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PMC:7473478 / 1173-16782 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T13 314-322 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T14 407-415 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T15 471-480 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T16 550-558 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T17 783-793 Body_part denotes Stem cells http://purl.org/sig/ont/fma/fma63368
T18 788-793 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T19 810-815 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 854-858 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T21 908-913 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22 915-936 Body_part denotes Mesenchymal stem cell http://purl.org/sig/ont/fma/fma0326143
T23 932-936 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T24 987-996 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T25 1065-1071 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T26 1283-1289 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T27 1391-1404 Body_part denotes IMMUNE SYSTEM http://purl.org/sig/ont/fma/fma9825
T28 1573-1579 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T29 1590-1594 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T30 1631-1639 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T31 1674-1684 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T32 1698-1705 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 1726-1729 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T34 1915-1920 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T35 1925-1933 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T36 1928-1933 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T37 1996-2001 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T38 2017-2030 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T39 2055-2069 Body_part denotes helper T cells http://purl.org/sig/ont/fma/fma70572
T40 2064-2069 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T41 2095-2100 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T42 2106-2124 Body_part denotes regulatory T cells http://purl.org/sig/ont/fma/fma84070
T43 2119-2124 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T44 2238-2256 Body_part denotes regulatory T cells http://purl.org/sig/ont/fma/fma84070
T45 2251-2256 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T46 2389-2394 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T47 2418-2423 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T48 2496-2501 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T49 2593-2601 Body_part denotes CYTOKINE http://purl.org/sig/ont/fma/fma84050
T50 2700-2704 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T51 2752-2766 Body_part denotes immune systems http://purl.org/sig/ont/fma/fma9825
T52 2812-2822 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T53 2827-2838 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T54 2914-2919 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T55 2938-2946 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T56 3011-3015 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T57 3032-3037 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T58 3046-3057 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T59 3370-3374 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T60 3441-3445 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T61 3481-3485 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T62 3560-3567 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T63 3623-3630 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 3910-3918 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T65 3930-3939 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T66 4105-4117 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T67 4105-4109 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T68 4178-4197 Body_part denotes extracellular space http://purl.org/sig/ont/fma/fma70022
T69 4327-4331 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T70 4449-4457 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T71 4492-4497 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T72 4513-4517 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T73 4567-4573 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T74 4677-4688 Body_part denotes bone marrow http://purl.org/sig/ont/fma/fma9608
T75 4690-4704 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T76 4706-4717 Body_part denotes dental pulp http://purl.org/sig/ont/fma/fma55631
T77 4719-4733 Body_part denotes umbilical cord http://purl.org/sig/ont/fma/fma85541
T78 4735-4750 Body_part denotes Wharton’s jelly http://purl.org/sig/ont/fma/fma323134
T79 4752-4760 Body_part denotes placenta http://purl.org/sig/ont/fma/fma63934
T80 4762-4776 Body_part denotes synovial fluid http://purl.org/sig/ont/fma/fma12277
T81 4778-4789 Body_part denotes endometrium http://purl.org/sig/ont/fma/fma17742
T82 4806-4811 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T83 4819-4824 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T84 4843-4855 Body_part denotes cell-surface http://purl.org/sig/ont/fma/fma67653
T85 4843-4847 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86 5336-5341 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T87 5378-5391 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T88 5453-5458 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T89 5596-5601 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T90 5800-5813 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T91 5956-5967 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T92 6055-6070 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T93 6065-6070 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T94 6104-6109 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T95 6208-6217 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T96 6378-6383 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T97 6392-6397 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T98 6427-6432 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T99 6489-6499 Body_part denotes hepatocyte http://purl.org/sig/ont/fma/fma14515
T100 6527-6549 Body_part denotes MESENCHYMAL STEM CELLS http://purl.org/sig/ont/fma/fma0326143
T101 6544-6549 Body_part denotes CELLS http://purl.org/sig/ont/fma/fma68646
T102 6771-6779 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T103 6791-6800 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T104 6802-6812 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T105 6912-6922 Body_part denotes Stem cells http://purl.org/sig/ont/fma/fma63368
T106 6917-6922 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T107 7065-7070 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T108 7236-7240 Body_part denotes tRNA http://purl.org/sig/ont/fma/fma67127
T109 7289-7297 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T110 7315-7320 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T111 7423-7438 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T112 7458-7463 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T113 7510-7514 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T114 7707-7712 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T115 7860-7867 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T116 8104-8109 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T117 8213-8217 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T118 8256-8261 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T119 8266-8274 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T120 8269-8274 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T121 8298-8303 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T122 8361-8366 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T123 8491-8496 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T124 8650-8658 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T125 8653-8658 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T126 8686-8697 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T127 9053-9057 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T128 9201-9211 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T129 9219-9224 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T130 9361-9364 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T131 9580-9584 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T132 9758-9763 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T133 10247-10252 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T134 10253-10258 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T135 10553-10562 Body_part denotes STEM CELL http://purl.org/sig/ont/fma/fma63368
T136 10558-10562 Body_part denotes CELL http://purl.org/sig/ont/fma/fma68646
T137 10598-10607 Body_part denotes stem-cell http://purl.org/sig/ont/fma/fma63368
T138 10603-10607 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T139 11139-11150 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T140 11175-11180 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T141 11198-11206 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T142 11397-11407 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T143 11402-11407 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T144 11449-11464 Body_part denotes Wharton’s jelly http://purl.org/sig/ont/fma/fma323134
T145 11538-11547 Body_part denotes stem-cell http://purl.org/sig/ont/fma/fma63368
T146 11543-11547 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T147 11639-11653 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T148 11873-11884 Body_part denotes dental pulp http://purl.org/sig/ont/fma/fma55631
T149 11904-11910 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T150 12143-12151 Body_part denotes hormones http://purl.org/sig/ont/fma/fma12278
T151 12301-12311 Body_part denotes Stem cells http://purl.org/sig/ont/fma/fma63368
T152 12306-12311 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T153 12480-12485 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T154 12494-12504 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T155 12499-12504 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T156 12551-12556 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T157 13014-13027 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T158 13014-13018 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T159 13110-13118 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T160 13254-13262 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T161 13478-13483 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T162 13544-13551 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T163 13572-13576 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T164 13629-13635 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T165 13699-13704 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T166 13991-13995 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T167 14282-14291 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 1065-1071 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 1283-1289 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T4 2017-2030 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T5 2752-2766 Body_part denotes immune systems http://purl.obolibrary.org/obo/UBERON_0002405
T6 4567-4573 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T7 4592-4598 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T8 4677-4688 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T9 4690-4704 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T10 4698-4704 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T11 4706-4717 Body_part denotes dental pulp http://purl.obolibrary.org/obo/UBERON_0001754
T12 4719-4733 Body_part denotes umbilical cord http://purl.obolibrary.org/obo/UBERON_0002331
T13 4752-4760 Body_part denotes placenta http://purl.obolibrary.org/obo/UBERON_0001987
T14 4762-4776 Body_part denotes synovial fluid http://purl.obolibrary.org/obo/UBERON_0001090
T15 4778-4789 Body_part denotes endometrium http://purl.obolibrary.org/obo/UBERON_0001295
T16 4806-4811 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T17 5378-5391 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T18 5800-5813 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T19 7662-7666 Body_part denotes mole http://purl.obolibrary.org/obo/UBERON_1000010
T20 8104-8109 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T21 8510-8514 Body_part denotes mole http://purl.obolibrary.org/obo/UBERON_1000010
T22 9219-9224 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T23 9580-9584 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T24 9758-9763 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T25 10247-10266 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T26 10247-10252 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T27 10253-10258 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T28 11639-11653 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T29 11647-11653 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T30 11873-11884 Body_part denotes dental pulp http://purl.obolibrary.org/obo/UBERON_0001754
T31 11904-11910 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T32 12480-12485 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T33 13572-13576 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T34 13629-13635 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T35 13699-13704 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T7 85-132 Disease denotes Severe Acute Respiratory Syndrome–Coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T8 85-118 Disease denotes Severe Acute Respiratory Syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T9 134-142 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 332-340 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 355-390 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T12 361-390 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T13 392-396 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T14 425-433 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 508-524 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T16 593-608 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T17 599-608 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T18 658-664 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T19 692-700 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 1374-1382 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T21 1517-1525 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 1557-1565 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T23 1956-1964 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 2157-2165 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 2305-2317 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T26 2576-2584 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 2608-2616 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 2717-2726 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 2879-2887 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 3073-3079 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T31 3521-3524 Disease denotes NOD http://purl.obolibrary.org/obo/MONDO_0007435
T32 3672-3675 Disease denotes ASC http://purl.obolibrary.org/obo/MONDO_0019018
T33 4038-4046 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 4574-4580 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T35 7662-7666 Disease denotes mole http://purl.obolibrary.org/obo/MONDO_0005073
T36 8405-8417 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T37 8510-8514 Disease denotes mole http://purl.obolibrary.org/obo/MONDO_0005073
T38 8543-8555 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T39 8832-8840 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 9465-9473 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T41 9477-9485 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 9585-9591 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T43 9616-9620 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T44 9787-9795 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T45 9908-9917 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T46 10377-10382 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T47 10503-10511 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 10514-10523 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 10580-10588 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T50 10642-10650 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T51 10788-10796 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 10858-10862 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T53 11325-11333 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T54 11429-11437 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T55 11604-11612 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T56 11662-11664 Disease denotes AD http://purl.obolibrary.org/obo/MONDO_0004975
T57 11737-11745 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T58 12264-12272 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T59 12697-12705 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T60 12862-12870 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T61 13151-13159 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T62 13328-13336 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T63 13679-13687 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T64 14402-14410 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T65 14596-14604 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T66 14689-14697 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T67 15009-15017 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T68 15045-15053 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 15125-15134 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T70 15504-15512 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T71 15600-15608 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T11 23-26 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T12 32-38 http://purl.obolibrary.org/obo/UBERON_0001456 denotes facing
T13 39-40 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 458-459 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 548-549 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 744-745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 783-793 http://purl.obolibrary.org/obo/CL_0000034 denotes Stem cells
T18 810-815 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19 854-858 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20 908-913 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21 915-936 http://purl.obolibrary.org/obo/CL_0000134 denotes Mesenchymal stem cell
T22 1093-1096 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T23 1152-1155 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T24 1391-1404 http://purl.obolibrary.org/obo/UBERON_0002405 denotes IMMUNE SYSTEM
T25 1573-1579 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T26 1611-1615 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T27 1631-1639 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T28 1657-1664 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T29 1724-1729 http://purl.obolibrary.org/obo/PR_000005932 denotes G-CSF
T30 1913-1920 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T31 1925-1933 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T32 1996-2001 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T33 2017-2030 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T34 2055-2069 http://purl.obolibrary.org/obo/CL_0000912 denotes helper T cells
T35 2093-2100 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T36 2106-2124 http://purl.obolibrary.org/obo/CL_0000815 denotes regulatory T cells
T37 2238-2256 http://purl.obolibrary.org/obo/CL_0000815 denotes regulatory T cells
T38 2319-2321 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T39 2340-2341 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 2381-2394 http://purl.obolibrary.org/obo/CL_0000898 denotes naïve T cells
T41 2416-2423 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T42 2496-2501 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T43 2509-2510 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T44 2700-2704 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T45 2752-2766 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune systems
T46 2799-2804 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T47 2914-2919 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T48 2982-2987 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T49 3011-3015 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T50 3032-3037 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T51 3108-3118 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytes
T52 3254-3255 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T53 3261-3262 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T54 3264-3274 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T55 3310-3311 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T56 3411-3418 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T57 3511-3520 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T58 3642-3643 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 3828-3837 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T60 3930-3939 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T61 3982-3990 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T62 4105-4109 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T63 4327-4331 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T64 4353-4354 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T65 4356-4366 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T66 4405-4415 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T67 4447-4448 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T68 4492-4497 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T69 4513-4517 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T70 4592-4598 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T71 4677-4681 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone
T72 4690-4704 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T73 4719-4733 http://purl.obolibrary.org/obo/UBERON_0002331 denotes umbilical cord
T74 4719-4733 http://www.ebi.ac.uk/efo/EFO_0001415 denotes umbilical cord
T75 4752-4760 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placenta
T76 4752-4760 http://www.ebi.ac.uk/efo/EFO_0001407 denotes placenta
T77 4778-4789 http://purl.obolibrary.org/obo/UBERON_0001295 denotes endometrium
T78 4806-4811 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T79 4806-4811 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T80 4819-4824 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T81 4843-4847 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T82 4884-4885 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 5277-5279 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T84 5336-5341 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T85 5378-5391 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T86 5453-5458 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T87 5473-5481 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T88 5596-5601 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T89 5800-5813 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T90 5900-5905 http://purl.obolibrary.org/obo/CL_0000792 denotes Tregs
T91 6001-6003 http://purl.obolibrary.org/obo/CLO_0002860 denotes E2
T92 6055-6070 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T93 6104-6109 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T94 6111-6113 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T95 6360-6363 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T96 6378-6383 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T97 6385-6388 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T98 6390-6397 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T99 6422-6432 http://purl.obolibrary.org/obo/CL_0000623 denotes (NK) cells
T100 6515-6518 http://purl.obolibrary.org/obo/CLO_0003740 denotes HGF
T101 6527-6549 http://purl.obolibrary.org/obo/CL_0000134 denotes MESENCHYMAL STEM CELLS
T102 6578-6581 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T103 6656-6657 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 6912-6922 http://purl.obolibrary.org/obo/CL_0000034 denotes Stem cells
T105 7065-7070 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T106 7109-7119 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T107 7121-7123 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T108 7423-7429 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T109 7430-7438 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T110 7458-7463 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T111 7510-7514 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T112 7707-7712 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T113 7946-7947 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T114 8240-8243 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T115 8249-8252 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T116 8254-8261 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T117 8266-8274 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T118 8296-8303 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T119 8361-8366 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T120 8475-8478 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T121 8484-8487 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T122 8489-8496 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T123 8650-8658 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T124 8707-8709 http://purl.obolibrary.org/obo/CLO_0007448 denotes M1
T125 8707-8709 http://purl.obolibrary.org/obo/CLO_0050175 denotes M1
T126 8937-8939 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T127 9060-9062 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T128 9146-9148 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T129 9368-9373 http://purl.obolibrary.org/obo/CLO_0008407 denotes PD-L1
T130 9505-9508 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T131 9580-9584 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T132 9580-9584 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T133 9626-9628 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T134 9758-9763 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T135 9848-9856 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T136 9902-9907 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T137 9918-9925 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T138 10048-10050 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T139 10247-10252 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T140 10247-10252 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T141 10253-10258 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T142 10253-10258 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T143 10452-10453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T144 10553-10562 http://purl.obolibrary.org/obo/CL_0000034 denotes STEM CELL
T145 10598-10607 http://purl.obolibrary.org/obo/CL_0000034 denotes stem-cell
T146 10754-10756 http://purl.obolibrary.org/obo/CLO_0001997 denotes BM
T147 10775-10781 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T148 11011-11012 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 11062-11063 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T150 11156-11157 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T151 11175-11180 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T152 11397-11407 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T153 11538-11547 http://purl.obolibrary.org/obo/CL_0000034 denotes stem-cell
T154 11624-11626 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T155 11639-11653 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T156 11688-11689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T157 11770-11771 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T158 11904-11910 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T159 11912-11914 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T160 12277-12279 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T161 12301-12311 http://purl.obolibrary.org/obo/CL_0000034 denotes Stem cells
T162 12494-12504 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T163 12551-12556 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T164 12638-12644 http://purl.obolibrary.org/obo/CLO_0037308 denotes hiPSCs
T165 12651-12652 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T166 12710-12713 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T167 13014-13018 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T168 13019-13027 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T169 13478-13483 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T170 13572-13576 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T171 13572-13576 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T172 13699-13704 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T173 13991-13995 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T174 14113-14114 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T175 14206-14207 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T176 14331-14334 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T177 14500-14502 http://purl.obolibrary.org/obo/CLO_0053755 denotes es
T178 15054-15057 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T179 15145-15148 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 188-197 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T2 1253-1262 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T3 1590-1592 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T5 1597-1599 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T7 1605-1607 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T9 1611-1613 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T11 1617-1619 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T13 1657-1664 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T14 1666-1669 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T16 1698-1705 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T17 2632-2643 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T18 3257-3259 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T21 3306-3308 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T24 3323-3330 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T25 3370-3372 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T27 3441-3443 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T29 3481-3483 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T31 3560-3567 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T32 3623-3630 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33 3772-3775 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T35 3875-3882 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T37 3910-3918 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T38 4148-4162 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T39 4160-4162 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T40 4164-4169 Chemical denotes AngII http://purl.obolibrary.org/obo/CHEBI_2719
T41 4230-4235 Chemical denotes AngII http://purl.obolibrary.org/obo/CHEBI_2719
T42 4275-4280 Chemical denotes AngII http://purl.obolibrary.org/obo/CHEBI_2719
T43 4315-4317 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T45 4349-4351 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T48 5914-5916 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T50 5987-6003 Chemical denotes prostaglandin E2 http://purl.obolibrary.org/obo/CHEBI_15551|http://purl.obolibrary.org/obo/CHEBI_606564
T52 5987-6000 Chemical denotes prostaglandin http://purl.obolibrary.org/obo/CHEBI_26333
T53 6005-6009 Chemical denotes PGE2 http://purl.obolibrary.org/obo/CHEBI_15551
T54 6031-6038 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T55 6095-6103 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T56 6269-6271 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T58 6280-6284 Chemical denotes PGE2 http://purl.obolibrary.org/obo/CHEBI_15551
T59 6771-6779 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T60 7086-7095 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T61 7177-7186 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T62 7289-7297 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T63 7303-7309 Chemical denotes lipids http://purl.obolibrary.org/obo/CHEBI_18059
T64 7315-7320 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T65 7474-7483 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T66 7927-7940 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T67 8315-8317 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T69 8333-8335 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T71 8707-8709 Chemical denotes M1 http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826
T75 8717-8719 Chemical denotes M2 http://purl.obolibrary.org/obo/CHEBI_34827|http://purl.obolibrary.org/obo/CHEBI_51112
T77 9036-9038 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T79 9042-9044 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T81 9053-9055 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T83 9123-9125 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T85 9129-9131 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T87 9368-9370 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T88 10101-10110 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T89 11662-11664 Chemical denotes AD http://purl.obolibrary.org/obo/CHEBI_73803
T90 12087-12095 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T91 12119-12124 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T92 12130-12141 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T93 12143-12151 Chemical denotes hormones http://purl.obolibrary.org/obo/CHEBI_24621
T94 12153-12171 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T95 12177-12189 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T96 12586-12591 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T97 12665-12673 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T98 12921-12926 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T99 13033-13044 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T100 13049-13059 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T101 13082-13087 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T102 13198-13203 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T103 13384-13408 Chemical denotes anti-inflammatory agents http://purl.obolibrary.org/obo/CHEBI_67079
T104 14115-14119 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T105 15433-15442 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
29 85-132 Species denotes Severe Acute Respiratory Syndrome–Coronavirus-2 Tax:2697049
30 134-144 Species denotes SARS-CoV-2 Tax:2697049
31 730-738 Species denotes patients Tax:9606
32 332-340 Disease denotes COVID-19 MESH:C000657245
33 355-390 Disease denotes acute respiratory distress syndrome MESH:D012128
34 392-396 Disease denotes ARDS MESH:D012128
35 425-433 Disease denotes COVID-19 MESH:C000657245
36 508-524 Disease denotes viral infections MESH:D001102
37 573-580 Disease denotes hypoxia MESH:D000860
38 593-608 Disease denotes viral infection MESH:D001102
39 692-700 Disease denotes COVID-19 MESH:C000657245
41 1374-1382 Disease denotes COVID-19 MESH:C000657245
68 1590-1595 Gene denotes IL-1β Gene:3552
69 1597-1603 Gene denotes IL-1RA Gene:3557
70 1605-1609 Gene denotes IL-7 Gene:3574
71 1611-1615 Gene denotes IL-8 Gene:3576
72 1617-1622 Gene denotes IL-10 Gene:3586
73 1624-1629 Gene denotes IFN-γ Gene:3458
74 1631-1672 Gene denotes monocyte chemoattrac-tant peptide (MCP)-1 Gene:6347
75 1674-1714 Gene denotes macrophage inflammatory protein (MIP)-1A Gene:6348
76 1716-1722 Gene denotes MIP-1B Gene:6351
77 1724-1729 Gene denotes G-CSF Gene:1440
78 1735-1740 Gene denotes TNF-α Gene:7124
79 2511-2515 Gene denotes plau Gene:5328
80 1534-1542 Species denotes patients Tax:9606
81 1557-1567 Species denotes SARS-CoV-2 Tax:2697049
82 1834-1842 Species denotes patients Tax:9606
83 1965-1973 Species denotes patients Tax:9606
84 2143-2151 Species denotes patients Tax:9606
85 2448-2456 Species denotes patients Tax:9606
86 2576-2586 Species denotes SARS-CoV-2 Tax:2697049
87 1517-1525 Disease denotes COVID-19 MESH:C000657245
88 1543-1551 Disease denotes infected MESH:D007239
89 1956-1964 Disease denotes COVID-19 MESH:C000657245
90 2157-2165 Disease denotes COVID-19 MESH:C000657245
91 2305-2317 Disease denotes inflammation MESH:D007249
92 2409-2417 Disease denotes memory T MESH:D008569
93 2439-2447 Disease denotes infected MESH:D007239
131 2632-2663 Gene denotes Angiotensin-converting enzyme 2 Gene:59272
132 2665-2669 Gene denotes ACE2 Gene:59272
133 3233-3255 Gene denotes nuclear factor kappa B Gene:4790
134 3257-3262 Gene denotes NF-κb Gene:4790
135 3291-3296 Gene denotes MyD88 Gene:4615
136 3306-3311 Gene denotes NF-κb Gene:4790
137 3366-3375 Gene denotes pro-IL-1β Gene:3553
138 3384-3393 Gene denotes caspase-1 Gene:834
139 3437-3446 Gene denotes pro-IL-1β Gene:3553
140 3481-3486 Gene denotes IL-1β Gene:3552
141 3491-3500 Gene denotes caspase 1 Gene:834
142 3521-3569 Gene denotes NOD-, LRR- and pyrin domain-containing protein 3 Gene:114548
143 3571-3576 Gene denotes NLRP3 Gene:114548
144 3708-3713 Gene denotes NLRP3 Gene:114548
145 3796-3815 Gene denotes P2X purino-ceptor 7 Gene:5027
146 3817-3822 Gene denotes P2RX7 Gene:5027
147 4056-4060 Gene denotes ACE2 Gene:59272
148 4083-4087 Gene denotes ACE2 Gene:59272
149 4148-4162 Gene denotes Angiotensin II Gene:183
150 4164-4169 Gene denotes AngII Gene:183
151 4207-4211 Gene denotes ACE2 Gene:59272
152 4230-4235 Gene denotes AngII Gene:183
153 4241-4248 Gene denotes Ang 1-9 Gene:284
154 4253-4259 Gene denotes Ang1-7 Gene:284
155 4275-4280 Gene denotes AngII Gene:183
156 4305-4310 Gene denotes TNF-α Gene:7124
157 4315-4319 Gene denotes IL-6 Gene:3569
158 4349-4354 Gene denotes NF-κb Gene:4790
159 2608-2618 Species denotes SARS-CoV-2 Tax:2697049
160 4038-4048 Species denotes SARS-CoV-2 Tax:2697049
161 3772-3775 Chemical denotes ATP MESH:D000255
162 3875-3882 Chemical denotes calcium MESH:D002118
163 2717-2726 Disease denotes infection MESH:D007239
164 2879-2887 Disease denotes COVID-19 MESH:C000657245
165 3930-3946 Disease denotes lysosomal damage MESH:D020140
166 4499-4507 Disease denotes necrosis MESH:D009336
167 4567-4580 Disease denotes tissue injury MESH:D017695
183 5822-5851 Gene denotes transforming growth factor b1 Gene:7040
184 5853-5858 Gene denotes TGFβ1 Gene:7040
185 5914-5918 Gene denotes IL-6 Gene:3569
186 6227-6232 Gene denotes IFN-γ Gene:3458
187 6263-6267 Gene denotes TGFβ Gene:7039
188 6269-6274 Gene denotes IL-10 Gene:3586
189 6360-6363 Gene denotes CD4 Gene:920
190 6479-6484 Gene denotes TGFβ1 Gene:7040
191 6489-6513 Gene denotes hepatocyte growth factor Gene:3082
192 6515-6518 Gene denotes HGF Gene:3082
193 6385-6388 Gene denotes CD8 Gene:925
194 5900-5905 Chemical denotes Tregs
195 5987-6003 Chemical denotes prostaglandin E2 MESH:D015232
196 6005-6009 Chemical denotes PGE2 MESH:D015232
197 6280-6284 Chemical denotes PGE2 MESH:D015232
201 7039-7047 Species denotes patients Tax:9606
202 7315-7320 Chemical denotes lipid MESH:D008055
203 7819-7827 Disease denotes fibrosis MESH:D005355
230 8315-8320 Gene denotes IL-17 Gene:3605
231 8333-8338 Gene denotes IL-10 Gene:3586
232 8526-8530 Gene denotes TGFβ Gene:7039
233 9022-9027 Gene denotes TNF-α Gene:7124
234 9029-9034 Gene denotes IFN-γ Gene:3458
235 9036-9040 Gene denotes IL-6 Gene:3569
236 9042-9047 Gene denotes IL-17 Gene:3605
237 9053-9058 Gene denotes IL-1β Gene:3552
238 9123-9127 Gene denotes IL-4 Gene:3565
239 9129-9134 Gene denotes IL-10 Gene:3586
240 9139-9144 Gene denotes TGF-β Gene:7039
241 9356-9359 Gene denotes IDO Gene:3620
242 9368-9373 Gene denotes PD-L1 Gene:29126
243 9378-9388 Gene denotes galectin-1 Gene:3956
244 8484-8487 Gene denotes CD8 Gene:925
245 8475-8478 Gene denotes CD4 Gene:920
246 8249-8252 Gene denotes CD8 Gene:925
247 8240-8243 Gene denotes CD4 Gene:920
248 8841-8849 Species denotes patients Tax:9606
249 8919-8923 Species denotes mice Tax:10090
250 8124-8131 Disease denotes hypoxia MESH:D000860
251 8405-8417 Disease denotes inflammation MESH:D007249
252 8543-8555 Disease denotes inflammation MESH:D007249
253 8792-8798 Disease denotes sepsis MESH:D018805
254 8832-8840 Disease denotes COVID-19 MESH:C000657245
255 8929-8935 Disease denotes sepsis MESH:D018805
257 9465-9473 Disease denotes COVID-19 MESH:C000657245
269 9891-9896 Species denotes swine Tax:9823
270 9902-9907 Species denotes human Tax:9606
271 9908-9925 Species denotes influenza viruses Tax:11308
272 9982-9990 Species denotes patients Tax:9606
273 9477-9485 Disease denotes COVID-19 MESH:C000657245
274 9527-9535 Disease denotes infected MESH:D007239
275 9580-9591 Disease denotes lung injury MESH:D055370
276 9616-9620 Disease denotes ARDS MESH:D012128
277 9787-9795 Disease denotes COVID-19 MESH:C000657245
278 10377-10382 Disease denotes tumor MESH:D009369
279 10503-10523 Disease denotes SARS-CoV-2 infection MESH:C000657245
281 10580-10588 Disease denotes COVID-19 MESH:C000657245
301 11254-11258 Gene denotes ACE2 Gene:59272
302 11262-11269 Gene denotes TMPRSS2 Gene:7113
303 10788-10798 Species denotes SARS-CoV-2 Tax:2697049
304 10799-10807 Species denotes patients Tax:9606
305 10820-10828 Species denotes patients Tax:9606
306 10907-10915 Species denotes patients Tax:9606
307 10949-10957 Species denotes patients Tax:9606
308 11028-11036 Species denotes patients Tax:9606
309 12130-12141 Chemical denotes oseltamivir MESH:D053139
310 12153-12171 Chemical denotes hydroxychloroquine MESH:D006886
311 12177-12189 Chemical denotes azithromycin MESH:D017963
312 10642-10650 Disease denotes COVID-19 MESH:C000657245
313 10858-10862 Disease denotes ARDS MESH:D012128
314 11311-11319 Disease denotes infected MESH:D007239
315 11325-11333 Disease denotes COVID-19 MESH:C000657245
316 11429-11437 Disease denotes COVID-19 MESH:C000657245
317 11604-11612 Disease denotes COVID-19 MESH:C000657245
318 11737-11745 Disease denotes COVID-19 MESH:C000657245
319 12264-12272 Disease denotes COVID-19 MESH:C000657245
335 13160-13168 Species denotes patients Tax:9606
336 12935-12953 Chemical denotes camo-stat mesylate MESH:C034532
337 13033-13044 Chemical denotes favipiravir MESH:C462182
338 13049-13059 Chemical denotes remdesivir MESH:C000606551
339 12697-12705 Disease denotes COVID-19 MESH:C000657245
340 12862-12870 Disease denotes COVID-19 MESH:C000657245
341 13151-13159 Disease denotes COVID-19 MESH:C000657245
342 13328-13336 Disease denotes COVID-19 MESH:C000657245
343 13532-13540 Disease denotes fibrosis MESH:D005355
344 13572-13588 Disease denotes lung dysfunction MESH:D008171
345 13679-13687 Disease denotes COVID-19 MESH:C000657245
346 14402-14410 Disease denotes COVID-19 MESH:C000657245
347 14596-14604 Disease denotes COVID-19 MESH:C000657245
348 14689-14697 Disease denotes COVID-19 MESH:C000657245
349 15009-15017 Disease denotes COVID-19 MESH:C000657245
354 15045-15053 Disease denotes COVID-19 MESH:C000657245
355 15125-15134 Disease denotes infection MESH:D007239
356 15504-15512 Disease denotes COVID-19 MESH:C000657245
357 15600-15608 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 508-524 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T3 593-608 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T4 854-867 http://purl.obolibrary.org/obo/GO_0051301 denotes cell division
T5 1597-1603 http://purl.obolibrary.org/obo/GO_0005152 denotes IL-1RA
T6 2305-2317 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T7 2409-2415 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T8 2489-2495 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T9 2996-3006 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T10 3011-3021 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T11 3264-3274 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T12 3349-3362 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13 3591-3600 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T14 3591-3600 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T15 3750-3762 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T16 3800-3813 http://purl.obolibrary.org/obo/GO_0004931 denotes purino-ceptor
T17 3800-3813 http://purl.obolibrary.org/obo/GO_0001614 denotes purino-ceptor
T18 4499-4507 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T19 4499-4507 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T20 4499-4507 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T21 4499-4507 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T22 4513-4523 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T23 5835-5841 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T24 6031-6051 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T25 6055-6089 http://purl.obolibrary.org/obo/GO_0044565 denotes dendritic cells and proliferations
T26 6500-6506 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T27 6814-6820 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T28 7099-7119 http://purl.obolibrary.org/obo/GO_0038001 denotes paracrine signalling
T29 7109-7119 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T30 7236-7240 http://purl.obolibrary.org/obo/GO_0030533 denotes tRNA
T31 7273-7279 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T32 7496-7521 http://purl.obolibrary.org/obo/GO_0001558 denotes regulation of cell growth
T33 7496-7506 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T34 7510-7521 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T35 7515-7521 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T36 7552-7568 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T37 7794-7803 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T38 7794-7803 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T39 8405-8417 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T40 8543-8555 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T41 10383-10392 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T42 12896-12913 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T43 12896-12913 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T44 13209-13234 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T45 13217-13234 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T46 13217-13234 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T47 13605-13617 http://purl.obolibrary.org/obo/GO_0031099 denotes regeneration
T48 14541-14548 http://purl.obolibrary.org/obo/GO_0051235 denotes storage

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 314-328 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T2 361-381 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T3 407-421 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T4 550-564 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T5 573-580 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T6 2593-2607 Phenotype denotes CYTOKINE STORM http://purl.obolibrary.org/obo/HP_0033041
T7 2938-2952 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T8 4449-4463 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T9 7662-7666 Phenotype denotes mole http://purl.obolibrary.org/obo/HP_0003764
T10 8124-8131 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T11 8510-8514 Phenotype denotes mole http://purl.obolibrary.org/obo/HP_0003764
T12 8792-8798 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T13 8929-8935 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T14 10377-10382 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T15 11198-11212 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T16 13110-13124 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T17 13254-13268 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T10 0-12 Sentence denotes INTRODUCTION
T11 13-150 Sentence denotes The world has been facing a dreadful situation due to the spread of the Severe Acute Respiratory Syndrome–Coronavirus-2 (SARS-CoV-2) (1).
T12 151-270 Sentence denotes However, neither confirmed effective antiviral medications nor vaccines are available to deal with this emer-gency (2).
T13 271-402 Sentence denotes Many reports have suggested that it is the cytokine storm in COVID-19 that leads to acute respiratory distress syndrome (ARDS) (3).
T14 403-529 Sentence denotes The cytokine storm in COVID-19 refers to the fact that a variety of cytokines are rapidly produced after viral infections (4).
T15 530-635 Sentence denotes In addition, such a cytokine storm induces hypoxia, and direct viral infection can cause cellular damage.
T16 636-782 Sentence denotes Multiorgan damage and injury have been concomitant with COVID-19, and can be observed more in patients with a more severe form of the disease (5).
T17 783-914 Sentence denotes Stem cells are specialized cells that can renew themselves by means of cell division and can differentiate into multilineage cells.
T18 915-1076 Sentence denotes Mesenchymal stem cell (MSCs) have immunomodulatory features and secrete cytokines and immune receptors that regulate the microenvironment in the host tissue (6).
T19 1077-1203 Sentence denotes In addition, it has been observed that the crucial role of MSCs in therapy has been mediated by exosomes released by the MSCs.
T20 1204-1372 Sentence denotes These exo-somes have exhibited immunomodulatory, antiviral, anti-fibrotic, and tissue-repair-related functions in vivo; similar effects have been observed in vitro (6).
T21 1374-1404 Sentence denotes COVID-19 AND THE IMMUNE SYSTEM
T22 1405-1530 Sentence denotes The dynamic equilibrium maintained by innate and adaptive immunity is essential for impeding the progression of COVID-19 (7).
T23 1531-1783 Sentence denotes In patients infected with SARS-CoV-2, the plasma levels of IL-1β, IL-1RA, IL-7, IL-8, IL-10, IFN-γ, monocyte chemoattrac-tant peptide (MCP)-1, macrophage inflammatory protein (MIP)-1A, MIP-1B, G-CSF, and TNF-α are significantly higher than in controls.
T24 1784-1873 Sentence denotes The levels of these factors are also increased in patients who were admitted to ICUs (8).
T25 1874-1978 Sentence denotes Similarly, reductions in the levels of T cells and NK cells have been observed in COVID-19 patients (9).
T26 1979-2036 Sentence denotes The loss of such cells can impair the immune system (10).
T27 2037-2217 Sentence denotes The levels of the helper T cells, cytotoxic suppressive T cells, and regulatory T cells are much lower in patients with COVID-19 than in their healthy and less severe counterparts.
T28 2218-2323 Sentence denotes The decrease in the regulatory T cells may hamper their ability to inhibit the chronic inflammation (11).
T29 2324-2462 Sentence denotes Interes-tingly, a remarkable increase is observed in the naïve T cells, where as the memory T cells are reduced in infected patients (10).
T30 2463-2587 Sentence denotes The reduced expression of memory cells may be a plau-sible explanation for the increased rates of reinfection by SARS-CoV-2.
T31 2589-2607 Sentence denotes THE CYTOKINE STORM
T32 2608-2709 Sentence denotes SARS-CoV-2 binds to the Angiotensin-converting enzyme 2 (ACE2) receptor and enters the host cell (1).
T33 2710-2805 Sentence denotes During infection, the innate and adaptive immune systems work together to inactivate the virus.
T34 2806-2958 Sentence denotes Since leukocytes and neutrophils are present in higher concentrations in COVID-19 individuals, these immune cells may result in the cytokine storm (10).
T35 2959-3022 Sentence denotes After viral entry, the virus induces pyroptosis and cell death.
T36 3023-3103 Sentence denotes The dead cells recruit macrophages to the site of injury that phago-cytose them.
T37 3104-3305 Sentence denotes The phagocytes then express damage-associated molecular patterns (DAMPs), which bind to the toll-like receptors (TLR) and induce nuclear factor kappa B (NF-κb) signalling by means of the MyD88 pathway.
T38 3306-3394 Sentence denotes NF-κb enters the nucleus and catalyzes the transcription of pro-IL-1β and pro-caspase-1.
T39 3395-3506 Sentence denotes When additional signals are detected, the pro-IL-1β and procaspase 1 are cleaved into IL-1β and caspase 1 (12).
T40 3507-3732 Sentence denotes The activated NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) recruits the apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and pro-cas-pase-1 to form the NLRP3 inflammasome (13).
T41 3733-3860 Sentence denotes In addition, the phagocytosis releases ATP, which binds to the P2X purino-ceptor 7 (P2RX7) and activates the inflammasome (14).
T42 3861-4013 Sentence denotes The increased calcium levels caused by the viral proteins results in lysosomal damage, thereby releasing cathepsins that activate the inflammasome (15).
T43 4014-4118 Sentence denotes Further, the binding of SARS-CoV-2 to the ACE2 reduces the available ACE2 receptors on the cell surface.
T44 4119-4274 Sentence denotes This increases the levels of Angiotensin II (AngII) in the extracellular space, because ACE2 converts AngI and AngII into Ang 1-9 and Ang1-7, respectively.
T45 4275-4389 Sentence denotes AngII increases the levels of TNF-α and IL-6 in the cell that upregulates NF-κb, activating the inflammasome (12).
T46 4390-4524 Sentence denotes The continuous activation of the inflammasome results in a cytokine storm, which recruits more immune cells, necrosis, and cell death.
T47 4525-4608 Sentence denotes This inflamma-some pathway further causes tissue injury in various organs (Fig. 1).
T48 4610-4635 Sentence denotes MSCs AND IMMUNOMODULATION
T49 4636-4812 Sentence denotes MSCs are predominantly isolated from the bone marrow, adipose tissue, dental pulp, umbilical cord, Wharton’s jelly, placenta, synovial fluid, endometrium, and peripheral blood.
T50 4813-4925 Sentence denotes These cells exhibit different cell-surface markers and can be used for a variety of treatment options (Table 1).
T51 4926-5105 Sentence denotes MSCs can undergo in vitro amplification and self-renewal, and have low immunogenicity and immune-modulatory functions; the latter have attracted attention in clinical trials (16).
T52 5106-5281 Sentence denotes MSCs have been widely used in various cellular therapies, such as pre-clinical studies, as well as in some clinical trials, because of their high safety and efficacy (17, 18).
T53 5282-5392 Sentence denotes MSCs can exert immune-modu-latory effects in the host cells of both the innate and the adaptive immune system.
T54 5393-5518 Sentence denotes The direct or indirect interactions of MSCs with the immune cells make the MSCs activate the immunomodulatory responses (19).
T55 5519-5694 Sentence denotes The immunomodulatory functions of MSCs depend on the environment of the host cells; based on the inflammatory status, the MSCs decide the type of immunoregulatory effect (20).
T56 5695-5781 Sentence denotes MSCs represent pro-inflammatory immune reactions and anti-inflammatory reactions (21).
T57 5782-6119 Sentence denotes MSCs regulate the immune system via the transforming growth factor b1 (TGFβ1), which can trigger the proliferation of Tregs, induce IL-6, which prevents the proliferation of neutrophils, and stimulate the prostaglandin E2 (PGE2), which inhibits the antigen presentation by dendritic cells and proliferations of T-effector cells (22, 23).
T58 6120-6290 Sentence denotes MSCs mediate these kinds of effects by direct contact, where it releases the regulatory cytokines, such as IFN-γ, indoleamine 2,3-dioxygenase, TGFβ, IL-10, and PGE2 (24).
T59 6291-6525 Sentence denotes Moreover, MSCs can hinder the proliferation and/or func-tions of the CD4+ Th1 and TH17 cells, CD8+ T cells, and the natural killer (NK) cells, mainly by secreting soluble factors, such as TGFβ1 and hepatocyte growth factor (HGF) (16).
T60 6527-6574 Sentence denotes MESENCHYMAL STEM CELLS (MSCs) AND MSC SECRETOME
T61 6575-6735 Sentence denotes It has currently become apparent that MSCs induce therapeutic characteristics by a paracrine pathway by releasing bioactive substances known as secretomes (25).
T62 6736-6911 Sentence denotes MSC-secretomes are made of soluble proteins, including cytokines, chemokines, growth factors, and extracellular vesicles (EVs), which include micro-vesicles and exosomes (26).
T63 6912-6979 Sentence denotes Stem cells release these secretomes by common secretory mechanisms.
T64 6980-7125 Sentence denotes When the culture medium or secretome are injected into the patients, the neighboring cells assimilate the molecules by paracrine signalling (27).
T65 7126-7310 Sentence denotes The exosomes themselves contain numerous bioactive molecules, which include microRNAs (miRNA), transfer RNAs (tRNA), long noncoding RNAs (lncRNA), growth factors, proteins, and lipids.
T66 7311-7469 Sentence denotes The lipid content of the exosomes provide an added advantage by aiding in the infusion of the exosomes with the plasma membrane of the neighboring cells (28).
T67 7470-7633 Sentence denotes The molecules involved in regulation of cell growth, proliferation, survival, and immune responses are released by exosomes, are elaborately illustrated in Fig. 2.
T68 7634-7873 Sentence denotes Upon internalization of the mole-cules in the secretome, the neighboring cells modulate various downstream pathways, including immunomodulation, suppression of apoptosis, prevention of fibrosis, and remodelling of the injured tissues (25).
T69 7875-7913 Sentence denotes IMMUNOMODULATORY POTENTIAL OF MSC-EXOS
T70 7914-7970 Sentence denotes Exosomes are nanoparticles with a diameter of 40-150 nm.
T71 7971-8137 Sentence denotes To generate and isolate the exosomes, MSCs can be conditioned to increase the release of exosomes by treatment with cyto-kines or by serum starvation or hypoxia (29).
T72 8138-8218 Sentence denotes The exosomes are then purified and can be subsequently introduced into the body.
T73 8219-8280 Sentence denotes MSC-Exos can inhibit CD4+ and CD8+ T cells and NK cells (30).
T74 8281-8418 Sentence denotes They inhibited T cells expressing IL-17 and induced IL-10-expressing regulatory cells that are involved with suppression of inflammation.
T75 8419-8569 Sentence denotes MSC-Exos also aid in suppressing the differentiation of CD4+ and CD8+ T cells by releasing mole-cules like TGFβ and prevent inflammation in vivo (31).
T76 8570-8664 Sentence denotes Similarly, treatment with MSC-Exos reduced the proliferation and activa-tion of NK cells (32).
T77 8665-8781 Sentence denotes MSC-Exos could shift macrophages from the M1 to the M2 phenotype, further suppressing pro-inflam-matory states (33).
T78 8782-8941 Sentence denotes Moreover, sepsis is an important lethal factor in COVID-19 patients, and treatments with MSC-Exos have increased the rate of survival in mice with sepsis (34).
T79 8942-9150 Sentence denotes Concomitantly, MSC-Exos also suppressed release of the pro-inflammatory factors TNF-α, IFN-γ, IL-6, IL-17, and IL-1β (35) and promoted release of anti-inflammatory factors, such as IL-4, IL-10 and TGF-β (36).
T80 9151-9244 Sentence denotes Additionally, MSC-Exos also reduced the number of chemokines in the serum when injected (37).
T81 9245-9398 Sentence denotes These immunomodulatory effects of MSC-Exos have also been attributed to their anti-inflammatory cargo, such as IDO, HLA-G, PD-L1 and galectin-1 (38, 39).
T82 9399-9442 Sentence denotes These mechanisms are illustrated in Fig. 3.
T83 9444-9473 Sentence denotes MSC-EXOS THERAPY FOR COVID-19
T84 9474-9548 Sentence denotes In COVID-19, multiorgan damage has been seen in many-infected individuals.
T85 9549-9630 Sentence denotes MSC-Exos is known to alleviate lung injury in asthmatic models and ARDS (40, 41).
T86 9631-9724 Sentence denotes MSC-Exos may also be useful in the treatment of cardiovascular (42) and renal pro-blems (43).
T87 9725-9796 Sentence denotes Hence, they can be used to treat organ damage associated with COVID-19.
T88 9797-9931 Sentence denotes Similarly, MSC-EVs have also exhi-bited inhibitory activity on the hemagglutination of avian, swine, and human influenza viruses (44).
T89 9932-10052 Sentence denotes Likewise, MSC-Exos lowered the death rate in H7N9 patients without any toxic effects during follow-up examinations (45).
T90 10053-10158 Sentence denotes In addition, these exosomes consist of adhesion molecules that accurately guide them to the injured site.
T91 10159-10393 Sentence denotes The usage of the exosomes may be preferred to the MSCs, since they can easily cross the blood-brain barrier, are inexpensive, and cannot undergo independent self-renewal, hence preventing adverse consequences, such as tumor formation.
T92 10394-10524 Sentence denotes In this pandemic situation, MSC-Exos may be considered as a good treatment option to alleviate the effect of SARS-CoV-2 infection.
T93 10526-10588 Sentence denotes CURRENT CLINICAL TRIALS OF STEM CELL-BASED THERAPY IN COVID-19
T94 10589-10678 Sentence denotes Of late, stem-cell-based studies in the treatment of COVID-19 have been gaining momentum.
T95 10679-10813 Sentence denotes The efficiency and safety of usage of exosomes that had been obtained from BM-MSCs was recently tested on 24 SARS-CoV-2 patients (46).
T96 10814-10863 Sentence denotes These patients exhibited moderate to severe ARDS.
T97 10864-11007 Sentence denotes When the exosomes were introduced into the patients, there were no side effects, and patients improved in clinical status and oxygenation (46).
T98 11008-11213 Sentence denotes In a similar study, patients treated with MSCs showed a remark-able improvement in pulmonary function, higher levels of peripheral lymphocytes, and a reduction in the cells that trigger the cytokine storm.
T99 11214-11339 Sentence denotes Interestingly, the MSCs did not exhibit ACE2 or TMPRSS2 expression, showing that they may not be infected with COVID-19 (47).
T100 11340-11448 Sentence denotes Several clinical trials are in the pipeline for usage of stem cells for the treatment of COVID-19 (Table 2).
T101 11449-11628 Sentence denotes Wharton’s jelly-derived MSCs (WJ-MSCs), which have been used in various studies based on stem-cell therapy and trials, are in progress for their usage for COVID-19 treatment (48).
T102 11629-11759 Sentence denotes Moreover, adipose tissue-derived AD-MSCs have been used in a few studies in various doses and protocols for COVID-19 therapy (49).
T103 11760-11849 Sentence denotes Likewise, a novel trial includes inhalation of MSC-Exos for alleviation of symptoms (50).
T104 11850-11951 Sentence denotes In addition, MSCs from dental pulp (51) and olfactory mucosa (52) were administered in various doses.
T105 11952-12199 Sentence denotes MSCs in the clinical trials are predominantly administered intravenously; i.v. injection and, in some studies, MSCs have been given as adjuvant therapy in addition to drugs like oseltamivir, hormones, hydroxychloroquine, and azithromycin (53, 54).
T106 12200-12281 Sentence denotes These trials reveal promising new routes for the battle against COVID-19 (55-94).
T107 12283-12300 Sentence denotes FUTURE DIRECTIONS
T108 12301-12416 Sentence denotes Stem cells have been studied extensively for their ability to regenerate and for the treatment of various diseases.
T109 12417-12562 Sentence denotes Recently, we devised an improved protocol for the isolation of urine-derived stem cells and their further differentiation into immune cells (95).
T110 12563-12679 Sentence denotes Moreover, our research group promoted the hematopoietic differentiation of hiPSCs using a novel small molecule (96).
T111 12680-12814 Sentence denotes At the advent of COVID-19, it has become mandatory to discover therapeutic strategies that are easily reproducible and cost effective.
T112 12815-12914 Sentence denotes Drugs currently available for the treatment of COVID-19 include ones that target viral replication.
T113 12915-13088 Sentence denotes These drugs include camo-stat mesylate, which is involved in the inhibition of viral fusion to the cell membrane, and favipiravir and remdesivir, which are anti-viral drugs.
T114 13089-13269 Sentence denotes However, because the cytokine storm is found predominantly in COVID-19 patients, it is essential to consider drugs that inhibit viral replication while treating the cytokine storm.
T115 13270-13342 Sentence denotes Hence, MSC-Exos may be appropriate therapeutic agents for COVID-19 (97).
T116 13343-13484 Sentence denotes MSCs can be more advantageous than other anti-inflammatory agents, because they can provide immunomodulatory effects based on the host cells.
T117 13485-13721 Sentence denotes In addition to these effects, MSCs can prevent fibrosis of tissues, enable reversal of lung dysfunction, and aid in the regeneration of damaged tissue, which can be significantly beneficial for COVID-19-associated organ damage (98, 99).
T118 13722-13884 Sentence denotes Because the healing properties of the MSCs can be primarily attributed to the secretomes or exosomes, using them may be more effective than using MSCs themselves.
T119 13885-14021 Sentence denotes Exosomes can be mass-produced, administered systematically with minimaltoxicity, and be able to reach the cell targets more efficiently.
T120 14022-14142 Sentence denotes In addition to their inherent immunomodulatory potential, the MSC-Exos can also be used as a drug-delivery system (100).
T121 14143-14336 Sentence denotes MSC-Exos can be modified in vivo to release exosomes that have a higher immunomodulatory potential (101) and can be cultured using various cytokines to exhibit an anti-inflammatory state (102).
T122 14337-14483 Sentence denotes Although MSC-Exos appear to be promising thera-peutic agents for COVID-19, more experimental research is necessary for them to be used clinically.
T123 14484-14605 Sentence denotes Moreover, it is es-sential to optimize the protocols for storage and isolation of MSC-Exos for the treatment of COVID-19.
T124 14606-14754 Sentence denotes It is also imperative to do experiments to understand the underlying mechanisms of COVID-19 in order to optimize MSC-Exo therapy for treatment (97).
T125 14755-14874 Sentence denotes Further, it is also essential to find the optimum dosage, route of administration, and treatment schedule for MSC-Exos.
T126 14875-15024 Sentence denotes Hence, since MSCs are more widely studied in these aspects than are MSC-Exos, they are predominantly preferred in clinical trials for COVID-19 (103).
T127 15026-15044 Sentence denotes CONCLUDING REMARKS
T128 15045-15098 Sentence denotes COVID-19 has invoked frenzy in individuals worldwide.
T129 15099-15206 Sentence denotes The unceasing increase of infection and death has halted the lives of the citizens of countries everywhere.
T130 15207-15322 Sentence denotes Hence, it is important to discover novel therapeutic platforms and productive measures without further delay (104).
T131 15323-15513 Sentence denotes The therapies produced must be easily reproducible and available in large quantities so that enough bioactive molecules will be available for all indivi-duals who have succumbed to COVID-19.
T132 15514-15609 Sentence denotes MSCs and MSC-Exos can be used for their immunomodulatory effects in indi-viduals with COVID-19.

2_test

Id Subject Object Predicate Lexical cue
32731913-32278175-8028451 147-148 32278175 denotes 1
32731913-32336317-8028452 267-268 32336317 denotes 2
32731913-32250385-8028453 399-400 32250385 denotes 3
32731913-32360420-8028454 526-527 32360420 denotes 4
32731913-32360909-8028455 779-780 32360909 denotes 5
32731913-32562911-8028456 1073-1074 32562911 denotes 6
32731913-32562911-8028457 1369-1370 32562911 denotes 6
32731913-31981224-8028458 1527-1528 31981224 denotes 7
32731913-32161940-8028459 1870-1871 32161940 denotes 8
32731913-32299202-8028460 2032-2034 32299202 denotes 10
32731913-20559327-8028461 2319-2321 20559327 denotes 11
32731913-32299202-8028462 2458-2460 32299202 denotes 10
32731913-32278175-8028463 2706-2707 32278175 denotes 1
32731913-32299202-8028464 2954-2956 32299202 denotes 10
32731913-32324968-8028465 3502-3504 32324968 denotes 12
32731913-32347747-8028466 3728-3730 32347747 denotes 13
32731913-32324968-8028467 4385-4387 32324968 denotes 12
32731913-27769637-8028468 5273-5275 27769637 denotes 17
32731913-25529339-8028469 5277-5279 25529339 denotes 18
32731913-19172693-8028470 5514-5516 19172693 denotes 19
32731913-18371435-8028471 5690-5692 18371435 denotes 20
32731913-20436665-8028472 5777-5779 20436665 denotes 21
32731913-20382885-8028473 6111-6113 20382885 denotes 22
32731913-17932421-8028474 6115-6117 17932421 denotes 23
32731913-26294919-8028475 6286-6288 26294919 denotes 24
32731913-32283815-8028476 6731-6733 32283815 denotes 25
32731913-28736264-8028477 6907-6909 28736264 denotes 26
32731913-32371362-8028478 7121-7123 32371362 denotes 27
32731913-29523213-8028479 7465-7467 29523213 denotes 28
32731913-32283815-8028480 7869-7871 32283815 denotes 25
32731913-28620221-8028481 8133-8135 28620221 denotes 29
32731913-30526632-8028482 8276-8278 30526632 denotes 30
32731913-30058282-8028483 8565-8567 30058282 denotes 31
32731913-30328799-8028484 8660-8662 30328799 denotes 32
32731913-30190615-8028485 8777-8779 30190615 denotes 33
32731913-28090688-8028486 8937-8939 28090688 denotes 34
32731913-27115513-8028487 9060-9062 27115513 denotes 35
32731913-31407157-8028488 9146-9148 31407157 denotes 36
32731913-30378105-8028489 9390-9392 30378105 denotes 38
32731913-31887849-8028490 9394-9396 31887849 denotes 39
32731913-29277503-8028491 9622-9624 29277503 denotes 40
32731913-26231094-8028492 9626-9628 26231094 denotes 41
32731913-28936747-8028493 9695-9697 28936747 denotes 42
32731913-30651737-8028494 9720-9722 30651737 denotes 43
32731913-29378639-8028495 9927-9929 29378639 denotes 44
32731913-32380908-8028496 10809-10811 32380908 denotes 46
32731913-32380908-8028497 11003-11005 32380908 denotes 46
32731913-32257537-8028498 11335-11337 32257537 denotes 47
32731913-32197458-8028499 12558-12560 32197458 denotes 95
32731913-32131506-8028500 12675-12677 32131506 denotes 96
32731913-31938077-8028501 13338-13340 31938077 denotes 97
32731913-32661867-8028502 13717-13719 32661867 denotes 99
32731913-32622963-8028503 14137-14140 32622963 denotes 100
32731913-32616467-8028504 14331-14334 32616467 denotes 102
32731913-31938077-8028505 14750-14752 31938077 denotes 97
32731913-32456070-8028506 15019-15022 32456070 denotes 103
32731913-32271461-8028507 15317-15320 32271461 denotes 104