449-4457 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T71 | 4492-4497 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T72 | 4513-4517 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T73 | 4567-4573 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T74 | 4677-4688 | Body_part | denotes | bone marrow | http://purl.org/sig/ont/fma/fma9608 |
T75 | 4690-4704 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
T76 | 4706-4717 | Body_part | denotes | dental pulp | http://purl.org/sig/ont/fma/fma55631 |
T77 | 4719-4733 | Body_part | denotes | umbilical cord | http://purl.org/sig/ont/fma/fma85541 |
T78 | 4735-4750 | Body_part | denotes | Wharton’s jelly | http://purl.org/sig/ont/fma/fma323134 |
T79 | 4752-4760 | Body_part | denotes | placenta | http://purl.org/sig/ont/fma/fma63934 |
T80 | 4762-4776 | Body_part | denotes | synovial fluid | http://purl.org/sig/ont/fma/fma12277 |
T81 | 4778-4789 | Body_part | denotes | endometrium | http://purl.org/sig/ont/fma/fma17742 |
T82 | 4806-4811 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T83 | 4819-4824 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T84 | 4843-4855 | Body_part | denotes | cell-surface | http://purl.org/sig/ont/fma/fma67653 |
T85 | 4843-4847 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T86 | 5336-5341 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T87 | 5378-5391 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
T88 | 5453-5458 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T89 | 5596-5601 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T90 | 5800-5813 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
T91 | 5956-5967 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
T92 | 6055-6070 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
T93 | 6065-6070 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T94 | 6104-6109 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T95 | 6208-6217 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T96 | 6378-6383 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T97 | 6392-6397 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T98 | 6427-6432 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T99 | 6489-6499 | Body_part | denotes | hepatocyte | http://purl.org/sig/ont/fma/fma14515 |
T100 | 6527-6549 | Body_part | denotes | MESENCHYMAL STEM CELLS | http://purl.org/sig/ont/fma/fma0326143 |
T101 | 6544-6549 | Body_part | denotes | CELLS | http://purl.org/sig/ont/fma/fma68646 |
T102 | 6771-6779 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T103 | 6791-6800 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T104 | 6802-6812 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
T105 | 6912-6922 | Body_part | denotes | Stem cells | http://purl.org/sig/ont/fma/fma63368 |
T106 | 6917-6922 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T107 | 7065-7070 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T108 | 7236-7240 | Body_part | denotes | tRNA | http://purl.org/sig/ont/fma/fma67127 |
T109 | 7289-7297 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T110 | 7315-7320 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
T111 | 7423-7438 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
T112 | 7458-7463 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T113 | 7510-7514 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T114 | 7707-7712 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T115 | 7860-7867 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T116 | 8104-8109 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T117 | 8213-8217 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
T118 | 8256-8261 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T119 | 8266-8274 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T120 | 8269-8274 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T121 | 8298-8303 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T122 | 8361-8366 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T123 | 8491-8496 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T124 | 8650-8658 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T125 | 8653-8658 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T126 | 8686-8697 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T127 | 9053-9057 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T128 | 9201-9211 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
T129 | 9219-9224 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T130 | 9361-9364 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
T131 | 9580-9584 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T132 | 9758-9763 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
T133 | 10247-10252 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T134 | 10253-10258 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T135 | 10553-10562 | Body_part | denotes | STEM CELL | http://purl.org/sig/ont/fma/fma63368 |
T136 | 10558-10562 | Body_part | denotes | CELL | http://purl.org/sig/ont/fma/fma68646 |
T137 | 10598-10607 | Body_part | denotes | stem-cell | http://purl.org/sig/ont/fma/fma63368 |
T138 | 10603-10607 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T139 | 11139-11150 | Body_part | denotes | lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
T140 | 11175-11180 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T141 | 11198-11206 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T142 | 11397-11407 | Body_part | denotes | stem cells | http://purl.org/sig/ont/fma/fma63368 |
T143 | 11402-11407 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T144 | 11449-11464 | Body_part | denotes | Wharton’s jelly | http://purl.org/sig/ont/fma/fma323134 |
T145 | 11538-11547 | Body_part | denotes | stem-cell | http://purl.org/sig/ont/fma/fma63368 |
T146 | 11543-11547 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T147 | 11639-11653 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
T148 | 11873-11884 | Body_part | denotes | dental pulp | http://purl.org/sig/ont/fma/fma55631 |
T149 | 11904-11910 | Body_part | denotes | mucosa | http://purl.org/sig/ont/fma/fma85355 |
T150 | 12143-12151 | Body_part | denotes | hormones | http://purl.org/sig/ont/fma/fma12278 |
T151 | 12301-12311 | Body_part | denotes | Stem cells | http://purl.org/sig/ont/fma/fma63368 |
T152 | 12306-12311 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T153 | 12480-12485 | Body_part | denotes | urine | http://purl.org/sig/ont/fma/fma12274 |
T154 | 12494-12504 | Body_part | denotes | stem cells | http://purl.org/sig/ont/fma/fma63368 |
T155 | 12499-12504 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T156 | 12551-12556 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T157 | 13014-13027 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
T158 | 13014-13018 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T159 | 13110-13118 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T160 | 13254-13262 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T161 | 13478-13483 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T162 | 13544-13551 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T163 | 13572-13576 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T164 | 13629-13635 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T165 | 13699-13704 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
T166 | 13991-13995 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T167 | 14282-14291 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T2 | 1065-1071 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T3 | 1283-1289 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T4 | 2017-2030 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
T5 | 2752-2766 | Body_part | denotes | immune systems | http://purl.obolibrary.org/obo/UBERON_0002405 |
T6 | 4567-4573 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T7 | 4592-4598 | Body_part | denotes | organs | http://purl.obolibrary.org/obo/UBERON_0000062 |
T8 | 4677-4688 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
T9 | 4690-4704 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
T10 | 4698-4704 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T11 | 4706-4717 | Body_part | denotes | dental pulp | http://purl.obolibrary.org/obo/UBERON_0001754 |
T12 | 4719-4733 | Body_part | denotes | umbilical cord | http://purl.obolibrary.org/obo/UBERON_0002331 |
T13 | 4752-4760 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
T14 | 4762-4776 | Body_part | denotes | synovial fluid | http://purl.obolibrary.org/obo/UBERON_0001090 |
T15 | 4778-4789 | Body_part | denotes | endometrium | http://purl.obolibrary.org/obo/UBERON_0001295 |
T16 | 4806-4811 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T17 | 5378-5391 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
T18 | 5800-5813 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
T19 | 7662-7666 | Body_part | denotes | mole | http://purl.obolibrary.org/obo/UBERON_1000010 |
T20 | 8104-8109 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T21 | 8510-8514 | Body_part | denotes | mole | http://purl.obolibrary.org/obo/UBERON_1000010 |
T22 | 9219-9224 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T23 | 9580-9584 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T24 | 9758-9763 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
T25 | 10247-10266 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
T26 | 10247-10252 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T27 | 10253-10258 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T28 | 11639-11653 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
T29 | 11647-11653 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T30 | 11873-11884 | Body_part | denotes | dental pulp | http://purl.obolibrary.org/obo/UBERON_0001754 |
T31 | 11904-11910 | Body_part | denotes | mucosa | http://purl.obolibrary.org/obo/UBERON_0000344 |
T32 | 12480-12485 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
T33 | 13572-13576 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T34 | 13629-13635 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T35 | 13699-13704 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T7 | 85-132 | Disease | denotes | Severe Acute Respiratory Syndrome–Coronavirus-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T8 | 85-118 | Disease | denotes | Severe Acute Respiratory Syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
T9 | 134-142 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T10 | 332-340 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T11 | 355-390 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
T12 | 361-390 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
T13 | 392-396 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
T14 | 425-433 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T15 | 508-524 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
T16 | 593-608 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
T17 | 599-608 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T18 | 658-664 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T19 | 692-700 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T20 | 1374-1382 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T21 | 1517-1525 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T22 | 1557-1565 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T23 | 1956-1964 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T24 | 2157-2165 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T25 | 2305-2317 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T26 | 2576-2584 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T27 | 2608-2616 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T28 | 2717-2726 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T29 | 2879-2887 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T30 | 3073-3079 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T31 | 3521-3524 | Disease | denotes | NOD | http://purl.obolibrary.org/obo/MONDO_0007435 |
T32 | 3672-3675 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
T33 | 4038-4046 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T34 | 4574-4580 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T35 | 7662-7666 | Disease | denotes | mole | http://purl.obolibrary.org/obo/MONDO_0005073 |
T36 | 8405-8417 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T37 | 8510-8514 | Disease | denotes | mole | http://purl.obolibrary.org/obo/MONDO_0005073 |
T38 | 8543-8555 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T39 | 8832-8840 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T40 | 9465-9473 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T41 | 9477-9485 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T42 | 9585-9591 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T43 | 9616-9620 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
T44 | 9787-9795 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T45 | 9908-9917 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
T46 | 10377-10382 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T47 | 10503-10511 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T48 | 10514-10523 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T49 | 10580-10588 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T50 | 10642-10650 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T51 | 10788-10796 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T52 | 10858-10862 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
T53 | 11325-11333 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T54 | 11429-11437 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T55 | 11604-11612 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T56 | 11662-11664 | Disease | denotes | AD | http://purl.obolibrary.org/obo/MONDO_0004975 |
T57 | 11737-11745 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T58 | 12264-12272 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T59 | 12697-12705 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T60 | 12862-12870 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T61 | 13151-13159 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T62 | 13328-13336 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T63 | 13679-13687 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T64 | 14402-14410 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T65 | 14596-14604 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T66 | 14689-14697 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T67 | 15009-15017 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T68 | 15045-15053 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T69 | 15125-15134 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T70 | 15504-15512 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T71 | 15600-15608 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11 | 23-26 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T12 | 32-38 | http://purl.obolibrary.org/obo/UBERON_0001456 | denotes | facing |
T13 | 39-40 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T14 | 458-459 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T15 | 548-549 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T16 | 744-745 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T17 | 783-793 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | Stem cells |
T18 | 810-815 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T19 | 854-858 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T20 | 908-913 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T21 | 915-936 | http://purl.obolibrary.org/obo/CL_0000134 | denotes | Mesenchymal stem cell |
T22 | 1093-1096 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T23 | 1152-1155 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T24 | 1391-1404 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | IMMUNE SYSTEM |
T25 | 1573-1579 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
T26 | 1611-1615 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
T27 | 1631-1639 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
T28 | 1657-1664 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
T29 | 1724-1729 | http://purl.obolibrary.org/obo/PR_000005932 | denotes | G-CSF |
T30 | 1913-1920 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T31 | 1925-1933 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T32 | 1996-2001 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T33 | 2017-2030 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
T34 | 2055-2069 | http://purl.obolibrary.org/obo/CL_0000912 | denotes | helper T cells |
T35 | 2093-2100 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T36 | 2106-2124 | http://purl.obolibrary.org/obo/CL_0000815 | denotes | regulatory T cells |
T37 | 2238-2256 | http://purl.obolibrary.org/obo/CL_0000815 | denotes | regulatory T cells |
T38 | 2319-2321 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T39 | 2340-2341 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T40 | 2381-2394 | http://purl.obolibrary.org/obo/CL_0000898 | denotes | naïve T cells |
T41 | 2416-2423 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T42 | 2496-2501 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T43 | 2509-2510 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T44 | 2700-2704 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T45 | 2752-2766 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune systems |
T46 | 2799-2804 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T47 | 2914-2919 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T48 | 2982-2987 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T49 | 3011-3015 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T50 | 3032-3037 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T51 | 3108-3118 | http://purl.obolibrary.org/obo/CL_0000234 | denotes | phagocytes |
T52 | 3254-3255 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T53 | 3261-3262 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T54 | 3264-3274 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
T55 | 3310-3311 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T56 | 3411-3418 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signals |
T57 | 3511-3520 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
T58 | 3642-3643 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T59 | 3828-3837 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
T60 | 3930-3939 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
T61 | 3982-3990 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
T62 | 4105-4109 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T63 | 4327-4331 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T64 | 4353-4354 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T65 | 4356-4366 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
T66 | 4405-4415 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T67 | 4447-4448 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T68 | 4492-4497 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T69 | 4513-4517 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T70 | 4592-4598 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organs |
T71 | 4677-4681 | http://purl.obolibrary.org/obo/UBERON_0002481 | denotes | bone |
T72 | 4690-4704 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
T73 | 4719-4733 | http://purl.obolibrary.org/obo/UBERON_0002331 | denotes | umbilical cord |
T74 | 4719-4733 | http://www.ebi.ac.uk/efo/EFO_0001415 | denotes | umbilical cord |
T75 | 4752-4760 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
T76 | 4752-4760 | http://www.ebi.ac.uk/efo/EFO_0001407 | denotes | placenta |
T77 | 4778-4789 | http://purl.obolibrary.org/obo/UBERON_0001295 | denotes | endometrium |
T78 | 4806-4811 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T79 | 4806-4811 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T80 | 4819-4824 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T81 | 4843-4847 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T82 | 4884-4885 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T83 | 5277-5279 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
T84 | 5336-5341 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T85 | 5378-5391 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
T86 | 5453-5458 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T87 | 5473-5481 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
T88 | 5596-5601 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T89 | 5800-5813 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
T90 | 5900-5905 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Tregs |
T91 | 6001-6003 | http://purl.obolibrary.org/obo/CLO_0002860 | denotes | E2 |
T92 | 6055-6070 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
T93 | 6104-6109 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T94 | 6111-6113 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
T95 | 6360-6363 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
T96 | 6378-6383 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T97 | 6385-6388 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
T98 | 6390-6397 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T99 | 6422-6432 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | (NK) cells |
T100 | 6515-6518 | http://purl.obolibrary.org/obo/CLO_0003740 | denotes | HGF |
T101 | 6527-6549 | http://purl.obolibrary.org/obo/CL_0000134 | denotes | MESENCHYMAL STEM CELLS |
T102 | 6578-6581 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T103 | 6656-6657 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T104 | 6912-6922 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | Stem cells |
T105 | 7065-7070 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T106 | 7109-7119 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
T107 | 7121-7123 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
T108 | 7423-7429 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
T109 | 7430-7438 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T110 | 7458-7463 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T111 | 7510-7514 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T112 | 7707-7712 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T113 | 7946-7947 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T114 | 8240-8243 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
T115 | 8249-8252 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
T116 | 8254-8261 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T117 | 8266-8274 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T118 | 8296-8303 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T119 | 8361-8366 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T120 | 8475-8478 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
T121 | 8484-8487 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
T122 | 8489-8496 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T123 | 8650-8658 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T124 | 8707-8709 | http://purl.obolibrary.org/obo/CLO_0007448 | denotes | M1 |
T125 | 8707-8709 | http://purl.obolibrary.org/obo/CLO_0050175 | denotes | M1 |
T126 | 8937-8939 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
T127 | 9060-9062 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
T128 | 9146-9148 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
T129 | 9368-9373 | http://purl.obolibrary.org/obo/CLO_0008407 | denotes | PD-L1 |
T130 | 9505-9508 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T131 | 9580-9584 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T132 | 9580-9584 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T133 | 9626-9628 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
T134 | 9758-9763 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
T135 | 9848-9856 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T136 | 9902-9907 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T137 | 9918-9925 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T138 | 10048-10050 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
T139 | 10247-10252 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T140 | 10247-10252 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T141 | 10253-10258 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T142 | 10253-10258 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T143 | 10452-10453 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T144 | 10553-10562 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | STEM CELL |
T145 | 10598-10607 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem-cell |
T146 | 10754-10756 | http://purl.obolibrary.org/obo/CLO_0001997 | denotes | BM |
T147 | 10775-10781 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T148 | 11011-11012 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T149 | 11062-11063 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T150 | 11156-11157 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T151 | 11175-11180 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T152 | 11397-11407 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
T153 | 11538-11547 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem-cell |
T154 | 11624-11626 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
T155 | 11639-11653 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
T156 | 11688-11689 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T157 | 11770-11771 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T158 | 11904-11910 | http://purl.obolibrary.org/obo/UBERON_0000344 | denotes | mucosa |
T159 | 11912-11914 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
T160 | 12277-12279 | http://purl.obolibrary.org/obo/CLO_0001527 | denotes | 94 |
T161 | 12301-12311 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | Stem cells |
T162 | 12494-12504 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
T163 | 12551-12556 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T164 | 12638-12644 | http://purl.obolibrary.org/obo/CLO_0037308 | denotes | hiPSCs |
T165 | 12651-12652 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T166 | 12710-12713 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T167 | 13014-13018 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T168 | 13019-13027 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T169 | 13478-13483 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T170 | 13572-13576 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T171 | 13572-13576 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T172 | 13699-13704 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
T173 | 13991-13995 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T174 | 14113-14114 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T175 | 14206-14207 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T176 | 14331-14334 | http://purl.obolibrary.org/obo/CLO_0054060 | denotes | 102 |
T177 | 14500-14502 | http://purl.obolibrary.org/obo/CLO_0053755 | denotes | es |
T178 | 15054-15057 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T179 | 15145-15148 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1 | 188-197 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T2 | 1253-1262 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T3 | 1590-1592 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T5 | 1597-1599 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T7 | 1605-1607 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T9 | 1611-1613 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T11 | 1617-1619 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T13 | 1657-1664 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
T14 | 1666-1669 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
T16 | 1698-1705 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T17 | 2632-2643 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
T18 | 3257-3259 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T21 | 3306-3308 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T24 | 3323-3330 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
T25 | 3370-3372 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T27 | 3441-3443 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T29 | 3481-3483 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T31 | 3560-3567 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T32 | 3623-3630 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T33 | 3772-3775 | Chemical | denotes | ATP | http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616 |
T35 | 3875-3882 | Chemical | denotes | calcium | http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320 |
T37 | 3910-3918 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T38 | 4148-4162 | Chemical | denotes | Angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719 |
T39 | 4160-4162 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T40 | 4164-4169 | Chemical | denotes | AngII | http://purl.obolibrary.org/obo/CHEBI_2719 |
T41 | 4230-4235 | Chemical | denotes | AngII | http://purl.obolibrary.org/obo/CHEBI_2719 |
T42 | 4275-4280 | Chemical | denotes | AngII | http://purl.obolibrary.org/obo/CHEBI_2719 |
T43 | 4315-4317 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T45 | 4349-4351 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T48 | 5914-5916 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T50 | 5987-6003 | Chemical | denotes | prostaglandin E2 | http://purl.obolibrary.org/obo/CHEBI_15551|http://purl.obolibrary.org/obo/CHEBI_606564 |
T52 | 5987-6000 | Chemical | denotes | prostaglandin | http://purl.obolibrary.org/obo/CHEBI_26333 |
T53 | 6005-6009 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
T54 | 6031-6038 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T55 | 6095-6103 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
T56 | 6269-6271 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T58 | 6280-6284 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
T59 | 6771-6779 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T60 | 7086-7095 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T61 | 7177-7186 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T62 | 7289-7297 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T63 | 7303-7309 | Chemical | denotes | lipids | http://purl.obolibrary.org/obo/CHEBI_18059 |
T64 | 7315-7320 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
T65 | 7474-7483 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T66 | 7927-7940 | Chemical | denotes | nanoparticles | http://purl.obolibrary.org/obo/CHEBI_50803 |
T67 | 8315-8317 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T69 | 8333-8335 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T71 | 8707-8709 | Chemical | denotes | M1 | http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826 |
T75 | 8717-8719 | Chemical | denotes | M2 | http://purl.obolibrary.org/obo/CHEBI_34827|http://purl.obolibrary.org/obo/CHEBI_51112 |
T77 | 9036-9038 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T79 | 9042-9044 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T81 | 9053-9055 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T83 | 9123-9125 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T85 | 9129-9131 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T87 | 9368-9370 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756 |
T88 | 10101-10110 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T89 | 11662-11664 | Chemical | denotes | AD | http://purl.obolibrary.org/obo/CHEBI_73803 |
T90 | 12087-12095 | Chemical | denotes | adjuvant | http://purl.obolibrary.org/obo/CHEBI_60809 |
T91 | 12119-12124 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T92 | 12130-12141 | Chemical | denotes | oseltamivir | http://purl.obolibrary.org/obo/CHEBI_7798 |
T93 | 12143-12151 | Chemical | denotes | hormones | http://purl.obolibrary.org/obo/CHEBI_24621 |
T94 | 12153-12171 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T95 | 12177-12189 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
T96 | 12586-12591 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
T97 | 12665-12673 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
T98 | 12921-12926 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T99 | 13033-13044 | Chemical | denotes | favipiravir | http://purl.obolibrary.org/obo/CHEBI_134722 |
T100 | 13049-13059 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
T101 | 13082-13087 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T102 | 13198-13203 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T103 | 13384-13408 | Chemical | denotes | anti-inflammatory agents | http://purl.obolibrary.org/obo/CHEBI_67079 |
T104 | 14115-14119 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T105 | 15433-15442 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
29 | 85-132 | Species | denotes | Severe Acute Respiratory Syndrome–Coronavirus-2 | Tax:2697049 |
30 | 134-144 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
31 | 730-738 | Species | denotes | patients | Tax:9606 |
32 | 332-340 | Disease | denotes | COVID-19 | MESH:C000657245 |
33 | 355-390 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
34 | 392-396 | Disease | denotes | ARDS | MESH:D012128 |
35 | 425-433 | Disease | denotes | COVID-19 | MESH:C000657245 |
36 | 508-524 | Disease | denotes | viral infections | MESH:D001102 |
37 | 573-580 | Disease | denotes | hypoxia | MESH:D000860 |
38 | 593-608 | Disease | denotes | viral infection | MESH:D001102 |
39 | 692-700 | Disease | denotes | COVID-19 | MESH:C000657245 |
41 | 1374-1382 | Disease | denotes | COVID-19 | MESH:C000657245 |
68 | 1590-1595 | Gene | denotes | IL-1β | Gene:3552 |
69 | 1597-1603 | Gene | denotes | IL-1RA | Gene:3557 |
70 | 1605-1609 | Gene | denotes | IL-7 | Gene:3574 |
71 | 1611-1615 | Gene | denotes | IL-8 | Gene:3576 |
72 | 1617-1622 | Gene | denotes | IL-10 | Gene:3586 |
73 | 1624-1629 | Gene | denotes | IFN-γ | Gene:3458 |
74 | 1631-1672 | Gene | denotes | monocyte chemoattrac-tant peptide (MCP)-1 | Gene:6347 |
75 | 1674-1714 | Gene | denotes | macrophage inflammatory protein (MIP)-1A | Gene:6348 |
76 | 1716-1722 | Gene | denotes | MIP-1B | Gene:6351 |
77 | 1724-1729 | Gene | denotes | G-CSF | Gene:1440 |
78 | 1735-1740 | Gene | denotes | TNF-α | Gene:7124 |
79 | 2511-2515 | Gene | denotes | plau | Gene:5328 |
80 | 1534-1542 | Species | denotes | patients | Tax:9606 |
81 | 1557-1567 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
82 | 1834-1842 | Species | denotes | patients | Tax:9606 |
83 | 1965-1973 | Species | denotes | patients | Tax:9606 |
84 | 2143-2151 | Species | denotes | patients | Tax:9606 |
85 | 2448-2456 | Species | denotes | patients | Tax:9606 |
86 | 2576-2586 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
87 | 1517-1525 | Disease | denotes | COVID-19 | MESH:C000657245 |
88 | 1543-1551 | Disease | denotes | infected | MESH:D007239 |
89 | 1956-1964 | Disease | denotes | COVID-19 | MESH:C000657245 |
90 | 2157-2165 | Disease | denotes | COVID-19 | MESH:C000657245 |
91 | 2305-2317 | Disease | denotes | inflammation | MESH:D007249 |
92 | 2409-2417 | Disease | denotes | memory T | MESH:D008569 |
93 | 2439-2447 | Disease | denotes | infected | MESH:D007239 |
131 | 2632-2663 | Gene | denotes | Angiotensin-converting enzyme 2 | Gene:59272 |
132 | 2665-2669 | Gene | denotes | ACE2 | Gene:59272 |
133 | 3233-3255 | Gene | denotes | nuclear factor kappa B | Gene:4790 |
134 | 3257-3262 | Gene | denotes | NF-κb | Gene:4790 |
135 | 3291-3296 | Gene | denotes | MyD88 | Gene:4615 |
136 | 3306-3311 | Gene | denotes | NF-κb | Gene:4790 |
137 | 3366-3375 | Gene | denotes | pro-IL-1β | Gene:3553 |
138 | 3384-3393 | Gene | denotes | caspase-1 | Gene:834 |
139 | 3437-3446 | Gene | denotes | pro-IL-1β | Gene:3553 |
140 | 3481-3486 | Gene | denotes | IL-1β | Gene:3552 |
141 | 3491-3500 | Gene | denotes | caspase 1 | Gene:834 |
142 | 3521-3569 | Gene | denotes | NOD-, LRR- and pyrin domain-containing protein 3 | Gene:114548 |
143 | 3571-3576 | Gene | denotes | NLRP3 | Gene:114548 |
144 | 3708-3713 | Gene | denotes | NLRP3 | Gene:114548 |
145 | 3796-3815 | Gene | denotes | P2X purino-ceptor 7 | Gene:5027 |
146 | 3817-3822 | Gene | denotes | P2RX7 | Gene:5027 |
147 | 4056-4060 | Gene | denotes | ACE2 | Gene:59272 |
148 | 4083-4087 | Gene | denotes | ACE2 | Gene:59272 |
149 | 4148-4162 | Gene | denotes | Angiotensin II | Gene:183 |
150 | 4164-4169 | Gene | denotes | AngII | Gene:183 |
151 | 4207-4211 | Gene | denotes | ACE2 | Gene:59272 |
152 | 4230-4235 | Gene | denotes | AngII | Gene:183 |
153 | 4241-4248 | Gene | denotes | Ang 1-9 | Gene:284 |
154 | 4253-4259 | Gene | denotes | Ang1-7 | Gene:284 |
155 | 4275-4280 | Gene | denotes | AngII | Gene:183 |
156 | 4305-4310 | Gene | denotes | TNF-α | Gene:7124 |
157 | 4315-4319 | Gene | denotes | IL-6 | Gene:3569 |
158 | 4349-4354 | Gene | denotes | NF-κb | Gene:4790 |
159 | 2608-2618 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
160 | 4038-4048 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
161 | 3772-3775 | Chemical | denotes | ATP | MESH:D000255 |
162 | 3875-3882 | Chemical | denotes | calcium | MESH:D002118 |
163 | 2717-2726 | Disease | denotes | infection | MESH:D007239 |
164 | 2879-2887 | Disease | denotes | COVID-19 | MESH:C000657245 |
165 | 3930-3946 | Disease | denotes | lysosomal damage | MESH:D020140 |
166 | 4499-4507 | Disease | denotes | necrosis | MESH:D009336 |
167 | 4567-4580 | Disease | denotes | tissue injury | MESH:D017695 |
183 | 5822-5851 | Gene | denotes | transforming growth factor b1 | Gene:7040 |
184 | 5853-5858 | Gene | denotes | TGFβ1 | Gene:7040 |
185 | 5914-5918 | Gene | denotes | IL-6 | Gene:3569 |
186 | 6227-6232 | Gene | denotes | IFN-γ | Gene:3458 |
187 | 6263-6267 | Gene | denotes | TGFβ | Gene:7039 |
188 | 6269-6274 | Gene | denotes | IL-10 | Gene:3586 |
189 | 6360-6363 | Gene | denotes | CD4 | Gene:920 |
190 | 6479-6484 | Gene | denotes | TGFβ1 | Gene:7040 |
191 | 6489-6513 | Gene | denotes | hepatocyte growth factor | Gene:3082 |
192 | 6515-6518 | Gene | denotes | HGF | Gene:3082 |
193 | 6385-6388 | Gene | denotes | CD8 | Gene:925 |
194 | 5900-5905 | Chemical | denotes | Tregs | |
195 | 5987-6003 | Chemical | denotes | prostaglandin E2 | MESH:D015232 |
196 | 6005-6009 | Chemical | denotes | PGE2 | MESH:D015232 |
197 | 6280-6284 | Chemical | denotes | PGE2 | MESH:D015232 |
201 | 7039-7047 | Species | denotes | patients | Tax:9606 |
202 | 7315-7320 | Chemical | denotes | lipid | MESH:D008055 |
203 | 7819-7827 | Disease | denotes | fibrosis | MESH:D005355 |
230 | 8315-8320 | Gene | denotes | IL-17 | Gene:3605 |
231 | 8333-8338 | Gene | denotes | IL-10 | Gene:3586 |
232 | 8526-8530 | Gene | denotes | TGFβ | Gene:7039 |
233 | 9022-9027 | Gene | denotes | TNF-α | Gene:7124 |
234 | 9029-9034 | Gene | denotes | IFN-γ | Gene:3458 |
235 | 9036-9040 | Gene | denotes | IL-6 | Gene:3569 |
236 | 9042-9047 | Gene | denotes | IL-17 | Gene:3605 |
237 | 9053-9058 | Gene | denotes | IL-1β | Gene:3552 |
238 | 9123-9127 | Gene | denotes | IL-4 | Gene:3565 |
239 | 9129-9134 | Gene | denotes | IL-10 | Gene:3586 |
240 | 9139-9144 | Gene | denotes | TGF-β | Gene:7039 |
241 | 9356-9359 | Gene | denotes | IDO | Gene:3620 |
242 | 9368-9373 | Gene | denotes | PD-L1 | Gene:29126 |
243 | 9378-9388 | Gene | denotes | galectin-1 | Gene:3956 |
244 | 8484-8487 | Gene | denotes | CD8 | Gene:925 |
245 | 8475-8478 | Gene | denotes | CD4 | Gene:920 |
246 | 8249-8252 | Gene | denotes | CD8 | Gene:925 |
247 | 8240-8243 | Gene | denotes | CD4 | Gene:920 |
248 | 8841-8849 | Species | denotes | patients | Tax:9606 |
249 | 8919-8923 | Species | denotes | mice | Tax:10090 |
250 | 8124-8131 | Disease | denotes | hypoxia | MESH:D000860 |
251 | 8405-8417 | Disease | denotes | inflammation | MESH:D007249 |
252 | 8543-8555 | Disease | denotes | inflammation | MESH:D007249 |
253 | 8792-8798 | Disease | denotes | sepsis | MESH:D018805 |
254 | 8832-8840 | Disease | denotes | COVID-19 | MESH:C000657245 |
255 | 8929-8935 | Disease | denotes | sepsis | MESH:D018805 |
257 | 9465-9473 | Disease | denotes | COVID-19 | MESH:C000657245 |
269 | 9891-9896 | Species | denotes | swine | Tax:9823 |
270 | 9902-9907 | Species | denotes | human | Tax:9606 |
271 | 9908-9925 | Species | denotes | influenza viruses | Tax:11308 |
272 | 9982-9990 | Species | denotes | patients | Tax:9606 |
273 | 9477-9485 | Disease | denotes | COVID-19 | MESH:C000657245 |
274 | 9527-9535 | Disease | denotes | infected | MESH:D007239 |
275 | 9580-9591 | Disease | denotes | lung injury | MESH:D055370 |
276 | 9616-9620 | Disease | denotes | ARDS | MESH:D012128 |
277 | 9787-9795 | Disease | denotes | COVID-19 | MESH:C000657245 |
278 | 10377-10382 | Disease | denotes | tumor | MESH:D009369 |
279 | 10503-10523 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
281 | 10580-10588 | Disease | denotes | COVID-19 | MESH:C000657245 |
301 | 11254-11258 | Gene | denotes | ACE2 | Gene:59272 |
302 | 11262-11269 | Gene | denotes | TMPRSS2 | Gene:7113 |
303 | 10788-10798 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
304 | 10799-10807 | Species | denotes | patients | Tax:9606 |
305 | 10820-10828 | Species | denotes | patients | Tax:9606 |
306 | 10907-10915 | Species | denotes | patients | Tax:9606 |
307 | 10949-10957 | Species | denotes | patients | Tax:9606 |
308 | 11028-11036 | Species | denotes | patients | Tax:9606 |
309 | 12130-12141 | Chemical | denotes | oseltamivir | MESH:D053139 |
310 | 12153-12171 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
311 | 12177-12189 | Chemical | denotes | azithromycin | MESH:D017963 |
312 | 10642-10650 | Disease | denotes | COVID-19 | MESH:C000657245 |
313 | 10858-10862 | Disease | denotes | ARDS | MESH:D012128 |
314 | 11311-11319 | Disease | denotes | infected | MESH:D007239 |
315 | 11325-11333 | Disease | denotes | COVID-19 | MESH:C000657245 |
316 | 11429-11437 | Disease | denotes | COVID-19 | MESH:C000657245 |
317 | 11604-11612 | Disease | denotes | COVID-19 | MESH:C000657245 |
318 | 11737-11745 | Disease | denotes | COVID-19 | MESH:C000657245 |
319 | 12264-12272 | Disease | denotes | COVID-19 | MESH:C000657245 |
335 | 13160-13168 | Species | denotes | patients | Tax:9606 |
336 | 12935-12953 | Chemical | denotes | camo-stat mesylate | MESH:C034532 |
337 | 13033-13044 | Chemical | denotes | favipiravir | MESH:C462182 |
338 | 13049-13059 | Chemical | denotes | remdesivir | MESH:C000606551 |
339 | 12697-12705 | Disease | denotes | COVID-19 | MESH:C000657245 |
340 | 12862-12870 | Disease | denotes | COVID-19 | MESH:C000657245 |
341 | 13151-13159 | Disease | denotes | COVID-19 | MESH:C000657245 |
342 | 13328-13336 | Disease | denotes | COVID-19 | MESH:C000657245 |
343 | 13532-13540 | Disease | denotes | fibrosis | MESH:D005355 |
344 | 13572-13588 | Disease | denotes | lung dysfunction | MESH:D008171 |
345 | 13679-13687 | Disease | denotes | COVID-19 | MESH:C000657245 |
346 | 14402-14410 | Disease | denotes | COVID-19 | MESH:C000657245 |
347 | 14596-14604 | Disease | denotes | COVID-19 | MESH:C000657245 |
348 | 14689-14697 | Disease | denotes | COVID-19 | MESH:C000657245 |
349 | 15009-15017 | Disease | denotes | COVID-19 | MESH:C000657245 |
354 | 15045-15053 | Disease | denotes | COVID-19 | MESH:C000657245 |
355 | 15125-15134 | Disease | denotes | infection | MESH:D007239 |
356 | 15504-15512 | Disease | denotes | COVID-19 | MESH:C000657245 |
357 | 15600-15608 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2 | 508-524 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
T3 | 593-608 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
T4 | 854-867 | http://purl.obolibrary.org/obo/GO_0051301 | denotes | cell division |
T5 | 1597-1603 | http://purl.obolibrary.org/obo/GO_0005152 | denotes | IL-1RA |
T6 | 2305-2317 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T7 | 2409-2415 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
T8 | 2489-2495 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
T9 | 2996-3006 | http://purl.obolibrary.org/obo/GO_0070269 | denotes | pyroptosis |
T10 | 3011-3021 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T11 | 3264-3274 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T12 | 3349-3362 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T13 | 3591-3600 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T14 | 3591-3600 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T15 | 3750-3762 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
T16 | 3800-3813 | http://purl.obolibrary.org/obo/GO_0004931 | denotes | purino-ceptor |
T17 | 3800-3813 | http://purl.obolibrary.org/obo/GO_0001614 | denotes | purino-ceptor |
T18 | 4499-4507 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
T19 | 4499-4507 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
T20 | 4499-4507 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
T21 | 4499-4507 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
T22 | 4513-4523 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T23 | 5835-5841 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T24 | 6031-6051 | http://purl.obolibrary.org/obo/GO_0019882 | denotes | antigen presentation |
T25 | 6055-6089 | http://purl.obolibrary.org/obo/GO_0044565 | denotes | dendritic cells and proliferations |
T26 | 6500-6506 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T27 | 6814-6820 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T28 | 7099-7119 | http://purl.obolibrary.org/obo/GO_0038001 | denotes | paracrine signalling |
T29 | 7109-7119 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T30 | 7236-7240 | http://purl.obolibrary.org/obo/GO_0030533 | denotes | tRNA |
T31 | 7273-7279 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T32 | 7496-7521 | http://purl.obolibrary.org/obo/GO_0001558 | denotes | regulation of cell growth |
T33 | 7496-7506 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T34 | 7510-7521 | http://purl.obolibrary.org/obo/GO_0016049 | denotes | cell growth |
T35 | 7515-7521 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T36 | 7552-7568 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T37 | 7794-7803 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T38 | 7794-7803 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T39 | 8405-8417 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T40 | 8543-8555 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T41 | 10383-10392 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
T42 | 12896-12913 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T43 | 12896-12913 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T44 | 13209-13234 | http://purl.obolibrary.org/obo/GO_1903901 | denotes | inhibit viral replication |
T45 | 13217-13234 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T46 | 13217-13234 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T47 | 13605-13617 | http://purl.obolibrary.org/obo/GO_0031099 | denotes | regeneration |
T48 | 14541-14548 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | storage |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 314-328 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T2 | 361-381 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
T3 | 407-421 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T4 | 550-564 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T5 | 573-580 | Phenotype | denotes | hypoxia | http://purl.obolibrary.org/obo/HP_0012418 |
T6 | 2593-2607 | Phenotype | denotes | CYTOKINE STORM | http://purl.obolibrary.org/obo/HP_0033041 |
T7 | 2938-2952 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T8 | 4449-4463 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T9 | 7662-7666 | Phenotype | denotes | mole | http://purl.obolibrary.org/obo/HP_0003764 |
T10 | 8124-8131 | Phenotype | denotes | hypoxia | http://purl.obolibrary.org/obo/HP_0012418 |
T11 | 8510-8514 | Phenotype | denotes | mole | http://purl.obolibrary.org/obo/HP_0003764 |
T12 | 8792-8798 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
T13 | 8929-8935 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
T14 | 10377-10382 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
T15 | 11198-11212 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T16 | 13110-13124 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T17 | 13254-13268 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T10 | 0-12 | Sentence | denotes | INTRODUCTION |
T11 | 13-150 | Sentence | denotes | The world has been facing a dreadful situation due to the spread of the Severe Acute Respiratory Syndrome–Coronavirus-2 (SARS-CoV-2) (1). |
T12 | 151-270 | Sentence | denotes | However, neither confirmed effective antiviral medications nor vaccines are available to deal with this emer-gency (2). |
T13 | 271-402 | Sentence | denotes | Many reports have suggested that it is the cytokine storm in COVID-19 that leads to acute respiratory distress syndrome (ARDS) (3). |
T14 | 403-529 | Sentence | denotes | The cytokine storm in COVID-19 refers to the fact that a variety of cytokines are rapidly produced after viral infections (4). |
T15 | 530-635 | Sentence | denotes | In addition, such a cytokine storm induces hypoxia, and direct viral infection can cause cellular damage. |
T16 | 636-782 | Sentence | denotes | Multiorgan damage and injury have been concomitant with COVID-19, and can be observed more in patients with a more severe form of the disease (5). |
T17 | 783-914 | Sentence | denotes | Stem cells are specialized cells that can renew themselves by means of cell division and can differentiate into multilineage cells. |
T18 | 915-1076 | Sentence | denotes | Mesenchymal stem cell (MSCs) have immunomodulatory features and secrete cytokines and immune receptors that regulate the microenvironment in the host tissue (6). |
T19 | 1077-1203 | Sentence | denotes | In addition, it has been observed that the crucial role of MSCs in therapy has been mediated by exosomes released by the MSCs. |
T20 | 1204-1372 | Sentence | denotes | These exo-somes have exhibited immunomodulatory, antiviral, anti-fibrotic, and tissue-repair-related functions in vivo; similar effects have been observed in vitro (6). |
T21 | 1374-1404 | Sentence | denotes | COVID-19 AND THE IMMUNE SYSTEM |
T22 | 1405-1530 | Sentence | denotes | The dynamic equilibrium maintained by innate and adaptive immunity is essential for impeding the progression of COVID-19 (7). |
T23 | 1531-1783 | Sentence | denotes | In patients infected with SARS-CoV-2, the plasma levels of IL-1β, IL-1RA, IL-7, IL-8, IL-10, IFN-γ, monocyte chemoattrac-tant peptide (MCP)-1, macrophage inflammatory protein (MIP)-1A, MIP-1B, G-CSF, and TNF-α are significantly higher than in controls. |
T24 | 1784-1873 | Sentence | denotes | The levels of these factors are also increased in patients who were admitted to ICUs (8). |
T25 | 1874-1978 | Sentence | denotes | Similarly, reductions in the levels of T cells and NK cells have been observed in COVID-19 patients (9). |
T26 | 1979-2036 | Sentence | denotes | The loss of such cells can impair the immune system (10). |
T27 | 2037-2217 | Sentence | denotes | The levels of the helper T cells, cytotoxic suppressive T cells, and regulatory T cells are much lower in patients with COVID-19 than in their healthy and less severe counterparts. |
T28 | 2218-2323 | Sentence | denotes | The decrease in the regulatory T cells may hamper their ability to inhibit the chronic inflammation (11). |
T29 | 2324-2462 | Sentence | denotes | Interes-tingly, a remarkable increase is observed in the naïve T cells, where as the memory T cells are reduced in infected patients (10). |
T30 | 2463-2587 | Sentence | denotes | The reduced expression of memory cells may be a plau-sible explanation for the increased rates of reinfection by SARS-CoV-2. |
T31 | 2589-2607 | Sentence | denotes | THE CYTOKINE STORM |
T32 | 2608-2709 | Sentence | denotes | SARS-CoV-2 binds to the Angiotensin-converting enzyme 2 (ACE2) receptor and enters the host cell (1). |
T33 | 2710-2805 | Sentence | denotes | During infection, the innate and adaptive immune systems work together to inactivate the virus. |
T34 | 2806-2958 | Sentence | denotes | Since leukocytes and neutrophils are present in higher concentrations in COVID-19 individuals, these immune cells may result in the cytokine storm (10). |
T35 | 2959-3022 | Sentence | denotes | After viral entry, the virus induces pyroptosis and cell death. |
T36 | 3023-3103 | Sentence | denotes | The dead cells recruit macrophages to the site of injury that phago-cytose them. |
T37 | 3104-3305 | Sentence | denotes | The phagocytes then express damage-associated molecular patterns (DAMPs), which bind to the toll-like receptors (TLR) and induce nuclear factor kappa B (NF-κb) signalling by means of the MyD88 pathway. |
T38 | 3306-3394 | Sentence | denotes | NF-κb enters the nucleus and catalyzes the transcription of pro-IL-1β and pro-caspase-1. |
T39 | 3395-3506 | Sentence | denotes | When additional signals are detected, the pro-IL-1β and procaspase 1 are cleaved into IL-1β and caspase 1 (12). |
T40 | 3507-3732 | Sentence | denotes | The activated NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) recruits the apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and pro-cas-pase-1 to form the NLRP3 inflammasome (13). |
T41 | 3733-3860 | Sentence | denotes | In addition, the phagocytosis releases ATP, which binds to the P2X purino-ceptor 7 (P2RX7) and activates the inflammasome (14). |
T42 | 3861-4013 | Sentence | denotes | The increased calcium levels caused by the viral proteins results in lysosomal damage, thereby releasing cathepsins that activate the inflammasome (15). |
T43 | 4014-4118 | Sentence | denotes | Further, the binding of SARS-CoV-2 to the ACE2 reduces the available ACE2 receptors on the cell surface. |
T44 | 4119-4274 | Sentence | denotes | This increases the levels of Angiotensin II (AngII) in the extracellular space, because ACE2 converts AngI and AngII into Ang 1-9 and Ang1-7, respectively. |
T45 | 4275-4389 | Sentence | denotes | AngII increases the levels of TNF-α and IL-6 in the cell that upregulates NF-κb, activating the inflammasome (12). |
T46 | 4390-4524 | Sentence | denotes | The continuous activation of the inflammasome results in a cytokine storm, which recruits more immune cells, necrosis, and cell death. |
T47 | 4525-4608 | Sentence | denotes | This inflamma-some pathway further causes tissue injury in various organs (Fig. 1). |
T48 | 4610-4635 | Sentence | denotes | MSCs AND IMMUNOMODULATION |
T49 | 4636-4812 | Sentence | denotes | MSCs are predominantly isolated from the bone marrow, adipose tissue, dental pulp, umbilical cord, Wharton’s jelly, placenta, synovial fluid, endometrium, and peripheral blood. |
T50 | 4813-4925 | Sentence | denotes | These cells exhibit different cell-surface markers and can be used for a variety of treatment options (Table 1). |
T51 | 4926-5105 | Sentence | denotes | MSCs can undergo in vitro amplification and self-renewal, and have low immunogenicity and immune-modulatory functions; the latter have attracted attention in clinical trials (16). |
T52 | 5106-5281 | Sentence | denotes | MSCs have been widely used in various cellular therapies, such as pre-clinical studies, as well as in some clinical trials, because of their high safety and efficacy (17, 18). |
T53 | 5282-5392 | Sentence | denotes | MSCs can exert immune-modu-latory effects in the host cells of both the innate and the adaptive immune system. |
T54 | 5393-5518 | Sentence | denotes | The direct or indirect interactions of MSCs with the immune cells make the MSCs activate the immunomodulatory responses (19). |
T55 | 5519-5694 | Sentence | denotes | The immunomodulatory functions of MSCs depend on the environment of the host cells; based on the inflammatory status, the MSCs decide the type of immunoregulatory effect (20). |
T56 | 5695-5781 | Sentence | denotes | MSCs represent pro-inflammatory immune reactions and anti-inflammatory reactions (21). |
T57 | 5782-6119 | Sentence | denotes | MSCs regulate the immune system via the transforming growth factor b1 (TGFβ1), which can trigger the proliferation of Tregs, induce IL-6, which prevents the proliferation of neutrophils, and stimulate the prostaglandin E2 (PGE2), which inhibits the antigen presentation by dendritic cells and proliferations of T-effector cells (22, 23). |
T58 | 6120-6290 | Sentence | denotes | MSCs mediate these kinds of effects by direct contact, where it releases the regulatory cytokines, such as IFN-γ, indoleamine 2,3-dioxygenase, TGFβ, IL-10, and PGE2 (24). |
T59 | 6291-6525 | Sentence | denotes | Moreover, MSCs can hinder the proliferation and/or func-tions of the CD4+ Th1 and TH17 cells, CD8+ T cells, and the natural killer (NK) cells, mainly by secreting soluble factors, such as TGFβ1 and hepatocyte growth factor (HGF) (16). |
T60 | 6527-6574 | Sentence | denotes | MESENCHYMAL STEM CELLS (MSCs) AND MSC SECRETOME |
T61 | 6575-6735 | Sentence | denotes | It has currently become apparent that MSCs induce therapeutic characteristics by a paracrine pathway by releasing bioactive substances known as secretomes (25). |
T62 | 6736-6911 | Sentence | denotes | MSC-secretomes are made of soluble proteins, including cytokines, chemokines, growth factors, and extracellular vesicles (EVs), which include micro-vesicles and exosomes (26). |
T63 | 6912-6979 | Sentence | denotes | Stem cells release these secretomes by common secretory mechanisms. |
T64 | 6980-7125 | Sentence | denotes | When the culture medium or secretome are injected into the patients, the neighboring cells assimilate the molecules by paracrine signalling (27). |
T65 | 7126-7310 | Sentence | denotes | The exosomes themselves contain numerous bioactive molecules, which include microRNAs (miRNA), transfer RNAs (tRNA), long noncoding RNAs (lncRNA), growth factors, proteins, and lipids. |
T66 | 7311-7469 | Sentence | denotes | The lipid content of the exosomes provide an added advantage by aiding in the infusion of the exosomes with the plasma membrane of the neighboring cells (28). |
T67 | 7470-7633 | Sentence | denotes | The molecules involved in regulation of cell growth, proliferation, survival, and immune responses are released by exosomes, are elaborately illustrated in Fig. 2. |
T68 | 7634-7873 | Sentence | denotes | Upon internalization of the mole-cules in the secretome, the neighboring cells modulate various downstream pathways, including immunomodulation, suppression of apoptosis, prevention of fibrosis, and remodelling of the injured tissues (25). |
T69 | 7875-7913 | Sentence | denotes | IMMUNOMODULATORY POTENTIAL OF MSC-EXOS |
T70 | 7914-7970 | Sentence | denotes | Exosomes are nanoparticles with a diameter of 40-150 nm. |
T71 | 7971-8137 | Sentence | denotes | To generate and isolate the exosomes, MSCs can be conditioned to increase the release of exosomes by treatment with cyto-kines or by serum starvation or hypoxia (29). |
T72 | 8138-8218 | Sentence | denotes | The exosomes are then purified and can be subsequently introduced into the body. |
T73 | 8219-8280 | Sentence | denotes | MSC-Exos can inhibit CD4+ and CD8+ T cells and NK cells (30). |
T74 | 8281-8418 | Sentence | denotes | They inhibited T cells expressing IL-17 and induced IL-10-expressing regulatory cells that are involved with suppression of inflammation. |
T75 | 8419-8569 | Sentence | denotes | MSC-Exos also aid in suppressing the differentiation of CD4+ and CD8+ T cells by releasing mole-cules like TGFβ and prevent inflammation in vivo (31). |
T76 | 8570-8664 | Sentence | denotes | Similarly, treatment with MSC-Exos reduced the proliferation and activa-tion of NK cells (32). |
T77 | 8665-8781 | Sentence | denotes | MSC-Exos could shift macrophages from the M1 to the M2 phenotype, further suppressing pro-inflam-matory states (33). |
T78 | 8782-8941 | Sentence | denotes | Moreover, sepsis is an important lethal factor in COVID-19 patients, and treatments with MSC-Exos have increased the rate of survival in mice with sepsis (34). |
T79 | 8942-9150 | Sentence | denotes | Concomitantly, MSC-Exos also suppressed release of the pro-inflammatory factors TNF-α, IFN-γ, IL-6, IL-17, and IL-1β (35) and promoted release of anti-inflammatory factors, such as IL-4, IL-10 and TGF-β (36). |
T80 | 9151-9244 | Sentence | denotes | Additionally, MSC-Exos also reduced the number of chemokines in the serum when injected (37). |
T81 | 9245-9398 | Sentence | denotes | These immunomodulatory effects of MSC-Exos have also been attributed to their anti-inflammatory cargo, such as IDO, HLA-G, PD-L1 and galectin-1 (38, 39). |
T82 | 9399-9442 | Sentence | denotes | These mechanisms are illustrated in Fig. 3. |
T83 | 9444-9473 | Sentence | denotes | MSC-EXOS THERAPY FOR COVID-19 |
T84 | 9474-9548 | Sentence | denotes | In COVID-19, multiorgan damage has been seen in many-infected individuals. |
T85 | 9549-9630 | Sentence | denotes | MSC-Exos is known to alleviate lung injury in asthmatic models and ARDS (40, 41). |
T86 | 9631-9724 | Sentence | denotes | MSC-Exos may also be useful in the treatment of cardiovascular (42) and renal pro-blems (43). |
T87 | 9725-9796 | Sentence | denotes | Hence, they can be used to treat organ damage associated with COVID-19. |
T88 | 9797-9931 | Sentence | denotes | Similarly, MSC-EVs have also exhi-bited inhibitory activity on the hemagglutination of avian, swine, and human influenza viruses (44). |
T89 | 9932-10052 | Sentence | denotes | Likewise, MSC-Exos lowered the death rate in H7N9 patients without any toxic effects during follow-up examinations (45). |
T90 | 10053-10158 | Sentence | denotes | In addition, these exosomes consist of adhesion molecules that accurately guide them to the injured site. |
T91 | 10159-10393 | Sentence | denotes | The usage of the exosomes may be preferred to the MSCs, since they can easily cross the blood-brain barrier, are inexpensive, and cannot undergo independent self-renewal, hence preventing adverse consequences, such as tumor formation. |
T92 | 10394-10524 | Sentence | denotes | In this pandemic situation, MSC-Exos may be considered as a good treatment option to alleviate the effect of SARS-CoV-2 infection. |
T93 | 10526-10588 | Sentence | denotes | CURRENT CLINICAL TRIALS OF STEM CELL-BASED THERAPY IN COVID-19 |
T94 | 10589-10678 | Sentence | denotes | Of late, stem-cell-based studies in the treatment of COVID-19 have been gaining momentum. |
T95 | 10679-10813 | Sentence | denotes | The efficiency and safety of usage of exosomes that had been obtained from BM-MSCs was recently tested on 24 SARS-CoV-2 patients (46). |
T96 | 10814-10863 | Sentence | denotes | These patients exhibited moderate to severe ARDS. |
T97 | 10864-11007 | Sentence | denotes | When the exosomes were introduced into the patients, there were no side effects, and patients improved in clinical status and oxygenation (46). |
T98 | 11008-11213 | Sentence | denotes | In a similar study, patients treated with MSCs showed a remark-able improvement in pulmonary function, higher levels of peripheral lymphocytes, and a reduction in the cells that trigger the cytokine storm. |
T99 | 11214-11339 | Sentence | denotes | Interestingly, the MSCs did not exhibit ACE2 or TMPRSS2 expression, showing that they may not be infected with COVID-19 (47). |
T100 | 11340-11448 | Sentence | denotes | Several clinical trials are in the pipeline for usage of stem cells for the treatment of COVID-19 (Table 2). |
T101 | 11449-11628 | Sentence | denotes | Wharton’s jelly-derived MSCs (WJ-MSCs), which have been used in various studies based on stem-cell therapy and trials, are in progress for their usage for COVID-19 treatment (48). |
T102 | 11629-11759 | Sentence | denotes | Moreover, adipose tissue-derived AD-MSCs have been used in a few studies in various doses and protocols for COVID-19 therapy (49). |
T103 | 11760-11849 | Sentence | denotes | Likewise, a novel trial includes inhalation of MSC-Exos for alleviation of symptoms (50). |
T104 | 11850-11951 | Sentence | denotes | In addition, MSCs from dental pulp (51) and olfactory mucosa (52) were administered in various doses. |
T105 | 11952-12199 | Sentence | denotes | MSCs in the clinical trials are predominantly administered intravenously; i.v. injection and, in some studies, MSCs have been given as adjuvant therapy in addition to drugs like oseltamivir, hormones, hydroxychloroquine, and azithromycin (53, 54). |
T106 | 12200-12281 | Sentence | denotes | These trials reveal promising new routes for the battle against COVID-19 (55-94). |
T107 | 12283-12300 | Sentence | denotes | FUTURE DIRECTIONS |
T108 | 12301-12416 | Sentence | denotes | Stem cells have been studied extensively for their ability to regenerate and for the treatment of various diseases. |
T109 | 12417-12562 | Sentence | denotes | Recently, we devised an improved protocol for the isolation of urine-derived stem cells and their further differentiation into immune cells (95). |
T110 | 12563-12679 | Sentence | denotes | Moreover, our research group promoted the hematopoietic differentiation of hiPSCs using a novel small molecule (96). |
T111 | 12680-12814 | Sentence | denotes | At the advent of COVID-19, it has become mandatory to discover therapeutic strategies that are easily reproducible and cost effective. |
T112 | 12815-12914 | Sentence | denotes | Drugs currently available for the treatment of COVID-19 include ones that target viral replication. |
T113 | 12915-13088 | Sentence | denotes | These drugs include camo-stat mesylate, which is involved in the inhibition of viral fusion to the cell membrane, and favipiravir and remdesivir, which are anti-viral drugs. |
T114 | 13089-13269 | Sentence | denotes | However, because the cytokine storm is found predominantly in COVID-19 patients, it is essential to consider drugs that inhibit viral replication while treating the cytokine storm. |
T115 | 13270-13342 | Sentence | denotes | Hence, MSC-Exos may be appropriate therapeutic agents for COVID-19 (97). |
T116 | 13343-13484 | Sentence | denotes | MSCs can be more advantageous than other anti-inflammatory agents, because they can provide immunomodulatory effects based on the host cells. |
T117 | 13485-13721 | Sentence | denotes | In addition to these effects, MSCs can prevent fibrosis of tissues, enable reversal of lung dysfunction, and aid in the regeneration of damaged tissue, which can be significantly beneficial for COVID-19-associated organ damage (98, 99). |
T118 | 13722-13884 | Sentence | denotes | Because the healing properties of the MSCs can be primarily attributed to the secretomes or exosomes, using them may be more effective than using MSCs themselves. |
T119 | 13885-14021 | Sentence | denotes | Exosomes can be mass-produced, administered systematically with minimaltoxicity, and be able to reach the cell targets more efficiently. |
T120 | 14022-14142 | Sentence | denotes | In addition to their inherent immunomodulatory potential, the MSC-Exos can also be used as a drug-delivery system (100). |
T121 | 14143-14336 | Sentence | denotes | MSC-Exos can be modified in vivo to release exosomes that have a higher immunomodulatory potential (101) and can be cultured using various cytokines to exhibit an anti-inflammatory state (102). |
T122 | 14337-14483 | Sentence | denotes | Although MSC-Exos appear to be promising thera-peutic agents for COVID-19, more experimental research is necessary for them to be used clinically. |
T123 | 14484-14605 | Sentence | denotes | Moreover, it is es-sential to optimize the protocols for storage and isolation of MSC-Exos for the treatment of COVID-19. |
T124 | 14606-14754 | Sentence | denotes | It is also imperative to do experiments to understand the underlying mechanisms of COVID-19 in order to optimize MSC-Exo therapy for treatment (97). |
T125 | 14755-14874 | Sentence | denotes | Further, it is also essential to find the optimum dosage, route of administration, and treatment schedule for MSC-Exos. |
T126 | 14875-15024 | Sentence | denotes | Hence, since MSCs are more widely studied in these aspects than are MSC-Exos, they are predominantly preferred in clinical trials for COVID-19 (103). |
T127 | 15026-15044 | Sentence | denotes | CONCLUDING REMARKS |
T128 | 15045-15098 | Sentence | denotes | COVID-19 has invoked frenzy in individuals worldwide. |
T129 | 15099-15206 | Sentence | denotes | The unceasing increase of infection and death has halted the lives of the citizens of countries everywhere. |
T130 | 15207-15322 | Sentence | denotes | Hence, it is important to discover novel therapeutic platforms and productive measures without further delay (104). |
T131 | 15323-15513 | Sentence | denotes | The therapies produced must be easily reproducible and available in large quantities so that enough bioactive molecules will be available for all indivi-duals who have succumbed to COVID-19. |
T132 | 15514-15609 | Sentence | denotes | MSCs and MSC-Exos can be used for their immunomodulatory effects in indi-viduals with COVID-19. |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32731913-32278175-8028451 | 147-148 | 32278175 | denotes | 1 |
32731913-32336317-8028452 | 267-268 | 32336317 | denotes | 2 |
32731913-32250385-8028453 | 399-400 | 32250385 | denotes | 3 |
32731913-32360420-8028454 | 526-527 | 32360420 | denotes | 4 |
32731913-32360909-8028455 | 779-780 | 32360909 | denotes | 5 |
32731913-32562911-8028456 | 1073-1074 | 32562911 | denotes | 6 |
32731913-32562911-8028457 | 1369-1370 | 32562911 | denotes | 6 |
32731913-31981224-8028458 | 1527-1528 | 31981224 | denotes | 7 |
32731913-32161940-8028459 | 1870-1871 | 32161940 | denotes | 8 |
32731913-32299202-8028460 | 2032-2034 | 32299202 | denotes | 10 |
32731913-20559327-8028461 | 2319-2321 | 20559327 | denotes | 11 |
32731913-32299202-8028462 | 2458-2460 | 32299202 | denotes | 10 |
32731913-32278175-8028463 | 2706-2707 | 32278175 | denotes | 1 |
32731913-32299202-8028464 | 2954-2956 | 32299202 | denotes | 10 |
32731913-32324968-8028465 | 3502-3504 | 32324968 | denotes | 12 |
32731913-32347747-8028466 | 3728-3730 | 32347747 | denotes | 13 |
32731913-32324968-8028467 | 4385-4387 | 32324968 | denotes | 12 |
32731913-27769637-8028468 | 5273-5275 | 27769637 | denotes | 17 |
32731913-25529339-8028469 | 5277-5279 | 25529339 | denotes | 18 |
32731913-19172693-8028470 | 5514-5516 | 19172693 | denotes | 19 |
32731913-18371435-8028471 | 5690-5692 | 18371435 | denotes | 20 |
32731913-20436665-8028472 | 5777-5779 | 20436665 | denotes | 21 |
32731913-20382885-8028473 | 6111-6113 | 20382885 | denotes | 22 |
32731913-17932421-8028474 | 6115-6117 | 17932421 | denotes | 23 |
32731913-26294919-8028475 | 6286-6288 | 26294919 | denotes | 24 |
32731913-32283815-8028476 | 6731-6733 | 32283815 | denotes | 25 |
32731913-28736264-8028477 | 6907-6909 | 28736264 | denotes | 26 |
32731913-32371362-8028478 | 7121-7123 | 32371362 | denotes | 27 |
32731913-29523213-8028479 | 7465-7467 | 29523213 | denotes | 28 |
32731913-32283815-8028480 | 7869-7871 | 32283815 | denotes | 25 |
32731913-28620221-8028481 | 8133-8135 | 28620221 | denotes | 29 |
32731913-30526632-8028482 | 8276-8278 | 30526632 | denotes | 30 |
32731913-30058282-8028483 | 8565-8567 | 30058282 | denotes | 31 |
32731913-30328799-8028484 | 8660-8662 | 30328799 | denotes | 32 |
32731913-30190615-8028485 | 8777-8779 | 30190615 | denotes | 33 |
32731913-28090688-8028486 | 8937-8939 | 28090688 | denotes | 34 |
32731913-27115513-8028487 | 9060-9062 | 27115513 | denotes | 35 |
32731913-31407157-8028488 | 9146-9148 | 31407157 | denotes | 36 |
32731913-30378105-8028489 | 9390-9392 | 30378105 | denotes | 38 |
32731913-31887849-8028490 | 9394-9396 | 31887849 | denotes | 39 |
32731913-29277503-8028491 | 9622-9624 | 29277503 | denotes | 40 |
32731913-26231094-8028492 | 9626-9628 | 26231094 | denotes | 41 |
32731913-28936747-8028493 | 9695-9697 | 28936747 | denotes | 42 |
32731913-30651737-8028494 | 9720-9722 | 30651737 | denotes | 43 |
32731913-29378639-8028495 | 9927-9929 | 29378639 | denotes | 44 |
32731913-32380908-8028496 | 10809-10811 | 32380908 | denotes | 46 |
32731913-32380908-8028497 | 11003-11005 | 32380908 | denotes | 46 |
32731913-32257537-8028498 | 11335-11337 | 32257537 | denotes | 47 |
32731913-32197458-8028499 | 12558-12560 | 32197458 | denotes | 95 |
32731913-32131506-8028500 | 12675-12677 | 32131506 | denotes | 96 |
32731913-31938077-8028501 | 13338-13340 | 31938077 | denotes | 97 |
32731913-32661867-8028502 | 13717-13719 | 32661867 | denotes | 99 |
32731913-32622963-8028503 | 14137-14140 | 32622963 | denotes | 100 |
32731913-32616467-8028504 | 14331-14334 | 32616467 | denotes | 102 |
32731913-31938077-8028505 | 14750-14752 | 31938077 | denotes | 97 |
32731913-32456070-8028506 | 15019-15022 | 32456070 | denotes | 103 |
32731913-32271461-8028507 | 15317-15320 | 32271461 | denotes | 104 |