PMC:7464876 / 5954-7131
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7464876","sourcedb":"PMC","sourceid":"7464876","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7464876","text":"In addition to the mature virions, HBV produces and releases subviral particle types—in particular, noninfectious, spherical empty envelope subviral particles (SVPs) [26]. These particles, also referred to as hepatitis B surface antigen (HBsAg) particles, are secreted in extreme surplus compared to the infectious HBV particles and are thought to act as decoys to the immune system [26,27]. The viral S envelope protein alone is sufficient for the production of spherical SVPs with diameters of about 22 nm that are formed by self-assembly of about 100 S molecules in the ER-Golgi intermediate compartment (ERGIC) and are released via the constitutive pathway of secretion [28,29]. Remarkably, the budding and secretion of spherical SVPs does neither require N146-linked glycans [11,13,14] nor ESCRTs [21,23], implicating that HBV exploits distinct cellular pathways and host factors to release its particle types. Besides spherical SVPs, HBV-infected hepatocytes also secrete filamentous SVPs with 22-nm diameters and variable lengths. Unlike spheres, filaments are characterized by a large content of the L envelope protein and exploit ESCRT functions for cell exit [21,23].","tracks":[{"project":"2_test","denotations":[{"id":"32806600-29675010-20296176","span":{"begin":387,"end":389},"obj":"29675010"},{"id":"32806600-32017353-20296177","span":{"begin":678,"end":680},"obj":"32017353"},{"id":"32806600-29604477-20296178","span":{"begin":781,"end":783},"obj":"29604477"},{"id":"32806600-24899172-20296179","span":{"begin":784,"end":786},"obj":"24899172"},{"id":"32806600-17551004-20296180","span":{"begin":803,"end":805},"obj":"17551004"},{"id":"32806600-26719264-20296181","span":{"begin":806,"end":808},"obj":"26719264"},{"id":"32806600-17551004-20296182","span":{"begin":1170,"end":1172},"obj":"17551004"},{"id":"32806600-26719264-20296183","span":{"begin":1173,"end":1175},"obj":"26719264"}],"attributes":[{"subj":"32806600-29675010-20296176","pred":"source","obj":"2_test"},{"subj":"32806600-32017353-20296177","pred":"source","obj":"2_test"},{"subj":"32806600-29604477-20296178","pred":"source","obj":"2_test"},{"subj":"32806600-24899172-20296179","pred":"source","obj":"2_test"},{"subj":"32806600-17551004-20296180","pred":"source","obj":"2_test"},{"subj":"32806600-26719264-20296181","pred":"source","obj":"2_test"},{"subj":"32806600-17551004-20296182","pred":"source","obj":"2_test"},{"subj":"32806600-26719264-20296183","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93a3ec","default":true}]}]}}